224 results about "Photothermal therapy" patented technology

The invention discloses a photoacoustic temperature imaging method based on coherent factor weighted fusion. The method comprises the following steps: step 1, hardware composition and configuration of a multi-bandwidth photoacoustic imaging system based on photoacoustic and ultrasonic dual modes; step 2, ultrasonic modal signal preprocessing; and step 3, calculating a coherence factor and weighting a reconstructed image. According to the invention, high-precision non-intrusive temperature measurement capability is shown, and a more advanced non-intrusive temperature monitoring means is provided for photothermal therapy of tumors. According to the method, functional modules of imaging, segmentation, temperature measurement, treatment and the like are integrated, the reconstructed image is weighted through the coherence factor, high artifacts and multiple side lobes in the FBP reconstructed image are removed, the resolution of temperature imaging is remarkably improved, and the method has remarkable advantages and huge application potential in the application of photo-thermal treatment. And a multi-modal image fusion method is assisted, so that the multi-modal information of the target region can be obtained in the treatment process, more intuitive visual tumor state feedback is provided for workers, and the treatment effect is improved.

The invention discloses a method for preparing a methylacryloyl chitosan / gelatin-based hydrogel wound dressing through 3D printing and application, and relates to a method for preparing a hydrogel wound dressing and application. The problems that existing MXene is high in photo-thermal conversion temperature, and bacteria rapidly breed again after near-infrared irradiation is closed are solved. The ZGC composite hydrogel wound dressing integrates multiple functions, can simultaneously realize hemostasis, antibiosis, anti-inflammation, vascularization promotion and cell regeneration, and is especially suitable for infectious wounds. The antibacterial performance can be achieved under the activation of near-infrared light through the dual effects of a photothermal therapy and a photodynamic therapy, and meanwhile, the antibacterial effect can be achieved in cooperation with Zn < 2 + >. The ZGC composite hydrogel wound dressing can be accurately customized and printed through a 3D printing technology according to the shape and depth of a wound, the composite dressing can achieve accurate low-temperature photo-thermal treatment, meanwhile, the continuous release of Zn < 2 + > and the physical antibacterial function of MXene are maintained, normal tissue is protected while bacteria are killed, and the healing rate of an infected wound is remarkably increased.

The invention discloses an OTX-015 (Ox-015) loaded cascaded responsive nano particle and a preparation method thereof. The nanoparticle has a three-layer core-shell structure, wherein the innermost layer is a cross-linked nanoparticle of chitosan and paclitaxel; the middle layer is a polydopamine layer loaded with a bromodomain inhibitor OTX-015; the outermost layer is a gelatin layer grafted with babali; wherein the cross-linked substance of the chitosan and the paclitaxel is a cross-linked substance containing a disulfide bond. The invention also provides a preparation method of the cascade responsive nano-particle and application of the cascade responsive nano-particle in preparation of an antitumor drug targeted delivery system. The nanoparticle provided by the invention improves the tumor microenvironment while activating in-vivo autoimmunity, and kills tumor cells by using photothermal therapy assisted chemotherapy drugs, so that the synergistic effect of chemotherapy / photothermal therapy / immunotherapy is realized, and a new idea is provided for clinical tumor treatment.

The invention provides an engineered membrane coated nano drug delivery system and application thereof, and belongs to the technical field of nano biomedices.The drug delivery system comprises an inner core combined with a drug, the inner core is coated with a cell membrane, based on the nano drug loading technology and the membrane coating technology, DOX and SRF are loaded on mPDA mesoporous nanoparticles, and thyroid cancer synergistic killing nanoparticles mPDS are formed; the bionic drug delivery system is characterized in that mPDS is used as a target drug delivery system, mPDS is coated with a genetically engineered tumor cell membrane, a dual-targeting membrane-coated nano drug delivery system (mPDS-coated CAR-M) is obtained, and the bionic drug delivery system can penetrate through thyroid cancer in a targeted manner, gather in a focus and reduce side effects of chemotherapy; when near-infrared irradiation is carried out on local tumor, DOX and SRF in mPDS are released, the synergistic effect of photothermal therapy-chemotherapy-targeted therapy is achieved, and the thyroid cancer is killed synergistically.

The invention belongs to the technical field of medicines, and particularly relates to a bionic nano-drug for resisting subcutaneous drug-resistant bacterial infection as well as a preparation method and application thereof. Dopamine hydrochloride is added in the synthesis process of a metal-organic framework to prepare a dandelion-shaped carbon nano-enzyme precursor, then the nano-enzyme precursor is carbonized to obtain a carbon nano-enzyme with targeting property, photoresponse and peroxidase activity, and finally berberine hydrochloride is loaded on the carbon nano-enzyme to obtain the bionic nano-drug. The bionic nano-drug provided by the invention firstly has good biocompatibility, secondly has a unique dandelion-shaped form, is beneficial to playing a targeting role, and finally has relatively strong light response capability in a near-infrared region, and can synergistically and efficiently sterilize through action mechanisms of antibacterial drugs, photothermal therapy and chemical kinetics, so that the bionic nano-drug has a good application prospect. The compound has an important application value in preparation of drugs for treating subcutaneous drug-resistant bacterium infection.

The present invention relates to: a temperature-sensitive hydrogel for cancer treatment; a photothermal composition comprising the hydrogel as an active ingredient; and a preparation method for the temperature-sensitive hydrogel for cancer treatment. The temperature-sensitive hydrogel of the present invention includes gold nanostars as active ingredients, and thus can generate heat by light irradiation, thereby exhibiting a photothermal therapy effect. In addition, the hydrogel temperature increases so that the release of nitric oxide (NO) from S-nitrosocysteine can be induced. In addition, the temperature-sensitive hydrogel of the present invention includes S-nitrosocysteine as an active ingredient so that, upon a temperature rise due to a photothermal reaction, the penetration of drugs into a tumor site can be improved by the release of NO, and at the same time, apoptosis of cancer cells can be directly caused; and includes an immunotherapy agent as an active ingredient so that tumor size can be effectively suppressed even with the passage of time. Therefore, as a material that enables complex treatment combined with photothermal therapy and immunotherapy, the temperature-sensitive hydrogel of the present invention having the aforementioned effect can be usefully utilized in the field of medicine for cancer treatment.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

The invention discloses a microneedle patch loaded with a sorafenib and copper-doped Prussian blue nano material and application of the microneedle patch in in-situ triple-negative breast cancer treatment. The sorafenib and the copper-doped Prussian blue nano material are loaded in a needle body of the microneedle patch. The microneedle patch can accurately deliver nanoparticles and sorafenib to tumor tissues, the chemical kinetics effect is enhanced through an efficient and mild photothermal therapy, the ferroptosis of triple negative breast cancer cells is enhanced through ferroptosis induced by the nanoparticles and sorafenib in cooperation with drugs, then cell death is induced, and the curative effect is improved. And a brand-new and promising treatment method is provided for in-situ triple-negative breast cancer treatment.

The invention discloses an adriamycin-tetravalent platinum drug-norcantharidin three-drug combined nano-drug as well as a preparation method and application thereof, and belongs to the technical field of medical materials. A tetravalent platinum drug modified by demethylated cantharidin and adriamycin are used as raw materials, a novel nano-drug is constructed through Cu < 2 + > coordination, and then the nano-drug combining adriamycin, the tetravalent platinum drug and demethylated cantharidin is prepared by polymerizing polydopamine with a mild photo-thermal effect. The polymer has the capacity of controllably releasing drugs under acidity and reduction, can realize photo-thermal conversion under laser irradiation to generate a mild photo-thermal effect, has a better tumor cell killing effect, has the capacity of consuming glutathione and generating hydroxyl radicals, can enter cancer cells in an endocytosis mode and release DOX, and can be used for killing tumor cells. And a new thought is provided for multi-drug combination and chemotherapy-chemokinetics therapy-photothermal therapy multi-mode combined therapy.

The invention relates to an experimental system and method for photodynamic therapy, photothermal therapy and combined research of photodynamic therapy and photothermal therapy. The experiment system comprises an optical irradiation module which comprises a plurality of laser light sources, each laser light source can output collimated light beams, the collimated light beams are combined to form a coaxial light path, and the coaxial light paths are projected to the surface of an observation object through a light beam adjusting assembly; the light path position adjusting module comprises an electric Z-axis displacement mechanism; the temperature monitoring module comprises an active temperature control substrate, an infrared thermal imager and an optical fiber temperature probe interface; the data acquisition and control module is configured to synchronously acquire laser output power, light spot area, electric Z-axis position, temperature of the active temperature control substrate, temperature sequences of a plurality of different areas and optical fiber temperature probe data, and associatively record the data with a unified timestamp; the power density can be calculated based on the real-time output power of the laser light source and the light spot area; and when the data of any temperature monitoring channel exceeds a preset safety threshold value, the laser light source is automatically controlled to close the output.

The invention discloses a multi-mode synergistic antibacterial nano material as well as a preparation method and application thereof. The multi-mode synergistic antibacterial nano material comprises a two-dimensional silylene nanosheet and a copper nanocluster loaded on the surface of the two-dimensional silylene nanosheet. According to the Si-coated Cu NSs composite material disclosed by the invention, copper nanoclusters (CuNCs) are loaded on the surface of a two-dimensional silylene nanosheet, the catalytic activity of copper is enhanced by utilizing a p-d orbital hybridization effect, and meanwhile, photo-thermal therapy (PTT) and chemical kinetic therapy (CDT) are combined to synergistically remove drug-resistant bacteria and biological membranes, so that the limitation of traditional two-dimensional silylene in antibacterial application is overcome.

The invention discloses a preparation method and application of a novel polysaccharide molybdenum-loaded nano material. The polysaccharide molybdenum-loaded nano material has good water dispersibility, stability, photo-thermal effect and glutathione consumption capability, and can relieve toxic and side effects of normal cells and improve the anti-tumor curative effect. The polysaccharide molybdenum-loaded nano material can selectively generate enough ROS and consume GSH at the same time under the mild in-vivo condition, so that oxidative stress in a tumor is seriously unbalanced, meanwhile, photothermal therapy is combined, the aim of killing tumor cells is achieved, theoretical and experimental bases are provided for clinical treatment of tumors, and the polysaccharide molybdenum-loaded nano material has good application prospects.

The invention discloses a symmetric azaindole-heptamethine cyanine J-aggregate as well as a preparation method and application thereof, and aims to solve the problems of short absorption wavelength, poor stability and the like in the prior art. The cyanine J-aggregate has the maximum absorption wavelength as long as 1035 nm, is located in an NIR-II region and has excellent photo-thermal performance and stability, and the photo-thermal stability is improved by nearly 68% compared with that of an existing J-aggregate. The preparation method comprises multiple steps of reaction, and finally self-assembly is carried out in a PBS solution to form the J-aggregate. The cyanine J-aggregate shows the capabilities of efficiently killing tumor cells and completely ablating tumors in vivo in tumor photothermal therapy, is good in biocompatibility, expands the application scene of diagnosis and treatment integration, and has a wide prospect in the field of tumor photothermal therapy.

An antibody gold nanocage drug delivery system, a preparation method, and a use. LA-DOX-mPEG and a gold nanocage are first prepared independently; reaction between LA-DOX-mPEG and the gold nanocage is enabled to obtain DOX@GNC; then HS-PEG-COOH and an antibody are added for reaction to obtain the antibody gold nanocage drug delivery system. In addition to the advantages of nano drug delivery systems in the prior art, the gold nanocage drug delivery system further has the active targeting capability for tumor cells and can reduce the toxic and side effects of chemotherapeutic drugs on normal cells; pH responsive DOX drug release in an acidic tumor microenvironment can improve drug accumulation in tumor tissue. In addition, under the irradiation of near-infrared light, the gold nanocage converts light energy into heat energy, and the pH responsive drug release combined with high temperature enables rapid pulsed release of DOX carried by the gold nanocage, thereby achieving synergistic treatment of photothermal therapy and chemotherapy.

The invention provides a gallium nitrate modified Prussian blue nano composite material as well as a preparation method and application thereof, and the gallium nitrate modified Prussian blue nano composite material comprises Prussian blue nano particles and gallium nitrate loaded on the Prussian blue nano particles, according to the preparation method, gallium ions are loaded on the Prussian blue nanoparticles in an ion replacement manner. Through the synergistic effect of Prussian blue and gallium ions, the synergistic effect of photothermal therapy and ion release is achieved, damage to normal tissue or cells is avoided, the sterilization effect can be improved, the concentration needed for antibiosis is low, and meanwhile the good biocompatibility, antioxidant activity and spectrum sterilization effect are achieved.

The present invention belongs to the field of biomedical materials and specifically relates to anti-tumor nanoparticles, their preparation methods, and applications. The present invention claims protection for an anti-tumor nanoparticle comprising compound PTe N25, wherein the nanoparticles are simultaneously encapsulated with a camptothecin compound and compound PTe N25 using a phospholipid. The structural formula of compound PTe N25 is: #imgabs0# The present invention utilizes cRGD and camptothecin compounds in conjunction with an organic conjugated polymer material to prepare a dual-targeted chemotherapy-photothermal therapy combined treatment system. This system achieves cRGD-targeted recognition of cancer cells, controlled drug release responsive to spatiotemporal light dual stimulation in the context of a diseased environment, and integrated chemotherapy and photothermal therapy synergistic treatment, significantly reducing drug toxicity and side effects while maintaining anti-tumor efficacy.

The application discloses a kind of sulphur-containing polydopamine melanin nanoparticles and preparation method and application, preparation raw materials include polyhydroxy compound and sulphur-containing compound, the weight ratio of the polyhydroxy compound and the sulphur-containing compound is (1-100) :(1-100), the preparation raw materials also include water, organic solvent and acid-base regulator.The application occurs self-polymerization reaction under alkaline condition with dopamine and sulphur-containing compound, without additional crosslinking agent and oxidant, and the nanoparticles obtained have excellent photothermal performance.In photothermal therapy, biomedical imaging, water purification, functional coating and other aspects, it shows great application potential.And preparation reaction condition is mild, without additional catalyst and oxidant, process is safe, post-processing is simple, and no harmful waste water and waste residue to environment, meet the requirements of green chemistry.

The application discloses a kind of magnetically responsive hydrogel optical fiber and its preparation and application, belong to medical biomaterial field.The optical fiber includes from inside to outside: polyethylene glycol diacrylate and acrylamide photocrosslinking light transmission core layer;Calcium alginate low refractive index skin layer;Doped nano-magnetic response layer of ferriferrous oxide;And polydopamine grafting polyvinylpyrrolidone lubricating layer.It is prepared by coaxial extrusion and light / calcium step-by-step crosslinking.The structure realizes the spatial isolation and anti-interference of light transmission and magnetic drive, has low background light loss and anti-bending stability, has biomechanics matching, ultra-low friction and magnetic field accurate active navigation ability, solves the pain point that extremely soft optical fiber is difficult to directional intervention.Suitable for deep tissue precise photothermal therapy, in vivo continuous optical sensing and minimally invasive diagnosis and treatment integration and other frontier medical fields.

The invention discloses a preparation method of cryptotanshinone-loaded PDA (Polydopamine) nano drug-loaded particles. The technical scheme adopted by the invention is as follows: the cryptotanshinone is loaded on PDA (Polydopamine) nano particles. Photo-thermal therapy and pharmaceutical chemotherapy are integrated into designed nano-delivery to impart a targeted synergistic effect thereto. In addition, the PDA nanoparticles show photoacoustic imaging capability, and aggregation of the nanoparticles at the ovary part can be monitored in real time. The cryptotanshinone is loaded by utilizing aperture adsorption of PDA and pi-pi conjugation and hydrophobic interaction with the cryptotanshinone, so that a drug delivery system is constructed, the biological solubility and the utilization rate of the cryptotanshinone are improved, a slow release effect is achieved, the application of the cryptotanshinone is widened, and the purpose of treating the polycystic ovarian syndrome is achieved.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The invention discloses composite hydrogel for wound repair as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of medical materials. The preparation method comprises the following steps: mixing methylacryloylated gelatin, hydroxyethyl methylacrylate and oxidized dextran, adding copper sulfide nanoparticles, a cross-linking agent and a photoinitiator, uniformly stirring, placing in a mold, irradiating by adopting ultraviolet light, carrying out Schiff base reaction on an aldehyde group on an ODex chain and an amino group on a GelMA chain to form a dynamic covalent bond, and forming a reversible cross-linking point, so as to obtain the copper sulfide nanoparticle / GelMA composite hydrogel. The preparation method comprises the following steps: carrying out a copolymerization reaction on HEMA and methacryloyl on a GelMA molecular chain to form a stable covalent cross-linked network, effectively capturing CuS NPs through a physical effect and stably dispersing the CuS NPs in the network in the process, and soaking the cross-linked hydrogel in deionized water for balancing to obtain the target composite hydrogel. The composite hydrogel has excellent mechanical strength, pH response swelling property and biocompatibility, can realize efficient antibacterial and endogenous immune regulation by combining near-infrared photothermal therapy, and effectively promotes wound repair.

The invention discloses a preparation method and application of a gold-platinum-iron flower-shaped nano composite material with cascade catalytic capacity, and relates to the technical field of tumor hunger therapy, chemical power therapy and near-infrared photothermal therapy. According to the preparation method of the gold-platinum-iron flower-shaped nano composite material with the cascade catalytic capability, the flower-shaped zeolite imidazole framework is further modified and pyrolyzed, and the iron element is anchored on the carbon framework in a monatomic state; gold-platinum nanoparticles and hyaluronic acid which are tightly combined and grow in situ are further loaded on the surface of the nano-material, so that the nano-material has good biocompatibility and targeting property and can be used as a nano-composite material for tumor chemotherapy and near-infrared photothermal therapy. According to the invention, the variety of nano composite materials for tumor targeted hunger therapy, chemotherapy and near-infrared photothermal therapy by taking a zeolite-like imidazole skeleton as a substrate is enriched. The invention can obtain the preparation method and application of the gold-platinum-iron flower-shaped nano composite material with the cascade catalytic capability.

The invention provides a polycarbonate conductive elastomer based on MXene doping and a preparation method and application thereof, the conductive elastomer comprises aliphatic polycarbonate (APC), a deep eutectic solvent (PDES) and MXene, the mass ratio of the aliphatic polycarbonate to the deep eutectic solvent is 1: 0.5-3, and the addition amount of the MXene is 1-5 wt% of the total mass of the APC and the PDES. The conductive elastomer obtained by the invention is simple in preparation process, environment-friendly and free of high temperature and high pressure; the comprehensive performance of mechanical strength, electrical sensitivity, biocompatibility and degradability, photo-thermal response and antibacterial performance is realized; the material is stable in structure and suitable for the fields of flexible sensors, electronic skin, health monitoring, photo-thermal therapy, intelligent antibacterial materials and the like.

The application provides a preparation method of a near-infrared fluorescent dye using indoline as an electron donor. The method comprises the following steps: under the action of a palladium catalyst, through a Suzuki coupling, using a 1,4-dioxane:water mixed liquid as a solvent, coupling indoline boronic acid and a halogen-containing acceptor, and performing compound purification after high-temperature reaction. The near-infrared fluorescent dye using indoline as an electron donor has strong electron-donating properties, can realize aggregation-induced emission, can emit near-infrared light, and can improve light stability and molar absorption coefficient, so that a large Stokes shift can be realized, the near-infrared fluorescent dye is used for photothermal therapy, and good photothermal therapy efficiency is achieved.

The invention belongs to the field of preparation processes of porous nano materials, and relates to a preparation method of ZnFe2O4 aerogel for glioma photothermal therapy. The preparation method comprises the following steps: firstly, preparing a ZnFe2O4 precursor by adopting a sol-gel method in combination with a supercritical drying process, and carrying out supercritical drying; then polyethylene glycol (PEG), EDC, NHS and FA are introduced for functional modification, and the ZnFe2O4 aerogel is prepared through high-temperature heat treatment. The method is simple in process, raw materials are environmentally friendly and easy to obtain, and the prepared ZnFe2O4 aerogel is high in specific surface area, low in density and good in photo-thermal performance. The research provides a new thought for targeted treatment of glioma, and promotes the development of nano medicine and material science.

The invention discloses a load ICGamp. The invention discloses ZIF-8 nano-particles of CBF, and belongs to the technical field of preparation of nano-drug particles. The multifunctional nanoparticles are formed by simultaneously encapsulating indocyanine green (ICG) and cinobufagin (CBF) components by ZIF-8, and the drug loading capacities of the two drugs are both not lower than 5%. The preparation method comprises the following steps: slowly adding a solution containing cinobufagin and zinc nitrate into a mixed solution containing indocyanine green, bovine serum albumin and 2-methylimidazole, and carrying out centrifugal filtration, washing and drying on a reaction product to obtain the cinobufagin zinc oxide. The multifunctional nano-particles prepared by a one-step synthesis method are uniform in particle size and good in stability, indocyanine green and cinobufagin are uniformly distributed in a carrier, the multifunctional nano-particles have pH and near-infrared light dual response drug release characteristics, triple synergy of chemotherapy, photothermal therapy and photodynamic therapy can be realized, and the multifunctional nano-particles are simple in preparation process and suitable for popularization and application.

The application discloses a novel AIE photosensitizer and a preparation method and application thereof. The AIE photosensitizer of the application comprises TDQ shown in the following structural formula, has superior photo-thermal conversion performance and photodynamic performance, and can be used for preparing a tumor diagnosis reagent or a tumor treatment drug. The co-loading liposome of TDQ and a senescence-inducing molecule (Ali) can be used as a multi-modal light diagnosis and treatment agent to realize efficient delivery of drugs to tumor tissues, and the photo-thermal therapy and the photodynamic therapy based on TDQ not only induce cell apoptosis through oxidative stress and mitochondrial dysfunction, but also trigger cancer cell senescence and promote the secretion of SASPs, so that the anti-tumor immunity is significantly enhanced, and finally the growth of primary tumors, tumor recurrence and re-metastasis are inhibited. The material of the application has simple preparation process, low cost, and is suitable for scale production and clinical medical use.

The present invention provides a multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system and its preparation method and application, belonging to the field of biomedicine technology. In the present invention, chromium ion-doped zinc gallate nanocrystals are embedded in silica-coated gold nanorod nanoparticles GNR@MSNs to prepare composite nanoparticles cGNR@MSNs, and then multi-arm DOTV is modified on the surface of the nanoparticles, and then anti-CD40 antibodies are covalently coupled to obtain the multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system. The multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system improves diagnostic accuracy by combining multimodal imaging, promotes the development of imaging-guided combined therapy, exerts the synergistic effect of chemotherapy, immunotherapy and photothermal therapy, optimizes the tumor treatment effect, is suitable for the treatment of various malignant solid tumors, and has good practicality.

The invention relates to a cell membrane bionic drug-loaded carbon dot nano-material as well as a preparation method and application thereof. The nano-composite is prepared by the following steps: preparing carbon dots, cross-linking to form a reduction responsive carbon dot nano-cluster, sequentially loading chemotherapeutic drugs and coating a cancer cell membrane to form a nano-vaccine. After the nano vaccine is injected into the body of a mouse through caudal vein, the enrichment of the nano vaccine in a tumor part can be enhanced by utilizing the active tumor targeting characteristic of a cancer cell membrane, and tumor cells can be induced to generate immunogenic death through carried chemotherapy drugs and photothermal therapy, so that chemotherapy / photothermal / immune combined therapy on tumors is realized; the obvious anti-tumor effect is realized. In addition, as a nano vaccine, after subcutaneous injection, the nano vaccine can also utilize the tumor antigen carried by a cancer cell membrane and the adjuvant characteristics of the carbon dots to activate the anti-tumor immunity of an organism so as to prevent tumors, and has potential clinical application value.

The invention relates to an organic germanium-tungsten wheel cluster material, which has a chemical formula of Na16H26 [W36Ge6 (CH2CH2COOH) 6O138]. 82H2O, and belongs to a triclinic system. The organic germanium-tungsten wheel cluster material is prepared from dicarboxyethyl germanium trioxide and sodium tungstate in an acetic acid-sodium acetate buffer solution through a one-step self-assembly reaction, the operation is simple, and the cost is relatively low. In order to further improve the performance of the organic germanium-tungsten wheel cluster material, the organic germanium-tungsten wheel cluster material is compounded with gold nanoparticles and hyaluronic acid to obtain a composite material capable of effectively prolonging the cycle time and enhancing the photo-thermal performance and catalytic toxic active oxygen. The composite material has an excellent treatment effect when being used as a photothermal agent for tumor treatment.