516 results about "Photothermal therapy" patented technology

The present invention relates to a method for effectively delivering an anticancer drug into cancer cells by binding the anticancer drug to pH-sensitive metal nanoparticles so as to be separated from cancer cells. The pH-sensitive metal nanoparticles according to the present invention may be heated by photothermal therapy, thereby effectively killing cancer cells in conjunction with the isolated anticancer drug.

A system configured for photodynamic or photothermal therapy and photodynamic diagnosis of a tissue is 5 disclosed. The system comprises in combination an assembly of: a proximal end adapter for a catheter comprising an adapter body (32), having proximal and distal ends, defining an axial lumen extending between the proximal and distal ends, a catheter mounting element at the distal end 10 of the adapter body (32) for sealingly mounting a catheter to the adapter body, and a hollow catheter (31), wherein the catheter mounting element connects a catheter body to the hollow catheter so that the hollow catheter extends from the distal end of the catheter body; a first light 15 guide (36) having proximal and distal ends, wherein said first light guide is sealingly contained in said axial lumen defining an axial optical path extending between the proximal and distal ends of the adapter body (32) towards said tissue (8) and into close proximity thereof or 20 interstitially into said tissue; an optical connector mounting element at the proximal end having mounted an optical connector (37) to the adapter body, and wherein said optical connector (37) is coupled to a light source via a second light guide (38), such that light from said 25 light source is transmittable from said light source via said second light guide (38) and further via said optical connector (37) to said first light guide (36) via said proximal end adapter towards said tissue (8) through said catheter (31).

The invention discloses a rapid preparation method of a gold nano rod with a small aspect ratio. In the preparation method, ultraviolet illumination is introduced in the course of preparing the gold nano rod through a seed mediated grown method, so as to control the grown speed and the aspect ratio of the gold nano rod, wherein the ultraviolet illumination is introduced in the stage of preparing seeds by using a seed mediated grown method and in the growth stage of gold nano rod, the ultraviolet illumination can promote the reduction of Au3<+> ions in the seed preparation stage so as to accelerate the growth of the seeds and shorten the preparation time of the seeds; and in the gold nano rod growing stage, the ultraviolet illumination can strip the Au3<+> ions from the gold nano rod so that the length of the gold nano rod is reduced, and the resonance absorption peak of surface plasma performs blue shift. In the invention, the preparation time of the seeds can be shortened through the ultraviolet illumination on the basis of preparing the gold nano rod by using the seed mediated grown method, and the length of the gold nano rod is controlled. The gold nano rod with the small aspect ratio prepared by the invention can be widely applied in the fields such as photobiology sense, photothermal therapy, medicinal fluorescence imaging, solar cells and the like.

The invention discloses a method for preparing a CuS photothermal therapy nano material with good biocompatibility. A one-pot method is adopted and the preparation method comprises the following steps: weighing a biomacromolecule in a container, adding water, stirring and dissolving, adding a Cu(NO3)2 solution, fully stirring and mixing uniformly, adding a NaOH solution, and finally adding a Na2S solution (the mol ratio of Cu to S is 1:2), fully stirring and uniformly mixing, putting into a water bath pot at the temperature of 90 DEG C, and stirring for 30 min to obtain a dark green solution; dialyzing and purifying the obtained CuS nano material, wherein the dialyzing time is 24h, and water is changed every 4h; and freezing and drying the obtained dialyzate to obtain the product. The reagent used in the invention is green and environmentally friendly, the preparation method is simple by performing heating reaction at the temperature of 90 DEG C, the operation is safe and simple, toxin is small, the cost is low and the large-scale popularization can be easily realized. The prepared nano material is small in size, good in water solubility, stable in near-infrared thermal performance and good in biocompatibility without immunogenicity.

The invention provides an Au-ICG (gold-indocyanine green) lipidosome multifunctional nano probe and application thereof. The nano probe consists of a kernel and a shell, wherein the kernel is a nanogold particle of which the surface is wrapped with a poly-dopamine layer and adsorbs indocyanine green; the shell is a DSPE-PEG (distearoyl phosphatidyl ethanolamine-polyethylene glycol) lipidosome film which is coupled with lactobionic acid and is chelated with Gd<3+> ions. The Au-ICG lipidosome multifunctional nano probe disclosed by the invention can be used for various image modes such as MRI (nuclear magnetism imaging), CT (computed tomography) imaging and near infrared fluorescence imaging of the liver cancer; a patient only needs to stand medicine supplying of a contrast agent, and various diagnosis effects can be achieved; furthermore, by virtue of the improvement of the sensitivity, the using amount of the contrast agent can be reduced, so that the toxic and side effect is further relieved; under near infrared illumination at 808 nm, adsorbed ICG molecules can effectively convert light energy into heat energy to produce superhigh heat of 60-70 DEG C, so that liver cancer cells can be killed thermally; therefore, the multifunctional nano probe can be used as a multimodal contrast agent for liver cancer diagnosis and can be used as a photothermal therapy agent for the liver cancer.

The invention provides a nickel doped copper sulfide nano material. The chemical general formula of the nickel doped copper sulfide nano material is Cu1-xNixS, wherein CuS refers to a substrate, Ni<2+> refers to doping ions, and the value range of x is that x is larger than 0 and is smaller than or equal to 0.8; the nickel doped copper sulfide nano material provided by the invention is a multifunctional nano material and simultaneously has a magnetic resonance imaging function and a photothermal therapy effect, so that the nickel doped copper sulfide nano material can be used as a magnetic resonance imaging probe and a photothermal therapy reagent and is a nano material integrating detection and therapy. The invention further provides a preparation method and an application of the nickel doped copper sulfide nano material.

The invention provides a composite nano-grade novel material based on cancer early-stage integrated detection, diagnoses, and treatment, and a preparation method thereof. According to the invention, gold nano-cage (gold nano-box) and nano-grade iron oxide are assembled, such that gold nano-cage (box)/nano-grade iron oxide composite particles are synthesized. With an assembling method from the inside to the outside, the gold nano-cage (box) is first prepared; iron oxide is nucleated and grown in the gold nano-cage (box); with a surfactant (such as glucan or the like), mono-dispersed iron oxide is obtained; the iron oxide is packaged by using biological molecules, such that the gold nano-cage (box)/nano-grade iron oxide composite particles are obtained; surface modification is carried out by using biological targeting molecules (antibodies or DNA molecules). The material is used in tumor magnetic resonance imaging, fluorescence imaging, dark field imaging, specific targeting multifunctional diagnosis, and photothermal therapy. The material can also be used as a targeting medicine carrier.

The invention relates to a preparation method and application of core-shell magnetic/gold nanocomposite particles. The preparation method is characterized by preparing magnetic nanoparticles by using a coprecipitation method; transferring the magnetic nanoparticles to an organic solvent through a surfactant; and then reducing a gold precursor with organic amine by using the magnetic particles as seed crystals to form a gold shell layer on the surface of the magnetic particles. After adding a chain transfer agent, the nanoparticles can be transferred from the solvent into aqueous phase. The nanoparticles can be used for marking, separation, enrichment and detection of biological and non-biological, and can also be used in the fields of magnetic resonance contrast agents, targeting drug carriers, photothermal therapy for cancer cells and the like.

The invention belongs to the fields of material science and biomedical application, and in particular relates to an MRI and PTT diagnosis and treatment integration functional microsphere with a core-shell structure and a preparation method thereof. The functional microsphere comprises a polypyrrole nano particle core and a polydopamine shell coated on the outer surface of the core, Fe3+ particles are arranged on the polydopamine shell in a complexing manner, the weight ratio of polypyrrole nano particles to polydopamine is 1: (3.1-10.2), and the weight ratio of the Fe3+ particles to the polydopamine is 1: (9.3-11.2). The preparation method comprises the following three steps: S1, preparation of the polypyrrole nano particles; S2, preparation of the nano microsphere with the core-shell structure; and S3, preparation of the MRI and PTT diagnosis and treatment integration functional microsphere. The functional microsphere is prepared by using the nontoxic polypyrrole and polydopamine with excellent biocompatibility, and is high in stability in blood of human bodies; moreover, the functional microsphere has T1 radiography effect and optothermal effect, can be used for magnetic resonance imaging (MRI) and photothermal therapy (PTT), and is a diagnosis and treatment integration functional material with great potential value.

The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and include methods of treating cancer, methods of re-shaping or removing adipose tissue, and methods of delivering drugs or co-delivering drugs and energy to selected tissue.

The invention belongs to the technical field of optical nano probe, and in particular, relates to a photoluminescence-photothermal nano composite structural material and a preparation method and an application thereof. The composite structural material takes a rare earth fluoride as a core and is a core-shell structural nano material with the exterior wrapped with an organic photothermal substance layer; the material generates 800-1200 nm near infrared fluorescence emission under excitation by a 700-1000 nm near infrared laser, the photo-thermal substance layer can convert optical energy into heat energy to achieve photothermal therapy of tumor. During use, the probe temperature is monitored while the probe performs photothermal therapy; furthermore, the probe is co-incubated with tumor cells or is injected into tumor mice through veins, and high-resolution cancer photothermal therapy and simultaneous optical temperature monitoring can be achieved. The invention provides an effective temperature monitoring tool for photothermal therapy, the damage to normal tissues in tumor thermotherapy can be reduced, and significant application prospects in the field of biomedicine are achieved.

The invention discloses hyaluronic acid and polydopamine-modified drug-loaded mesoporous titanium dioxide nanoparticles. On the one hand, the nanoparticles can be aggregated at tumor sites through active targeting of hyaluronic acid, the selectivity of the preparation is increased, and thus the toxic and side effects of the preparation are reduced. On the other hand, mesoporous titanium dioxide can generate singlet oxygen under the ultrasonic condition, meanwhile, polydopamine can convert light energy into heat energy under the irradiation of near-infrared laser, and the combined application of sonodynamic therapy, photothermal therapy and chemotherapy can be realized along with the release of drugs.

The invention discloses a gold nanocomposite particle having plasma photothermal/photodynamic therapy performance, and a preparation method thereof. The structure of the gold nanocomposite particle contains a gold nanoparticle used for the photodynamic therapy, a plasma photothermal therapy photosensitizer attached to the gold nanoparticle, and a hydrophilic polymer polyethylene glycol modifying the surface. The invention also relates to a use of the gold nanocomposite particle in the photodynamic/plasma photothermal collaborative therapy. The gold nanocomposite particle has the advantages of simple preparation, low price and substantial curative effect.

The invention provides a black phosphorus quantum dot composite material comprising a black phosphorus quantum dot, positive ions modified on the surface of the black phosphorus quantum dot and polyethylene glycol or polyethylene glycol derivatives. The positive ions comprise the metal positive ions or the ammonium ions. The positive ions are combined with the black phosphorus quantum dot through electrostatic force, and the pieces of polyethylene glycol or the polyethylene glycol derivatives are combined with the black phosphorus quantum dot through Van der Waals force. According to the black phosphorus quantum dot composite material, the positive ions are combined with the black phosphorus quantum dot through the electrostatic force, so that the oxidation resistance ability of the positive ions is improved greatly, and the pieces of polyethylene glycol or the polyethylene glycol derivatives are combined with the black phosphorus quantum dot through the Van der Waals force so that the black phosphorus quantum dot can be stably dispersed in water. The invention provides a preparation method of the black phosphorus quantum dot composite material in the second aspect. The method is simple and easy to operate. The black phosphorus quantum dot composite material can be used for preparing photoacoustic imaging drugs, or photothermal therapy drugs, or photodynamic therapy drugs or drug-loading targeted therapy drugs.

The invention relates to copper selenide/mesoporous silica core-shell nanoparticles and a preparation method and application thereof. The copper selenide/mesoporous silica core-shell nanoparticles are Cu2<-x>Se/mSiO2-PEG core-shell nanoparticles, where x is 0-1, and m is mesoporous. The preparation method comprises the following steps: preparing a Cu2<-x>Se nanocrystalline, transferring the hydrophobic Cu2<-x>Se nanocrystalline into an aqueous phase through CTAB (Cetyltrimethyl Ammonium Bromide), and growing a mesoporous silica layer on the surface of the CTAB through a sol-gel method by taking the CTAB as a template; and finally, modifying and coupling polyethylene glycol to the surface, and obtaining the copper selenide/mesoporous silica core-shell nanoparticles. The invention also discloses application in preparation of diagnosis and treatment preparations. The obtained Cu2<-x>Se/mSiO2-PEG has extremely low cytotoxicity, so that cancer cells can be effectively killed through light and heat, and the anti-cancer drug DOX can be effectively transmitted into the cells and has pH and laser-sensitive drug sustained release performance, so that a synergistic effect between photothermal therapy and chemotherapy can be realized.

The invention relates to a photoelectric catalytic unit and a photoelectric catalytic method. The photoelectric catalytic unit comprises a photocatalytic film deposited on a conducting substrate, and a thermoelectric device electrically connected with the photocatalytic film, wherein the surface of the thermoelectric device is provided with a photothermal material. The photoelectric catalytic method comprises the following steps: photogenerated electrons and holes generated on the photocatalytic film deposited on the conducting substrate under the light excitation are utilized to degrade organic pollutants in contact with the photocatalytic film; and the thermoelectric device is utilized to convert heat energy, which is generated by the photothermal material on the surface under the irradiation of visible light or infrared light, into electric energy, and apply the electric energy onto the photocatalytic film electrically connected with the photocatalytic film to promote the separation of the photogenerated electrons and the holes.

The invention discloses shape and size controllable gold nanoparticles and a preparation method and application thereof. The water-soluble and monodispersed gold nanoparticles with different shapes and sizes are synthesized by adopting a seed growth method, and the shapes comprise the spherical shape, the bar shape, the dumbbell shape, the bipyramid shape, the cube shape and the star shape with abranch structure. The series of nanogold with different sizes can be obtained in the mode of changing a seed solution by taking ascorbic acid or sodium borohydride or hydroquinone as a reducing agent,taking hexadecyl trimethyl ammonium bromide as a cationic surface active agent and a stabilizing agent and taking sodium citrate as a reducing agent and a stabilizing agent, fine control over the shape and the size of the nanogold is achieved, the high yield, the high purity and the good water solubility are achieved, no biotoxicity is generated, and a purification technology is simple. The shapeand size controllable gold nanoparticles can be applied to the fields of photoacoustic imaging, photothermal therapy and biosensing.

The invention relates to a folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as a preparation method and an application thereof. The nano-composite particle consists of Fe3O4@mSiO2 core-shell structural nanoparticles, wherein the core-shell structural nanoparticles take Fe3O4 nanoparticles as cores and mSiO2 as shells, and copper sulfide nanoparticles and folic acid cover the surfaces of the shells; the folic acid is grated on one part of the mesoporous silica (mSiO2) and the copper sulfide particles are loaded on the other part of the mesoporous silica; and polyethylene glycol is grated on the surface of the copper sulfide nanoparticles. Compared with the prior art, the nano-composite particles disclosed by the invention has a broad application prospect in the aspects of nuclear magnetic resonance imaging, drug loading and photothermal therapy; anti-cancer drugs and photothermal reagents can be transmitted to tumor parts in a targeted mode; the nano-composite particle can reduce toxic and side effects on normal tissues and cells, and meanwhile, the nano-composite particle can effectively kill cells, so that a treatment effect is further improved; and moreover, the nano-composite particle is relatively low in preparation condition demand and cost.

The invention provides a preparation method of a hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets. The preparation method comprises following steps: step 1, molybdenum disulfide nano tablets are obtained via hydro-thermal synthesis; step 2, the molybdenum disulfide nano tablets are added into a gelatin solution, and gelatinized molybdenum disulfide nano tablets are obtained via sufficient reaction; step 3, lactobionic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and N-hydroxy succinimide are weighed and added into the gelatinized molybdenum disulfide nano tablets so as to obtain lactobionic acid modified molybdenum disulfide nano tablets; and step 4, a doxorubicin hydrochloride aqueous solution is prepared, and the lactobionic acid modified molybdenum disulfide nano tablets obtained via step 3 are added into the doxorubicin hydrochloride aqueous solution, an obtained mixture is stirred for 8 to 24h under vacuum conditions, and is subjected to centrifugalization and washing so as to obtain the hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets via collecting. The hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets can be used for photothermal therapy and CT imaging, and can be used for realizing combination of diagnosis and treatment of hepatoma carcinoma.

The invention belongs to the technical field of biology, and in particular relates to a polydopamine coated gold nanorod material as well as a preparation method and application of the polydopamine coated gold nanorod material. The preparation method disclosed by the invention comprises the following steps: by taking CTAB (cetyl trimethyl ammonium bromide) as a template agent, synthesizing a polydopamine coated gold nanorod material; modifying an antibody onto the surface of the material, thereby obtaining a multifunctional polydopamine coated gold nanorod material. Thus, a tumor cell Raman imaging detection and real-time photothermal therapy platform is constructed. The experiments prove that the gold nanorod material is capable of realizing specific effective tumor target cell marking and performing rapid surface-enhanced Raman spectral imaging scanning on the tumor cells under excitation of near-infrared light; and the tumor target cells are accurately identified by the imaging results, and after the target cells are identified, the infrared light can be focused onto the tumor target cells, the irradiation time is prolonged, and the material is heated by utilizing the photo-thermal conversion effect of the gold nanorod material so as to kill the tumor cells in real time. The polydopamine coated gold nanorod material disclosed by the invention is novel, convenient, practical and efficient and has huge clinical application potential.

A series of conjugated polymer-based nanoparticles having far-red/near infrared emission ranges are disclosed. Cross coupling methods to prepare the conjugated polymers and methods of nanoparticle preparation are also discussed. The conjugated polymer nanoparticles are used as FR/NIR fluorescent probes in in vitro and in vivo biosensing and bioimaging applications, and are also used in photoacoustic imaging as contrast agents. Finally, use of the conjugated polymer nanoparticles in photothermal therapy is described.