1640 results about "Vomiting" patented technology

A system and method for treating nausea and vomiting are provided, including one or more electrodes (10, 12) applied on or under the skin, the electrodes being connected to an external current source (34). The electrodes can be implanted under the skin and connect to internal stimulator electronics (22), which can form a magnetic inductive link to the external current source (34). Alternatively, the electrodes can be placed on the skin and directly linked by wires to the external current source. As a further alternative, the vagus nerve can be directly stimulated in the neck, or the esophagus, stomach, duodenum, or intestines can be directly stimulated by magnetic stimulation. The electrodes can stimulate the vagus nerve in the neck to reduce nausea and vomiting, or can be arranged near the chest or abdomen, so as to stimulate the esophagus, stomach, duodenum or intestines. Because the current source is provided outside the body, it is not necessary to implant batteries or another power supply in the body.

A prosthesis (13) for implanting in an upper stomach to prevent gastric reflux in an esophagus comprising a tube (17) made of a biocompatible polymer that is resistant to gastric acid, the tube having an upper end and a lower end, a length, and a generally constant diameter along the entire length thereof, the upper end having means (16) for securing to the upper stomach, the lower end having at least one slit (18) to facilitate inversion of the tube during vomiting but to facilitate collapsing of the tube under pressure generated by gastric reflux.

The present invention provides therapeutic formulations for solutions of DELTA9-tetrahydrocannabinol (DELTA9 THC) to be delivered by metered dose inhalers. The formulations, which use non-CFC propellants, provide a stable aerosol-deliverable source of DELTA9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.

A compound of formula:

where Ar₁, Ar₂, X, R₃, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Tetrahydropiperidyl Compound”); compositions comprising an effective amount of a Tetrahydropiperidyl Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Tetrahydropiperidyl Compound are disclosed herein.

Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula:

and pharmaceutically acceptable salts thereof, wherein Ar₁, Ar₂, X, R₃, R₄, and m are as disclosed herein.

The invention discloses a new Chinese medicinal composition for treating medial headache and migraine and a preparation method thereof. The Chinese medicinal composition comprises the following raw material medicaments: szechuan lovage rhizome, root of red-rooted salvia, costustoot, fenugreek lysimachia, benzoin, tangerine peel, radix curcumae, cyperus rotunus, golden thread, baical skullcap root, cassia twig, incised notopterygium rhizome, angelica dahurlica, kudzuvine root, peach seed, safflower, common burreed rhizome, zedoary, pangolin scales, raw astragalus, radix paeoniae alba, red paeony root, tall gastrodia tuber, gambir plant, storax, grassleaf sweelflag rhizome, fineleaf schizonepeta herb, divaricate saposhnikovia root, radix ephedrae, weeping forsythia, manchurian wildginger, biond magnolia flower, mentha haplocalyx, raw rehmannia root, szechwan chinaberry fruit, rose, radix pseudo-ginseng, rosewood heart wood, garden burnet root, leonurus heterophyllus, cowherb seed, ground beeltle, sappan wood, dragon's blood, pinellia tuber and the like. The Chinese medicinal composition can be prepared into any oral administration preparation used commonly according to the conventional method of Chinese medicinal preparations. The Chinese medicinal composition can improve headaches of bitamporal, foreheads and orbital parts, pulsatile headache or boring pain and the like, and associated symptoms of nausea, vomiting, blurred vision, frequent micturition, urination disorder, stuffy nose, palpitation, hypertension, hypotension, arrhythmia, megrim, ataxia, diplopia, hearing loss, tinnitus, disturbance of consciousness and the like obviously, and has definite clinical effects, obvious curative effect and quick response. The Chinese medicinal composition of the invention is combined by adopting medicinal and edible medicaments formulated by National Formulary basically, and thus, the Chinese medicinal composition has the advantages of low cost and no toxic or side effect.

The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.

Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.

The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

The invention is the compounds

• 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)-4-o-tolyl-pyridin-3-yl]-N-methyl-isobutyramide and
• 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide.

Compounds of the invention are useful in pharmaceutical compositions for the treatment of migraine, rheumatoid arthritis, asthma, bronchial hyperreactivity, inflammatory bowel disease or for the treatment of disorders including Parkinson's disease, anxiety, depression, pain, headache, Alzheimer's disease, multiple sclerosis, edema, allergic rhinitis, Crohn's disease, ocular injury, ocular inflammatory diseases, psychosis, motion sickness, induced vomiting, emesis, urinary incontinence, psychoimmunologic or psychosomatic disorders, cancer, withdrawal symptoms of addictive drugs from opiates or nicotine, traumatic brain injury or benign prostatic hyperplasia.

The invention discloses a jujube-ginger compound beverage and a preparation method thereof. The beverage comprises the following raw materials in percentage by weight: 40% of jujube-ginger compound juice, 8% of sugar, 0.20% of sour agent, 0.003% of jujube essence, 0.4% of potassium sorbate and the balance of pure water, wherein the volume ratio of ginger juice to jujube juice in the jujube-ginger compound juice is 1:5. The beverage processed by using the method disclosed by the invention is unique in fragrance, and most of functional nutritional ingredients in jujubes and gingers are dissolved, therefore, the nutrition value of the beverage is greatly improved, and the beverage not only has stronger antioxidant properties, but also has the effects of invigorating the stomach, soothing the nerves, removing coldness, stopping vomiting, building the body, preventing diseases, and the like.

The invention relates to a traditional Chinese medicine for helping digestion and nourishing the stomach. The traditional Chinese medicine comprises the following components by weight part: 1 to 1.4 parts of bran sauted atractylis ovata, 0.6 to 1 part of tuckahoe, 0.6 to 1 part of vinegar sauted rhizome cyperi, 0.6 to 1 part of fructus amomi, 0.6 to 1 part of sauted rhizome atractylodis, 0.6 to 1 part of ginger roasted officinal magnolia bark, 1.4 to 1.8 parts of dried orange peel, 0.1 to 0.5 part of licorice, 0.1 to 0.5 part of elecampane, 0.6 to 1 part of fructus crataegi cuneatae, 0.6 to 1 part of bran sauted medicated leaven, 0.6 to 1 part of coloured malt, 0.6 to 1 part of ageratum, 0.2 to 0.6 part of sauted radish seed, 0.6 to 1 part of bran sauted core-removed bitter orange, 0.2 to 0.6 part of pinellia ternate, and 0.2 to 0.6 part of reed removed radix codonopsitis. The components are processed into the medicine according to a specific production method. The traditional Chinese medicine not only has the functions of harmonizing the stomach and preventing or stopping vomiting, relieving qi and widening chest, and treating insufficiency of the stomach and spleen and the gastric cavity pain caused by indigestion, but also has the function of nourishing the stomach, and heals gastrosis radically; and the effective rate is more than 98 percent, and the cure rate reaches 88.6 percent.

The invention relates to a dragon and tiger rentan plant medicine composition, a preparation method and application thereof. The dragon and tiger rentan plant medicine composition comprises the following active components by weight proportions: 32-48g of menthol, 24-36g of borneol, 20-30g of cloves, 20-30g of villous amomum, 12-18g of star aniseeds, 32-48g of cinnamon, 12-18g of pepper, 12-18g ofcostus roots, 20-30g of dried ginger, 160-240g of catechu, 291.28-436.92g of glycyrrhiza, and the like. The preparation method comprises the following steps: preparing catechu pulp; and adding the mixed powder to prepare pills. The invention has short preparation period, low cost and good quality; and the dragon and tiger rentan plant medicine composition is used for preventing or treating heat stroke dizziness, nausea and vomiting, diarrhea, train and ship sickness, and the like.

Dosage regimens of buprenorphine achieving rapid pain relief without increasing nausea, vomiting, or other adverse effects, are described. Also described are buprenorphine dosage regimens for treating chronic pain comprising administering to the patient (1) a first buprenorphine-containing transdermal dosage form for a first dosing period that is no more than about 5 days; (2) a second buprenorphine-containing transdermal dosage form for a second dosing period that is no more than 5 days, the second dosage form comprising the same dosage of buprenorphine as, or a greater dosage of buprenorphine than, the first dosage form; and (3) a third buprenorphine-containing transdermal dosage form for a third dosing period, the third dosage form comprising a greater dosage of buprenorphine than the second dosage form.

The invention discloses a dealcoholic sobering-up pharmaceutical preparation and a preparing method thereof; the pharmaceutical preparation is prepared by poria, hawthorn, pueraria, ganoderma lucidum, and hoveniae semoveniae semen. Compared with the prior art, the pharmaceutical preparation has very significant dealcoholic sobering-up effect, protects gastric mucosa, does not hurt the gaster, adjusts gastric motility in two ways, inhibits vomiting, nausea and abdominal distention, directly decomposes alcohol and improves capacity for liquor, resists hypnosis and alleviates headache and head halo, speeds up the emptying time of alcohol in the intestine and gaster, reduces the metabolism burden of the liver and kidney, accelerates the alcohol metabolism in the blood, protects the liver, enhances the immunity and relieves the fatigue. The pharmaceutical preparation is prepared by pure natural plants, and has less medicinal odor, easy quality control, and excellent effects for protecting liver, nourishing gaster and strengthening spleen.

A compound of formula: wherein A, Ar, R<3>, R<6>, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a "Cyanoiminopiperazine Compound"), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.

The invention discloses a Chinese medicinal composition for treating malignant tumor, belonging to the field of Chinese medicines. The Chinese medicinal composition is a medicament preparation formed from herba oldenlandiae, astragalus root, tuckahoe, prepared pinellia tuber, herba scutellariae barbatae, teloon, scorpion, scolopendra and the like by adopting advanced processes including extraction with water, extraction with ethanol, enzymolysis of trypsinase and the like according to a certain compatible requirement, and the medicament preparation is preferably prepared into capsules and tablets. The Chinese medicinal composition has a certain function for relieving symptoms for lung cancer, liver cancer, gastric cancer, intestinal cancer, breast cancer, encephaloma, lymph cancer and other malignant tumors, reducing tumor bodies, inhibiting the growth of the tumors and the like; and according to the Chinese medicinal composition, the human immune capability can be improved, the lives of patients suffered from tumors can be prolonged and the adverse reactions of leukocytopenia, dizzy, weakness and fatigue, skinniness, poor appetite, nausea and vomiting and the like due to radiotherapy chemotherapy for cancers can be effectively relieved.