45 results about "Vomiting" patented technology

The invention provides a nicotine orally disintegrating tablet with a multi-layer composite sustained-release structure and a preparation method of the nicotine orally disintegrating tablet. The nicotine orally disintegrating tablet comprises an inner layer, a middle layer and an outer layer, wherein the middle layer and the outer layer sequentially coat the inner layer from inside to outside; the outer layer comprises nicotine, instant starch and a lubricant; the middle layer comprises nicotine, ethyl cellulose, polyethylene glycol and a flow aid; the inner layer comprises the following components: nicotine nanoparticles coated with chitosan and sodium tripolyphosphate, an oral microenvironment regulator and a filling agent. According to the nicotine orally disintegrating tablet provided by the invention, due to the gradient coating structure design of the inner layer, the middle layer and the outer layer, the multi-stage accurate release of nicotine, namely early-stage quick release, middle-stage stable release and later-stage slow release, is realized, the reactions of dizziness, vomiting and the like caused by excessive release of nicotine are avoided, and the use comfort is improved. Meanwhile, the pH value of the oral cavity is adjusted, micro-ecological balance of the oral cavity is maintained, the content of volatile sulfide in breath is reduced, and breath is refreshed.

This invention provides a novel GABA structure with better efficacy, reduced side effects, and greater safety for clinical use. A This invention relates to receptor agonists, specifically a phenol derivative, its preparation method, and its use in the central nervous system. The phenol derivative provided by this invention offers more and better drug options for inducing or maintaining anesthesia in animals or humans, promoting sedation and hypnosis, and treating and / or preventing anxiety, nausea, vomiting, migraines, seizures, epilepsy, neurodegenerative diseases, and other central nervous system-related disorders.

The application belongs to the technical field of emetic, and specifically discloses an emetic device for emergency department, which comprises an emetic trolley, a buffer soft negative pressure production device, a pharyngeal stimulation device and a vomit collection device. The emetic device is capable of realizing individualized and accurate emesis for different patients through double self-adaptive adjustment of height and stimulation frequency, and significantly improves the emetic efficiency and comfort. The innovative integrated air self-purification system can actively eliminate the irritating odor of vomit, and fundamentally improves the diagnosis and treatment environment. The device synchronously solves the four core problems of adaptability, efficiency, hygiene and environmental friendliness in an integrated manner, and provides a revolutionary emetic solution for clinical treatment.

A traditional Chinese medicine composition for alleviating gastrointestinal toxic side effects caused by chemotherapy, the traditional Chinese medicine composition for daily administration is prepared from the following weight ratio of traditional Chinese medicine formula: Taizishen 20-30g, Fuling 10-15g, Fried Baizhu 10-15g, Zhigancao 5-10g, Jiangbanxia 5-10g, Chenpi 5-15g. The formula can effectively alleviate the gastrointestinal toxic side effects caused by chemotherapy, such as nausea, vomiting, diarrhea, poor appetite, etc.

The invention relates to the technical field of massage, in particular to an anti-vomiting massage device for chemotherapy nursing, and provides the following scheme aiming at the defect that in the prior art, the neck is inconvenient to massage at the same time, so that the use feeling is poor, the anti-vomiting massage device for chemotherapy nursing comprises a wearing main body, and a first air bag is mounted on the inner wall of the wearing main body; a first air pump is fixedly mounted on the wearing main body, and the output end of the first air pump is fixedly connected with the first air bag; the number of the connecting blocks is two, the two connecting blocks are both fixedly installed at the top of the wearing main body, a shell is fixedly installed on the two connecting blocks, a second air bag is installed on the inner wall of the shell, a second air pump is fixedly installed on the shell, and the output end of the second air pump is fixedly connected with the second air bag. And the massage plate is mounted on the inner wall of the shell, so that the neck can be massaged at the same time, and the use feeling is improved.

The suppression of the gag reflex response, administered through a training device and associated desensitization method(s), without medical intervention, is desirable for many people who suffer from gag reflex response issues. An oral acclimation training device comprise various thickness(es) and length(s) and may have components to prevent swallowing or choking of the device by the user. Further, the device may be part of a kit having multiple training objects with specific attributes (e.g. thickness, depth, shape, finish, texture) that are designed for a specific stage in the training sequence and tailored for the user's inherent gag reflex sensitivity. Training objects are designed to provide optimal stimulus range to cause desensitization but not cause severe gagging or vomiting. The gag suppression stemming from this device is long-term, meaning that it may last for many weeks or months, depending on the individual. This duration may be extended indefinitely by occasional re-training or similar conditioning.

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

The present invention relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has the effects of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis and reducing triglyceride levels.

Provided herein are formulations for use in enteral tube feeding, that contain one or more whole food-based ingredients, mineral nutrients, small molecules, and / or large molecules, the combination of which is effective to bind bile acids when administered to a subject in need thereof. The combination of crafted ingredients for tube feeding reduce symptoms of gastroesophageal reflux, vomiting, abdominal pain, irregular stooling (diarrhea or constipation) and to reduce organ damage including pneumonia, pharyngitis, aspiration, esophagitis, gastritis and enteritis.

Disclosed are the use of methods for reducing one or more gastrointestinal side effects in a subject receiving glucagon-like peptide-1 (GLP-1) receptor agonist (RA) therapy. The methods include administering to a subject receiving GLP-1 RA therapy an amount of homotaurine-like gastrointestinal distress-relieving (HTL-GIDR) composition effective to reduce gastrointestinal side effects of GLP-1 RA therapy, e.g., nausea, vomiting, and constipation. Generally, the HTL-GIDR composition can be homotaurine or a homotaurine analog such as acamprosate calcium and valiltramiprosate (ALZ-801), or a combination thereof. Furthermore, the HTL-GIDR composition may facilitate tolerance during the GLP-1 RA dose escalation phases and enable administration of higher GLP-1 RA doses, thereby enhancing therapeutic outcomes in conditions including diabetes, obesity, and neurodegenerative diseases.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related nausea and vomiting, an acupoint patch and a preparation method, and belongs to the technical field of traditional Chinese medicine research. According to a fine-tuning external application formula, acupoint external application is achieved, medicine transdermal absorption is matched with acupoints to stimulate channel and qi combination, and the effect is special and strong; the medication route is changed, oral administration is avoided, and the gastrointestinal burden is relieved. Aromatic traditional Chinese medicines are used for guiding channels, promoting qi circulation, dredging collaterals and promoting transdermal absorption; and the aromatic traditional Chinese medicines enter spleen and stomach channels, enlivene spleen and please stomach, and are helpful for improving gastrointestinal reactions such as nausea and vomiting. The acupoint patch is simple and easy to operate and learn, has a high degree of recognition by the masses, and is easy to popularize in western medicine hospitals and primary hospitals.

The invention discloses a traditional Chinese medicine composition for treating a warm disease clinically belonging to the same disease of defensive qi and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 5-35 parts of bupleurum chinense, 9-50 parts of scutellaria baicalensis, 9-50 parts of artemisia apiacea, 5-35 parts of radix paeoniae rubra, 5-35 parts of moutan bark and 4-26 parts of folia perillae acutae. According to the traditional Chinese medicine composition, the effects of all the medicines are utilized to generate a synergistic effect, and the effects of relieving fever, eliminating evil and detoxifying are achieved together. The traditional Chinese medicine composition is used for treating fever or hyperpyrexia, slight aversion to wind-cold, headache, sweating, thirst, cough and pharyngalgia caused by cold, viral cold and upper respiratory tract infection febrile disease defensive qi, and can be accompanied by nausea, vomiting, neck stiffness, rash appearance, red eye swelling and pain and the like, so that the febrile disease is effectively treated.

The utility model is suitable for medical product technical field, provide a dual -purpose vomiting device, including hanging and vomiting cup, the bottom of hanging is groove support portion, the top opening of vomiting cup is inwards and downward forms the groove, and the front wall of vomiting cup forms the convex part inwards and convexly, the back of vomiting cup has handle, the outer side wall of groove support portion extends upward and forms extension, and the central part of extension corresponds to handle and forms avoidance mouth. The hanging can be used alone as patient meal nursing, the vomiting cup can be used alone, can be placed in the hanging, the patient can not hold the vomiting cup, the operation is convenient, when cleaning, the vomiting cup can be taken out from the hanging, the operation is also more convenient, and the vomiting cup can be repeatedly used.

The utility model discloses a combined probe electronic gastroscopy instrument, which relates to the technical field of gastroscopes, and comprises a gastroscopy tube body, an operating part is arranged at the top of one end of the gastroscopy tube body, a connecting part is arranged on one side of the operating part, a control panel is arranged at the top of the operating part, and a probe is arranged on the control panel. The electronic gastroscopy device comprises an operation portion, two ends of the operation portion are provided with water supply ports, the other side of the operation portion is provided with an air supply port, and the other ends of the water supply ports and the other end of the air supply port are provided with electric control valves. The problems that when a gastroscope tube needs to be rotated, friction force exists between the gastroscope tube and the throat, the throat is stimulated and injured, reactions such as vomiting and cough of a patient are increased, the examination quality and efficiency are affected, and the infection risk is increased are solved.

This utility model relates to the field of medical container technology, specifically to a vomit collection device, including a base and a collection assembly. The collection assembly includes a support component, a collection bucket, multiple fixing components, a guide column, a sliding column, a guide rod, a cover plate, and a handle. A collection bag or garbage bag is opened and placed inside the collection bucket, and the edges of the collection bag are fixed by the multiple fixing components. When a patient needs to vomit, they hold the handle and pull the cover plate slightly upward away from the collection bag, and then move the cover plate horizontally to remove it from the top of the collection bucket. The patient can then vomit into the collection bag. After the patient finishes vomiting, they first hold the handle and pull the cover plate slightly upward, then move the cover plate back to the top of the collection bucket, and then place the cover plate on top of the collection bucket. The cover plate will press on the collection bag in the collection bucket. The cover plate can prevent the odor of vomit from escaping after collection, avoiding any impact on the ward environment.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with vomiting stopping and blood rising effects and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following sixteen traditional Chinese medicines as raw materials: pinellia ternate, fingered citron, bamboo shavings, pericarpium citri reticulatae, mulberry, fried malt, endothelium corneum gigeriae galli, astragalus membranaceus, bighead atractylodes rhizome, citron, medlar, dogwood, poria cocos, lignum dalbergiae odoriferae, rhizoma polygonati and rhizoma zingiberis, and a formula system is constructed by taking the core compatibility target of calming adverse-rising energy and arresting vomiting, reinforcing qi and nourishing blood, tonifying spleen and kidney, and regulating qi and harmonizing stomach and following the compatibility theory of monarch, minister, assistant and guide in the traditional Chinese medicine. The traditional Chinese medicine composition has double effects of stopping vomiting and raising blood, is suitable for adverse reactions caused by various tumor treatment modes, can effectively improve the treatment tolerance and life quality of tumor patients, and has important clinical application value in the field of tumor adjuvant therapy.

GIP receptor agonists of the present disclosure have anti-emetic properties and therefore can be used to reduce or inhibit the frequency or severity of episodes of nausea or emesis in a patient in need thereof.

The present application relates to a compound as shown in formula (I), stereoisomer, tautomer, isotopically labeled, nitroxide, solvate, polymorph, pharmaceutically acceptable salt or prodrug thereof, and preparation method and pharmaceutical composition. The compound is an NK-3 receptor antagonist, which can be used for preventing and / or treating depression, anxiety, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory disease, vomiting, preeclampsia, airway related disease, reproductive disorder, contraception and sex hormone dependent disease, gynecological disease related disease, menopausal syndrome related disease.

The utility model relates to the technical field of receiving devices, in particular to a vomit receiving device which comprises a box body assembly, the box body assembly comprises a base, the upper surface of the base is fixedly connected with a cabinet body, the upper surface of the cabinet body is fixedly connected with a handrail, the upper surface of the cabinet body is fixedly connected with a flushing assembly, and the flushing assembly comprises a wash basin. The wash basin is fixedly connected with the upper surface of the cabinet body, the lower surface of the wash basin is fixedly connected with a sewer pipe, the upper surface of the cabinet body is fixedly connected with a faucet, the other end of the sewer pipe is fixedly connected with a water pump, the dirt receiving assembly comprises a placing frame, and one side of the placing frame is fixedly connected with a support. According to the vomitus cleaning device, the risk of pathogen and virus transmission is reduced, the health of patients and medical staff is protected, the wash basin and the faucet enable the patients to conveniently clean the oral cavity and the face after vomiting, more comfort is provided, discomfort and psychological stress after vomiting are reduced, and vomitus can be directly collected and treated due to the existence of the wash basin.

The invention provides a spleen-tonifying and detoxifying traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises a formula A and a formula B. The traditional Chinese medicine composition has a comprehensive conditioning effect and can relieve chemotherapy side effects, improve intestinal flora distribution, promote intestinal health, enhance the chemotherapy effect and improve the disease control rate. Wherein the formula A focuses on tonifying spleen and regulating qi, and improving nausea, vomiting and other symptoms at the initial stage of chemotherapy, and the formula B is added with medicines for clearing away heat and toxic materials and promoting blood circulation to remove blood stasis on the basis, is suitable for patients with myelosuppression with cancer toxicity residue, and strengthens the effects of clearing away heat and toxic materials and removing stasis; the composition has a multi-target action mechanism, and through the combined action of multiple ways, the treatment effect is enhanced, and the side effect is reduced.

The application discloses a splash-proof sealed chemotherapy and radiotherapy vomiting nursing device and a use method. The device comprises an outer cylinder, the bottom end of the outer cylinder is integrally fixedly connected with a base, the inner wall of the outer cylinder is sleeved with an inner cylinder, the top of the inner cylinder is provided with a receiving assembly for receiving vomitus, the base is internally provided with a power assembly for driving the inner cylinder to rotate, the base is internally provided with a burying body for burying vomitus, the outer wall of the inner cylinder is fixedly connected with a lifting device, and the side wall of the inner cylinder is provided with a plurality of feeding ports. When the inner cylinder drives the lifting device to rotate, the burying body is upwardly conveyed, the receiving assembly is used for receiving and collecting vomitus, the vomitus enters the inner cylinder and is covered with a cylinder cover, the power assembly can drive the inner cylinder to rotate, and when the inner cylinder drives the lifting device to rotate, the burying body contained in the base is conveyed to the top and falls into the inner cylinder through the feeding ports to bury the vomitus, so that the vomitus is made to be lumped and the peculiar smell is covered and adsorbed.

The present invention belongs to the field of polypeptide pharmaceuticals, and provides a dual agonist polypeptide compound and the pharmaceutical use thereof. An amino acid sequence of a GIP-R and GLP-1R dual agonist polypeptide compound is: Y1-X1-EGTFTSDYSI-X2-LDKI-X3-Q-Bn-X4-X5-VQWLI-X6-GGPSSG-X7-PPPS, and the C-terminal amino acid is amidated. The GIP-R and GLP-1R dual agonist polypeptide compound has a more significant dual agonistic effect on human glucose-dependent insulinotropic polypeptide (GIP) and human glucagon-like peptide-1 (GLP-1) receptors. The compound not only has the effects of lowering blood sugar and reducing weight, but also has a longer half-life and a higher bioavailability. The compound can avoid adverse reactions such as nausea and vomiting caused by the long-term use of existing drugs, and thus can be used as an effective raw material for the preparation of a drug for treating or preventing diabetes or an anti-obesity drug.

The utility model relates to the field of medical devices, in particular to a vomiting promoting device for emergency nursing, which comprises a frame body. A first U-shaped frame is fixedly connected to the frame body, a forceps body is fixedly connected to the front end of the first U-shaped frame, a connecting strip is rotationally arranged at the front end of the forceps body, elastic frames are fixedly connected to the upper end and the lower end of the connecting strip, and tooth placement grooves are formed in the outer walls of the elastic frames. The included angle distance of the clamp body is adjusted by rotating the nuts on the two screws, so that the two connecting strips are close to each other, the two elastic frames are arched towards opposite distances, the mouth is changed into an O shape, and when in use, the connecting rod is limited by the length of the connecting rod, so that the front-back displacement distance of the push handle is limited, and the push handle is prevented from moving forwards and backwards. The problem that the tongue depressor stretches too deep or too shallow, and consequently vomiting cannot be normally promoted can be solved, when cleaning is needed, a rubber sleeve on the tongue depressor is pulled out of a connecting rod, and then a vomiting promoting assembly is taken out of a second U-shaped frame to be cleaned.

1. The name of the design product: anti-vomit lying feeding slope pillow. 2. The use of the design product: for baby pillow, lying, and prone, instead of mother's embrace, slope to reduce choking and vomiting. 3. The design points of the design product: in the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: perspective drawing. 5. The design claimed contains color.

This invention belongs to the field of medical auxiliary device technology and discloses a chemotherapy support device for oncology. It includes a seat body, a respiratory status detection device, and a controller. The seat body is connected to armrests, a Neiguan acupoint massage component, a Zusanli acupoint massage component, an abdominal heat therapy component, a headrest, and a speaker. The Neiguan acupoint massage component includes a base, a motor, a fixed gear ring, a sun gear, planetary gears, and massage balls. The Zusanli acupoint massage component includes an air pump and an airbag. The abdominal heat therapy component includes a strap, a medicine storage box, a heat therapy bag, and an electric heating wire. The respiratory status detection device includes a pressure sensor. This invention utilizes the Neiguan acupoint massage component to stimulate and massage the Neiguan acupoint, the Zusanli acupoint massage component to compress the Zusanli acupoint, and the abdominal heat therapy component to provide heat therapy to the abdomen, effectively relieving symptoms such as nausea and vomiting, numbness in the hands and feet, and abdominal cold pain after chemotherapy.

The application belongs to the technical field of medicine, and specifically provides an entero-soluble ibrexin tablet with high bioavailability and a preparation method thereof. The entero-soluble tablet comprises a tablet core and an enteric coating, wherein the tablet core comprises an ibrexin coating compound, microcrystalline cellulose and magnesium stearate, and the ibrexin coating compound comprises ibrexin or a pharmaceutically acceptable salt thereof, an acid regulator, povidone and cross-linked sodium carboxymethyl cellulose. The ibrexin entero-soluble tablet of the application can make the drug reach the end of the small intestine or the colon for release, thereby avoiding the metabolism of cytochrome P450 (CYP) 3A, and at the same time, the acid regulator can locally provide an acidic environment for the active ingredient, so that the ibrexin is rapidly dissolved and released, and the side effects such as vomiting in the gastrointestinal tract are reduced.

The invention belongs to the technical field of medical instruments, and particularly relates to an auxiliary device suitable for paranasal sinus negative pressure replacement and a using method.The auxiliary device comprises two clamping handles and a controller, an elastic bent strip is arranged between the two clamping handles, and the two ends of the elastic bent strip are fixedly connected with the inner walls of the two clamping handles correspondingly; the inner side wall of the tail end of the clamping handle is fixedly connected with a first induction piece, the tail end of the clamping handle is fixedly connected with an expansion air bag, and the clamping handle is of a cavity structure. An air pump is further included, the output end of the air pump is fixedly communicated with a catheter, the outer end of the catheter is fixedly communicated with a three-way pipe, and the other two ends of the three-way pipe are communicated with the two clamping handle cavities respectively. Compared with a traditional method, the requirement for the body position of a patient is not very strict, the matching degree of the patient is greatly increased, the possibility that medicine flows into the throat and the lower respiratory tract is limited through the expansion air bag of the rear nostril, the reaction degree of nausea and vomiting of the patient is greatly reduced, and complications are also reduced.

The invention discloses a sectional type gastric bypass stent conveying and releasing system, and relates to the technical field of medical instruments. The sectional type gastric bypass stent conveying and releasing system comprises a sectional type stent and a conveying and releasing mechanism, the sectional bracket comprises an upper bracket, a lower bracket, a connecting rope and a membrane tube, the upper bracket and the lower bracket are connected through the connecting rope, and one end, far away from the upper bracket, of the lower bracket is connected with the membrane tube; the lower support and the membrane pipe are both contained in a containing pipe of the conveying and releasing mechanism, the membrane pipe is connected with the releasing small ball, the lower support makes contact with the support pushing block, the connecting rope is led out of the rope passing groove, and the upper support is contained in a gap between a conveying pipe of the conveying and releasing mechanism and an outer sleeve. The sectional stent provided by the invention reduces the incidence rate of gastrointestinal tract events (vomiting, nausea, stomachache and the like) and stent displacement, reduces the occurrence rate of gastric retention or obstruction, and is not easy to form pressure ulcer. The sectional type support and the conveying and releasing mechanism are high in matching performance, and the conveying and releasing effects are better.

This invention discloses a dual-activator polypeptide compound and its pharmaceutical uses, belonging to the field of polypeptide pharmaceuticals. The amino acid sequence of the GIP-R and GLP-1R dual-activator polypeptide compound is: Y-Z-EGTFTSDYSI-X2-LDKI-A-Q-B n -X4-X5-VQWLI-X6-GGPSSG-A-PPPS, with the C-terminal amino acid being amidated. The GIP-R and GLP-1R dual-agonist polypeptide compounds of this invention exhibit more significant dual-agonist activity against human glucose-dependent insulinotropic peptide (GIP) and human glucagon-like peptide-1 (GLP-1) receptors. They not only possess hypoglycemic and weight-loss effects but also have a longer half-life and higher bioavailability, avoiding adverse reactions such as nausea and vomiting caused by long-term use of existing drugs. They can be used as effective raw materials for preparing drugs for treating or preventing diabetes or weight-loss drugs.