135 results about "Tumor chemotherapy" patented technology

The invention provides an anti-cold stimulation nursing device used after tumor chemotherapy, and belongs to the field of nursing tools. Comprising a wrapping piece; a heat conduction pipe is arranged in the wrapping part, the two ends of the heat conduction pipe are movably connected with a heating device, the heating device comprises an outer shell, an air blowing structure and a heat adjusting structure are arranged in the outer shell, and a leakage-proof structure is connected between the heat conduction pipe and the outer shell; the air blowing structure comprises a center shaft rod rotationally connected to the axis of the outer shell, a variable frequency motor is fixedly connected to the interior of the outer shell, and the output end of the variable frequency motor is fixedly connected with a first bevel gear. The air conditioner can be used by people of different heights, heat can be rapidly generated, cyclic heating is formed, heat in all areas is more uniform, the heat can be automatically adjusted according to the air speed, and the sealing effect of the structure at the joint of the outer shell and the heat passing pipe is automatically adjusted according to the air speed.

The present invention discloses an intelligent preparation device for tumor chemotherapy drugs, which relates to the technical field of chemotherapy drug preparation, including a straight guide rail, an arc guide rail, a vertical slider installed on the straight guide rail, and an arc slider installed on the arc guide rail. A rotating motor is fixedly provided on the upper surface of the arc slider, a preparation table is fixedly provided at the output end of the rotating motor, and a placement rack for placing medicine bottles is provided at equal angles on the edge of the preparation table. A rotating shaft is fixedly provided in the middle of both sides of the multiple placement racks, and one end of the rotating shaft is rotatably connected to the preparation table. The present invention extracts the liquid medicine in the bottle by simulating the manual side hole needle syringe drug extraction method, and injects the extracted liquid medicine into the bottle again, and repeats this process until the liquid medicine is completely dissolved. The extraction and injection are mechanically controlled to reduce bubbles, and the needle is attached to the side wall of the inclined medicine bottle, which reduces the generation of bubbles while allowing the liquid medicine in the medicine bottle to be completely extracted, thereby increasing the stability of drug dissolution, effectively protecting the operator, and improving the efficiency of tumor chemotherapy drug preparation.

The invention discloses a nano-carrier based on charge crosslinking, a preparation method of the nano-carrier and application of the nano-carrier as a tumor chemotherapy drug. Wherein the nano-carrier is formed by assembling two polymer chains with positive and negative charges through electrostatic interaction, a precursor ligand on a polymer chain B releases an organic ligand under exogenous or endogenous stimulation, and competes for metal ions on a polymer chain A with positive charges to generate a metal complex in situ, and meanwhile, the electrostatic interaction of the nano-carrier is weakened, so that the metal complex is formed. The dissociation of the nano-carrier is caused, a macromolecular chain B containing an organic ligand is released, and the effect of tumor chemotherapy or immunoregulation is achieved. The method is simple to operate, short in time consumption and mild in reaction condition; the material is good in biocompatibility and high in safety degree. Pharmacodynamic experiments in some embodiments show that the nano-carrier can effectively kill the breast cancer and trigger cellular immunogenic death, meanwhile, tumor cell metastasis is inhibited, and a new thought and means are provided for the clinical problem of breast cancer lung metastasis urgently needing to be solved at present.

The invention relates to the technical field of disease curative effect evaluation, and discloses a method for evaluating the curative effect of granulocyte deficiency accompanying fever after hematologic tumor chemotherapy based on machine learning, and the method comprises the steps: S1, collecting and preprocessing multi-center medical data, the data comprising structured clinical data and multi-modal unstructured data; s2, a curative effect prediction model is constructed based on a graph neural network, and a central moment constraint-based graph federal learning training model is adopted, wherein a patient graph is constructed as an original graph and an enhanced graph is generated; respectively processing the original image and the enhanced image through a two-channel image convolutional neural network, and extracting a high-order representation vector; constructing an enhanced perception loss function based on the high-order representation vectors of the original image and the enhanced image; combining a federated learning framework with multi-center data to train a model; and S3, predicting a curative effect evaluation result through the trained curative effect prediction model. The accuracy, the stability and the clinical interpretability of curative effect evaluation are improved.

The invention provides a drug combination composition for tumor chemotherapy. The drug combination composition comprises a safe and effective dose of a platinum chemotherapeutic drug and a safe and effective dose of an NAMPT inhibitor. Compared with a single platinum chemotherapeutic drug, the combined drug composition provided by the invention has higher sensitivity to cancers such as liver cancer, gastric cancer, colorectal cancer, lung cancer, cervical cancer, kidney cancer, pancreatic cancer, breast cancer and the like, the effective rate is remarkably improved, and the toxic and side effects are remarkably reduced, so that the combined drug composition has a wide application prospect.

The invention provides a multifunctional intelligent anti-thrombus PICC (peripherally inserted central catheter) for tumor chemotherapy, which comprises a catheter body, a catheter tip, a main infusion cavity, a first auxiliary cavity and a second auxiliary cavity, and the first auxiliary cavity and the second auxiliary cavity are arranged around the main infusion cavity to form a spiral structure; a micro pressure sensor array is embedded in the pipe wall of the first auxiliary cavity; a biological impedance measuring electrode pair is embedded in the pipe wall of the second auxiliary cavity; and the micro pressure sensor array, the biological impedance measuring electrode pair, the micro ultrasonic transducer and the temperature sensor are connected with a processor. According to the method, active thrombus prevention is achieved, passive treatment is changed into active prevention through a triple mechanism, and the thrombus occurrence rate is greatly reduced; meanwhile, the tube body is formed by mutually winding, fusing and extruding three independent cavities (a main infusion cavity, a first auxiliary cavity and a second auxiliary cavity) like a DNA double helix (triple helix is provided herein); and the mechanical stimulation and damage to the inner wall of the blood vessel are reduced.

The invention relates to the technical field of medical apparatus and instruments, and discloses a tumor chemotherapy breathing assisting device which comprises a bottom fixing base and a cylindrical shell arranged on the outer surface of the upper end of the bottom fixing base. A driving motor is fixedly connected to the outer surface of the upper end of the vertical supporting rod, a circular rotating disc is fixedly connected to the driving end of the driving motor, a movable pressing block is movably connected to the inner wall of the cylindrical shell, and a movable connecting piece is fixedly connected to the outer surface of the upper end of the movable pressing block. According to the breathing assisting device for tumor chemotherapy, firstly, the reciprocating structure is driven by the motor to automatically press the air bag, manpower is greatly liberated, patients, accompanying personnel and medical staff do not need to bear the physical burden of manual pressing any more, and especially under the condition that long-time continuous treatment is needed, the labor intensity of the patients is greatly relieved; the improvement undoubtedly greatly improves the use convenience and comfort.

The invention relates to the technical field of medicines, in particular to a tumor chemotherapy medicine liposome as well as a preparation method and application thereof. The preparation method comprises the following steps: taking an ethanol solution of lipid molecules as an organic phase, taking an aqueous solution containing transition metal acetate as a water phase, mixing the organic phase and the water phase in a microchannel, and collecting an outflowing transition metal acetate nano-liposome solution; carrying out medium exchange on the nano-liposome, and removing the transition metal acetate in the external water phase to obtain the liposome of which only the internal water phase contains the transition metal acetate; and mixing the liposome with an anthracycline chemotherapeutic drug, adjusting the pH value to near neutral-alkalescence, and heating to promote remote loading of the liposome on drug molecules, so as to obtain the chemotherapeutic drug-loaded nano-liposome. The liposome has a tumor acidic microenvironment slow release function, can specifically target tumor cells by using the targeting component, improves delivery and release of chemotherapy drugs into tumors, and can be used as a tumor chemotherapy and chemoradiotherapy combined treatment nano-drug.

The utility model belongs to the technical field of medical equipment, and discloses a vomiting relieving treatment device for tumor chemotherapy, which comprises a massage module, a fastening mechanism is arranged on the outer wall of the massage module, and a rolling mechanism is arranged on the outer wall of the massage module; the winding mechanism comprises a winding drum, a partition plate is fixedly connected to the inner wall of the winding drum, a rotating shaft is elastically connected to the outer wall of the partition plate through a volute spiral spring, a clamping groove is formed in the outer wall of the rotating shaft, a fixing block is fixedly connected to the outer wall of the front end of the winding drum, and a limiting block is elastically connected to the inner wall of the fixing block through a connecting spring. The pull-out length of the bandage can be fixed through clamping connection of the limiting block and the clamping groove, limiting of the rotating shaft is removed when the bandage is not used, the bandage can be automatically wound in the winding barrel, space is saved, and the problems that the bandage is wound disorderly due to the fact that the bandage is exposed all the time, and the bandage is inconvenient to tidy in the using process are solved.

The utility model discloses a clinical tumor chemotherapy pump portable protective device in the technical field of medical instruments, which comprises a box body and a chemotherapy pump body, the inner side of a sleeve is connected with a connecting rod in a sliding manner, the surface of the connecting rod is fixedly provided with a limiting block, a spring is sleeved on the surface of the connecting rod, the surface of the connecting rod is fixedly provided with a connecting block, and the connecting block is fixedly connected with the box body. One side of the connecting block is fixedly connected with one end of a spring, one end of the connecting rod is fixedly connected with a clamping plate, and one end of the connecting rod is fixedly provided with a connecting plate. Through the arranged box body, the chemotherapy pump body is inserted into the box body to be placed, and the protection effect on the chemotherapy pump body is improved; according to the chemotherapy pump convenient to use, the sleeve, the connecting rod, the limiting block, the spring, the connecting block, the clamping plate and the connecting plate are arranged, so that a chemotherapy pump body in the box body can be conveniently clamped and fixed, the stability of the chemotherapy pump in the using period is improved, and the situation that the chemotherapy pump shakes when a patient moves, and the liquid medicine infusion speed is affected is avoided.

The invention discloses a bladder tumor chemotherapy postoperative noninvasive thermal therapy device which comprises a base, a transparent supporting plate and an arc-shaped cover, the transparent supporting plate is arranged at the top of the base, the end of the arc-shaped cover is hinged to the base through a hinge, the arc-shaped cover is arranged above the transparent supporting plate, an operation panel is fixed to one side of the base, and the operation panel is fixed to the other side of the base. A bottom plate is fixed in the base, and an infrared irradiation distance adjusting mechanism, an infrared scanning irradiation mechanism, a storage battery, a control circuit board, a liquid medicine atomization groove, a liquid medicine atomization assembly, an ultrasonic thermal therapy assembly, an infrared distance sensor and a plurality of relays are fixed on the bottom plate. According to the device, infrared whole-body thermal therapy can be carried out through infrared irradiation, directional ultrasonic thermal therapy can be directly carried out on the bladder through ultrasonic waves, traditional Chinese medicine fumigation can be carried out at the same time, and the purpose of auxiliary treatment of bladder tumors is achieved; the infrared irradiation distance of the device can be adjusted according to the thermal therapy effect.

The present invention provides a cold-stimulus-resistant nursing device after tumor chemotherapy, belonging to the field of nursing appliances. It includes a wrapping member; a heat-conducting pipe is arranged inside the wrapping member, and heat-generating devices are movably connected to both ends of the heat-conducting pipe. The heat-generating device includes an outer housing, and a blowing structure and a heat-adjusting structure are respectively arranged inside the outer housing. A leak-proof structure is connected between the heat-conducting pipe and the outer housing; the blowing structure includes a central shaft rod rotatably connected to the axis of the outer housing, a variable-frequency motor is fixedly connected inside the outer housing, and an output end of the variable-frequency motor is fixedly connected with a first bevel gear. This application can meet the use of people with different heights, generate heat quickly at the same time, form a circulating heating, the heat in each area is more uniform, and the heat can be automatically adjusted according to the wind speed, and the sealing effect of the structure at the connection between the outer housing and the heat-conducting pipe can be automatically adjusted according to the wind speed.

The invention relates to the technical field of tumor chemotherapy, in particular to a nursing device used after tumor chemotherapy. According to the technical scheme, the nursing frame comprises a nursing frame body, a fixing frame and a supporting frame, the lower surface of the nursing frame body is connected with a sleeve frame, the upper surface of the nursing frame body is sleeved with the fixing frame, a fixing rod is fixed to the outer end face of one side of the fixing frame, and the outer end face of one side of the fixing rod is rotationally connected with a connecting bearing; a movable frame is rotationally connected to the outer end face of one side of the connecting bearing, a rotating plate is connected to the outer end face of one side of the movable frame, a mounting frame is connected to the lower surface of the supporting frame, a connecting frame sleeves the upper surface of the supporting frame, and a movable bearing is fixed to the outer end face of one side of the connecting frame; a rotating frame is rotationally connected to the outer end face of one side of the movable bearing, and massage layers are fixed to the inner walls of the nursing frame body, the sleeve frame, the supporting frame and the mounting frame. According to the invention, varicosity of a patient can be prevented, and liquid medicine exosmosis and phlebitis incidence rate can be reduced.

The invention discloses a gynecological tumor chemotherapy patient carry-on remote follow-up visit method and system based on an AI large model, relates to the field of medical treatment, and solves the problem that an existing gynecological tumor chemotherapy patient carry-on remote follow-up visit method is poor in effect. The method comprises the following steps: S1, carrying out periodic heart rate index monitoring on a gynecological tumor chemotherapy patient in a carry-on index monitoring period, and obtaining a heart rate carry-on monitoring abnormal value according to a monitoring result, S2, carrying out periodic blood oxygen index monitoring on the gynecological tumor chemotherapy patient in the carry-on index monitoring period, and obtaining a blood oxygen carry-on monitoring abnormal value according to the monitoring result, s3, the gynecological tumor chemotherapy patients are divided into the first follow-up diagnosis type gynecological tumor chemotherapy patients and the second follow-up diagnosis type gynecological tumor chemotherapy patients, remote follow-up diagnosis early warning is carried out, the accuracy of follow-up visit results is effectively improved, and therefore guarantee is provided for the clinical treatment effect of the patients.

The invention belongs to the technical field of biological medicine, and particularly provides application of a PLA1A gene / protein as an anti-tumor target. The key effect of the PLA1A gene / protein in promoting chemotherapy drug resistance is disclosed for the first time, and a new mechanism that the PLA1A gene / protein affects chemotherapy sensitivity by regulating a tumor microenvironment (especially macrophage polarization) is deeply clarified. Researches prove that knockdown of the PLA1A gene or inhibition of the protein activity of the PLA1A gene can significantly enhance the sensitivity of tumor cells to chemotherapeutic drugs (such as oxaliplatin), so that the therapeutic effect is improved, and the sensitization provides a new strategy for overcoming tumor chemotherapeutic drug resistance. In animal model experiments, knockdown of the PLA1A is combined with oxaliplatin for treatment, so that growth of mouse transplanted tumors and liver metastases is remarkably inhibited, the survival time of tumor-bearing mice is prolonged, and it is indicated that the PLA1A has important clinical application value and wide application prospects as an anti-tumor target.

The invention discloses application of cucurbitacine I in preparation of cisplatin sensitization drugs for treating ovarian cancer, and belongs to the technical field of sensitization drugs for tumor chemotherapy. CuI and CDDP have a good synergistic tumor inhibition effect on ovarian cancer, CuI may directly act on EGFR and can be combined with CDDP to significantly inhibit phosphorylation of EGFR and downstream STAT3 protein thereof, induce DNA damage and ROS accumulation, amplify a pyroptosis effect, increase release of TAAs and DAMPs, promote DC maturation and promote infiltration of CD8 + T cells and memory T cells in TIME in vivo, so that the tumor inhibition effect on ovarian cancer is improved. The expression of an inhibitory costimulatory molecule PD-1 in CD8 + T cells is reduced, the whole body immune effect is activated, and the TIME of the ovarian cancer is remarkably improved. The combined treatment strategy of CuI-CDDP controls the progress of ovarian cancer from a dual mechanism of directly inhibiting tumor cells and promoting anti-tumor immune activation.

The present disclosure relates to a use of Herombopag or a pharmaceutically acceptable salt thereof in treatment of tumor chemotherapy-induced thrombocytopenia. Specifically, the present disclosure relates to a disease treatment method, comprising: administering to a patient Herombopag or a pharmaceutically acceptable salt thereof, which can significantly increase the blood platelet count of a subject.

The invention discloses a preparation method and application of a gold-platinum-iron flower-shaped nano composite material with cascade catalytic capacity, and relates to the technical field of tumor hunger therapy, chemical power therapy and near-infrared photothermal therapy. According to the preparation method of the gold-platinum-iron flower-shaped nano composite material with the cascade catalytic capability, the flower-shaped zeolite imidazole framework is further modified and pyrolyzed, and the iron element is anchored on the carbon framework in a monatomic state; gold-platinum nanoparticles and hyaluronic acid which are tightly combined and grow in situ are further loaded on the surface of the nano-material, so that the nano-material has good biocompatibility and targeting property and can be used as a nano-composite material for tumor chemotherapy and near-infrared photothermal therapy. According to the invention, the variety of nano composite materials for tumor targeted hunger therapy, chemotherapy and near-infrared photothermal therapy by taking a zeolite-like imidazole skeleton as a substrate is enriched. The invention can obtain the preparation method and application of the gold-platinum-iron flower-shaped nano composite material with the cascade catalytic capability.

Through extensive and deep research, a new path Parkin / Park / Mul1 / Mfn2 for regulating and controlling the drug resistance of a tumor chemotherapy temozolomide (TMZ) drug by the TRPC5 is found, and the new path has a close relationship with the generation of the drug resistance of the tumor chemotherapy temozolomide (TMZ) drug. Compared with primary cells U87 and U251, the expression level of the TRPC5 in temozolomide tolerant cells U87R and U251R is remarkably improved, and a mitochondrial autophagy pathway is activated. By reducing the expression of the TRPC5 gene, the sensitivity of a cell strain to a temozolomide drug can be enhanced, and the proliferation capacity of tumor cells can be inhibited. According to the invention, not only is new data provided for a malignant glioma drug resistance mechanism, but also a new target spot is provided for the design of anti-tumor drug resistance drugs.

The application relates to the technical field of biological medicine, and discloses a micropeptide miPEP060 coded by a LINC00060 gene and application thereof; the application provides the following application of LINC00060 and the micropeptide miPEP060 coded thereby: preparing a product for predicting tumor chemotherapy efficacy, preparing a product for predicting tumor prognosis; preparing a tumor treatment product, preparing a product for enhancing tumor chemotherapy efficacy, preparing a product for overcoming tumor chemotherapy drug resistance, preparing a product for inhibiting PARP1 enzyme activity or PARylation modification, and preparing a product for inhibiting replication stress response and replication fork stability; the LINC00060 and the micropeptide miPEP060 coded thereby provided by the application can significantly enhance the chemotherapy killing effect of tumor cells or tumor tissues and reduce tumor volume.

The invention discloses an anti-cold stimulation nursing appliance after tumor chemotherapy, and relates to the field of tumor chemotherapy nursing, the anti-cold stimulation nursing appliance comprises a fixing layer, a skin-friendly heat conduction layer is arranged at the bottom of the fixing layer, a shell is arranged at the top of the fixing layer, a heat insulation adjusting mechanism is arranged at the upper part of the interior of the shell, and a phase change energy storage unit is arranged at the lower part of the interior of the shell. A penetrating groove is formed in the side wall of the shell, the phase change energy storage unit is slidably connected with the shell through the penetrating groove, and the phase change energy storage unit is located below the heat insulation adjusting mechanism. A power system is completely abandoned, risks of electric leakage, electromagnetic radiation and short circuit are eradicated, the device is particularly suitable for chemotherapy patients with fragile body functions, the device can be safely used in any environment (even during oxygen uptake), stable constant-temperature care for 4-6 hours is provided continuously through the physical characteristics of the heat-conducting phase-change material, and the service life of the device is prolonged. The one-time working time is far longer than that of a traditional hot water bag and most electric heating products, and the nursing burden of frequent replacement is reduced.

The invention discloses nanoparticles for tumor chemotherapy and immune combined treatment as well as a preparation method and application of the nanoparticles, and belongs to the technical field of biological medicines. The nanoparticles are rHF (at) Cel nanoparticles formed by wrapping tripterine (Cel) with recombinant human heavy chain ferritin (rHF). The preparation method comprises the following steps: obtaining recombinant rHF protein, mixing and assembling Cel and rHF under specific pH and temperature conditions, and purifying to obtain the recombinant rHF protein. The nanoparticles can effectively target tumor cells and release Cel to kill tumors; meanwhile, the rHF carrier can induce polarization of tumor-related macrophages from a tumor-promoting M2 type to an anti-tumor M1 type, reduce the proportion of regulatory T cells (Treg) in a tumor microenvironment and reverse an immunosuppression microenvironment. In-vitro and in-vivo experiments prove that the rHF (at) Cel nanoparticles have a remarkable killing effect on breast cancer cells and can effectively inhibit the growth of transplanted tumors of mice.

The utility model relates to the technical field of anti-cold stimulation nursing protectors, in particular to an anti-cold stimulation nursing protector used after tumor chemotherapy, which solves the problems mentioned in the background technology and comprises a fixing tube, air bags are connected to the inner walls of the two ends of the fixing tube, a communicating hole is formed in a body of the fixing tube and communicated with the air bags, and the air bags are communicated with the communicating hole. The outer wall of the fixing pipe is fixedly connected with an air inlet pipe communicated with the communicating hole, an air inlet assembly is installed on the air inlet pipe, the outer wall of the fixing pipe is connected with a heat preservation pipe, a water cavity is formed in a body of the fixing pipe, the middle of the outer wall of the fixing pipe is fixedly connected with a water injection pipe, the water injection pipe is communicated with the water cavity, and the water injection pipe is in threaded connection with a packaging cap. The moving assembly is installed on the fixing pipe, air is injected into the air bag through the air inlet assembly to enable the air bag to expand, the fixing pipe is fixed to the arm, the moving ring is pulled through the traction rope, the friction plate rubs the skin of the arm, the problem of arm itching is solved, and the device is simple in structure and convenient to operate.

The application discloses a steroid-indole alkaloid hybrid dimer compound, a preparation method thereof and application of the compound in preparation of an antitumor chemotherapy drug sensitizer, and first prepares the steroid-indole diketopiperazine alkaloid hybrid compound from a fungus Aspergillus sp. EGF15-0-3 rice culture medium. The compound is a new skeleton compound first discovered in nature. It is first discovered that the hybrid compound has Tdp1 inhibitory activity and can be applied as a tyrosine-DNA phosphodiesterase 1 (Tdp1) inhibitor. It is first discovered that the hybrid compound has chemotherapy sensitization activity on a tumor chemotherapy drug topotecan TPT, which provides a drug source molecule and data support for development of a new natural antitumor combination inhibitor, and has important significance for development and utilization of marine Aspergillus sp. fungus resources.

The invention relates to a medicinal and edible compound extract for improving myelosuppression of a tumor patient after chemotherapy, and a preparation method and application of the medicinal and edible compound extract. The compound extract is extracted from a composition at least comprising the following raw material medicines in parts by weight: 0.9-10 parts of tricholoma matsutake, 0.9-10 parts of mulberry and 0.5-10 parts of rhizoma polygonati. The raw material medicine composition further comprises the following raw material medicines in parts by weight: 0.7-10 parts of longan, 0.5-10 parts of pericarpium citri reticulatae, 0.5-10 parts of scorched hawthorn fruit, 0.5-10 parts of fructus amomi, 1.1-10 parts of cordyceps sinensis rice flour and 2.5-15 parts of rice peptide. The selected raw material medicines are all medicinal and edible components, do not cause adverse effects on liver and kidney functions and gastrointestinal tracts of eaters, and are high in safety and high in patient acceptance degree. Effect verification results show that the mulberry compound extract has an improvement effect on the side effect of bone marrow suppression of tumor patients, especially in the early stage, no related adverse reaction is found, and a safe and effective treatment choice is provided for bone marrow suppression.

The invention discloses a nursing device special for tumor chemotherapy, and relates to the technical field of chemotherapy nursing instruments, and the nursing device comprises a fixing device used for supporting and protecting parts required by chemotherapy nursing for the oncology department; the moving device is located on one side in the fixing device; the massage assembly is located on one side of the moving device and located in the fixing device. The telescopic rod lifts the rotating rod, the motor drives the rotating rod to rotate, the massage rod is lifted alternately for massage, when vomiting is needed, a patient stands up, the pressure sensing device controls the moving plate to move outwards, the spittoon extends out of the device for vomiting, then the patient lies down, the pressure sensing device controls the moving plate to retract, and the clamping frame moves, so that the spittoon extends out of the device for vomiting. The spittoon can be automatically ejected, vomitus of a patient can be conveniently collected, the aim of massaging the body of the patient can be achieved, and the situation that muscle atrophy is caused due to the fact that blood is not circulated when the patient lies in a bed for a long time is avoided.

The application belongs to the technical field of medical information, and discloses a tumor chemotherapy scheme individualized adjustment and curative effect evaluation method and system. Static basic data, dynamic treatment data, single cell sequencing data and structured data of doctor-patient conversation are comprehensively collected in the data fusion quality control stage. Format adaptation and semantic alignment of cross-modal data are realized through a unified standardized interface. Data quality control is carried out in combination with an isolated forest algorithm, and only high-quality data with a score of 80 or more are included to provide a reliable basis for scheme development. In the multi-module collaborative prediction stage, a medical knowledge graph and a hybrid modeling framework are fused, multi-center data is jointly trained, and drug sensitivity scores are accurately output. When the scheme is generated, the clinical guidelines and patient needs are linked, multi-constraint rule reasoning and multi-objective optimization are used to develop individualized schemes that adapt to the patient's genetic characteristics, pathological types and quality of life demands, and reduce the risk of poor efficacy and serious adverse reactions caused by individual differences.

This invention discloses an intelligent PICC catheter and positioning system for tumor chemotherapy, belonging to the field of biomedical engineering technology. This invention addresses the problem of inaccurate puncture due to the inherent subjectivity in puncture point selection in existing technologies. By assessing the importance of vascular imaging features and blood flow parameters, it can identify the features most influential on predicting puncture results, thereby reducing model complexity and improving model efficiency and generalization ability. Furthermore, by weighting the input data according to feature importance, the random forest model focuses more on important features, thus improving the accuracy and reliability of model predictions. Through the collaborative work of multiple modules, the positioning system is more accurate and efficient in recommending the optimal puncture point, effectively improving the puncture success rate, reducing the risk of complications, providing strong decision support for medical staff, and enhancing the patient's treatment experience and safety.

The invention belongs to the field of biological medicine, and particularly discloses a method for preparing nanoparticles NCTD-LpEV-cRGD by adopting bacterial extracellular vesicles (LpEV) derived from lactobacillus paracasei to entrap tumor chemotherapeutic drug norcantharidin (NCTD) and modifying tumor targeting peptide cRGD on the surface of the LpEV. An anti-colorectal cancer effect test research shows that the NCTD-coated LpEV-cRGD nanoparticle can simultaneously exert a colorectal cancer cell targeting effect and an anti-colorectal cancer proliferation and metastasis effect, so that the anti-colorectal metastasis curative effects of chemotherapeutic drugs norcantharidin and bacterial extracellular vesicles are remarkably enhanced, and the NCTD-coated LpEV-cRGD nanoparticle has good safety. The NCTD-coated LpEV-cRGD nanoparticles prepared by the preparation method disclosed by the invention can be used for preparing medicines for resisting colorectal metastasis.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a verapamil derivative for enhancing the sensitivity of tumor cells to anti-cancer drugs and a preparation method of the verapamil derivative. According to the application of the verapamil derivative and / or the pharmaceutically acceptable salt of the verapamil derivative in preparation of drugs for enhancing the sensitivity of tumor cells to chemotherapeutic drugs or reversing the chemotherapeutic drug resistance of the tumor cells, the verapamil derivative is 5-[(3, 4-dimethoxyphenethyl) (methyl) amino]-2-(3, 4-dimethoxyphenyl)-2-isopropyl valeronitrile. The invention provides the application of the verapamil derivative in reversing tumor chemotherapy drug tolerance and enhancing sensitivity to malignant solid tumors for the first time, and provides a synthesis method of the verapamil derivative. The safe concentration of the verapamil derivative is higher than that of parent verapamil, and a new solution is provided for solving the problem of insufficient curative effect caused by concentration limitation of verapamil.