9 results about "Thromboxane" patented technology

The invention discloses application of compound resina draconis in preparation of a medicine for treating acute myocardial infarction. The compound resina draconis has the effects of resisting free radical oxidation and platelet aggregation, expanding coronary artery, inhibiting increase of myocardial enzymology CPK and LDH and reducing myocardial oxygen consumption, so that the myocardial infarction range is reduced, and myocardial ischemic ST segment elevation is improved; the compound is combined with aspirin for treating acute myocardial infarction, and the compound and aspirin have a synergistic effect, play a role in resisting platelet aggregation and inhibit synthesis of thromboxane A2, and show a good ischemic myocardial protection effect. Meanwhile, according to the technical scheme that the compound resina draconis is used independently or combined with aspirin, the application range of the medicine is widened, contribution is made for research and development of the medicine for relieving side effects caused by aspirin treatment, and the application prospect is good.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

The invention discloses a plasma metabolism composition for predicting atrial fibrillation related cerebral apoplexy and application of the plasma metabolism composition. The plasma metabolism composition is prepared from a plasma metabolite, namely 7-hydroxy-6-methoxy-2H-chromene-2-ketone, deoxyadenosine, arachidonic acid, choline glycerophosphate, eicosapentaenoic acid, fumaric acid and thromboxane B3. The invention further discloses a preparation method of the plasma metabolism composition. The seven screened metabolites are more intuitive, so that researchers can analyze the key metabolites more intensively. The method has the advantages that the detection time is effectively saved, the detection efficiency is improved, the detection cost is reduced, the plasma metabolism composition prediction method based on the molecular level is remarkably different from a traditional clinical complication scoring strategy-based prediction mode, the prediction accuracy is higher, and the method is suitable for popularization and application. And a new technical means is provided for solving the problem of predicting the cerebral apoplexy related to the atrial fibrillation.

The present disclosure provides a method of detecting thromboxane B2 metabolites (TXB2-M) in a urine sample, including determining the amount of thromboxane B2 metabolites (TXB2-M) in the urine sample, adjusting or normalizing the amount of thromboxane B2 metabolites (TXB2-M) to creatinine (e.g., urine creatinine or creatinine level) in the urine sample (e.g., picogram (pg) of thromboxane B2 metabolites (TXB2-M) / milligram (mg) of creatinine), and adjusting or normalizing the creatinine (e.g., pg / mg) in the urine sample to renal function. The present disclosure further comprises methods of examining or determining mortality risk or hear failure risk in a subject, as well as methods of treating subjects (i) at increased risk for heart failure and / or (ii) at increased mortality risk of cardiovascular disease, heart failure, and / or stroke.

The present disclosure relates to the synthesis, uses, methods and pharmaceutical compositions of hydroxyepoxide cyclopropane analogs of Formula I: Formula (I). The hydroxyepoxide cyclopropane analogs are useful in the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, pain deficiency, and in the modulation of intracellular calcium concentration. Formula (I)

The invention belongs to the field of medical chemistry and fine chemical synthesis, and relates to a borate-substituted aryl sulfane compound as well as a preparation method and application thereof. And carrying out photochemical reaction on the compound I and the compound II under the action of a base catalyst to prepare the borate-substituted aryl sulfane compound III. The borate-substituted aryl sulfane compound shown in the formula III has an antagonistic effect on a thromboxane A2 receptor, and can be used for molecular screening of drugs for treating cardiovascular diseases and asthma and preventing lung shock. The unique free radical migration mechanism of the method provided by the invention opens up a new dimension for molecular diversity expansion in drug discovery and precise modification in subsequent industrial products and material science, and the newly synthesized borate substituted aryl sulfane compound provides more possibilities for drug molecule design and modification. And a solid foundation is laid for subsequent drug research and development.

The invention discloses a negative ion saliva metabolite marker related to brain glioma, a product and application of the negative ion saliva metabolite marker and relates to the field of biological medicine. The negative ion saliva metabolite marker is prepared from one or more of heptadecanoic acid, phosphatidylcholine 36: 5, 11-dehydrothromboxane B2 and flavone diacetate. The invention provides a kit, which is used for detecting negative ion saliva metabolite markers related to brain glioma and comprises a specific detection reagent. In addition, the invention also provides a computer program product which is specially used for evaluating brain glioma. The products have good feasibility and accuracy, the risk of brain glioma can be effectively evaluated, and a brand new powerful tool is provided for clinical diagnosis.

The invention discloses a Hu sheep heat stress serum metabolism marker thromboxane B2 as well as a screening method and application thereof, and belongs to the technical field of livestock serum markers. The Hu sheep heat stress serum metabolism marker is thromboxane B2; the screening method of the heat-stress-resistant Hu sheep comprises the following steps: (1) preparing a serum sample of to-be-detected Hu sheep; (2) detecting the concentration of thromboxane B2 in the serum sample by using an ELISA (enzyme-linked immuno sorbent assay) method; and (3) analyzing the difference of the concentration of the thromboxane B2 in the heat-sensitive Hu sheep and the heat-resistant Hu sheep, performing omics analysis, judging a critical value, comparing the critical value with the concentration of the thromboxane B2 in the serum sample, distinguishing the heat-sensitive Hu sheep and the heat-resistant Hu sheep, and screening out the heat-resistant stress Hu sheep. Thrombin B2 is used as a marker for detection, has the characteristics of high accuracy and high sensitivity, and can be directly used as an evaluation index for distinguishing heat-sensitive Hu sheep from heat-resistant Hu sheep.

The invention relates to a traditional Chinese medicine for treating migraine in traditional Chinese medicine internal medicine. According to the traditional Chinese medicine formula provided by the invention, various traditional Chinese medicinal materials are selected, the ligusticum wallichii can reduce generation of thromboxane and prevent headache caused by vascular obstruction, the radix angelicae can inhibit release of pain media and relieve neurogenic inflammation, the notopterygium root, the divaricate saposhnikovia root and the schizonepeta can promote blood circulation and relieve muscular tension through volatile oil, and the gastrodia elata can promote blood circulation through volatile oil and relieve muscular tension through volatile oil. The herba asari contains methyleugenol and has the effects of local anesthesia and central analgesia, the flos chrysanthemi and the herba menthae can generate cool feeling and relieve pain, and the radix aconiti inhibits pain signal transmission by blocking a sodium ion channel. Through synergic cooperation and complementation of the medicines, the migraine symptom of a patient can be effectively treated. In addition, the medicinal materials are common traditional Chinese medicines, low in price, easy to obtain, safe, reliable and free of side effects.