17 results about "Senna" patented technology

The invention discloses a preparation method of a composition for dispelling effects of alcohol and protecting liver, and belongs to the technical field of traditional Chinese medicines. The liver protection composition is prepared from the following raw materials: gynostemma pentaphyllum powder, honeysuckle flower powder, hawthorn fruit powder, green tea powder, lotus leaf powder, cassia seed powder and folium sennae powder. The preparation method of the liver protection composition comprises the following steps: enzymolysis, fermentation and freeze-drying. According to the invention, through an extraction method of firstly performing enzymolysis and then performing fermentation, various different types of active effective components are reserved as far as possible. Tests prove that the finally obtained composition has a statistical therapeutic effect on alcoholic liver injury.

The invention discloses an algae species with both efficient denitrification and high free ammonia tolerance and application thereof. The invention provides an inflatedfruit senna herb which is preserved in China General Microbiological Culture Collection Center (CGMCC) on December 11, 2024, and the preservation number of the inflatedfruit senna herb is CGMCC No.46280. The inflatedfruit senna herb has the advantages that the inflatedfruit senna herb is preserved in the China General Microbiological Culture Collection Center (CGMCC); the inflatedfruit senna provided by the invention has efficient assimilation removal capability on NO3 <->-N, NO2 <->-N and NH4 < + >-N, and has relatively strong tolerance on high-concentration free ammonia (FA). A bacterial-algae symbiotic system is constructed by the inflator and activated sludge, and is coupled with a dynamic membrane process, so that the denitrification efficiency of the nitrogen-containing wastewater can be remarkably improved, the addition of exogenous organic matters, the aeration energy consumption and the N2O emission are reduced, meanwhile, high-value microalgae biomass is obtained, and efficient, stable and resourceful treatment of the nitrogen-containing wastewater is realized.

The invention relates to hair conditioning compositions with a combability-improving effect, containing cetyl palmitate in combination with a conditioning agent selected from cationized polygalactomannans from Senna spp., in particular from Senna tora or Senna obtusifolia, and ethylenediamine-N,N'-disuccinic acid (salts) or at least one alkali metal salt or ammonium salt of this acid.

The application relates to the technical field of animal model construction, in particular to a construction method and application of a spleen-kidney yang deficiency syndrome ovarian reserve function decline animal model. The construction method comprises the following steps: a model group animal is subjected to modeling by adopting the method of senna leaf water decoction gavage and hydrocortisone and cyclophosphamide injection, and a spleen-kidney yang deficiency syndrome ovarian reserve function decline animal model is obtained. In the application, the three of senna leaf, hydrocortisone and cyclophosphamide are used in synergy to administer the animal model, and the complex syndrome of the clinical spleen-kidney yang deficiency type DOR is accurately reproduced, and modern scientific basis is provided for the theories of traditional Chinese medicine such as the same treatment for different diseases.

The invention discloses a Chinese medicine suppository for treating acute pancreatitis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The Chinese medicine suppository comprises the following raw materials in parts by weight: 28-35 parts of rhubarb, 28-32 parts of knotweed, 5-12 parts of senna, 5-15 parts of dandelion, 5-12 parts of radix scutellariae, 5-12 parts of radix scutellariae, 5-15 parts of scutellariae, 5-15 parts of scutellariae, 5-15 parts of borneol and 1-2 parts of borneol. Animal experiments and clinical practice confirm that the Chinese medicine suppository prepared by the present invention can significantly alleviate the clinical symptoms and serum indicators of patients with acute pancreatitis, provide new therapeutic drugs and selections for treating acute pancreatitis, and have the value of extensive promotion and application.

The invention provides Chinese herbaceous peony soup and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations, the preparation method comprises the following steps: S1, mixing 15-17 parts by weight of coptis chinensis, 2-2.5 parts by weight of folium sennae, 13-15 parts by weight of scutellaria baicalensis and 1.7-2 parts by weight of cinnamon, crushing to obtain a mixture I, decocting twice, and combining the filtrates of the two times to obtain an extracting solution I; s2, 25-28 parts by weight of radix paeoniae alba, 6-7 parts by weight of fructus aurantii immaturus, 5-6 parts by weight of rhizoma cyperi and 2.6-3.2 parts by weight of cortex cinnamomi are mixed and smashed, a second mixture is obtained and decocted twice, filtrate obtained after two times of decoction is combined, and a second extracting solution is obtained; s3, 12-14 parts by weight of angelica sinensis, 4-5 parts by weight of honey-fried licorice roots and 1-1.2 parts by weight of cinnamon are mixed and smashed, a third mixture is obtained and decocted twice, filtrate obtained after two times of decoction is combined, and a third extracting solution is obtained; s4, uniformly mixing the extracting solution I, the extracting solution II and the extracting solution III, and concentrating to obtain the Chinese herbaceous peony soup. Under the condition of fixed dosage, the blood concentration can be effectively improved, and the drug effect is further enhanced.

A method for constructing a diarrhea model of experimental mice using a combined medicament, characterized in that: using mice as the modeling object, after adaptive feeding, the combined medicament is given by gavage once a day for 7 consecutive days. After the gavage each day, the mice are placed in a breeding cage lined with filter paper, and the diarrhea situation is observed 4 hours after gavage; wherein the combined medicament is prepared by extracting senna leaf and fibraurea recisa. A method for constructing a diarrhea model of experimental mice using a combined medicament has good repeatability in the construction method, is simple and convenient, has good compliance of mice during the modeling process, high compliance, good living state, no restlessness phenomenon, small weight loss, long duration after modeling, which can be up to more than 28 hours, and the loose stool rate of mice is relatively high, comparable to that of the conventional senna leaf modeling, but the mice have better tolerance compared with the traditional senna leaf modeling. During the modeling process, the weight loss of mice is relatively small, and the modeling success rate is improved.

This invention discloses a method for extracting, separating, and purifying senna-based alkaloids from *Trionyx sinensis*. The method employs an alcohol-water system for extraction from *Trionyx sinensis* raw materials. Based on the properties of alkaloids, a stepwise acid-base precipitation method is used to obtain crude senna-based alkaloids. Molecular imprinting technology is then used to further purify the crude senna-based alkaloids. A high-purity senna-based alkaloid product with a purity greater than 98% can be prepared by a single recrystallization. Compared with traditional extraction and refining processes, this method effectively avoids repeated material transfers, shortens production time, and reduces solvent consumption. Compared with traditional separation and purification methods, it effectively shortens the process route, increases the yield of active ingredients, and reduces the production cycle.

The invention provides a peony decoction and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: S1, by weight, mixing 15-17 parts of coptis root, 2-2.5 parts of senna leaf, 13-15 parts of scutellaria baicalensis and 1.7-2 parts of cinnamon bark, crushing to obtain a mixture, decocting twice, combining the two filtrates, and obtaining an extract; S2, by weight, mixing 25-28 parts of white peony root, 6-7 parts of immature bitter orange, 5-6 parts of Cyperus rotundus and 2.6-3.2 parts of cinnamon bark are mixed and crushed to obtain a second mixture, which is decocted twice and the two filtrates are combined to obtain a second extract; S3, by weight, 12-14 parts of Angelica sinensis, 4-5 parts of Radix Glycyrrhizae Preparata and 1-1.2 parts of cinnamon bark are mixed and crushed to obtain a third mixture, which is decocted twice and the two filtrates are combined to obtain a third extract; S4, the first extract, the second extract and the third extract are mixed and concentrated to obtain Shaoyao Decoction. The present invention can effectively increase blood drug concentration and thus enhance drug efficacy in the case of a fixed dose.

The invention provides a method for assisting MALDI-MS (Matrix Assisted Laser Desorption / Ionization Mass Spectrometry) to analyze small molecular compounds in positive and negative ion modes by taking zinc sulfide as a substrate and loading a composite nano material (ZnS at Au) of gold nanoparticles as a matrix. The optimized ZnS (at) Au material can realize high-sensitivity comprehensive analysis of bioactive small molecules in traditional Chinese medicinal materials, and panoramic research is carried out on the reprogramming effect of the ZnS (at) Au material and tumor cell metabolism. Through comprehensive analysis of small molecule fingerprints of 11 Chinese herbal medicine extracts (including ailanthus altissima, walnuts, rheum officinale, madder, polygonum multiflorum, polygonum cuspidatum, semen cassiae, folium sennae, aloe, salvia miltiorrhiza and lithospermum) containing anthraquinone substances in a positive and negative double-ion mode, totally 12 types and 50 types of small molecule compounds are preliminarily identified; the method can provide powerful technical support for traditional Chinese medicine active ingredient research and new medicine development.

The application discloses a breathable massage health-care cup and a preparation method thereof, and relates to the technical field of health-care bras. The cup comprises a cup pad and plant particles fixed to the inner surface of the cup pad. The plant particles are one or more of Zanthoxylum bungeanum seeds, chia seeds or senna seeds. The breathable massage health-care cup and the preparation method thereof are provided, the plant particles with health-care effects are implanted into the cup, the multiple health-care effects of acupoint massage, meridian dredging, sterilization and itch relief on the breast are realized, the breathability and comfort of the cup are improved, and the blank of the realization mode of the health-care function of the existing technology in the underwear is filled.

The invention discloses a traditional Chinese medicine composition for treating wound ulcer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The prescription is composed of 5-15 parts of slender gouania root, 5-10 parts of maggot, 0.01-0.5 part of venenum bufonis, 5-10 parts of American cockroach, 5-15 parts of abelmoschus manihot, 3-9 parts of rheum officinale, 1-5 parts of safflower and 5-15 parts of fructus chebulae, the dosage form is external ointment, powder, oil, liquid preparation and the like, the traditional Chinese medicine composition is remarkable in curative effect, the cure rate can reach 85% or above after 2 months of treatment, the average healing time is shortened by 40 days or above, safety is high, and the traditional Chinese medicine composition is suitable for clinical application. The traditional Chinese medicine composition is suitable for chronic intractable wound ulcer such as diabetic foot ulcer, and the problem of poor treatment effect in the prior art is solved.

The application discloses a preparation method of a uric acid reducing composition and application thereof, and belongs to the technical field of traditional Chinese medicines. The preparation method of the uric acid reducing composition comprises the following steps: alcohol extraction is performed on raw material liquid obtained by mixing smilax glabra powder, adenosma powder, dioscorea opposita powder, green tea powder, senna leaf powder and grass cassia powder and water, and then the extract is dissolved in water and subjected to anaerobic fermentation by using microorganisms, so that the fermentation liquid is obtained after concentration, freeze-drying and other steps. The multiple traditional Chinese medicines are used in cooperation and have been verified to have the uric acid reducing effect. Further, the steps of performing alcohol extraction on the traditional Chinese medicines first and then performing fermentation treatment on the obtained alcohol extract make the finally prepared composition have better uric acid reducing effect. Moreover, the preparation method is simple and easy to implement, safe and environment-friendly, has important significance for improving or treating hyperuricemia, and has a wide application prospect.

The application provides a VIGS-based sida gene silencing system and method, and belongs to the technical field of genetic engineering. The application provides a recombinant gene silencing vector suitable for sida VIGS, which is based on a BSMV_pCaBS-gamma-LIC carrier as a basic skeleton carrier, wherein a silencing fragment of a target gene of sida is connected, and the silencing fragment is transformed into agrobacterium with a BSMV alpha carrier and a BSMV beta carrier respectively, and then is used to infect nicotiana benthamiana to proliferate virus liquid; and then, based on a mechanical friction method, the sida leaf is infected to complete the silencing of the target gene. The VIGS provided by the application can successfully silence the gene, and provides a feasible method for studying the gene function of sida; the method can be implemented in a laboratory, and does not need in vitro transcription and p2 laboratory extraction, thereby saving a large amount of cost; meanwhile, the yield of virus particles is improved, and the success rate and efficiency of silencing are improved.

The present invention discloses a method for forming an animal model of spleen yang deficiency syndrome based on a decoction of coptis chinensis, comprising taking male SD rats as model animals and adaptively raising them for several days; gavage-feeding the model animals with the decoction of coptis chinensis; then placing the model animals in a cold environment for 60 to 90 minutes for cold stimulation; after the cold stimulation is completed, removing the model animals and placing them in a room temperature environment for normal feeding; and continuously treating them for multiple days to obtain an animal model of spleen yang deficiency syndrome. The present invention uses a decoction of coptis chinensis combined with cold stimulation in a cold environment to induce spleen yang deficiency syndrome in rats. The high-dose decoction of coptis chinensis is a bitter and cold medicine, which can have a similar effect on spleen yang damage caused by the bitter and cold purgative effects of rhubarb and senna. At the same time, the coptis chinensis is treated at low temperatures before gavage, which further aggravates its cold effect. Therefore, although the coptis chinensis has no purgative effect, its enhanced cold property can still contribute to the formation of spleen yang deficiency syndrome.

The invention discloses a traditional Chinese medicine extract composition as well as a preparation method and application thereof, and the traditional Chinese medicine extract composition comprises the following components in percentage by dry matter content of 100%: 1-10% of sennoside A, 1-10% of sennoside B, 1-10% of magnolol, 1-10% of honokiol, 30-50% of paeoniflorin, 5-10% of albiflorin, 0.1-0.5% of corydaline and 0.1-0.5% of tetrahydropalmatine. The raw medicinal materials comprise mangnolia officinalis, folium sennae, radix paeoniae alba (or radix paeoniae rubra) and rhizoma corydalis (or vinegar-processed rhizoma corydalis). The composition disclosed by the invention is rigorous in traditional Chinese medicine compatibility structure, ingenious in formula and unique in formula; the processing technology is advanced, green, environment-friendly and free of pollutants, medicine compound processing, medicine residue ecological utilization, quality control and reasonable development are integrated, the utilization rate is high, the purpose of the extract is special, and the market application prospect is wide.

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for inhibiting lung cancer and application thereof.The traditional Chinese medicine composition is prepared from 15 + / -1 parts of edible tulip, 30 + / -1 parts of turtle shell, 10 + / -1 parts of spina gleditsiae, 30 + / -1 parts of semen coicis, 15 + / -1 parts of thunberg fritillary bulb, 20 + / -1 parts of salvia chinensis, 15 + / -1 parts of radix ophiopogonis, 30 + / -1 parts of hairyvein agrimony and 20 + / -1 parts of dendrobe. The traditional Chinese medicine composition for inhibiting lung cancer has a certain inhibiting effect on lung cancer transplantation tumor. The traditional Chinese medicine composition for inhibiting the lung cancer is excellent in high-dose tumor inhibition effect and obvious in dose-effect relationship, and has a synergistic effect when being combined with chemotherapeutic drugs (such as cis-platinum).