8 results about "Innate immune system" patented technology

The application discloses an immunoregulatory antibacterial peptide targeting LPS and a preparation method and application thereof, and belongs to the technical field of biology. The amino acid sequence of the antibacterial peptide FF2 is shown as SEQ ID No. 1, and the antibacterial peptide FF2 of the application can specifically target the bacterial membrane surface component LPS to make the bacterial membrane leak and inhibit the growth of bacteria. The antibacterial peptide can capture bacteria and trigger the innate immune system to achieve the antibacterial purpose, and can also target the bacterial membrane to break the membrane and kill bacteria, thereby fully avoiding the killing of beneficial bacteria in the host body, avoiding the overuse of the antibacterial peptide, effectively reducing the generation of drug resistance, and mobilizing the immune function of the body to synergistically resist bacterial infection. In conclusion, the antibacterial peptide FF2 is a targeted LPS forming nanofiber antibacterial peptide with immunoregulatory function, which has great development potential and high application value.

The present application belongs to the field of functional substance research, and particularly relates to a kind of nutritional composition for regulating immunity and purposes thereof.The nutritional composition provided by the present application comprises essential active ingredients shown in (I) and (II) as follows: (I) lysophosphatidyl ethanolamine; (II) 2'-FL; and in the nutritional composition, the mass ratio of the essential active ingredients shown in (I) to the essential active ingredients shown in (II) is 1:(1-2000). Lysophosphatidyl ethanolamine and 2'-FL are compounded, which can take T cell development activation as core, promote the overall construction and functional regulation of adaptive immune and innate immune system.

This invention belongs to the field of functional substance research, specifically relating to a nutritional composition that helps enhance immunity and its uses. The nutritional composition provided by this invention comprises the essential active ingredients shown in (I) and (II) below: (I) lysophosphatidylethanolamine; (II) lactoferrin; wherein, the essential active ingredient shown in (I) contains at least unsaturated lysophosphatidylethanolamine, and the fatty acid chain length of the unsaturated lysophosphatidylethanolamine is 14-22 carbon atoms, and in the nutritional composition, the mass ratio of the essential active ingredient shown in (I) to the essential active ingredient shown in (II) is 1:(0.1-1500). The combination of unsaturated lysophosphatidylethanolamine with a specific fatty acid chain length and lactoferrin can promote the comprehensive construction and functional regulation of adaptive and innate immune systems, with T cell development and activation as the core.

The complement system is part of the innate immune system and is highly regulated by regulatory proteins belonging to the Regulators of Complement Activation (RCA) family. It is known that lack of regulation causes damage to host cells and deficiencies in the regulation is also linked to diseases such as age-related macular degeneration, atypical hemolytic uremic syndrome, and dense deposit disease. The regulatory proteins primarily include decay-accelerating factor (DAF; CD55), membrane cofactor protein (MCP; CD46), complement receptor 1 (CR1; CD35), factor H (FH) and C4b-binding protein (C4BP). Structurally, these proteins are composed of repeating complement control protein (CCP) domains where 2-4 successive domains contribute to the regulatory functions termed as decay-accelerating activity (DAA) and cofactor activity (CFA). However, no four-domain chimeric protein currently exists having both strong DAA (CP-DAA and AP-DAA) and strong CFA (C3b-CFA and C4b-CFA). Therefore, chimeric protein DCP (i.e., a dual-activity regulator) was created.

Complement is an arm of the innate immune system that plays an important role in defending the body against infectious agents. Although compositions that inhibit complement are known, there remains a need for compositions that can acutely inhibit complement. Methods and compositions comprising PEGylated compstatin analog for inhibiting complement are described.

The invention discloses a polypeptide and application thereof. The amino acid sequence of the polypeptide is as shown in SEQ ID NO: 1. The polypeptide provided by the invention can activate an MAPK signal channel and active oxygen accumulation of wheat, namely, the innate immune system of the wheat can be obviously activated, so that the resistance of the wheat to fusarium graminearum and pseudofusarium graminearum is improved. An immunity inducer developed by using the polypeptide has a good application prospect in prevention and treatment of wheat scab and basal stem rot.

The present invention relates to a novel compound of formula (I) and its composition: [Formula 1] TIFF2026513467000023.tif57115[in the formula, X is a halogen, alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, alkenyl, alkenyloxy, or alkenylcarbonyl; Y is a hydroxyl or alkoxy group; R is phenyl, cyanophenyl, or halogenated phenyl; R 1 [These are alkyl, branched alkyl, alkenyl, alkynyl, cycloalkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, alkenyloxy, alkenylcarbonyl, phenyl, phenylalkyl, dialkylphenyl, benzyl, or benzylalkyl]. The present invention also relates to the use of compounds of formula (I) and compositions thereof as immunomodulators useful for restoring the adaptive and innate immune systems to healthy baseline ranges. The present invention also relates to the use of compounds of formula (I) and compositions thereof in the treatment of undesirable immune-mediated physiological conditions such as inflammation, viral infections, and cancer, and in other medical applications.