613 results about "Triterpenoid" patented technology

The present invention overcomes limitations of the prior art by providing new compounds and methods for the treatment of conditions, such as neurodegenerative diseases (e.g., multiple sclerosis), psychiatric disorders (e.g., psychosis, bipolar disorder, depression, neuropathic pain), conditions involving CNS-mediated chronic pain, spinal cord injuries, and other diseases or injuries.

Compositions and methods for the prevention and treatment of neoplastic diseases are described. Individuals at a high risk of developing or having neoplasia undergoing conventional therapies may be treated with an effective dose of triterpene derivatives in limonoids, polyphenolic flavonoid compounds, tocotrienols or a combination of these agents.

The present invention concerns methods for treating cancer, such as pancreatic cancer, using combination therapies, including the combination of a synthetic triterpenoid, e.g., CDDO-Me, and gemcitabine.

The present invention relates to a pentacyclic triterpanoid derivative of multiple-oxide substitution of the A ring and the C ring and the medicine salt or solvate of the derivative, and the present invention also relates to the preparation method, the drug combination, and medical use of the derivative. The compound of the present invention has the functions of inhibiting the activity of six human tumor cell strains in vitro, such as human prostate cancer cell (PC-3), nasopharyngeal carcinoma cells (CNE), oral squamous carcinoma cell(KB), human lung cancer cell (A549), human hepatoma cell (BEL-7404), and human cervix cancer cell (Hela), and the function of the invention is at the same magnitude of the positive control of cisplatin, thereby the compound can be used as expected antitumor drug. The compound of the present invention also inhibits the alpha glucosidase strongly, and the inhibiting effect is greater than the positive control of acarbose, thereby the compound can be used as expected medicine for preventing and treating diabetes and the treatment of the virus diseases.

The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

The invention provides a method of effectively extracting ganoderma triterpenoids and ganoderan from mythic fungus germ entity by ultrasonic-alcohol extracting, complex enzyme-water extracting integration technology. The method is characterized by comprising the steps of: crashing the mythic fungus germ entity, using the ultrasound assisted alcohol extract (ultrasonic-alcohol extracting) to extract the ganoderma triterpenoids, then using complex enzyme assisted water extracting (complex enzyme-water extracting) to prepare ganoderan, then sponging drying to obtain ganoderma triterpenoids and ganoderan extractive. The solvents used by the method used in the invention is safe, innoxious and avoids the pollution to the environment by using chloroform, methanol and other organic solvents in the traditional method. And the invention has the features of low extraction temperature, simple device, convenient operation, low cost, fast speed, high effects and so on. Using the process to comprehensively extract triterpenoids and ganoderan active substances in glossy ganoderma can significantly increase the total active substance yield than the single extracting method.

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.

The present invention concerns methods for treating and preventing renal / kidney disease, insulin resistance / diabetes, fatty liver disease, and / or endothelial dysfunction / cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

An application of the pentacyclo-triterpenoid used as the glycogen phosphorylase for preparing the medicines to treat diabetes, ischemic cardiovascular and cerebrovascular diseases, and tumor is disclosed.

The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.

The invention described herein encompasses novel discovery of anticancer agents and its compositions comprising saponins, a group of triterpenoid and steroidal saponins found in plants including Quillaja saponaria Molina (soap tree), which are used as therapeutic compounds for the treatment and prevention of cancer diseases or as a dietary supplement that offers tumor cell killing and tumor cell inhibition, and also as a anticancer potentiator with other anticancer agents.

Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well as the stereo structures and the amounts of the triterpenoid compositions. The cytotoxicity of triterpenoids is also revealed. Based on the aforementioned techniques, the presence and amounts of ergostane and lanostane in the drugs, healthcare food or other goods are able to be detected.

The invention discloses total triterpene extract and total phenol extract extracted from Chinese herbal medicine glossy privet fruit and a preparation method thereof. The total triterpene extract mainly contains oleanolic acid, ursolic acid, acetyl oleanolic acid, indicant compound and other derivatives with acetyl oleanolic acid as the mother nucleus. The total phenol extract mainly contains hydroxyl mandelic, 3, 4-dihydroxy phenylethyl alcohol, salidroside and indicant compound and other derivatives with salidroside as the mother nucleus. The glossy privet fruit total triterpene extract and total phenol extract can be prepared by any method of solvent distillation, solvent extraction, deposition, macroporous resin absorption, supercritical fluid extraction, column chromatography and liquid-liquid countercurrent distribution chromatography, or any combination of these methods. The total percentage of various triterpenoids of the prepared glossy privet fruit total triterpene extract is 5 to 100 percent (w / w); wherein, the content of oleanolic acid and ursolic acid accounts for 5 to 100 percent (w / w) of the total triterpene. The total percentage of various phenols of the prepared glossy privet fruit total phenol extract is 5 to 100 percent (w / w); wherein, the content of salidroside accounts for 5 to 100 percent (w / w) of the total phenol.

The invention provides a camphor tree sesame fruiting body cultivation method which comprises the following steps: culture media containing leaven are taken for fermentation for 3 to 30 days under the temperature of 5 to 35 DEG C; saw dusts are added into the culture media after fermentation and stirred; the saw dusts and the culture media are arranged inside a vessel; the vessel provided with the saw dusts and the culture media is sterilized; camphor tree sesame spawns are taken to be inoculated into the vessel containing the saw dusts and the culture media and cultivated into mycelium under the temperature of 5 to 35 DEG C; saw dusts containing the camphor tree sesame mycelium are inoculated to a bed wood; the bed wood which has been inoculated with the spawns is cultivated under the temperature of 5 to 35 DEG C and in the humidity of 65 to 85 percents; after residual saw dusts on the bed wood are removed, the bed wood is cultivated under the temperature of 15 to 35 DEG C and in the humidity of 80 to 98 percents for a period of time, and a camphor tree sesame fruiting body can be formed. The invention also provides a cultivation method for camphor tree sesame mycelium and the camphor tree sesame fruiting body obtained by cultivation according to the method. The camphor tree sesame fruiting body cultivated by the invention has the characteristics of massiness of the fruiting body and content of triterpene close to wild camphor tree sesame.

The invention belongs to the technical field of artificial cultivation of medicinal fungi, and particularly relates to a method for cultivating ganoderma lucidum karst. The method includes the steps of obtaining ganoderma lucidum karst mother species, ganoderma lucidum karst protospecies and ganoderma lucidum karst cultispecies respectively, and conducting substitute cultivation of the ganoderma lucidum karst cultispecies to obtain ganoderma lucidum karst, wherein a cultispecies culture medium is prepared from corn straw, sawdust, pig manure, cow dung, rapeseed meal, humic acid, an amillariella mellea fermented liquid, a bacillus subtilis fermentation liquid and gypsum, and a culture medium of the substitute cultivation is same as the cultispecies culture medium. According to the method, the yield of ganoderma lucidum karst sporophore and conidial powder is significantly improved, and the contents of effective components, like ganoderma lucidum karst polysaccharide and ganoderma lucidum karst total triterpenoid, are significantly improved.

A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A. camphorata (AC); (b) extracting the fruiting bodies with a first ethanol solution; and (c) obtaining EEAC. EEAC further can be sequentially extracted or fractioned by n-hexane, ethyl acetate and ethanol, and an n-hexane fraction (FC), an ethyl acetate fraction (FA) and an ethanol fraction (FB) respectively are generated. The growth inhibition and apoptosis induction of leukemia cell line HL 60 are effectively mediated by FA product, in which zhankuic acid A is the bioactive marker. The amount of triterpenoid in the fruiting body of AC can be determined by NMR and HPLC analysis.

The invention provides an oleanolic acid triterpenoid, whose A ring and C ring contain multiple oxygen substituents, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby being applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.

The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.

The invention discloses a method for extracting functional ingredients from lucid ganoderma sporocarp. As a better implementation scheme, the method for extracting functional ingredients can comprises the following steps: lucid ganoderma sporocarp is firstly ground and then subjected to steam explosion treatment under the condition that the steam pressure is 0.6-2.4 Mpa for 60-210 seconds; after the steam explosion treatment, the lucid ganoderma sporocarp is extracted with water or an organic agent, filtered, concentrated and dried; and finally the active ingredients such as ganoderma lucidum polysaccharides and lucid ganoderma triterpenoid substances can be obtained. According to the method, a short-term steam explosion technology is adopted to pretreat the lucid ganoderma sporocarp, the thermal mechanochemistry action of steam explosion is utilized to break the cell wall of the lucid ganoderma sporocarp, the structure of the solid lucid ganoderma sporocarp is broken, so that the active ingredients of the lucid ganoderma sporocarp can be favorably dissolved out, the extraction time is shortened, the production cost is lowered, and the extraction rate of the functional ingredients is obviously improved compared with that of the conventional extraction method.

The present invention relates to a group of glycosyl transferase and applications thereof, and specifically provides applications of the glycosyl transferase gGT29-7 and a derived polypeptide thereof in terpene compound glycosylation catalysis and new saponin synthesis, wherein the glycosyl transferase can specifically and efficiently transfer the glycosyl from a glycosyl donor to the first glycosyl on C-3 site and / or C-6 site of a tetracyclic triterpene compound so as to extend the sugar chain. The glycosyl transferase of the present invention can further be used for constructing artificial ly-synthesized rare ginsenosides and a variety of new ginsenosides and derivatives thereof.

Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.