130 results about "Photothermal therapy" patented technology

The invention discloses an OTX-015 (Ox-015) loaded cascaded responsive nano particle and a preparation method thereof. The nanoparticle has a three-layer core-shell structure, wherein the innermost layer is a cross-linked nanoparticle of chitosan and paclitaxel; the middle layer is a polydopamine layer loaded with a bromodomain inhibitor OTX-015; the outermost layer is a gelatin layer grafted with babali; wherein the cross-linked substance of the chitosan and the paclitaxel is a cross-linked substance containing a disulfide bond. The invention also provides a preparation method of the cascade responsive nano-particle and application of the cascade responsive nano-particle in preparation of an antitumor drug targeted delivery system. The nanoparticle provided by the invention improves the tumor microenvironment while activating in-vivo autoimmunity, and kills tumor cells by using photothermal therapy assisted chemotherapy drugs, so that the synergistic effect of chemotherapy / photothermal therapy / immunotherapy is realized, and a new idea is provided for clinical tumor treatment.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

The invention relates to an experimental system and method for photodynamic therapy, photothermal therapy and combined research of photodynamic therapy and photothermal therapy. The experiment system comprises an optical irradiation module which comprises a plurality of laser light sources, each laser light source can output collimated light beams, the collimated light beams are combined to form a coaxial light path, and the coaxial light paths are projected to the surface of an observation object through a light beam adjusting assembly; the light path position adjusting module comprises an electric Z-axis displacement mechanism; the temperature monitoring module comprises an active temperature control substrate, an infrared thermal imager and an optical fiber temperature probe interface; the data acquisition and control module is configured to synchronously acquire laser output power, light spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of a plurality of different areas and optical fiber temperature probe data, and associatively record the data with a unified timestamp; the power density can be calculated based on the real-time output power of the laser light source and the light spot area; and when the data of any temperature monitoring channel exceeds a preset safety threshold value, the laser light source is automatically controlled to close the output.

The application discloses a kind of sulphur-containing polydopamine melanin nanoparticles and preparation method and application, preparation raw materials include polyhydroxy compound and sulphur-containing compound, the weight ratio of the polyhydroxy compound and the sulphur-containing compound is (1-100) :(1-100), the preparation raw materials also include water, organic solvent and acid-base regulator.The application occurs self-polymerization reaction under alkaline condition with dopamine and sulphur-containing compound, without additional crosslinking agent and oxidant, and the nanoparticles obtained have excellent photothermal performance.In photothermal therapy, biomedical imaging, water purification, functional coating and other aspects, it shows great application potential.And preparation reaction condition is mild, without additional catalyst and oxidant, process is safe, post-processing is simple, and no harmful waste water and waste residue to environment, meet the requirements of green chemistry.

The application discloses a kind of magnetically responsive hydrogel optical fiber and its preparation and application, belong to medical biomaterial field.The optical fiber includes from inside to outside: polyethylene glycol diacrylate and acrylamide photocrosslinking light transmission core layer;Calcium alginate low refractive index skin layer;Doped nano-magnetic response layer of ferriferrous oxide;And polydopamine grafting polyvinylpyrrolidone lubricating layer.It is prepared by coaxial extrusion and light / calcium step-by-step crosslinking.The structure realizes the spatial isolation and anti-interference of light transmission and magnetic drive, has low background light loss and anti-bending stability, has biomechanics matching, ultra-low friction and magnetic field accurate active navigation ability, solves the pain point that extremely soft optical fiber is difficult to directional intervention.Suitable for deep tissue precise photothermal therapy, in vivo continuous optical sensing and minimally invasive diagnosis and treatment integration and other frontier medical fields.

The invention discloses a preparation method of cryptotanshinone-loaded PDA (Polydopamine) nano drug-loaded particles. The technical scheme adopted by the invention is as follows: the cryptotanshinone is loaded on PDA (Polydopamine) nano particles. Photo-thermal therapy and pharmaceutical chemotherapy are integrated into designed nano-delivery to impart a targeted synergistic effect thereto. In addition, the PDA nanoparticles show photoacoustic imaging capability, and aggregation of the nanoparticles at the ovary part can be monitored in real time. The cryptotanshinone is loaded by utilizing aperture adsorption of PDA and pi-pi conjugation and hydrophobic interaction with the cryptotanshinone, so that a drug delivery system is constructed, the biological solubility and the utilization rate of the cryptotanshinone are improved, a slow release effect is achieved, the application of the cryptotanshinone is widened, and the purpose of treating the polycystic ovarian syndrome is achieved.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The invention discloses composite hydrogel for wound repair as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of medical materials. The preparation method comprises the following steps: mixing methylacryloylated gelatin, hydroxyethyl methylacrylate and oxidized dextran, adding copper sulfide nanoparticles, a cross-linking agent and a photoinitiator, uniformly stirring, placing in a mold, irradiating by adopting ultraviolet light, carrying out Schiff base reaction on an aldehyde group on an ODex chain and an amino group on a GelMA chain to form a dynamic covalent bond, and forming a reversible cross-linking point, so as to obtain the copper sulfide nanoparticle / GelMA composite hydrogel. The preparation method comprises the following steps: carrying out a copolymerization reaction on HEMA and methacryloyl on a GelMA molecular chain to form a stable covalent cross-linked network, effectively capturing CuS NPs through a physical effect and stably dispersing the CuS NPs in the network in the process, and soaking the cross-linked hydrogel in deionized water for balancing to obtain the target composite hydrogel. The composite hydrogel has excellent mechanical strength, pH response swelling property and biocompatibility, can realize efficient antibacterial and endogenous immune regulation by combining near-infrared photothermal therapy, and effectively promotes wound repair.

The invention provides a polycarbonate conductive elastomer based on MXene doping and a preparation method and application thereof, the conductive elastomer comprises aliphatic polycarbonate (APC), a deep eutectic solvent (PDES) and MXene, the mass ratio of the aliphatic polycarbonate to the deep eutectic solvent is 1: 0.5-3, and the addition amount of the MXene is 1-5 wt% of the total mass of the APC and the PDES. The conductive elastomer obtained by the invention is simple in preparation process, environment-friendly and free of high temperature and high pressure; the comprehensive performance of mechanical strength, electrical sensitivity, biocompatibility and degradability, photo-thermal response and antibacterial performance is realized; the material is stable in structure and suitable for the fields of flexible sensors, electronic skin, health monitoring, photo-thermal therapy, intelligent antibacterial materials and the like.

The application provides a preparation method of a near-infrared fluorescent dye using indoline as an electron donor. The method comprises the following steps: under the action of a palladium catalyst, through a Suzuki coupling, using a 1,4-dioxane:water mixed liquid as a solvent, coupling indoline boronic acid and a halogen-containing acceptor, and performing compound purification after high-temperature reaction. The near-infrared fluorescent dye using indoline as an electron donor has strong electron-donating properties, can realize aggregation-induced emission, can emit near-infrared light, and can improve light stability and molar absorption coefficient, so that a large Stokes shift can be realized, the near-infrared fluorescent dye is used for photothermal therapy, and good photothermal therapy efficiency is achieved.

The invention belongs to the field of preparation processes of porous nano materials, and relates to a preparation method of ZnFe2O4 aerogel for glioma photothermal therapy. The preparation method comprises the following steps: firstly, preparing a ZnFe2O4 precursor by adopting a sol-gel method in combination with a supercritical drying process, and carrying out supercritical drying; then polyethylene glycol (PEG), EDC, NHS and FA are introduced for functional modification, and the ZnFe2O4 aerogel is prepared through high-temperature heat treatment. The method is simple in process, raw materials are environmentally friendly and easy to obtain, and the prepared ZnFe2O4 aerogel is high in specific surface area, low in density and good in photo-thermal performance. The research provides a new thought for targeted treatment of glioma, and promotes the development of nano medicine and material science.

The invention discloses a load ICGamp. The invention discloses ZIF-8 nano-particles of CBF, and belongs to the technical field of preparation of nano-drug particles. The multifunctional nanoparticles are formed by simultaneously encapsulating indocyanine green (ICG) and cinobufagin (CBF) components by ZIF-8, and the drug loading capacities of the two drugs are both not lower than 5%. The preparation method comprises the following steps: slowly adding a solution containing cinobufagin and zinc nitrate into a mixed solution containing indocyanine green, bovine serum albumin and 2-methylimidazole, and carrying out centrifugal filtration, washing and drying on a reaction product to obtain the cinobufagin zinc oxide. The multifunctional nano-particles prepared by a one-step synthesis method are uniform in particle size and good in stability, indocyanine green and cinobufagin are uniformly distributed in a carrier, the multifunctional nano-particles have pH and near-infrared light dual response drug release characteristics, triple synergy of chemotherapy, photothermal therapy and photodynamic therapy can be realized, and the multifunctional nano-particles are simple in preparation process and suitable for popularization and application.

The application discloses a novel AIE photosensitizer and a preparation method and application thereof. The AIE photosensitizer of the application comprises TDQ shown in the following structural formula, has superior photo-thermal conversion performance and photodynamic performance, and can be used for preparing a tumor diagnosis reagent or a tumor treatment drug. The co-loading liposome of TDQ and a senescence-inducing molecule (Ali) can be used as a multi-modal light diagnosis and treatment agent to realize efficient delivery of drugs to tumor tissues, and the photo-thermal therapy and the photodynamic therapy based on TDQ not only induce cell apoptosis through oxidative stress and mitochondrial dysfunction, but also trigger cancer cell senescence and promote the secretion of SASPs, so that the anti-tumor immunity is significantly enhanced, and finally the growth of primary tumors, tumor recurrence and re-metastasis are inhibited. The material of the application has simple preparation process, low cost, and is suitable for scale production and clinical medical use.

The invention relates to a cell membrane bionic drug-loaded carbon dot nano-material as well as a preparation method and application thereof. The nano-composite is prepared by the following steps: preparing carbon dots, cross-linking to form a reduction responsive carbon dot nano-cluster, sequentially loading chemotherapeutic drugs and coating a cancer cell membrane to form a nano-vaccine. After the nano vaccine is injected into the body of a mouse through caudal vein, the enrichment of the nano vaccine in a tumor part can be enhanced by utilizing the active tumor targeting characteristic of a cancer cell membrane, and tumor cells can be induced to generate immunogenic death through carried chemotherapy drugs and photothermal therapy, so that chemotherapy / photothermal / immune combined therapy on tumors is realized; the obvious anti-tumor effect is realized. In addition, as a nano vaccine, after subcutaneous injection, the nano vaccine can also utilize the tumor antigen carried by a cancer cell membrane and the adjuvant characteristics of the carbon dots to activate the anti-tumor immunity of an organism so as to prevent tumors, and has potential clinical application value.

The invention relates to an organic germanium-tungsten wheel cluster material, which has a chemical formula of Na16H26 [W36Ge6 (CH2CH2COOH) 6O138]. 82H2O, and belongs to a triclinic system. The organic germanium-tungsten wheel cluster material is prepared from dicarboxyethyl germanium trioxide and sodium tungstate in an acetic acid-sodium acetate buffer solution through a one-step self-assembly reaction, the operation is simple, and the cost is relatively low. In order to further improve the performance of the organic germanium-tungsten wheel cluster material, the organic germanium-tungsten wheel cluster material is compounded with gold nanoparticles and hyaluronic acid to obtain a composite material capable of effectively prolonging the cycle time and enhancing the photo-thermal performance and catalytic toxic active oxygen. The composite material has an excellent treatment effect when being used as a photothermal agent for tumor treatment.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

This invention relates to the field of biomedicine, disclosing a drug carrier, its construction method, and its applications. The nanoprobe of this invention uses fluorescent nanomaterials as a matrix, with polysaccharide ligands and photosensitizers coupled to it. The polysaccharide ligands cross sugar-specific transport channels on the bacterial cell membrane to enter the bacterial interior, simultaneously carrying the photosensitizer into the bacteria. The inactivated bacteria lose their microbial activity but retain their ability to cross the blood-brain barrier, reaching brain lesions to deliver drugs. Furthermore, the photosensitizer can be used for photothermal therapy of central nervous system diseases such as brain tumors and inflammatory infections under light conditions.

The invention provides composite hydrogel, photo-thermal response drug release composite hydrogel as well as a preparation method and application of the photo-thermal response drug release composite hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is constructed by taking methylacryloyl gelatin as a matrix and combining lauric acid microspheres carrying an osteogenesis promoting drug baicalin, a reduced graphene oxide photothermal agent and a photoinitiator LAP. Under the irradiation of near-infrared light, the hydrogel can realize local mild temperature rise, induce the lauric acid microspheres to generate solid-liquid phase change, release the entrapped osteogenesis promoting drug as required, realize the synergistic effect of photothermal therapy and controlled release of the drug, and have a good osteogenesis repair effect. The hydrogel has good mechanical properties, biocompatibility and degradability, can be used for local treatment of bone defect parts, and effectively promotes regeneration and repair of oral and maxillofacial bone tissues. The invention provides a novel controllable and efficient treatment thought for bone tissue engineering and regenerative medicine.

The invention relates to preparation and application of a malignant tumor targeting gambogic acid preparation. An inner core-middle layer-shell three-layer structure is adopted, wherein the inner core is a gambogic acid-black phosphorus quantum dot compound and has chemical treatment and photo-thermal treatment functions; the middle layer is nano vesicles derived from frozen NK92 MI cells and provides natural immune targeting and killing ability; a shell is a hyaluronic acid chelate, and active targeting and pH / photo-thermal response type drug controlled release are achieved. The core of the preparation method is that a coaxial electrojet technology is adopted, three layers of materials are formed in one step, the process is efficient, and the preparation stability is good. The preparation can realize photo-thermal-chemical-immune triple synergistic treatment, has near-infrared fluorescence and photo-acoustic multimode imaging functions, effectively solves the problems of poor targeting property, large toxic and side effects and lack of real-time monitoring of traditional chemotherapy, and shows significant advantages and application potential in precise treatment and diagnosis of solid tumors.

The invention discloses a fusion membrane packaged gold-iron core-shell nano diagnosis and treatment preparation as well as a preparation method and application thereof. The preparation takes gold-iron core-shell nanoparticles as a core, and the surface of the gold-iron core-shell nanoparticles is coated with a biomimetic membrane formed by fusion of bacterial outer membrane vesicles and tumor cell membranes. The preparation method comprises the steps of synthesis of the gold-iron nano core, surface functionalization and self-assembly coating of the fusion membrane. The preparation can simultaneously exert photothermal therapy and ferroptosis induction effects under near-infrared light irradiation, effectively initiates tumor cell immunogenicity death, and cooperatively activates dendritic cells and enhances T cell immune response by means of a pathogen related molecular mode carried by the fusion membrane and a tumor related antigen. Experiments show that the preparation can significantly inhibit tumor growth and metastasis, induce long-acting anti-tumor immune memory, and provide a multi-mode synergistic nano platform for tumor immunotherapy.

The invention discloses a bionic hybrid nano regulator for enhancing cell copper death and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention designs a bionic nano-platform which simultaneously loads a lactic acid regulator cyclostilbene Su 3118 and a copper ion carrier disulfiram DSF, and the bionic nano-platform is combined with hybrid macrophages and tumor cell membranes to construct a nano-regulator SCTDM. The nano regulator can exert multiple functions, including tumor targeting, in-situ photothermal therapy, lactic acid regulation and enhanced copper death. The nano regulator provided by the invention is simple and convenient to manufacture, is combined with in-situ photothermal therapy and lactic acid regulation and is used for enhancing cell death immunotherapy of copper death so as to eliminate primary tumors and delay relapse, and a technical support is provided for regulating immunity by enhancing copper-induced cell death through metabolic reprogramming.

The application discloses a kind of selectively targeted PSMA's biomimetic nanoparticles and its preparation method and application.This application simulates the glutamic acid substrate of carboxypeptidase and designs new functional monomer N-acrylamido glutaric acid and N-acrylamido succinic acid, a series of targeted PSMA's biomimetic nanoparticles with high affinity and selectivity to PSMA are synthesized using new monomer.The nanoparticle has low cost, higher stability, longer service life and stronger ability to resist harsh environment, overcomes the shortcomings of high cost, low preparation efficiency, long screening cycle, difficult to save and other defects of protein antibody.This application synthesizes water-soluble carbon dots with near-infrared fluorescence and photothermal properties, combined with the targeted PSMA's biomimetic nanoparticles, can replace protein antibody, nuclide imaging molecule and be used for targeted recognition of tumor cells and effective fluorescence imaging to early diagnose cancer, further kill tumor cells through photothermal therapy.

The present application relates to a kind of based on heptamethine cyanine molecule, its preparation method and application, belong to medical technology field.Compounds B1-3, C1 and C3 can specifically examine nitroreductase, be activated by nitroreductase and photoacoustic signal is enhanced.Introducing heavy atom, significantly improve photo-thermal conversion efficiency and intersystem crossing, promote photothermal therapy and photodynamic therapy.Compound C1 shows specific tumor killing effect and obvious photoacoustic signal in vivo by excellent synergistic PTT / PDT effect, provides a general strategy for cancer photoacoustic diagnosis and enhanced phototherapy.Compound C3 realizes staphylococcus aureus in situ pneumonia photoacoustic imaging for the first time, and can detect bacteria in tumor with high sensitivity and specificity, provides a promising new method for early detection of deep bacterial infection in vivo.

The invention discloses a composite nanomaterial based on a semiconductor polymer-fullerene derivative and a preparation method and application of the composite nanomaterial, and relates to the field of nano biomedical materials and technologies.The preparation method comprises the steps that a conjugated polymer PCPDTBT and a fullerene C60 derivative PCBM are dissolved in chloroform and mixed, the mixed solution and a CTAB aqueous solution are mixed and subjected to ultrasonic emulsification, and the composite nanomaterial is obtained; removing the chloroform to obtain a nanometer core dispersion liquid; coating the surface of the nano core with a mesoporous silicon dioxide layer; and modifying polyethylene glycol on the surface of the mesoporous silica layer to obtain the composite nanoparticles based on the semiconductor polymer-fullerene derivative. The composite nanoparticle can efficiently generate < 1 > O2 and. OH under the irradiation of 660 nm laser, realizes I-type and II-type photodynamic therapy, has photothermal therapy performance and fluorescence imaging capability, can meet the requirement of near-infrared two-region imaging, and can be used as an optical therapy reagent guided by near-infrared fluorescence imaging.

The invention relates to the field of biological medicines and nano materials, in particular to a macrophage membrane-coated pH responsive bionic nanoparticle which can target tumors and is used for combination of photothermal therapy and immunotherapy as well as a preparation method and application of the macrophage membrane-coated pH responsive bionic nanoparticle. The bionic nano-drug delivery system disclosed by the invention can specifically target tumor cells and tissues, prolong the residence time of the drug in the bladder, improve the anti-tumor curative effect, enhance systemic immune activation, reduce adverse reactions and effectively inhibit tumor metastasis and relapse, and shows good clinical application potential.

1. Name of the product in this design: Photothermal Therapy Device. 2. Purpose of this design: To assist the human body in physical therapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The application discloses a kind of nanomedicine for tumor hypoxia, which is prepared by mPEG-SS-PLGA wrapping drug IR-1048, PFOB and 4-MU.The nanomedicine of the application is constructed by wrapping perfluorooctyl bromide (PFOB), 4-methyl umbelliferone (4-MU) and IR-1048 in tumor microenvironment-responsive amphiphilic polymer mPEG-SS-PLGA, and in response to high GSH in tumor area, 4-MU, PFOB and IR-1048 are released; 4-MU makes the dense tumor extracellular matrix loose, so that tumor vessels are normalized, which is conducive to PFOB carrying oxygen into the tumor interior, long-term solution of tumor hypoxia, remodeling of tumor microenvironment, and reduction of myeloid-derived suppressor cell (MDSC) infiltration; and under the action of 980nm laser in vitro, IR-1048 responds, and the effect of photothermal therapy of tumor is improved.

The invention relates to the technical field of biomedical materials, in particular to a gadolinium oxide-based nano preparation as well as a preparation method and application thereof. The preparation method of the preparation comprises the following steps: preparing gadolinium oxide nanoparticles through a hydrothermal method and amination modification, and dissolving the gadolinium oxide nanoparticles in deionized water to obtain a contrast agent solution; dropwise adding the nano-particles into a gold source solution under stirring at a certain temperature to obtain nano-particles with core-shell structures; and finally, slowly adding the synthesized dispersant solution of the water-soluble polymer into the core-shell nanoparticle solution to obtain a gadolinium oxide-based nano preparation solution. And performing post-treatment such as dialysis, freeze drying and the like to obtain the core-shell structure nanoparticles based on the gadolinium oxide nano preparation. The invention relates to a gadolinium oxide-based nano preparation for cancer diagnosis and treatment, gadolinium oxide is used as an MRI contrast agent, and a gold shell is grown on the periphery of the gadolinium oxide as a photo-thermal preparation; the hydrogel has the characteristics of good biocompatibility and the like, and has an important practical prospect in the field of preparation of diagnosis and treatment integrated medicines.

This invention relates to experimental systems and methods for research on photodynamic therapy, photothermal therapy, and their combinations. The experimental system includes: an optical irradiation module comprising multiple laser sources, each capable of outputting a collimated beam, which is then combined to form a coaxial optical path and projected onto the surface of the observed object via a beam adjustment component; an optical path position adjustment module including an electric Z-axis displacement mechanism; a temperature monitoring module including an active temperature control substrate, an infrared thermal imager, and a fiber optic temperature probe interface; and a data acquisition and control module configured to: synchronously acquire laser output power, spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of multiple different regions, and fiber optic temperature probe data, and record the above data with a unified timestamp; calculate power density based on the real-time output power and spot area of ​​the laser sources; and automatically control the laser source to shut off its output when the data from any temperature monitoring channel exceeds a preset safety threshold.

This invention discloses a nanomedicine and its application in the four-modal synergistic treatment of ER+ breast cancer, encompassing gas therapy, photothermal therapy, photodynamic therapy, and combined therapy, relating to the fields of biotechnology and new medicine. This nanomedicine uses an amphiphilic polymer as a carrier and organic compounds and photosensitizers as drug loading agents. Through the synergistic effects of four modes—photothermal, photodynamic, gas therapy, and combined therapy—it effectively inhibits the growth and metastasis of breast cancer cells. The amphiphilic polymer, based on PHHM-ADT, is modified with hydrogen sulfide gas as a donor, and its amphiphilicity allows for spontaneous assembly into nanoscale hollow, regular spheres. Utilizing the high permeability and retention effect (EPR effect) at the tumor site, it achieves efficient drug accumulation in tumor tissue. The prodrug PSF couples fulvestrant and pabuxiparin via disulfide bonds, and the photosensitizer IR808 integrates photothermal and photodynamic therapy. The synergistic effect of multiple mechanisms of action enhances the therapeutic effect.