5 results about "CGRP receptor" patented technology

The application provides an application of a hair follicle immune homeostasis regulation strategy in treating alopecia diseases. A group of pathological LAMP3 + CCR7 + IL4I1 + DC3 dendritic cell subpopulation. A DC3 dendritic cell subpopulation marker gene Il4i1 Drive conditionally knockout one of the CGRP receptor complexes Calcrl The constructed spontaneous alopecia areata animal model can well simulate the progressive and active hair loss of alopecia areata patients, form stable hair loss patches, and combine with pathological changes such as hair follicle immune cell infiltration, which indicates that the dendritic cell CGRP signal loss is an important inducement for mediating systemic alopecia areata. The application also discloses a pharmaceutical composition or kit for preparing a drug for relieving / treating hair loss, improving hair follicle homeostasis, or enhancing hair growth / black coloration (reducing white hair), which comprises: (a) a JAK kinase inhibitor, and (b) a neuropeptide CGRP or a receptor agonist thereof.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating headache and a preparation method thereof. The pharmaceutical composition comprises the following raw materials in parts by weight: 30-40 parts of a pharmaceutical active component, 2-4 parts of a disintegrating agent, 6-11 parts of a filler and 0.2-0.5 part of a lubricant, the active pharmaceutical ingredient consists of porphyridium polysaccharide and manganese gluconate in a mass ratio of 1: (0.5-1). The action mechanisms of the two active components in the pharmaceutical composition are clear and complementary: porphyridium polysaccharide reduces the expression of a proinflammatory factor by inhibiting an NF-kappa B signal channel so as to relieve the stimulation to trigeminal nerve endings, and the porphyridium polysaccharide is mild in action and can avoid the potential influence of strong immunosuppression on the immune system of children; manganese gluconate blocks a CGRP receptor in a targeting manner, directly inhibits nerve ending sensitization and central pain signal transduction mediated by the pain-inducing peptide, and intervenes migraine attack from a key path.

The invention relates to the technical field of biological medicines, in particular to application of a CGRP inhibitor remegapam and a PD-1 inhibitor in combined preparation of a medicine for treating colorectal cancer liver metastasis. Experimental results show that remegapam effectively reverses a liver immunosuppression microenvironment by blocking a CGRP receptor, and generates a remarkable synergistic anti-tumor effect with a PD-1 inhibitor, so that a brand new effective strategy is provided for overcoming immunotherapy drug resistance of colorectal cancer liver metastasis.

A method in which gepants (antagonists of calcitonin gene related peptide (CGRP) receptor) are used for direct treatment of nausea and vomiting including chemotherapy-induced nausea and vomiting (CINV). Among them, drugs frequently prompt nausea and vomiting, such as antitumor chemotherapeutics which often cause CINV which in turn can severely compromise efficacy of therapy, as well as patient quality of life. The method uses antagonists of the CGRP receptor recently approved for migraine treatment to target calcitonin gene related peptide (CGRP), a neuropeptide with pleiotypic effects in the human body to prevent and counteract drug-induced nausea and vomiting including CINV.

The present disclosure provides methods for the treatment of migraine, such as the acute treatment of migraine, in particular during the prodrome stage of a migraine attack, comprising administering a CGRP receptor antagonist. In particular, the present disclosure provides methods for administering ubrogepant during the prodrome or premonitory phase for the acute treatment of migraine.