241 results about "Deficiency syndrome" patented technology

The present invention relates to a kit and an intervenously administrable preparation, both, with a signal transmitter precursor, an enhancer of precursor uptake, and an inhibitor of neurotransmitter reuptake or signal transmitter catabolism. The kit also contains an appropriate swab for obtaining oral cells suitable for allelic analysis. The intervenous formulation contains similar materials and, in some cases, ethanol. Either the kit composition or the intervenous formulation may be used as guided by a subjects allelic analysis. Collections of particular alleles, especially those relating to neural system are comprehensible in terms of likelihood of success in the administration of an interveinous formulation or ingestion of components of the subject kit.

The invention relates to a preparation method of tryptanthrin compound and a new application of tryptanthrin compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor, in particular to an application of tryptanthrin compound in preparing IDO inhibitor and in preparing medicine for preventing and/or treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO. The structure of the tryptanthrin compound is shown in formula A in the description, wherein R1 and R2 are respectively and independently selected from hydrogen, nitryl, C1 to C5 alkyl, halogen or piperazinyl. The tryptanthrin compound can be used as an IDO inhibitor with high activity and is used for treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO such as tumor, cancer, Alzheimer disease, autoimmune disease, cataract, mental block, tristimania, anxiety neurosis, acquired immure deficiency syndrome (AIDS) and other serious diseases, and as a medicinal resource which is very difficult to get, the tryptanthrin compound has good potential on researching and developing new medicine.

The invention relates to a traditional Chinese medicine for treating lung-spleen qi deficiency syndrome of chronic obstructive pulmonary disease (COPD), which is used for effectively solving the medication problem of COPD. The traditional Chinese medicine is prepared from the following bulk drugs: 12-20g of astragalus root, 12-20g of solomonseal, 6-12g of pilose asiabell root, 9-15g of rhizoma atractylodis macrocephalae, 9-15g of Tuckahoe, 6-12g of Thunberg fritillary bulb, 9-15g of lumbricus, 6-12g of officinal magnolia bark, 9-15g of dried tangerine peel, 6-12g of aster tataricus, 15-30g ofJapanese ardisia herb and 6-12g of epimedium. The preparation method of the traditional Chinese medicine comprises the following steps: mixing the rhizoma atractylodis macrocephalae with the dried tangerine peel, steaming and decocting with water, collecting volatile oil, and filtering water decoction obtained after steaming and decocting to obtain first decoction; refluxing the officinal magnolia bark, the aster tataricus and the Thunberg fritillary bulb with ethanol, filtering, recovering the ethanol and concentrating to obtain first extract; decocting dregs of the rhizoma atractylodis macrocephalae and the dried tangerine peel, dregs of the officinal magnolia bark, the aster tataricus and the Thunberg fritillary bulb as well as the astragalus root, the solomonseal, the pilose asiabell root, the lumbricus, the Japanese ardisia herb, the epimedium and the Tuckahoe with water, filtering the decoction, mixing the filtrate with the first decoction, and concentrating the mixed decoction to obtain second extract; mixing the second extract with the first extract, and adding dextrin to obtain first dry powder; grinding and mixing the volatile oil and dextrin, and drying to obtain seconddry powder; and evenly mixing the second dry powder with the first dry powder, and adding honey to form granules. The traditional Chinese medicine has a scientific formula, and is easy for production.

The invention relates to the application of a prunus mume extract, and belongs to the field of biomedicines. The extract is obtained by extracting prunus mume with organic solvent, performing liquid extraction with organic solvent, and optionally refining; and can be used for preparing anti-HIV and antibacterial drugs. The inventive drugs have the advantages of high bioavailability of plant, good therapeutic effect, easily accessible raw material, and good safety. Researches and developments on the pharmacological activity of the extract are of great significance, and the extract has wide application prospect.

The invention belongs to the field of pharmaceutical chemistry and relates to a 1, 2, 3-triazole compound, comprising 4-(2-bromophenyl)-1H-1, 2, 3-triazole and 4-(2-chlorphenyl)-1H-1, 2, 3-triazole. The result of an inhibitory activity test of indoleamine 2, 3-dioxygenase indicates that the disclosed 1, 2, 3-triazole compound used as the indoleamine 2, 3-dioxygenase inhibitor has broad prospect of application and can be applied to the treatment of diseases with indoleamine 2, 3-dioxygenase-mediated tryptophan metabolic pathway pathological characteristics, including cancer, AIDS (Acquired Immure Deficiency Syndrome), Alzheimer disease, tristimania, cataract and other critical diseases.

The invention provides a walnut shell extract and anti-HIV pharmaceutical application thereof, in particular to relating to an extraction and separation method of effective parts of a walnut shell and medical application thereof. The walnut shell extract is prepared by soaking the crushed walnut shell with alkaline solution, extracting, performing alcohol precipitation, recovering a solvent and drying. The obtained walnut shell extract can effectively inhibit HIV (human immunodeficiency virus) and is expected to be developed into a drug for preventing and treating AIDS (acquired immure deficiency syndrome). Pharmacodynamics test results show that the walnut shell has in vitro anti-HIV-1 activity, and therapeutic index thereof is more than 400.

The invention provides gynostemma pentaphylla liver protecting and nourishing health-care tea which is characterized by comprising the following raw materials in parts by weight: 10-50 parts of gynostemma pentaphylla, 10-20 parts of glossy privet fruits, 10-20 parts of isatis roots, 10-20 parts of radix curcumae, 10-20 parts of salviae miltiorrhizae, 10-20 parts of poria cocos, 10-20 parts of notopterygium roots, 10-20 parts of capillary artemisia, 10-20 parts of radices trichosanthis, 10-20 parts of Scutellaria baicalensis, 10-20 parts of radix paeoniae alba, 10-20 parts of jasmine, 10-20 parts of loranthus parasiticus and 10-20 parts of schisandra chinensis, wherein gynostemma pentaphylla has the functions of reducing blood fat, blood pressure and blood sugar, calming, hypnotizing, resisting stress, ulcer and fatigue, prolonging lifetime of cells, enhancing appetite, enhancing resistance, promoting bowel movement, calming panting and suppressing cough, eliminating haemorrhoids, reducing weight, treating deficiency syndrome, inhibiting formation of gall-stone, preventing and treating side effects of glucocorticoid, preventing aging and the like. The tea has very high health-care effect to treat various liver diseases such as chronic hepatitis, forepart hepetocirrhosis, fatty liver, alcoholic liver and medicamentous liver lesion, and is strong in pertinence.

The invention provides a method for manufacturing animal model of the qi-deficiency and blood-stasis disease, which particularly comprises the following steps: manufacturing an animal model of qi-deficiency syndrome by exhaustive exercise and/or basic food intake control and/or large dose of propranolol administration; and establishing a cerebral ischemia qi-deficiency and blood-stasis disease model by recovering blood supply of an artery after the qi-deficiency syndrome animal model blocks the artery in the brain.

The invention discloses a homologous blood glucose reduction resistant composition, and belongs to the technical field of foods and health-care products. The composition comprises the following components in percentage by weight: 20-40% of an astragalus extract, 10-30% of a momordica charantia extract, 10-40% of common yam rhizome raw powder, 10-50% of inulin and 10-40% of pig pancreas powder. The composition disclosed by the invention can improve the own immunity of a human body and recover balance of environment in the human body, fundamentally assists improvement of the physiological functions of diabetes and recover the normal functions of the pancreas islet beta cell to realize the effect of treating both symptoms and root causes, and eliminates deficiency syndrome of the lung, spleen and kidney of the diabetes and prevents and alleviates diabetic complications.

The invention discloses a crystal form, preparation and application of a 4'-substituted nucleoside compound I with the structure shown in the description, as well as salts, prodrugs and composition ofthe compound. An animal pharmacokinetic study result proves that effective drug concentrations of compounds Ia and Ig in HIV (human immunodeficiency virus) target cells and PBMC (peripheral blood monouclear cells) can still effectively inhibit HIV replication after 7 days and 5 days respectively. Therefore, the compound I can serve as a long-acting drug for preventing and treating AIDS (acquiredimmune deficiency syndrome). R is selected from acetenyl, azide and cyanogroup; X is selected from hydrogen and fluorine; B is selected from B1 and B2.

Methods and kits for assessing severity index for alcohol abuse, drug abuse, and other reward deficiency syndromes. It has been discovered that a multifaceted non-specific RDS behaviors should be considered as the true “reward” phenotype (endophenotype) instead of a single subset RDS behavior such as alcoholism. In an embodiment of the present invention, it has been discovered that there are at least eleven risk alleles associated with ten candidate genes. The methods and kits of the present invention satisfy the need to classify patients at genetic risk for drug/alcohol seeking behavior prior to or upon entry to residential and or non-residential chemical dependency and pain programs.

The invention discloses a traditional Chinese medicinal preparation for treating IgA nephropathy due to deficiency of both qi and yin. The IgA nephropathy due to deficiency of both qi and yin belongs to the category of hematuria, edema, kidney wind pathogen, deficiency work and so on in Chinese medicine. The IgA nephropathy due to deficiency of both qi and yin belongs to deficiency syndrome, is characterized in deficiency of both spleen and kidney, deficiency of kidney-yin, and water failing to nourish wood, and can cause deficiency of liver-yin. The traditional Chinese medicinal materials with effects of tonifying liver, invigorating qi, invigorating spleen and kidney, and nourishing yin and blood, including Ilex cornuta bark, Parochetus communis, Panax pseudo-ginseng, Hypoxis aurea, Astragalus complanatus, Drynaria fortunei, Cypripedium margaritaceum, Herba Lespedezae, Limonium aureum, Solanum torvum and Lysimachia insignis are decocted in water to obtain decoction. According to clinical trails, the total effective rate is up to 97.9%. Therapeutic results show that the traditional Chinese medicinal preparation disclosed by the invention has distinct therapeutic effect on IgA nephropathy due to deficiency of both qi and yin.

The invention relates to a traditional Chinese medicine formula, in particular to a traditional Chinese medicine formula for treating heart qi deficiency and aims to solve the technical problems that the existing medicine for treating the heart qi deficiency has a great side effect, cures the symptoms not the disease, is not scientific in compatibility and is bad in treatment effect. The traditional Chinese medicine formula for treating the heart qi deficiency comprises the following raw materials in parts by weight: 8-12 parts of white ginseng, 8-12 parts of cassia twig, 13-17 parts of mongolian snakegourd, 13-17 parts of allium macrostemon, 8-12 parts of rhizoma pinelliae preparata, 13-17 parts of root of common peony, 13-17 parts of radix ophiopogonis and 3-7 parts of coptis chinensis. The traditional Chinese medicine formula for treating the heart qi deficiency, disclosed by the invention, can effectively improve the cardiac function of a model rat suffering from the heart qi deficiency, promotes recovery of scathing cardiac muscle tissues, adjusts biochemical criterion, and has an excellent treatment effect on the model rat suffering from the heart qi deficiency; as proved by clinical trial, the traditional Chinese medicine formula has a total effective rate of more than 90% in treating the heart qi deficiency, is free from toxic and side effects, and is used in the field of treating heart qi deficiency syndrome.

The invention relates to a traditional Chinese medicine for treating leukemia. The traditional Chinese medicine comprises the components as follows: 150-170 g of buffalo horns, 150-170 g of indigo naturalis, 150-170 g of moutan bark, 110-130 g of scutellaria baicalensis, 150-170 g of oldenlandia diffusa, 150-170 g of astragalus membranaceus, 58-62 g of coptis chinensis, 78-82 g of rehmannia and 18-22 g of American ginseng. A formula of the traditional Chinese medicine also can comprise the components as follows: 10-15 g of honeysuckles, 15-30 g of houttuynia cordata, 6-12 g of cacumen biotae and 3-15 g of folium artemisiae argyi. All the components are combined, functions of benefiting qi and nourishing blood, detoxifying and clearing marrow, cooling and activating blood and enabling juvenile cells to be subjected to differentiation and apoptosis are realized. The traditional Chinese medicine is used for treating poison stasis incubation, a qi-blood deficiency syndrome and various types of acute and chronic leukemia. By means of clinical application for many years, the effect is clear, and the toxic and side effects are small.

The invention relates to a Chinese medicinal capsule preparation for treating coronary heart disease. Angina pectoris belongs to the categories of chest blockage, cardiodynia, precordial pain with cold limbs, angina pectoris and the like of the traditional Chinese medicinal science, is usually caused by hemagglutination, deficiency of both qi and yin and the like, and is related to factors such as exciting emotion, overwork, oldness weak body and the like; the clinical characteristic of the angina pectoris is paroxysmal precordial compressing pain; and the pathogenesis is usually a deficiencysyndrome or an excess syndrome, wherein the excess syndrome is qi stagnation, blood stasis, turbid phlegm and obstruction of heart meridians, and the deficiency syndrome is deficiency of yin, yang, qi and blood, abnormal heart vessels, heart yang deficiency and weak beating of the heart meridians, and stagnant blood. Yin exuberance causes cold, so that stagnation of qi and blood and blood stasis in the heart vessels are caused; and the stagnation of qi and blood and the blood stasis in the heart vessels are direct reasons of the attack of the coronary heart disease. According to the characteristics of diseases such as heart yang deficiency, heart qi deficiency, stagnation of the heart blood and the like and a principle that the tangible blood cannot be quickly generated, intangible gas should be urgently fixed and the blood stasis is removed for promoting tissue regeneration, a method for strengthening the body resistance to eliminate pathogenic factors and activating blood circulation to dissipate the blood stasis is adopted, and the preparation actually has a good effect of treating the disease. Through clinical observation, the preparation has remarkable effects of improving the S-T segment of an electrocardiogram and reducing RT wave change. The preparation has whole prescription compatibility, and has good effects of tonifying qi, activating blood circulation, opening orifices and relieving pain. The preparation is specially developed into capsules; and medicines can be absorbed quickly, has quick response and small side effects, can be taken for a long time, is an ideal medicine for clinically treating the coronary heart disease and the angina pectoris, and is also panacea which is difficultly obtained by patients.

A Chinese patent medicine in the form of capsule for treating exhaustino syndrome is prepared from fresh gecko, fresh lizard and fresh little silver-banded krait through washing, disinfecting, mincing, grinding, mixing with water, freezing under -25 deg.C for 24 hr, thawing in water bath at 37 deg.c, filtering, centrifugal separating, ultra filtering the supernatant, adding beta-dextrin, vacuum freeze drying, grinding, mixing with powdered American ginsen and cordyceps, and loading in capsules. Its advantages is high curative effect.

The invention discloses a method and purpose for constructing a TCM spleen deficiency syndrome AIDS monkey model. Among existing AIDS experimental animals, a monkey resembles to mankind the most. The inventor successfully constructs an HIV infected rhesus monkey TCM spleen deficiency syndrome composite model by two methods respectively. The first method is to carry out gavage with raw rhubarb concentrate to a create spleen deficiency syndrome and then carry out intravenous injection of infected SIV viruses. The second method is to carry out gavage with raw rhubarb concentrate to create the spleen deficiency syndrome after rhesus monkeys is infected with SIV viruses through intravenous injection. Based on the understanding of infection course, pathogenic processes and pathological changes of AIDS viruses in a spleen deficiency syndrome model, research on attack of infected target organs, target tissue and target cells to the immune system, on response of cells of the immune system, on the evolution law of a TCM syndrome, etc., is carried out. The established TCM spleen deficiency syndrome HIV infected monkey composite model in the invention plays an irreplaceable role in studying TCM pathogenesis and evolution of symptomatology of TCM for AIDS and in evaluating drug effects of anti-AIDS TCMs and compounds.

The invention provides a traditional Chinese medicine composition used for treating lung cancer, and a preparation method and applications thereof. The traditional Chinese medicine composition is prepared from, radix stephaniae tetrandrae, bulbus fritillariae thunbergii, herb of spreading hedyotis, herba scutellariae barbatae, scolopendra, herb of black nightshade, rhizoma paridis, rhizoma imperatae, herba agrimoniae, and spica prunellae. The invention also discloses the preparation method. The preparation method comprises following steps: A, traditional Chinese medicine materials are weighed; B, dipping is carried out; C, heating decocting is carried out; D, heating is stopped, an obtained mixture is allowed to stand, and a supernatant 1 is collected; E, purified water is added for a second time of decoction; F, an obtained mixture is allowed to stand, and a supernatant 2 is collected, and is uniformly mixed with the supernatant 1; and G, concentration, subpackaging, and sterilizing are carried out. It is confirmed by animal experiments and clinical experiments that the traditional Chinese medicine composition can be used for therapy of advanced lung cancer and adjuvant therapy of early and middle stage lung cancer, and is capable of clearing heat and dissipating phlegm, detoxifying, softening hardness to dissipate stagnation, relieving swelling; and the traditional Chinese medicine composition also contains auxiliary raw materials capable of activating blood, stopping bleeding, and tonifying deficiency, so that the traditional Chinese medicine composition is capable of clearing phlegm-heat in lung, relieving swelling, avoiding bloody phlegm, and tonifying deficiency syndrome of the lung, and possesses excellent curative effect in treatment of lung cancer.

The invention provides a traditional Chinese medicine composition for a moxibustion medicine cake. The traditional Chinese medicine composition for the moxibustion medicine cake is mainly prepared from, by weight, 0.2-2 parts of angelica sinensis, 0.5-5 parts of radix aconiti carmichaeli, 0.5-5 parts of cortex cinnamomi, 0.2-2 parts of safflower, 0.2-2 parts of radix salviae miltiorrhizae, 0.2-2 parts of radix aucklandiae and 0.2-2 parts of borneol. The invention further provides a preparation method of the traditional Chinese medicine composition for the moxibustion medicine cake. The traditional Chinese medicine composition for the moxibustion medicine cake can be used by being combined with moxa floss, the double therapeutic effect of the moxa floss and the traditional Chinese medicines is achieved, and the clinical curative effect of moxibustion is greatly improved; the traditional Chinese medicine composition has the effects of warming and nourishing the spleens and the stomach, promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain; the traditional Chinese medicine composition is suitable for the cold syndromes, the deficiency syndromes, the pain syndromes and the stasis syndromes which are caused by deficiency cold of the spleens and the stomach, spleen-kidney yang deficiency, qi stagnancy, blood stasis and the like and is particularly suitable for difficult miscellaneous diseases such as chronic gastritis, refractory chronic enteritis and the like; carrying is convenient, and operation is easy; the substantial economical benefits can be brought.

The invention belongs to the field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine external preparation used for improving ascites due to cirrhosis and the preparation method. Based on the former experience and combined with the new related progress in the technique, the invention adopts the Chinese bulk drugs including fresh milk veteh, accessory piece, cinnamon, rhizoma cyperi, clove, borneol and muskiness, or adopts fresh rhubarb, radish seed, euphorbia kansui, tambac, clove, borneol and muskiness, thus preparing asthenia distension external used preparation for treating ascites due to cirrhosis (extracting cataplasm). The traditional Chinese medicine preparation carries out clinical experimental therapy according to clinical deficiency syndrome and demonstration syndrome; as result showing, the preparation has functions of improving abdominal distension, whetting the appetite and promoting ascites to fade, thereby being capable of treating ascites due to cirrhosis.

The invention discloses a lotus leaf, smoked plum and peanut butter which comprises the following raw materials in parts by weight: 300-330 parts of peanut butter, 80-90 parts of mango, 50-60 parts of snow pears, 50-60 parts of smoked plum, 10-15 parts of gorgon fruit meat, 30-40 parts of whey powder, 20-25 parts of fresh ginger powder, 30-40 parts of lemon juice, 8-10 parts of lotus leaves, 5-6 parts of semen boitae, 5-6 parts of cape jasmine, 3-5 parts of herba patriniae, 3-5 parts of common andrographis herb, 5-6 parts of isatis roots, and 4-5 parts of garden burnet leaves. The content of vitamins of the lotus leaf, smoked plum and peanut butter is increased when food materials such as the mango and the lemon juice are added; the lotus leaf, smoked plum and peanut butter has a yellow color of the mango, and pleased in color; because extracts of Chinese medicinal herbs such as the lotus leaves, the semen boitae, the cape jasmine, the herba patriniae, and the common andrographis herb are added, the lotus leaf, smoked plum and peanut butter has effects of treating chronic cough caused by deficiency syndrome of the lung, clearing away heat and toxic materials, cooling blood, and the like, and is suitable for being eaten by most of people.

The invention discloses a traditional Chinese medicinal composition for treating deficiency of lung Qi and a preparation method thereof. The traditional Chinese medicinal composition comprises the following raw materials: root of large flower morina, wahlenbergia marginata, mangnolia, radix semiaquilegiae, radix campanumoeae, grape, radix stemonae, Indian kalimeris herb, olive, buckwheat, taro leaf, andrographis laxiflora (Bl.) lindau, delavey greenleaf elaeagnus leaf, liquorice and peanut shell, and is prepared by the following steps: preprocessing the raw materials, carrying out ethanol centrifugal extraction and vapor extraction, removing impurities and settling the obtained liquid, and producing the liquid to the corresponding form of the medicine according to requirements of technologies and auxiliaries for the various form on pharmacy. The medicine can clear away heat and toxic materials, benefit lung and spleen, tonify qi and deficiency, moisten lung to arrest cough, supplement qi and blood, and strengthen bones and muscles, and can achieve significant effects on cough due to deficiency syndrome of the lung, spontaneous perspiration, cough, asthma and the like.