474 results about "Antitumor therapy" patented technology

Methods and compositions for restoring sensitivity to the antitumorigenic effects of antiestrogen therapy and / or cytotoxic therapy and inducing cell apoptosis are provided. Contacting tumor cells to GP88 antagonists (e.g., anti-GP88 antibodies, anti-GP88 antisense nucleic acids, GP88 siRNA, and small molecules) induces apoptosis and restores sensitivity to the antitumorigenic effects of antiestrogen therapy and cytotoxic therapy.

The invention discloses a ternary complex nanometer system and a preparation method and application thereof. The system comprises an iron compound, a benzene-ring-containing micromolecule antineoplastic active compound and a polyphenol compound; a weight ratio of the iron compound to the benzene-ring-containing micromolecule antineoplastic active compound to the polyphenol compound is (1 to 4):(2to 10):(5 to 20). Relative to the prior art, according to the invention, different micromolecule compounds or medicines can be stably assembled only by a physical assembling means; the formed complexnanometer medicine not only has an antineoplastic treatment effect of the micromolecule antineoplastic active compound, but also has a ferroptosis treatment effect that the iron compound reacts with the polyphenol compound are mediated on the basis of an intracellular Fenton reaction; moreover, the novel complex nanometer medicine formed by the preparation method disclosed by the invention furtherhas an outstanding photothermal effect; chemotherapy, ferroptosis treatment and photothermal therapy can be integrated into one whole body, take a synergistic effect, beneficiate each other and achieve an all-in-one combined antineoplastic treatment effect.

The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.