The invention relates to the technical field of
traditional Chinese medicine research, in particular to a quality marker for preventing and treating
kidney-
yang deficiency of a medicinal and edible formula composition as well as a preparation method and application of the quality marker. The medicinal and edible formula composition is prepared from the following raw materials in parts by weight: 1-2 parts of cortex cinnamomi, 6-8 parts of fructus momordicae, 2-4 parts of
pericarpium citri reticulatae, 2-4 parts of rhizoma zingiberis, 8-10 parts of radix
ginseng, 29-31 parts of radix astragali, 4-6 parts of radix glycyrrhizae preparata and 14-16 parts of poria cocos. The
mass markers comprise [6]-isoshogaol, 3, 5, 6, 7, 8, 3 ', 4'-heptamethoxyl flavone, 1-
dehydrogenation-[8]-zingiberendione, 6-methyl zingiberendiol,
nobiletin, peterolide and the like. The
ginseng formula for regulating the middle warmer is reasonably added and subtracted, so that the
traditional Chinese medicine composition is applied to prevention and treatment of the
kidney-
yang deficiency syndrome, and a new application prospect is given to the classic famous formula. Meanwhile, on the basis of spectrum-effect association research, a quality marker group associated with the
kidney-
yang deficiency effect is screened and established for the first time, and scientific, accurate, stable and controllable product quality of the medicinal and edible formula composition can be achieved.