5 results about "Thromboxane" patented technology

The invention discloses application of compound resina draconis in preparation of a medicine for treating acute myocardial infarction. The compound resina draconis has the effects of resisting free radical oxidation and platelet aggregation, expanding coronary artery, inhibiting increase of myocardial enzymology CPK and LDH and reducing myocardial oxygen consumption, so that the myocardial infarction range is reduced, and myocardial ischemic ST segment elevation is improved; the compound is combined with aspirin for treating acute myocardial infarction, and the compound and aspirin have a synergistic effect, play a role in resisting platelet aggregation and inhibit synthesis of thromboxane A2, and show a good ischemic myocardial protection effect. Meanwhile, according to the technical scheme that the compound resina draconis is used independently or combined with aspirin, the application range of the medicine is widened, contribution is made for research and development of the medicine for relieving side effects caused by aspirin treatment, and the application prospect is good.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

The present disclosure relates to the synthesis, uses, methods and pharmaceutical compositions of hydroxyepoxide cyclopropane analogs of Formula I: Formula (I). The hydroxyepoxide cyclopropane analogs are useful in the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, pain deficiency, and in the modulation of intracellular calcium concentration. Formula (I)

The invention belongs to the field of medical chemistry and fine chemical synthesis, and relates to a borate-substituted aryl sulfane compound as well as a preparation method and application thereof. And carrying out photochemical reaction on the compound I and the compound II under the action of a base catalyst to prepare the borate-substituted aryl sulfane compound III. The borate-substituted aryl sulfane compound shown in the formula III has an antagonistic effect on a thromboxane A2 receptor, and can be used for molecular screening of drugs for treating cardiovascular diseases and asthma and preventing lung shock. The unique free radical migration mechanism of the method provided by the invention opens up a new dimension for molecular diversity expansion in drug discovery and precise modification in subsequent industrial products and material science, and the newly synthesized borate substituted aryl sulfane compound provides more possibilities for drug molecule design and modification. And a solid foundation is laid for subsequent drug research and development.

The invention discloses a Hu sheep heat stress serum metabolism marker thromboxane B2 as well as a screening method and application thereof, and belongs to the technical field of livestock serum markers. The Hu sheep heat stress serum metabolism marker is thromboxane B2; the screening method of the heat-stress-resistant Hu sheep comprises the following steps: (1) preparing a serum sample of to-be-detected Hu sheep; (2) detecting the concentration of thromboxane B2 in the serum sample by using an ELISA (enzyme-linked immuno sorbent assay) method; and (3) analyzing the difference of the concentration of the thromboxane B2 in the heat-sensitive Hu sheep and the heat-resistant Hu sheep, performing omics analysis, judging a critical value, comparing the critical value with the concentration of the thromboxane B2 in the serum sample, distinguishing the heat-sensitive Hu sheep and the heat-resistant Hu sheep, and screening out the heat-resistant stress Hu sheep. Thrombin B2 is used as a marker for detection, has the characteristics of high accuracy and high sensitivity, and can be directly used as an evaluation index for distinguishing heat-sensitive Hu sheep from heat-resistant Hu sheep.