235 results about "Myocardial ischaemia" patented technology

One embodiment enables detection of MI/I and emerging infarction in an implantable system. A plurality of devices may be used to gather and interpret data from within the heart, from the heart surface, and/or from the thoracic cavity. The apparatus may further alert the patient and/or communicate the condition to an external device or medical caregiver. Additionally, the implanted apparatus may initiate therapy of MI/I and emerging infarction.

The present invention discloses thiopheno pyridine substituted acetyl hyarazine derivative compound as shown in expression I and its pharmaceutically acceptable salt, medicine composition with the compound as effective component, and their application as platelet aggregation resisting medicine, especially as medicine for preventing and treating platelet aggregation caused coronary artery syndromes, myocardial infarction, myocardial ischemia and other cardiac and cerebral vascular diseases.

The invention discloses a novel traditional Chinese medicine composition for treating the symptoms of myocardial ischemia, palpitation and severe palpitation and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw materials of medicines: radix codonopsis pilosulae, white peony root, tangerine peel, rhizoma cyperi, TurmericRoot-tuber, crude astragalus root, American ginseng, yam, licorice, Japanese sweetflag, benzoin, senega, prepared rehmannia root, tuber fleeceflower, radix adenophorae, noble dendrobium, radix polygonati officinalis, radix asparagi, spiny date seed, radix salviae miltiorrhizae, safflower, peach kernel, rhizoma ligustici wallichii, medicated leaven, malt, ginseng, white atractylodes rhizome, styrax, borneol, toad venom, radix rehmanniae, oyster, cortex albiziae, caulis polygoni multiflori, ganoderma lucidum, shelled cedar seed and the like. The traditional Chinese medicine composition can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can obviously improve the physical signs of the whole bodies of patients with the symptoms of the myocardial ischemia, the palpitation and the severe palpitation, regulates the functions of the hearts of the patients, nourishes qi and blood, regulates the circulation, smoothes the blood flow, calms down the spirit and the mind, relieves and improves the symptoms of dismay, palpitation and the like quickly, has definite clinical curative effect, obvious effect and quick acting and has the advantages of low cost, no toxic or side effect basically and the like.

The invention discloses a composition for treating cardiovascular diseases and a preparation method thereof. The composition comprises (by weight part) Radix Ginseng Rubra saponin 2-20, Ophiopogon japonicus saponin 0.2-3, and Ophiopogon japonicus flavone 0.02-3; wherein the Radix Ginseng Rubra saponin extract contains (by dry weight) ginsenoside Rg1 not less than 9.0%, ginsenoside Re not less than 3.0%, ginsenoside Rb1 not less than 12.0%, and Panax ginseng total saponins not less than 80%; the Ophiopogon japonicus saponin extract contains (by dry weight) ophiopogonin D not less than 6.0%, ophiopogonin D' not less than 6.0%, and Ophiopogon japonicus total saponins not less than 80%; and the Ophiopogon japonicus flavone extract contains (by dry weight) methylophiopogonone A and methylophiopogonone B in total not less than 80%. Animal experiments showed that the composition has good therapeutic action on myocardial ischemia and has better anti-shock effect.

The invention discloses a jasmine flower extract, a preparation method and an application thereof. The jasmine flower extract contains the following components: 70 percent to 75 percent of jasmine total flavonoids, 15 percent to 20 percent of jasmine non-flavonoid glycosides and 10 percent to 15 percent of jasmine volatile components. A main extraction solvents adopted by the invention when extracting jasmine flower is a mixed solution of ethanol and water in different proportions, and glycoside and aglucon in the flower can also be extracted; polyamide resin column is used for enriching total flavonoids so that impurities are removed and purity is increased; additionally, the method removes a plurality of jasmine fragrant ingredients, and the main effective components of the extract obtained is total flavonoids, the purity is high and the content of jasmine fragrant ingredients is greatly decreased. Pharmacology examination proves that, the extract has the functions of relaxing isolated vascular tissue, removing isolated oxygen free radical, reducing animal blood pressure, relieving myocardial ischemia, improving arrhythmia symptoms and anoxia test and can be applied to treating cardiovascular diseases.

Disclosed are (N)-methanocarba adenine nucleosides of formulas (I)-(V), for example, of formula (V):

as highly potent A₃ adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein R₁-R₆ are as defined in the specification. These nucleosides exhibit similar selectivities as agonists of the A₃ versus the A₁ receptor for both human and mouse adenosine receptors, and are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias.

The invention relates to a non-invasive attached telemetering electrocardiographic recording method having an ultra-long record period and an ultra-high storage capacity. By using the method, characteristic values of electrocardiographic waves can be safely, stably and clearly acquired under the natural physiological state of a human body within a long period (more than 15 days), microvolt-level measurements of T-wave alternans can be acquired, and the collection, processing and high-capacity storage of electrocardiographic waves can be completed; and multiple electrocardiographic recording pasters can be used to realize the simultaneous recording of multi-channel body surface electrocardiograms, and a computer data processing and analysis system can complete the data monitoring and analysis, image display, data storage and printing and output of the recorded signals and realize the networking transmission of the electrocardiosignals. The clinical indications of the device include: symptoms related to suspected arrhythmia; determination of arrhythmia property, and completion of reasonably evaluating anti-arrhythmia treatment and monitoring myocardial ischemia; evaluation of anemic heart disease treatment measures; instructions to acute myocardial infarction patients before leaving hospital and during convalescence; and installation, detection and function assessment of sudden cardiac death and heart pacemakers.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

An oral-applied solid Chinese medicine containing ophiopogonin for treating myocardial ischemia contains the ophiopogonin extract (5-40 wt%) and medical additive (60-95 wt.%). Its advantages are high quality stability and easy control to dosage.

The invention provides a piRNA combination for detecting the heart disease, and an application thereof. The piRNA combination comprises one or more of 16 RNA sequences represented by SEQ ID No. 1 to NO.16. The application of the piRNA combination is the application of the piRNA combination in the preparation of medicines or kits for predicting, diagnosing or, identifying and/or treating the heart disease. The piRNA playing a key role in the regulation of myocardial ischemial injury and myocardial infarction, and a complete method is provided for researching the regulation mechanism. The research method is helpful to elucidate the pathogenesis of myocardial infarction, provides a new idea for the prevention and diagnosis of the myocardial infarction, and is of great significance to especially develop the piRNA as a medicine for treating the heart disease.

The invention belongs to the field of traditional Chinese medicines and relates to an uncaria extract and new application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy. Proved by the animal experiment, the uncaria ethanol extract has the functions of reducing blood fat and resisting cardiac hypertrophy, and especially can reduce the triglyceride level in blood, the weight ratio of the left ventricle to the whole heart, and the weight ratio of the left ventricle to the right ventricle. The uncaria ethanol extract can be used as the raw material for pharmaceutical preparations to further prepare the medicines for reducing blood fat and resisting cardiac hypertrophy, so that the medicines can be used for treating disturbance of lipid metabolism and metabolic syndromes, and preventing and curing atherosclerosis, and hypertensive cardiopathy caused by hypertension and cardiac hypertrophy, including myocardial ischemia, myocardial damage, myocardial infarction and heart failure.

The invention discloses a medicinal composition for treating cardiovascular and cerebrovascular diseases, and a preparation method and application of the medicinal composition. The medicinal composition can prolong coagulation time, reduce cholesterol levels and contribute to reducing the formation rate of thrombus and atherosclerosis, can be used for treating cerebrovascular diseases such as cerebral ischemia, cerebral thrombosis, cerebral embolism and the like, and cardiovascular diseases such as coronary disease, hypertension, hyperlipaemia, atherosclerosis, myocardial ischemia, arrhythmia, heart failure, stenocardia, myocardial infarction and the like, particularly has good treatment effect when used for continued treatment on patients suffering the cardiovascular and cerebrovascular diseases after emergency treatment, and is a new choice for clinical medication.

The invention discloses application of a whole hemp extract in preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. The whole hemp extract is prepared by evenly mixing 0.3-99.7 parts of an industrial hemp and fructus cannabis extract and 0.3-99.7 parts of an industrial hemp and cannabis sativa L extract. Experiments prove that the whole hemp extract has the effects of improving the activity of SOD, GSH-PX and other anti-free-radical enzymes, scavenging free radicals and protecting cardio and cerebral blood vessels and tissues and preventing and controlling occurrence and development of the cardiovascular and cerebrovascular diseases. The whole hemp extract can be used for preparing the drugs for preventing and treating the cardiovascular and cerebrovascular diseases, such as cerebral ischemia, myocardial ischemia, neuronal damage caused by hypoxia-reoxygenation, cerebral infarction (stroke), cerebral thrombosis, cerebral hemorrhage, a coronary heart disease and myocardial infarction and has the good application prospect in treatment or prevention of the cardiovascular and cerebrovascular diseases.

The invention relates to the technical field of a cardioplegic solution, and in particular relates to an autoimmune hemolytic anemia (ALHA) cardioplegic solution and a preparation method thereof. Every 500ml of the ALHA cardioplegic solution contains 552.86-947.76mg of cobamamide, 4.739-5ml of a lidocaine solution of 2% in mass concentration, 30-60mg of pentazocine and 4.1-10ml of a magnesium sulfate solution of 25% in mass concentration. The cardioplegic solution disclosed by the invention can effectively shorten duration of induced cardiac arrest; and the ALHA cardioplegic solution can carry oxygen, so that just few ALHA cardioplegic solution can effectively promote cardiac arrest to avoid hurt of myocardial ischemia reperfusion to cardiac muscle, further improve re-beating success rate in one time and reduce arrhythmia incidence rate after re-beating, and effectively relieve an inflammatory response, so as to effectively protect the cardiac muscle cell.

The invention discloses an asymmetric syntheses method of (-)-sodium danshensu and an application thereof, which belongs to the medicine chemical field. The method comprises the following steps: A)taking levodopa shown in a formula I as a raw material, and performing a hydroxyl acetylation to obtain S-3-(3,4-acetylphenyl)-2-alanine hydrochloride; B)performing a diazotization reaction on S-3-(3,4-acetylphenyl)-2-alanine hydrochloride obtained in the step A) to obtain S-3-(3,4-acetylphenyl)-2-hydracrylicacid in a formula III; C)performing hydrolysis on the S-3-(3,4-acetylphenyl)-2-hydracrylicacid in the step B to obtain S-3-(3,4-dihydroxy phenyl)-2-hydracrylicacid shown in a formula IV; and D)dropping a sodium bicarbonate saturated solution in the S-3-(3,4-dihydroxy phenyl)-2-hydracrylicacid to react to obtain sodium salt (-)-sodium danshensu shown in a formula V. The method has the advantages of easily available raw material and simple operation, and the (-)-sodium danshensu has good effect for treating myocardial ischemia and myocardial infarction.

The invention relates to a traditional Chinese medicine composition preventing and curing cardiovascular and cerebrovascular diseases. With milkvetch roots being principal herbs, the composition of salvia roots, ginkgo leaves and pseudo-ginseng in a specific proportion has the obvious effect of preventing and curing the cardiovascular and cerebrovascular diseases, can obviously reduce blood lipid of rats with hyperlipemia, has the obvious effect of restraining artery, vein and vein bypass thrombus and can improve hemorheology, restrain ear swelling caused by xylene and inflammatory reaction caused by cotton ball granuloma and obviously prolong survival time of the rats which are suffered from normal-pressure hypoxia tolerance, sodium nitrite poisoning and acute cerebral ischemic anoxia. In this way, the hypoxia tolerance capacity of organisms is improved, and the traditional Chinese medicine composition has a certain effect of protecting myocardial ischaemia injuries and cerebral injuries, and is free of acute toxicity, genetic toxicity and chronic toxicity and suitable for preventing and curing the cardiovascular and cerebrovascular diseases.