40results about How to "With photothermal effect" patented technology

The invention provides a photosensitive liposome with encapsulated water-soluble medicament, which is composed of temperature-sensitive phospholipid, cholesterol and long circulation material and hollow gold nanoparticle, wherein, the hollow gold nanoparticle has a characteristic absorption peak at the near infrared zone with the wavelength of 700-900 nm, and the particle size distribution of the hollow gold nanoparticle is in the range of 20-100 nm. According to the invention, a brand new photosensitive liposome is composed by wrapping water-soluble medicament and hollow gold nanoparticle with temperature-sensitive liposome. Under the extraneous near infrared light, the wrapped hollow gold nanoparticle generates a photo-thermal treatment effect, simultaneously, the photo-thermal effect controls a rapid site-specific delivery of medicament in a large amount from the photosensitive liposome, thereby blood vessels in the tumour part can be damaged or the tumor cells can be killed effectively with a chemical treatment effect of the medicamen. The drug loaded liposome of the present invention realizes synchronous photo-thermal and medicament molecule treatment effect, and the treatment effect of disease such as tumour is substantially improved, and the invention has clinic applicability and real treatment meaning.

The invention discloses a polypyrrole-graphene / polyurethane antifouling paint, a preparation method and application thereof, wherein the polypyrrole-graphene / polyurethane antifouling paint is composed of component A and component B; in parts by weight, A The components are mainly composed of the following raw materials: 500 parts of group-hydrolyzed polyurethane prepolymer, 25-50 parts of bentonite, 25-50 parts of titanium dioxide, 60-120 parts of zinc oxide, 15-30 parts of talc, polypyrrole-graphene 15-30 parts of nanofillers; by weight, component B is mainly composed of the following raw materials: 5-7 parts of leveling agent, 5-7 parts of defoamer, 6-15 parts of chain extender, 10 parts of silane coupling agent ‑25 parts, 1-2 parts of catalyst. The present invention is a two-component polyurethane coating, which has good adhesion, anti-collision and crack resistance, and can also improve antifouling performance and antifouling durability.

The invention discloses a polydopamine nanometer diagnosis and treatment preparation and a preparation method thereof. The nano-therapeutic agent uses mesoporous polydopamine as a carrier, and carries rhodium nanoparticles in the pores and surfaces of mesoporous polydopamine respectively through hydrothermal synthesis reaction, and then absorbs photosensitizer chlorin (Ce6) on polydopamine and polydopamine. The polydopamine nanometer therapeutic agent with good dispersion is obtained on the composite nanoparticle of rhodium. The invention utilizes the photothermal effect of the carrier mesoporous polydopamine and the rhodium nanoparticle itself to locally heat up the tumor site. Combined with the catalytic properties of rhodium nanoparticles, it catalyzes the decomposition of hydrogen peroxide in the tumor microenvironment to generate oxygen. Under the conditions of photosensitizer Ce6 and external laser, it can realize the generation of singlet oxygen and effectively kill cancer cells. At the same time, combined with the photoacoustic imaging properties of polydopamine, the purpose of photoacoustic imaging-guided photothermal therapy and photodynamic synergistic therapy can be realized, which is expected to improve the effect of tumor treatment and has good biocompatibility, which has the potential for clinical application.

The invention relates to a layered double hydroxide nano drug-loaded complex and its preparation and application, and the complex is passed through Mn 2+ Doped layered double hydroxide MLDH nanosheets sequentially decorated with NH 2 ‑PEG‑COOH, loaded with heat shock protein inhibitor 17AAG, obtained. The reaction condition of the present invention is mild, easy to operate, and has the prospect of industrial implementation.

The invention relates to a coating material, in particular to an integrated coating material with anti-ice and wave absorbing functions, and a preparation method and application thereof. The present invention first provides a photocurable fluorinated epoxy resin, which can greatly reduce the surface free energy and improve the hydrophobicity of the material by introducing organic fluorine segments. The present invention also provides an integrated coating material system with anti-ice and wave absorbing functions, which comprises light-cured fluorinated epoxy resin, fluorinated Fe 3 O 4 Nanoparticles, photocuring initiators and organic solvents, this coating material system can realize the functional coupling of anti-icing and wave absorption, and has broad application prospects.

The invention provides a multifunctional nano-drug combination and a preparation method thereof. The combination comprises a carrier and active ingredients loaded on the carrier, wherein the carrier is a polymer formed by mPEG-PLGA and / or PEG-PLGA and a porphyrin compound through covalent-bond connection, and the active ingredients include hydrophobic and hydrophilic drugs. Preferentially, the carrier and the active ingredients loaded on the carrier form particles with the nano size of 50-1000 nm. The multifunctional nano-drug combination has photo-thermal effect so that the treatment efficiency can be improved based on traditional chemotherapy in combination with photo-thermal therapy, and the multifunctional nano-drug combination can be applied to cancer therapy drugs.

The invention provides a polymer drug carrier and a method for preparing the same. The polymer drug carrier is provided with a core-shell structure, a core comprises polyethylene glycol-distearoyl phosphoethanolamine nano-micelle, and a shell comprises poly-dopamine. The method includes forming the nano-micelle from polyethylene glycol-distearoyl phosphoethanolamine; forming the poly-dopamine shell on the outside of the nano-micelle to obtain the polymer drug carrier. The polymer drug carrier and the method have the advantages that the core and the shell of the polymer drug carrier comprise biodegradable polymers, accordingly, the polymer drug carrier is good in biocompatibility, and few toxic and side effects can be realized; the particle size of the polymer drug carrier is smaller than 50nm, tumor gathering effects and photo-thermal therapy effects can be realized, and tumor cell killing effects can be realized after near-infrared light irradiates on the polymer drug carrier; drugs can be encapsulated by the nano-micelle of the polymer drug carrier, diversified drugs can be loaded under chemical modification effects of the poly-dopamine, and accordingly the polymer drug carrier has an excellent application prospect in the field of medicine and pharmacology.

A Janus particle with chemotherapy / photothermal synergy and its preparation method, belonging to the field of biomedicine technology, can solve the technical problem that other materials are not easy to achieve multiple methods of combined treatment of cancer. The particle is gold-silica / mesoporous Silica Janus nanostructure, gold nanoparticles are in situ reduced on the surface of aminated mesoporous silica hemisphere by Pickering emulsion method, and different drugs are loaded on both ends. Aminated mesoporous silica Janus particles modified by gold nanoparticles are prepared by the Pickering emulsion method. The Janus particles of the present invention can simultaneously load two kinds of drugs, and can precisely control the ratio of the two kinds of drugs. The two kinds of drugs can pass pH, oxidation Reduction and other external signal stimuli respond to drug release, which solves the technical problem of drug burst release caused by existing drug nanocarriers.

The invention discloses a method for preparing rare earth ytterbium holmium double-doped pyrochlore phase nanofibers and its application. Using dimethylformamide as a solvent and adding polyvinylpyrrolidone, the droplets form Taylor cones under an electrostatic field, and on the surface of the liquid One-dimensional nanomaterials are prepared by electrospinning under the force of tension and electric field, and then the organic matter is removed through the process of heating, heat preservation and cooling, and cubic pyrochlore phase one-dimensional nanomaterials are prepared. One-dimensional nanofibers have good dispersibility in water, and have good upconversion performance and photothermal effect under near-infrared light irradiation. The preparation method is simple and easy, has good repeatability, and can meet the requirements of mass production. The matrix of the up-conversion photothermal material involved is an oxide, which has good chemical stability, is non-toxic, is cheap and is easily dispersed in water, and can meet the requirements of photothermal treatment and industrial production. It is expected to play an important role in the treatment of major diseases such as cancer and tumors.