33 results about "Photothermal therapy" patented technology

The application discloses a kind of sulphur-containing polydopamine melanin nanoparticles and preparation method and application, preparation raw materials include polyhydroxy compound and sulphur-containing compound, the weight ratio of the polyhydroxy compound and the sulphur-containing compound is (1-100) :(1-100), the preparation raw materials also include water, organic solvent and acid-base regulator.The application occurs self-polymerization reaction under alkaline condition with dopamine and sulphur-containing compound, without additional crosslinking agent and oxidant, and the nanoparticles obtained have excellent photothermal performance.In photothermal therapy, biomedical imaging, water purification, functional coating and other aspects, it shows great application potential.And preparation reaction condition is mild, without additional catalyst and oxidant, process is safe, post-processing is simple, and no harmful waste water and waste residue to environment, meet the requirements of green chemistry.

The application discloses a kind of magnetically responsive hydrogel optical fiber and its preparation and application, belong to medical biomaterial field.The optical fiber includes from inside to outside: polyethylene glycol diacrylate and acrylamide photocrosslinking light transmission core layer;Calcium alginate low refractive index skin layer;Doped nano-magnetic response layer of ferriferrous oxide;And polydopamine grafting polyvinylpyrrolidone lubricating layer.It is prepared by coaxial extrusion and light / calcium step-by-step crosslinking.The structure realizes the spatial isolation and anti-interference of light transmission and magnetic drive, has low background light loss and anti-bending stability, has biomechanics matching, ultra-low friction and magnetic field accurate active navigation ability, solves the pain point that extremely soft optical fiber is difficult to directional intervention.Suitable for deep tissue precise photothermal therapy, in vivo continuous optical sensing and minimally invasive diagnosis and treatment integration and other frontier medical fields.

The application discloses a novel AIE photosensitizer and a preparation method and application thereof. The AIE photosensitizer of the application comprises TDQ shown in the following structural formula, has superior photo-thermal conversion performance and photodynamic performance, and can be used for preparing a tumor diagnosis reagent or a tumor treatment drug. The co-loading liposome of TDQ and a senescence-inducing molecule (Ali) can be used as a multi-modal light diagnosis and treatment agent to realize efficient delivery of drugs to tumor tissues, and the photo-thermal therapy and the photodynamic therapy based on TDQ not only induce cell apoptosis through oxidative stress and mitochondrial dysfunction, but also trigger cancer cell senescence and promote the secretion of SASPs, so that the anti-tumor immunity is significantly enhanced, and finally the growth of primary tumors, tumor recurrence and re-metastasis are inhibited. The material of the application has simple preparation process, low cost, and is suitable for scale production and clinical medical use.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

This invention relates to experimental systems and methods for research on photodynamic therapy, photothermal therapy, and their combinations. The experimental system includes: an optical irradiation module comprising multiple laser sources, each capable of outputting a collimated beam, which is then combined to form a coaxial optical path and projected onto the surface of the observed object via a beam adjustment component; an optical path position adjustment module including an electric Z-axis displacement mechanism; a temperature monitoring module including an active temperature control substrate, an infrared thermal imager, and a fiber optic temperature probe interface; and a data acquisition and control module configured to: synchronously acquire laser output power, spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of multiple different regions, and fiber optic temperature probe data, and record the above data with a unified timestamp; calculate power density based on the real-time output power and spot area of ​​the laser sources; and automatically control the laser source to shut off its output when the data from any temperature monitoring channel exceeds a preset safety threshold.

This invention discloses a nanomedicine and its application in the four-modal synergistic treatment of ER+ breast cancer, encompassing gas therapy, photothermal therapy, photodynamic therapy, and combined therapy, relating to the fields of biotechnology and new medicine. This nanomedicine uses an amphiphilic polymer as a carrier and organic compounds and photosensitizers as drug loading agents. Through the synergistic effects of four modes—photothermal, photodynamic, gas therapy, and combined therapy—it effectively inhibits the growth and metastasis of breast cancer cells. The amphiphilic polymer, based on PHHM-ADT, is modified with hydrogen sulfide gas as a donor, and its amphiphilicity allows for spontaneous assembly into nanoscale hollow, regular spheres. Utilizing the high permeability and retention effect (EPR effect) at the tumor site, it achieves efficient drug accumulation in tumor tissue. The prodrug PSF couples fulvestrant and pabuxiparin via disulfide bonds, and the photosensitizer IR808 integrates photothermal and photodynamic therapy. The synergistic effect of multiple mechanisms of action enhances the therapeutic effect.

This invention relates to the field of hydrogel patch technology, specifically to a self-energized gelatin-based hydrogel patch and its preparation method. The patch comprises, from top to bottom, an upper encapsulation layer, a two-dimensional gelatin-based hydrogel functional layer, a conductive electrode layer, and a lower encapsulation layer. The functional layer uses gelatin as the hydrogel matrix and contains two-dimensional materials, plasticizers, and crosslinking agents. The two-dimensional materials and gelatin combine to form a three-dimensional network structure. The patch integrates self-energized electrical stimulation, photothermal therapy, and flexible sensing functions. It generates electricity through human movement without an external power source, achieving electrothermal synergy to promote wound healing. This patch achieves electrothermal synergy to promote wound healing without an external power source, also possesses physiological sensing functions, good biocompatibility, excellent mechanical properties and stability in use, and shows promising application prospects.

The application provides a multifunctional nano drug delivery system based on iron-doped MOF and a preparation method and application thereof. The system comprises: an Fe / MOF core loaded with a chemotherapeutic drug and an HO-1 inhibitor; a PDA coating layer coated on the surface of the Fe / MOF core for providing near-infrared light heat conversion capability and surface modification interface; and E3 aptamer covalently coupled on the PDA coating layer, constituting a synergistic nano platform with active targeting, pH / NIR dual-responsive drug release, chemical kinetics therapy, ferroptosis sensitization, photothermal therapy and immune regulation functions. The nano system can realize efficient accumulation at the tumor site through active targeting mediated by E3 aptamer, and controllably release drugs under an acidic microenvironment or near-infrared light. A new strategy for multi-mechanism synergistic treatment is provided to overcome the multiple drug resistance and immunosuppression of mCRPC, and has important clinical application prospects.

The inventive technology is directed to novel photoacoustic endoskeletal droplet compositions and methods of making the same. Specifically, the naphthalocyanine dye-loaded endoskeletal droplets having a solid hydrocarbon core surrounded by a fluorocarbon liquid, which can further be applied to photoacoustic imaging and sensing, as well as photothermal therapy.

The application provides an antitumor drug, a preparation method and application thereof, and belongs to the technical field of medicines. 4 The Fe3O NPs are deposited with polydopamine on the surface, then a COF layer is formed on the surface through a one-pot method, and an antitumor compound is loaded; further, doxorubicin is loaded on the surface, and then the antitumor drug is prepared by reacting with F127 coupled with folate and oligomeric hyaluronic acid. The antitumor drug prepared by the application has high anticancer activity and drug resistance reversal, high drug loading rate, is not prone to aggregation, has good biocompatibility, good targeting and slow release, and has good application in chemotherapy, photodynamic therapy, photothermal therapy and nuclear magnetic imaging, so that the antitumor drug becomes a new generation of diagnosis and treatment integrated reagent.

The application discloses a kind of self-adjusting laser power control method and system based on temperature prediction, belong to medical equipment intelligent control technical field.Through constructing a forward-looking adaptive control closed loop: system first real-time continuous acquisition and constructs the temperature sequence of target area;Using pre-trained time series prediction model, based on current and historical temperature and power data, predict the temperature change trend in future short term;When it is predicted that temperature will deviate from the preset safe and effective treatment window, calculate and output smooth laser power regulation instruction in advance, drive actuator to actively intervene.The application can dynamically compensate biological tissue thermal inertia and environmental disturbance, maintain the temperature of treatment area in the preset target range with high precision and high stability, significantly improve the safety and controllability of treatment, and provide a key intelligent control solution for the clinical transformation of photothermal therapy.

The application discloses a kind of nanocluster structures for improving light absorption efficiency, to provide a kind of nanocluster structure with stable high absorption efficiency under near-infrared light irradiation.The present application is based on the random agglomeration of nanochip cap structure monomer that only grows connecting molecule on cap surface, weaken the dependence of nanocluster structure on incident light polarization state;By wrapping the connecting surface into the cluster structure, reduce the contact between the connecting surface and the outside world, limit the number of particles in the cluster structure, limit the absorption spectrum widening of cluster structure by using the plasmonic coupling between limited particles, improve the light absorption efficiency of nanocluster structure.Based on the nanoprobes of the nanocluster structure have wide application prospect in photothermal therapy, biosensing, drug delivery and the like.

This invention discloses a targeted nanoparticle for calcium overload therapy combined with photothermal therapy, specifically involving a lipid-modified cRGD-targeting, MMP-responsive, and pH-sensitive calcium carbonate nanoparticle loaded with indocyanine green (ICG). This invention uses pH-sensitive calcium carbonate, which can decompose and exfoliate within lysosomes, as the matrix material. It leverages cRGD's specific targeting of tumor cells, the tumor microenvironment-specific high expression of matrix metalloproteinases (MMPs) to induce the release of DPPA-1 within the tumor microenvironment, and the low pH characteristic within lysosomes to achieve a combined anti-tumor effect of phototherapy and immunotherapy.

This invention discloses a composite drug delivery nanoparticle based on platelet exosomes, its preparation, and its application. The composite drug delivery nanoparticle comprises platelet exosomes, DPPS liposomes, and a multifunctional molecule; both the DPPS liposomes and the multifunctional molecule are embedded on the outer surface of the outer layer of the platelet exosome. The structural formula of the multifunctional molecule is: R1-R2-R3-R4. The composite drug delivery nanoparticle of this invention can increase the loading capacity of the hydrophobic chemotherapeutic drug PTX and the photothermal agent ICG without damaging the exosome particle size and membrane protein characteristics. It achieves controlled release of immune checkpoint inhibitors in a tumor-associated enzyme environment. This system exhibits good drug enrichment capacity, photothermal heating performance, and can effectively block PD-1 / PD-L1 interaction. This invention provides a feasible nanodelivery scheme for the synergistic application of chemotherapy, photothermal therapy, and immunotherapy.

This invention proposes a plasma-enhanced photothermal therapy embolization microsphere and its preparation method. The preparation method includes: preparing a gelatin solution and a modifying solution; adding the modifying solution to the gelatin solution to obtain an aqueous prepolymer; adding a nucleophilic reagent to the aqueous prepolymer and obtaining a first modified aqueous prepolymer under ultraviolet irradiation; sequentially adding a photosensitizer and a drug to the first modified aqueous prepolymer to obtain a third modified aqueous prepolymer; preparing a dispersion; gradually adding the dispersion to the third modified aqueous prepolymer under ice bath conditions and a first ultrasonic power, ultrasonically emulsifying, then adding a crosslinking agent, and performing ultrasonic crosslinking under ice bath conditions and a second ultrasonic power to obtain an intermediate product; post-processing the intermediate product to obtain a first microsphere; forming an adhesion layer on the first microsphere, reducing the adhesion layer, and forming nano-metal particles on the surface of the microsphere. Through this invention, the embolization microsphere has plasma-enhanced imaging function and can perform photothermal therapy in conjunction with drug release to eliminate tumors.

The application discloses a multimodal antibacterial biological heterojunction, a preparation method and application thereof, and comprises the following steps: S1, preparing a dispersion liquid of single-layer Ti3C2 nanosheet; S2, preparing Fe and Cu doped metal organic framework material: FeCu-MOF; S3, compounding the single-layer Ti3C2 nanosheet and the FeCu-MOF to prepare the multimodal antibacterial biological heterojunction. The MXene / FeCu-MOF heterojunction is innovatively constructed, the band structure and near-infrared plasmonic effect are regulated, the directional transfer of electric charges is effectively promoted, the chemical dynamic therapy (CDT) and photodynamic therapy (PDT) effects are significantly enhanced, and the synergistic effect with photothermal therapy (PTT) is generated. The application designs a new multimodal non-antibiotic treatment strategy, which can realize efficient killing and removal of methicillin-resistant Staphylococcus aureus.

The present invention relates to a reduced graphene oxide nanocomposite for targeting multiple drug-resistant cancer cells capable of simultaneously performing enhanced photothermal therapy and photodynamic therapy, and a method for manufacturing the same. The nanocomposite of the present invention comprises reduced graphene, poly(N-isopropylacrylamide)-acrylic acid, and folic acid, thereby exhibiting excellent targeting function for multiple drug-resistant cancer cells. In particular, when an anticancer agent including indocyanine green is encapsulated internally, it exhibits a synergistic effect of photothermal and photodynamic therapy against multiple drug-resistant cancer.

The application discloses a kind of composite hydrogel for wound repair and its preparation method and application, belong to medical material technical field.Methyl methacrylated gelatin, hydroxyethyl methacrylate and oxidized dextran are mixed, copper sulfide nanoparticles, crosslinking agent and photoinitiator are added, stirred uniformly and placed in mold, and UV irradiation is used.Aldehyde group on ODex chain and amino group on GelMA chain occur Schiff base reaction, form dynamic covalent bond, constitute reversible crosslinking point, copolymerization reaction occurs between HEMA and methacryloyl on GelMA molecular chain, and stable covalent crosslinking network is formed.In this process, CuS NPs are effectively captured and stably dispersed in the network by physical action, and the crosslinked hydrogel is soaked in deionized water to balance, to obtain the target composite hydrogel.The composite hydrogel has excellent mechanical strength, pH-responsive swelling performance and biocompatibility, and can realize efficient antibacterial and endogenous immune regulation by combining near-infrared photothermal therapy, effectively promoting wound repair.

This invention discloses the application of albumin-loaded drug-eluting nanoparticles for dual-phototherapy in the preparation of drugs for treating cervical cancer, belonging to the field of pharmaceutical technology. The albumin-loaded drug-eluting nanoparticles of this invention are formed by loading indocyanine green and hydroxyalizarin onto albumin; the nanoparticle system simultaneously contains ICG and purpurin; the ICG photothermal agent can not only convert light energy into heat energy through photothermal action, but also generate reactive oxygen species through photodynamic therapy to inhibit cell activity, while purpurin inhibits GDH1 activity, disrupting intracellular redox homeostasis and cutting off the nutrient supply to cancer cells. Based on the above three anti-tumor mechanisms, this invention overcomes the shortcomings of single-treatment chemotherapy, such as high toxicity and low therapeutic effect. By combining the nanosystem with photodynamic and photothermal therapy, the therapeutic effect of hydroxyalizarin on cervical cancer cells is improved, providing a new solution to the technical challenges of high recurrence and mortality rates in cervical cancer.

The application belongs to the technical field of biological medicine, and discloses a tumor local acute inflammation inducer, a preparation method and application thereof. Specifically, extracted bacterial outer membrane vesicles are loaded into prepared temperature-sensitive hydrogel for in-situ injection treatment of common clinical solid tumors, such as breast cancer, melanoma, colorectal cancer and the like. The temperature-sensitive hydrogel loaded with bacterial outer membrane vesicles constructed in the application induces acute inflammation at the tumor site, effectively activates anti-tumor immunity, and improves the immunosuppressive microenvironment; at the same time, the temperature-sensitive hydrogel causes rupture of tumor blood vessels, and can be combined with photothermal therapy to further eradicate tumors; and the temperature-sensitive hydrogel limits acute inflammation in the tumor, improves biological safety, and provides a new strategy for development of in-situ tumor treatment preparations.

This invention proposes an antitumor drug, its preparation method, and its application, belonging to the field of pharmaceutical technology. Fe3O 4 Polydopamine is deposited on the surface of NPs, and then a COF layer is formed on the surface through a one-pot method, and an antitumor compound is loaded onto it. Doxorubicin is further loaded onto the surface, and then reacted with F127 coupled with folic acid and oligomeric hyaluronic acid to obtain the antitumor drug. The antitumor drug prepared by this invention has high anticancer activity and drug resistance reversal, high drug loading rate, is not prone to aggregation, has good biocompatibility, and good targeting and sustained-release properties. It has good applications in chemotherapy, photodynamic therapy, photothermal therapy, and MRI, making it a new generation of integrated diagnostic and therapeutic reagent.

The application provides a near-infrared two-region fluoroborondye molecule with high photo-thermal conversion efficiency and a preparation method thereof, wherein the fluoroborondye molecule BDF-8OMe is obtained by dissolving BDF-2Br and N1-(4-(bis(4-methoxyphenyl)amino)phenyl)-N4,N4-bis(4-methylphenyl)benzene-1,4-diamine (TPA-NH) in a toluene medium under a nitrogen atmosphere, using palladium acetate as a catalyst, tri-tert-butylphosphine tetrafluoroborate as a ligand, and cesium carbonate as an inorganic base. The fluoroborondye molecule has a D-A-D structure and has good absorption in the NIR-II region. The photo-thermal reagent prepared from the fluoroborondye molecule has a high photo-thermal conversion efficiency of 62.5% under 1064nm laser excitation, and can be used for precise and efficient NIR-II photoacoustic / photo-thermal imaging mediated photothermal therapy of deep tumor tissue, reduces tumor treatment damage and side effects, and improves treatment efficiency and accuracy.

This application relates to the preparation and application of a gambogeylic acid formulation targeting malignant tumors. It employs a three-layer structure: the core is a gambogeylic acid-black phosphorus quantum dot complex, possessing both chemotherapy and photothermal therapy functions; the middle layer consists of cryogenically frozen NK92 MI cell-derived nanovesicles, providing natural immune targeting and killing capabilities; the outer shell is a hyaluronic acid chelate, enabling active targeting and pH / photothermal responsive drug release. The core of its preparation method lies in using coaxial electrospray technology to form the three layers in one step, resulting in a highly efficient process and good formulation stability. This formulation can achieve synergistic photothermal-chemo-immunotherapy and simultaneously possesses near-infrared fluorescence and photoacoustic multimodal imaging capabilities, effectively solving the problems of poor targeting, significant toxic side effects, and lack of real-time monitoring associated with traditional chemotherapy. It demonstrates significant advantages and application potential in the precision treatment and diagnosis of solid tumors.

This invention discloses a temperature monitoring and photothermal therapy system based on rare-earth optical fiber, comprising a computer, a spectrometer, a laser source, a coupler, a Y-type optical fiber (including a temperature-sensing fiber, a dual-mode fiber, and a laser fiber), a fiber optic probe, and a temperature monitor. The probe is filled with a photothermal therapy composite material and has a detachable structure for easy replacement with different filling materials. The laser is coupled to the temperature-sensing fiber via the laser fiber and the coupler, and then transmitted to the probe through the Y-type fiber to excite the photothermal therapy composite material. The excited fluorescence is transmitted to the spectrometer through the Y-type fiber for spectral analysis to read the fluorescence intensity of two different wavelengths. The computer performs real-time calculations using the fluorescence intensity ratio method to obtain the real-time temperature of the probe. The laser power is controlled by a temperature controller, thereby achieving real-time monitoring and temperature control. This invention is small in size, allows for real-time monitoring and control, has modular features, and allows for replacement of the laser source, optical fiber, and probe, achieving low-cost and safe treatment.

The application relates to the technical field of traditional Chinese medicine carbon quantum dot materials, and particularly relates to application of phellodendri chinensis carbon in a photothermal reagent for near-infrared photothermal treatment of tumors. The application comprises: using phellodendri chinensis carbon carbon quantum dots derived from phellodendri chinensis carbon to prepare the photothermal reagent for near-infrared photothermal treatment. The application solves the problems of poor biocompatibility and high toxicity of traditional photothermal reagents by using the natural traditional Chinese medicine material phellodendri chinensis carbon, solves the problems of weak photothermal stability and easy failure of traditional photothermal reagents by using the "old drug new use" of phellodendri chinensis carbon quantum dots, and truly realizes the dual breakthroughs of innovative utilization of traditional Chinese medicine resources and high-performance photothermal reagents.

This invention relates to a novel organic photothermal agent for photothermal therapy and a composition comprising the same, and more specifically, to an organic photothermal agent represented by the following formula 1 and a composition comprising the same: [Formula 1]; wherein: R 1 To R 6 Each of them is selected from hydrogen, halogen, straight-chain or branched alkyl groups having 1 to 10 carbon atoms, alkenyl groups having 2 to 10 carbon atoms, alkynyl groups having 2 to 10 carbon atoms, and haloalkyl groups having 1 to 10 carbon atoms.

The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. The present invention also shows application for imaging-guided phototheranostic with the integration of both photodynamic therapies and photothermal therapies. The in vitro and in vivo verification further confirmed that this system exhibits outstanding fluorescence-guided phototheranostics ability to eliminate tumors effectively.

This invention proposes a nanoaggregate based on a near-infrared II aggregation-induced emission (AIE) material, its preparation method, and its application, belonging to the field of medical technology. The nanoaggregate of this invention is self-assembled from an AIE material and an amphiphilic carrier material, a DSPE-PEG series polymer. This nanoaggregate exhibits AIE properties in the near-infrared II region and can downregulate the expression of heat shock protein 70 through a proteasome-dependent mechanism. In vitro and in vivo experiments show that this nanoaggregate can achieve complete tumor ablation under low-temperature photothermal therapy at 43-45℃ without the need for combined use with exogenous heat shock protein 70 inhibitors, while simultaneously achieving near-infrared II fluorescence imaging guidance. This invention has the advantages of being single-component, low-toxicity, and integrating imaging and therapy, and has broad application prospects in the field of low-temperature photothermal therapy for tumors.

The present application relates to the technical field of fluorescent materials, and particularly relates to an aggregation-induced emission (AIE) material, a preparation method of the AIE material, a drug delivery system, a preparation method of the drug delivery system and application, the AIE material has unique characteristics as a photosensitizer, compared with a traditional photosensitizer with a planar conformation, the AIE photosensitizer can utilize a larger proportion of absorbed energy to emit fluorescence, generate reactive oxygen species (ROS) or photothermal. Therefore, the AIE material provided by the present application can efficiently generate ROS and photothermal in a cell environment; and the AIE material has the characteristics of photodynamic, photothermal therapy and fluorescence, photoacoustic, photothermal imaging; in addition, the drug delivery system comprises the AIE material and bacteria, the bacteria are used as a delivery carrier, so that the accumulation and penetration of the drug in tumor tissue can be enhanced, the curative effect is optimized, the specific killing of tumor tissue is realized, and the multi-modal tumor imaging and anti-tumor efficacy of the AIE material are significantly enhanced.