345 results about "Antagonism" patented technology

The invention provides bacillus velezensis NR10, and the preservation number of the bacillus velezensis NR10 is CGMCC (China General Microbiological Culture Collection Center) NO.31771. The bacillus velezensis NR10 is a strawberry endophyte, has good bacteriostatic activity, has good antagonistic action on botrytis cinerea, fusarium oxysporum, colletotrichum gloeosporioides, colletotrichum oxysporum, trichoderma harzianum, trichoderma longibrachiatum and the like, is a potential biological preparation for preventing and treating strawberry diseases and the like, and has broad application prospects. And the bacteriostatic action of the bacillus velezensis NR10 has thermal stability. In addition, the bacillus velezensis also has good capacities of producing siderophores, fixing nitrogen and dissolving potassium, producing protease and cellulase and the like. The bacillus velezensis NR10 provided by the invention has wider-spectrum disease resistance, wide development space and good development and application prospects.

The invention discloses bacillus velezensis Scm3 and application thereof.The bacillus velezensis Scm3 is obtained by screening a strain Scm with an inhibition effect on aeromonas hydrophila from turbot intestinal contents and then conducting ultraviolet mutagenesis on the strain to obtain a strain Scm3 with an enhanced antagonism effect on aeromonas hydrophila, and the strain Scm3 is applied to the preparation of the bacillus velezensis Scm3 and the application of the bacillus velezensis Scm3 to prepare the bacillus velezensis Scm3. 16SrDNA (deoxyribonucleic acid) sequence identification and genome sequencing prove that the strain is bacillus velezensis, and the inhibition mechanism of the bacillus velezensis Scm3 on aeromonas hydrophila is researched by a non-contact co-culture method.

The invention discloses a bionic nano-composite, a preparation method thereof and application of the bionic nano-composite in preparation of a product for treating atherosclerosis, and belongs to the technical field of medicine preparation. The bionic nano compound is a metal nano enzyme Ir-TiO2 coated by an M2 macrophage cell membrane. According to the invention, the surfaces of Ir-TiO2 nanoparticles are coated with M2 macrophage membranes, so that the nanocomposite with a bionic structure is prepared. After intravenous injection, the formed bionic nanocomposite can actively target endothelial cells in atherosclerotic lesions, and release Ir-TiO2 antagonism to endothelial cells in plaques and cytoplasm of inflammatory macrophages. After the Ir-TiO2 reaches the diseased region, the Ir-TiO2 can play an enzyme role to achieve an anti-inflammatory effect, and can promote inflammatory cells such as macrophages and smooth muscle cells at the diseased region to discharge cholesterol, reduce lipid deposition in the cells, reduce the generation of foam cells and promote the growth of plaques. The nanotherapy can effectively prevent the progress of atherosclerosis lesion inflammation and relieve atherosclerosis.

The invention relates to a microbial agent prepared based on a new strain of bacillus velezensis, which has the function of broad-spectrum antagonism of common pathogenic bacteria of aquatic products and can effectively prevent and / or treat bacterial diseases and / or fungal diseases of aquatic organisms including crustaceans and fishes. Meanwhile, the content of nitrite and ammonia nitrogen in aquaculture water can be effectively reduced, and the usage amount and residual quantity of antibiotics and chemical drugs in aquaculture are reduced.

The invention discloses a water quality antibiotic traceability method and system based on data analysis, and the method comprises the steps: firstly constructing a water system network into a topological graph, building a physical information-graph attention network as a pollutant propagation prediction model, and enabling the model to integrate a pollutant convective diffusion partial differential equation as a physical constraint into a loss function, the physical fidelity prediction of the spatial and temporal distribution of the antibiotic concentration in the water body is realized; secondly, constructing a pollution source tracing problem as a reverse reinforcement learning task, and reversely learning a pollution source reward function capable of optimally explaining an observation result from real downstream monitoring data by adopting an antagonism reverse reinforcement learning framework and taking the propagation prediction model as a dynamic environment through antagonism training of a generator and a discriminator; and finally, generating a probability distribution diagram of the upstream candidate pollution source position according to the reward function, and performing accurate positioning in combination with a hydrodynamic constraint condition, thereby remarkably improving the accuracy, robustness and calculation efficiency of traceability.

The invention discloses actinomucor elegans EM-27, a microbial agent and application, and belongs to the technical field of microbial application. The strain is preserved in China General Microbiological Culture Collection Center (CGMCC) on April 24, 2025, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO.41924. According to the invention, an actinomucor elegans strain is separated from wheat rhizosphere, and antagonism experiments find that 8.7% of rhizosphere bacteria have antagonism on the actinomucor elegans, and 91.3% of rhizosphere bacteria and actinomucor elegans can coexist. And by applying actinomucor elegans, the growth and development of wheat can be obviously promoted. Therefore, the actinomucor elegans has a good application prospect in the aspect of improving plant growth and development.

A disulfiram derivative of formula (I)wherein R1 and R2 are independently —CH2CH2COOH, —CH2CH2COOEt, optionally substituted methylenepyridyl, optionally substituted methylenefuranyl, or optionally substituted methylenethiopenyl, may be useful in aldehyde dehydrogenase 1a1 (ALDH1a1) and / or monoacylglycerol lipase (MAGL)-mediated diseases or disorders. Such derivatives may avoid or limit aldehyde dehydrogenase 2 (ALDH2) and / or fatty acid amide hydrolase (FAAH) antagonism.

Provided in the present invention are a TSHR antagonist compound, a pharmaceutical composition, and a preparation method therefor and the use thereof. The compound has good TSHR antagonism, and is used in the treatment of thyroid-associated conditions and / or diseases, such as hyperthyroidism, Graves' disease, Graves' ophthalmopathy, and thyroid eye disease, and in the preparation of a drug for treating such conditions or diseases.

The invention discloses application of brevibacillus laterosporus in degradation of ochratoxin A, and belongs to the technical field of microbiology and biodegradation. The preservation number of the brevibacillus laterosporus is CCTCC NO: M 2022932, the brevibacillus laterosporus can degrade the ochratoxin A and prepare a product for degrading the ochratoxin A, the brevibacillus laterosporus participates in degradation of the ochratoxin A in the form of viable bacteria or fermentation liquor, and the degradation rate of the brevibacillus laterosporus to the ochratoxin A is as high as 98.26%. Besides, tests prove that the brevibacillus laterosporus has an antagonistic effect on the aspergillus ochraceus and can be used for preparing an antibacterial product of the aspergillus ochraceus, so that the ochratoxin A is treated from the source.

The invention discloses 7-aminobenzopyrone or 7-aminoquinolinone compounds and application thereof, the structural general formula of the compounds is as shown in formula (I), and the compounds are compounds with androgen receptor antagonistic activity. The compound provided by the invention has relatively high activity of antagonizing androgen receptor transcription, shows relatively good biological activity at molecular level, cellular level and animal level, and has relatively good safety. Therefore, the compound can be used as an androgen receptor antagonist in preparation of drugs for treating androgen receptor mediated diseases, including but not limited to prostate cancer, metastatic prostate cancer, castration-resistant prostate cancer, breast cancer, ovarian cancer, androgen-derived alopecia and acne. The side effect of systemic androgen antagonism caused by systemic distribution can be avoided, and a safer and more targeted treatment choice is provided for patients.

Provided in the present invention are a TSHR antagonist compound, a pharmaceutical composition, a preparation method therefor and the use thereof. The compound (I) has a good TSHR antagonistic effect, and is used for treating thyroid-associated disorders and / or diseases, such as hyperthyroidism, Graves' disease, Graves' ophthalmopathy, and thyroid eye disease, and for preparing drugs for such disorders or diseases.

The invention relates to the technical field of microorganisms, and particularly provides application of bacillus amyloliquefaciens BA-89 in crop growth promotion and verticillium dahliae antagonism. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.36498. The strain can secrete multiple extracellular enzymes (including protease, amylase, cellulase and glucanase), has the growth promoting characteristics of producing ammonia, dissolving potassium and the like, and can tolerate high temperature and ultraviolet stress; the compound has a remarkable antagonistic effect on various plant pathogenic bacteria (such as verticillium dahliae, fusarium oxysporum and phytophthora capsici); by inoculating the strain on cotton, the plant growth can be obviously promoted, the plant height, stem diameter, root length, leaf area and biomass are improved, and meanwhile, the disease index of verticillium wilt and the colonization amount of pathogenic bacteria at the root are effectively reduced. The strain disclosed by the invention can be used as a biological fertilizer and a biological pesticide, is used for cotton cultivation and disease prevention and control, and has a wide application prospect.

The invention relates to the field of electrocardiosignal processing, and particularly discloses an electrocardiosignal classification method, device and equipment based on multi-mode electrocardiosignal characteristics and a medium thereof.The method comprises the steps that firstly, an original electrocardiosignal is preprocessed, including denoising, resampling and heartbeat segmentation; then three types of complementary features are extracted in parallel: wavelet energy features are extracted through discrete wavelet transform, deep abstract features are extracted through a neural network comprising a multi-scale residual block, a Transform encoder and a windowed global-local attention module, a knowledge graph is constructed based on clinical prior knowledge, and clinical concept features are extracted through a graph convolutional network; adaptive weighted fusion is carried out on the three types of features through a multi-modal feature fusion module; and finally, classification is performed based on the fusion features, and an unsupervised domain adaptation strategy combining antagonism domain alignment and class condition alignment is adopted in the training process. The method effectively solves the problems that a traditional method is single in feature and insufficient in cross-domain generalization ability.

The invention belongs to the field of microorganisms, and particularly relates to trichoderma longibrachiatum CM5J-9 capable of efficiently antagonizing strawberry diseases as well as a screening method and application of the trichoderma longibrachiatum CM5J-9. The preservation number of the trichoderma longibrachiatum CM5J-9 is CGMCC (China General Microbiological Culture Collection Center) NO.41989, the trichoderma longibrachiatum CM5J-9 is preserved in the China General Microbiological Culture Collection Center on May 30, 2025, and the trichoderma longibrachiatum CM5J-9 is classified and named as trichoderma longibrachiatum. The trichoderma longibrachiatum CM5J-9 screened by the invention has a remarkable antagonistic effect on main pathogenic bacteria of strawberry continuous cropping planting soil, and has a remarkable prevention and treatment effect on strawberry related diseases caused by the main pathogenic bacteria. The trichoderma longibrachiatum CM5J-9 provided by the invention is separated from strawberry continuous cropping soil, has good environmental adaptability and disease prevention effect, is large in sporulation quantity, and has great application potential.

The invention provides a compound as shown in a formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof. The compound disclosed by the invention has a relatively good MRGPRX2 antagonism effect. # imgabs0 #

The invention discloses delayed coagulation type super-early-strength quick-hardening mortar and a preparation method thereof, and relates to the technical field of building materials, a shell-core structure targeted modified early strength agent is designed, a staged dry-wet mixing technology is adopted, seabed in-situ curing is combined, cooperation of mortar delayed coagulation construction and super-early-strength development is achieved, and the construction efficiency is improved. According to the present invention, with the design of the targeted modified early strength agent, the surface delayed coagulation shell and the core early strength core structure are formed through the grafting reaction of the sodium nitrite and the hydroxyl carboxylic acid monomer, and the 15-25% accurate grafting rate control is matched, such that the antagonism problem of the traditional early strength agent and the delayed coagulation agent can be solved, and the deep sea open caisson grouting temporary support requirement can be met; in the deep sea environment, the delayed coagulation shell can guarantee a construction window of 75-105 min, the requirement for long-distance grouting of the seabed is met, deep sea high pressure can trigger the delayed coagulation shell to be broken, the core early strength core rapidly activates cement to be hydrated, and the mortar can rapidly form the requirement for rapid bearing of the open caisson temporary support with enough strength.

The present invention relates to a drug carrier system in the form of nanocapsules and nanospheres loaded with luteolin and oleuropein, which have a counteracting effect on tumour cell growth, invasion and angiogenesis, and to a production method (100) of this drug carrier system.

The invention provides heat-resistant bacillus pumilus P2-7 and application thereof in disease prevention and control of prawn culture, and belongs to the technical field of bioengineering. The heat-resistant bacillus pumilus P2-7 provided by the invention is preserved in Guangdong Microbial Culture Collection Center on November 4, 2024, and the preservation number of the heat-resistant bacillus pumilus P2-7 is GDMCC NO. 65408. The strain is different from the traditional antibacterial bacillus in antagonism mode, cannot secrete metabolites with antibacterial activity, plays a role in a phagocytosis mode, can remarkably remove / inhibit pathogenic bacteria in water, can effectively prevent and control shewanella disease of prawns, and has a good application prospect. The composition also has a good effect of simultaneously preventing septicemia, acute hepatopancreas necrosis, white spot syndrome and infectious subcutaneous and hematopoietic necrosis in prawn culture production.

The invention relates to the technical field of medicines, in particular to application of OpiCa1 or a nano-liposome thereof in preparation of medicines for treating and / or preventing myocardial fibrosis related diseases. The research on modeling and administration of myocardial infarction mice finds that the OpiCa1 and the nano-liposome thereof can inhibit myocardial fibrosis and improve myocardial remodeling in the myocardial remodeling period after myocardial infarction, and have a better antagonistic effect on myocardial infarction and subsequent heart failure. Further transcriptomics analysis shows that in the process of treating the myocardial infarction of mice, the OpiCa1 and the nano-liposome thereof may participate in extracellular matrix degradation in myocardial remodeling and fibrosis pathways (such as TGF-beta signal pathways) to inhibit fibrosis and improve myocardial remodeling, and the purpose of relieving deterioration of the myocardial infarction is achieved.

The invention provides an application of a selenium-containing preparation in a drug for antagonizing NK cell injury caused by chemotherapy and a drug for antagonizing cisplatin or adriamycin induced NK cell injury. At present, common cancer treatment methods include operative treatment, chemotherapy, radiotherapy and immunotherapy, and chemotherapy is still a main treatment means for most advanced malignant tumors. Meanwhile, chemotherapy has an inhibition effect on an immune system, which is mainly manifested in that the immune system of a patient is damaged and T cells and NK cells are reduced due to direct killing of chemotherapy drugs on immune cells, so that the normal physiological function of the immune system is influenced, tumor cells can be induced to generate immune tolerance, and the metastasis of the tumor cells is accelerated. The selenium-containing preparation is applied to antagonism of induced damage of cis-platinum or adriamycin to NK cells, damage of cis-platinum or adriamycin to NK cells can be antagonized, and effectiveness of chemotherapy and immunotherapy is improved.

The invention provides a multi-feature fusion-based black box attack detection method (MFBA), device and system, different features are extracted by using a multi-model fusion strategy, the effectiveness and quality of opposite samples are improved, and the MFBA comprises the following three key steps: firstly, obtaining an initial data set from a target model; a decision boundary is approached by using a multi-feature fusion model; secondly, the stability of the model is enhanced through multiple rounds of training application data expansion and incremental learning technologies; and finally, generating opposite examples by using the optimized fusion model. By constructing the comprehensive attack framework, how to combine various model features to improve the performance against the resistance attack is demonstrated; compared with a single substitution model, the antagonism examples generated by the MFBA have higher mobility under different disturbance levels and have better attack effects; according to the method, an effective solution is provided for black box antagonism attacks, and the model in the generation of the advantage opposite paradigm of multi-feature fusion is verified.

The invention discloses a streptomyces rimosus strain and application thereof, and belongs to the field of development and utilization of microbial germplasm resources, the strain is separated from a rice seedling bed rice sample in Wei village town in Xiaoshan area of Hangzhou City in Zhejiang Province, is classified and named as streptomyces rimosus, has a strain number of ZJU55, is preserved in China Center for Type Culture Collection (CCTCC) on November 22, 2024, and has a preservation number of CCTCC M 20242624. The streptomyces rimosus ZJU55 strain provided by the invention has an efficient antagonistic effect on fusarium ramosissimum, and a biocontrol inoculant prepared from fermentation liquor of the streptomyces rimosissimum ZJU55 strain can effectively inhibit the growth of fusarium ramosissimum hyphae, the production of spores and the germination of the spores, and can be used for preventing and treating rice bakanae disease caused by fusarium ramosissimum infection; the prevention and control efficiency of a pot experiment is stabilized to be 80% or above.

The invention provides application of bifidobacterium breve in preparation of a product for resisting gastric ulcer and gastric inflammation caused by helicobacter pylori, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve NKU BB1-2 is GDMCC NO: 65956, and the bifidobacterium breve NKU BB1-2 can antagonize helicobacter pylori colonization and relieve gastric ulcer aggravation caused by helicobacter pylori. The bifidobacterium breve NKU BB 1-2 has good helicobacter pylori antagonism ability in an in-vitro environment, and can significantly inhibit colonization growth of helicobacter pylori; animal experiments show that the bifidobacterium breve NKU BB 1-2 can relieve gastric ulcer aggravation caused by helicobacter pylori infection in vivo, and the gastric mucosa lesion is relieved, the stomach inflammation is relieved, and the stomach pH value is increased; in addition, the bifidobacterium breve NKU BB1-2 can also significantly improve the diversity of stomach microorganisms, regulate and improve the structure of the stomach microorganisms, and assist antagonism and removal of helicobacter pylori infection.

The invention provides an endophyte Gliocladium roseum NG-12, which is named as Gliocladium roseum NG-12, and the preservation number of the endophyte Gliocladium roseum NG-12 is CGMCC (China General Microbiological Culture Collection Center) No. 41801. The endophyte Gliocladium roseum NG-12 provided by the invention has good root-knot nematode killing activity and antibacterial activity, has a good antagonistic effect on various plant pathogens such as fusarium oxysporum, colletotrichum gloeosporioides and colletotrichum gloeosporioides, is a potential biological preparation for preventing and treating root-knot nematode diseases, fusarium wilt, anthracnose and the like, and also has the effects of dissolving potassium, fixing nitrogen, dissolving phosphorus, preventing and treating the root-knot nematode diseases and the like. The capability of producing siderophore, protease and cellulase is realized. The gliocladium roseum provided by the invention has a wide development space and a good development and application prospect.

The present invention relates to a novel anti-CD40 antibody and use thereof and, more specifically, to a novel anti-CD40 antibody and use thereof, wherein the antibody comprises a complementarity determining region of a specific sequence and exhibits an excellent antagonistic effect by blocking CD40-CD40L signaling. The novel anti-CD40 antibody of the present invention exhibits an excellent antagonistic effect by blocking CD40-CD40L signaling, and thus can be widely used as a preparation for preventing or treating various diseases, such as autoimmune diseases and chronic inflammatory diseases, and as a preparation for inhibiting immune rejection at the time of transplantation.

The invention discloses staphylococcus xylosus and application of the staphylococcus xylosus in antagonism of ralstonia solanacearum, and relates to the technical field of agricultural biological control, the staphylococcus xylosus CQZY-H-XJ-0002 provided by the invention is preserved in Guangdong Microbial Culture Collection Center on October 14, 2024, and the preservation number of the strain is GDMCC NO.65264. The staphylococcus xylosus CQZY-H-XJ-0002 provided by the invention is named as KQZY-H-XJ-0002. The staphylococcus xylosus CQZY-H-XJ-0002. The strain has a remarkable effect of inhibiting the growth of ralstonia solanacearum, and can effectively prevent and treat bacterial wilt and promote plant growth. The strain has the advantages of being simple in process, easy to operate, low in cost, green, safe, non-toxic and the like when being used for biological control.

Provided in the present invention is a compound as represented by formula (I), or a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt or prodrug thereof. The compound has a good antagonistic effect against MRGPRX2.

The invention discloses bacillus subtilis Bs1 as well as an antagonistic substance and application thereof. According to the invention, Bs1 with antagonism on colletotrichum gloeosporioides is separated and screened for the first time, an antagonistic substance is clear as Bs1 serine-producing protease Vpr, a Bs1 bacteriostasis mechanism and biological control potential excavation are analyzed in a multi-omics manner, a peripheral colonization rule of Bs1-Rif is clear, and an indoor control strategy of the strain Bs1 on cunninghamia lanceolata anthracnose is optimized. When the strain Bs1 is applied on the day when pathogenic bacteria are inoculated, a certain prevention and treatment effect is achieved, and it is indicated that the strain Bs1 can rapidly occupy the ecological niche; the average antibacterial rate of the strain Bs1 can reach 66.69%. The biocontrol strain and theoretical basis are provided for prevention and control of Chinese fir diseases, the application of biological prevention and control in forestry is promoted, the interaction mechanism of biocontrol bacteria and pathogenic bacteria can be deeply understood, and the sustainable development requirement of modern forestry is met.

The invention discloses Erwinia phyllostachys ZX-13 and application thereof in antagonism of epidemic disease pathogenic bacteria of Eupin, and belongs to the technical field of microorganisms. The invention discloses a Erwinia phyllostachys ZX-13, and the preservation number of the Erwinia phyllostachys ZX-13 is GDMCC No: 66800. The Erwinia phyllostachys ZX-13 disclosed by the invention can be used for preventing and treating the epidemic disease of the elaphus japonicus caused by the cryptophyton pseudophyllanthus of the elaphus japonicus; the Erwinia rhizosphere ZX-13 is a biological control potential strain with good antagonism effect, high control effect and good environmental safety, and has good development and application prospects.

In various examples, a technique for processing sensor data includes generating, using a machine learning model and based on a first instance of sensor data, a first set of confidence for a set of output types, and a first antagonism confidence representing a likelihood that the first instance of sensor data is antagonistic. The technique further includes determining, based on the first antagonism confidence, that the first sensor data instance is antagonistic. The technique further includes transmitting a first indication to one or more downstream components indicating that the first instance of sensor data is antagonistic, such that the one or more downstream components perform one or more operations based at least on the indication.