15 results about "Immune network" patented technology

The invention discloses a bionic nano-vesicle preparation method, which comprises: dissolving epigallotein gallate and selenomethionine in deionized water, adding a formaldehyde solution, stirring in a dark environment, and carrying out centrifugal purification to obtain spherical nano-particles; extracting exosomes from the stem cells; and adding the spherical nano-particles and the exosome into deionized water, and stirring to obtain the bionic nano-vesicle. The bionic nano vesicles prepared by the invention can regulate and control macrophages and T cells, have anti-inflammatory and immune network regulation and control effects, and are applied to the protection effect on acute kidney injury.

This invention provides a method for establishing a rat model of COPD to study the medicinal uses and pharmacological effects of Liuwei Buqi Decoction in the treatment of COPD. The traditional Chinese medicines in Liuwei Buqi Decoction are ginseng, astragalus, alpinia oxyphylla, polygonatum odoratum, tangerine peel, and cinnamon. This application provides a basis for the syndrome differentiation and treatment strategy of Liuwei Buqi Decoction by exploring the molecular mechanisms by which Liuwei Buqi Decoction regulates the COPD inflammatory immune network and the molecular mechanisms by which it regulates the lung-gut microecological axis and the inflammatory immune network. Taking the high-incidence syndromes of major diseases during the TCM-advantage stage as a starting point, and based on clinical needs, this study, building upon previous clinical research, uses various techniques such as scRNA-seq, CBA, and metagenomics to explore the molecular mechanism by which Liuwei Buqi Decoction improves airway immune inflammation by regulating the lung microecology in rats with COPD lung-kidney qi deficiency syndrome from the perspective of regulating the lung immune microenvironment and alveolar macrophage polarization. Its mechanism of action was further studied and verified through in vitro experiments.

The present invention relates to the use of PACSIN2 in promoting activation of the STING signaling pathway. This invention fully demonstrates that PACSIN2 can effectively promote activation of the type I interferon-mediated innate immune network, particularly participating in STING transport and promoting STING-mediated activation of the type I interferon pathway. At the effector level, it is confirmed that exogenously overexpressing PACSIN2 in immune cell systems can significantly enhance the response of the STING signaling pathway, providing an effective solution for improving the therapeutic efficacy of diseases requiring innate immune activation. The discovery of this innovative mechanism for achieving sustained activation of the innate immune response in the tumor microenvironment and the implementation of a targeted strategy will overcome the difficulty in activating innate immune signals in tumor cells, providing an important scientific basis for achieving the "cold-hot" transition of tumor cells.

The present disclosure relates to methods for testing the health of a subject's immune system and treating the subject based on the condition of the immune system. In particular, disclosed herein is a method comprising the steps of obtaining a sample of blood from the subject, reverse transcribing DNA from RNA in the sample; amplifying all seven chains of T and B cell receptors in the DNA sample using multiplex PCR to form amplicons; sequencing the amplicons to generate a sequencing library; identifying nodetypes, clonotypes, v genes, d genes, and j genes and corresponding read counts in the sequencing library; performing the foregoing steps using two or more healthy samples to form a consensus reference pool; identifying the number of nodetypes associated with each V gene sequence in the consensus reference pool and in the subject's sequencing library; comparing the number of nodetypes for each V gene in the consensus reference pool and the subject's sequencing library; and treating the subject if the number of nodetypes is significantly less than the number of nodetypes for V genes in the consensus reference pool. The disclosed method is able to identify gaps in an individual's immune system and treat that individual to improve the diversity of the individual's immune response.

This invention discloses a multi-robot collaborative immune network control method. First, a single-robot time-varying quadratic optimization model is established based on the kinematics of the single robot. Then, a multi-robot collaborative controller is designed based on decision variables for real-time recursion of a recursive neural network. Finally, a fitness evaluation criterion and a recursive error compensation term are integrated into the immune recursive network, and a vaccine operation is introduced to output the optimal joint angle. This invention solves the joint angle during multi-robot trajectory tracking, enabling adaptive tracking of different trajectories by multiple robots. This improves the precision, coordination, and repeatability of multi-robot control, and is of great significance for achieving multi-robot collaborative control in intelligent manufacturing.

This invention relates to the fields of artificial intelligence and big data processing, specifically disclosing a method for constructing high-dimensional user profiles based on multi-source data fusion and dynamic updates. This method constructs an initial high-dimensional feature vector, introduces an immune mechanism to identify "self" and "non-self" behaviors, establishes a dynamic antibody library with a lifecycle, and combines clonal selection, high-frequency mutation, and natural apoptosis mechanisms to achieve adaptive evolution of the profile. It also constructs a cross-user immune network, utilizes common group behaviors to generate regulatory factors to correct individual biases, and integrates adversarial attack detection, version management, and viability assessment modules. Through the above technical solutions, this invention improves the accuracy, timeliness, and anti-interference capability of user profiles, providing highly reliable data support for precision marketing, intelligent recommendation, and risk prevention and control.

The application of recombinant ultra-high molecular weight hyaluronic acid in regulating intestinal immunity in colitis belongs to the field of biomedical technology. This invention addresses the limitations of existing treatments for inflammatory bowel disease (IBD), which suffer from limited efficacy, significant side effects, and difficulty in targeting and repairing the intestinal immune barrier. It provides the application of recombinant ultra-high molecular weight hyaluronic acid in regulating intestinal immunity in colitis. This recombinant ultra-high molecular weight hyaluronic acid can activate the intestinal IgA-producing immune network, regulate inflammation-related genes, and repair the physical and immune barriers of the colonic mucosa, thus exhibiting a superior protective effect against colitis compared to conventional hyaluronic acid, providing a new candidate drug for the treatment of IBD.

The invention relates to the technical field of medical treatment, in particular to a soluble microneedle patch and application thereof in vaccine delivery. The soluble micro-needle patch creatively adopts a non-uniformly arranged'core-shell-crown 'structure micro-needle array, comprises a high-density central area and a low-density edge area, cooperatively activates a skin immune network through differentiated puncture depth and density, has three advantages of painless and efficient delivery, high room temperature stability and high immune synergy, and can be applied to the field of medical treatment. And the preparation method adopts a low-temperature centrifugation-freeze drying integrated process, is suitable for various vaccine types such as mRNA, protein and the like, and provides an autonomous inoculation solution for sudden epidemic situations and large-scale immunization.

The present invention discloses a dynamic defense system based on an immune data network, which is configured with a network architecture of dynamic networking. The network architecture includes a user terminal, a communication base station and a cloud. The user terminals are connected through a communication module, and the user terminal and the cloud communicate through the communication base station. The system includes an anomaly recognition strategy, an immune generation strategy, and an immune operation strategy. The anomaly recognition strategy executes a response instruction and calculates an immune value through an anomaly characterization database, triggers feature extraction, and generates an intrusion immune feature group that is uploaded to the cloud. The cloud constructs a feature recognition immune network through the immune generation strategy. The immune operation strategy encapsulates network nodes into antibody data packets and distributes them to the terminal update database. The dynamic immune network realizes the self-growth of defense capabilities. The existing method requires the cloud to centrally process all detection tasks, reduces the cloud load through the antibody data packet distribution mechanism, and realizes cross-terminal collaborative defense through the feature recognition immune network to block the attack propagation path.

The invention discloses a composition helpful for relieving and improving anxiety type insomnia and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 1.5-2.5 parts of poria cocos, 1.5-2.5 parts of lily, 1.5-2.5 parts of spina date seeds, 0.5-0.7 part of rhizoma polygonati, 0.4-0.6 part of lucid ganoderma, 0.4-0.6 part of angelica sinensis, 0.4-0.6 part of codonopsis pilosula, 0.4-0.6 part of polygala tenuifolia, 0.4-0.6 part of cortex albiziae, 0.3-0.5 part of liquorice and 0.2-0.3 part of coptis chinensis. The invention solves the problems that the existing medicine for relieving and improving anxiety type insomnia is easy to cause tolerance, dependence and even withdrawal reaction in the use process, and is difficult to fundamentally regulate the unbalance state of nerves, internal secretion and immune networks, and the treatment effect is reduced.

The invention discloses a traditional Chinese medicine navel application agent for activating an abdominal cavity immune network and a preparation method thereof, through specific compatibility of 11 pungent and warm medicines (including five medicines for resolving dampness with aromatics, five medicines for warming the interior and one medicine for astringing the intestine), and in combination with a superfine grinding technology (the particle size is less than or equal to 30 microns) and a beta-cyclodextrin inclusion process, the transdermal absorption rate of the medicines is increased to 3-5 times that of common navel therapy. Animal experiments show that the preparation can increase the phagocytic rate of macrophages in the abdominal cavity of a mouse by 32.7%, the CD4 + / CD8 + ratio of T lymphocytes is recovered from 1.2 to 1.8 + / -0.2, and the slgA concentration of mucous membranes is increased by 2.3 times. Clinical observation shows that the effective rates for diarrhea, stomachache and vomiting symptoms caused by deficiency-cold of spleen and stomach of children within 24 hours respectively reach 90.2%, 85.6% and 80.4%, and liver and kidney dysfunction is not found.

The invention belongs to the technical field of all-ginseng soup, and discloses immunoregulation all-ginseng soup integrating ginseng components and pharmacology, the all-ginseng soup comprises the following raw materials by weight: 50%-55% of ginseng red ginseng root, 20%-25% of ginseng leaf, 10%-15% of ginseng flower, and 8%-10% of ginseng seed. Through a full-component synergistic interaction mechanism, two-way regulation is realized in the aspect of immune regulation, an immune system can be activated through components such as red ginseng roots and polysaccharide, macrophage activity and immune factor secretion are improved, Th17 cell differentiation can be inhibited by utilizing a ginseng leaf component, Treg cell markers are up-regulated, the inflammatory response of autoimmune diseases is effectively relieved, and the immune regulation effect is improved. Meanwhile, the ginseng flower volatile oil and the ginseng seed polypeptide form whole body-local immune network linkage by regulating intestinal flora; in the aspects of tumor resistance and chemotherapy assistance, red ginseng saponin Rg3, Rh2 and the like have a direct cancer inhibition effect, ginseng seed saponin Rd, poria cocos triterpene and the like can be used for chemotherapy synergistic attenuation, and lycium barbarum polysaccharide can be used for enhancing immune surveillance and improving the killing activity on tumor cells.

The invention provides application of combined use of cerium ions and luteolin in preparation of an external medicine for treating specific dermatitis. The invention also provides a Lut-Ce-MOF nanoparticle, which is prepared by synthesizing the amino functionalized zirconium-based metal organic framework UIO-66-NHH loaded cerium ions and luteolin by a solvothermal method, and then preparing the nanoparticle. The invention also provides a Lut (at) M / C-O hydrogel. The Lut (at) M / C-O hydrogel is prepared from the Lut (at) Ce-MOF nanoparticles, carboxymethyl chitosan (CMCS) and trihydroxymethyl aminomethane-oxidized hyaluronic acid (OHT) as raw materials. The hydrogel provided by the invention can provide a long-acting moisturizing microenvironment, passively promote repair and a more comprehensive immunoregulation network, can also avoid the problem of drug resistance of antibiotics, and is a comprehensive strategy of immunoregulation, physical barrier and component antibiosis.

The invention discloses a dynamic defense system based on an immune data network, a dynamic networking network architecture is configured, the network architecture comprises clients, a communication base station and a cloud, the clients are connected through a communication module, and the clients and the cloud communicate through the communication base station. Comprising an abnormity identification strategy, an immune generation strategy and an immune operation strategy; the exception identification strategy executes a response instruction through an exception representation database and calculates an immune value, after triggering feature extraction, an intrusion immune feature group is generated and uploaded to the cloud, the cloud constructs a feature identification immune network through an immune generation strategy, and the immune operation strategy encapsulates network nodes into antibody data packets and distributes the antibody data packets to a terminal update database; a dynamic immune network realizes self-growth of defense capability, and an existing method needs a cloud to process all detection tasks in a centralized manner, reduces a cloud load through an antibody data packet distribution mechanism, realizes cross-terminal cooperative defense through a feature recognition immune network, and blocks an attack propagation path.

The invention provides a computing power network scheduling method and device based on an immune network algorithm, equipment and a medium, and the method comprises the steps: carrying out the analysis of a task submitted by an equipment node in a computing power network, and obtaining a computing power resource request; performing task initialization through Latin hypercube sampling based on a to-be-scheduled resource range of computing power nodes in the computing power network and the number of equipment nodes to obtain an initial antibody group; carrying out cloning, variation and inhibition operations on individuals in the current-generation antibody population to obtain a next-generation antibody population, and circularly carrying out cloning, variation and inhibition operations on the next-generation antibody population as the current-generation antibody population until an iteration termination condition is reached; and determining a computing power scheduling scheme of the computing power resource request based on the last-generation antibody group. According to the computing power network scheduling method and device, the equipment and the medium provided by the invention, the convergence speed of resource allocation of the computing power network can be accelerated, the efficiency and the performance of task scheduling are also remarkably improved, and finally a global optimal computing power resource scheduling scheme is realized.