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40results about How to "With photothermal effect" patented technology
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Photosensitive liposome with encapsulated water-soluble medicament
ActiveCN103284951AControl the effect of heat therapyEffective damageEnergy modified materialsAntineoplastic agentsChemical treatmentDisease
Owner:ZHEJIANG UNIV
MRI and PTT diagnosis and treatment integration functional microsphere with core-shell structure and preparation method thereof
InactiveCN105920624AImprove stabilityWith photothermal effectEnergy modified materialsEmulsion deliveryMicrospherePolypyrrole
The invention belongs to the fields of material science and biomedical application, and in particular relates to an MRI and PTT diagnosis and treatment integration functional microsphere with a core-shell structure and a preparation method thereof. The functional microsphere comprises a polypyrrole nano particle core and a polydopamine shell coated on the outer surface of the core, Fe3+ particles are arranged on the polydopamine shell in a complexing manner, the weight ratio of polypyrrole nano particles to polydopamine is 1: (3.1-10.2), and the weight ratio of the Fe3+ particles to the polydopamine is 1: (9.3-11.2). The preparation method comprises the following three steps: S1, preparation of the polypyrrole nano particles; S2, preparation of the nano microsphere with the core-shell structure; and S3, preparation of the MRI and PTT diagnosis and treatment integration functional microsphere. The functional microsphere is prepared by using the nontoxic polypyrrole and polydopamine with excellent biocompatibility, and is high in stability in blood of human bodies; moreover, the functional microsphere has T1 radiography effect and optothermal effect, can be used for magnetic resonance imaging (MRI) and photothermal therapy (PTT), and is a diagnosis and treatment integration functional material with great potential value.
Owner:HUBEI UNIV
Ultra-small metal chalcogenide compound nano crystal and biological synthesis method and application thereof
InactiveCN106315663AMild reaction conditionsEasy to operateMaterial nanotechnologyEnergy modified materialsSynthesis methodsFluorescence
The invention discloses an ultra-small metal chalcogenide compound nano crystal and a biological synthesis method and application thereof. In one embodiment, the synthesis method is as follows: a protein with the isoelectric point PI lower than 9.0 and a metal salt are mixed with water evenly to form a mixed solution, the mixed solution is adjusted to alkaline, a reducing agent and a sulfur source are added for reaction to form the ultra-small metal chalcogenide compound nano crystal with the particle size less than 10nm. The method has the characteristics of mild reaction conditions, simple operation, direct use of particles without additional surface modification in biological photothermal therapy, and the like, the prepared ultra-small metal chalcogenide compound nano crystal is uniform in size, good in dispersion and high in stability, and the prepared ultra-small metal chalcogenide compound nano crystal has very good bio-compatibility without any surface modification, also has the photothermal effect, and is a great-application-prospect nano material used for photothermal therapy and biological fluorescence imaging.
Owner:SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Janus particle with chemotherapy/photo-thermal synergistic effect and preparation method thereof
ActiveCN108704133AIncrease loadWith photothermal effectPowder deliveryOrganic active ingredientsHydrogenNano structuring
The invention provides a Janus particle with a chemotherapy / photo-thermal synergistic effect and a preparation method thereof and belongs to the technical field of biomedicines, aiming at solving thetechnical problem that combined treatment of various methods on cancers is not easy to realize by other materials. The particle is of a gold-silicon dioxide / mesoporous silicon dioxide Janus nano-structure; a gold nanoparticle is reduced on the surface of an aminated mesoporous silicon dioxide semi-sphere in situ through a Pickering emulsion method and different medicines are loaded at two ends respectively. The gold nanoparticle modified aminated mesoporous silicon dioxide Janus particle is prepared through the Pickering emulsion method. The Janus particle provided by the invention can be usedfor loading the two medicines at the same time and the ratio of the two medicines can be accurately controlled; the two medicines can respond medicine releasing through external signal stimulation including pH (Potential of Hydrogen), oxidization reduction and the like, and the technical problem that sudden releasing of the medicines is caused by an existing medicine nano-carrier is solved.
Owner:SHANXI UNIV
Preparation method of flame-retardant superhydrophobic sponge with photothermal effect and magnetic driving function
InactiveCN110003519AImprove flame retardant performanceImprove separation efficiencyCoatingsOrganic solventMicroparticle
The invention discloses a preparation method of flame-retardant superhydrophobic sponge with a photothermal effect and a magnetic driving function. The preparation method comprises the following steps: Step 10) pretreating melamine sponge: immersing the melamine sponge in deionized water, ultrasonically washing the melamine sponge, taking out and drying the melamine sponge, then ultrasonically cleaning the melamine sponge in an organic solvent, and drying the melamine sponge to obtain pretreated melamine sponge; Step 20) preparing nano magnetic particle and PDMS treatment liquid; and Step 30)immersing the pretreated melamine sponge in the nano magnetic particle and PDMS treatment liquid for ultrasonic treatment, squeezing out excessive treatment liquid in the melamine sponge, and then drying the immersed melamine sponge in vacuum to obtain the superhydrophobic sponge. The preparation method can improve the hydrophilic sponge material into high-selectivity superhydrophobic superlipophilic sponge to improve the efficiency of oil-water separation.
Owner:SOUTHEAST UNIV
Master batch with heat storage and insulation functions, master batch product and preparation method of master batch
ActiveCN107641297AStrong absorption capacityWith photothermal effectMonocomponent polyesters artificial filamentArtifical filament manufactureTitanium nitrideBronze
The invention relates to a master batch with heat storage and insulation functions, a master batch product and a preparation method of the master batch. The master batch comprises a polymeric carrierand ceramic powder, and the ceramic powder is one or a combined and compounded object of a tungsten bronze compound, antimony-doped, fluorine-doped or antimony and fluorine co-doped tin oxide and titanium nitride. The heat storage and insulation product simultaneously applicable to indoor space and outdoor space can be prepared by the master batch, and the master batch is simultaneously applicableto underwear and coats with heat insulation functions when being used for garment fabrics.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Multifunctional bone filling material containing black phosphorus nanosheets and preparation method thereof
InactiveCN111494721AFacilitate cross-linkingDoes not affect biocompatibilityPharmaceutical delivery mechanismTissue regenerationPolyvinyl alcoholBone defect
The invention discloses a multifunctional bone filling material containing black phosphorus nanosheets and a preparation method thereof. The multifunctional bone filling material is prepared from black phosphorus nanosheets, nano magnesium oxide, polyvinyl alcohol and chitosan. The specific preparation method comprises the following steps: preparing black phosphorus nanosheets; preparing a polyvinyl alcohol and chitosan hydrogel compound; loading the black phosphorus nanosheets and a nano magnesium oxide hydrogel compound, and the like. The multifunctional hydrogel bone filling stent disclosedby the invention overcomes the defects of poor complex disease resistance and poor osteogenesis induction of a stent system in the prior art, and the progress of bone defect repair under complex disease conditions is improved effectively.
Owner:JILIN UNIV
Polymer drug carrier and method for preparing same
ActiveCN105031656APlay a combined effectGood biocompatibilityEnergy modified materialsPharmaceutical non-active ingredientsSide effectBiocompatibility Testing
The invention provides a polymer drug carrier and a method for preparing the same. The polymer drug carrier is provided with a core-shell structure, a core comprises polyethylene glycol-distearoyl phosphoethanolamine nano-micelle, and a shell comprises poly-dopamine. The method includes forming the nano-micelle from polyethylene glycol-distearoyl phosphoethanolamine; forming the poly-dopamine shell on the outside of the nano-micelle to obtain the polymer drug carrier. The polymer drug carrier and the method have the advantages that the core and the shell of the polymer drug carrier comprise biodegradable polymers, accordingly, the polymer drug carrier is good in biocompatibility, and few toxic and side effects can be realized; the particle size of the polymer drug carrier is smaller than 50nm, tumor gathering effects and photo-thermal therapy effects can be realized, and tumor cell killing effects can be realized after near-infrared light irradiates on the polymer drug carrier; drugs can be encapsulated by the nano-micelle of the polymer drug carrier, diversified drugs can be loaded under chemical modification effects of the poly-dopamine, and accordingly the polymer drug carrier has an excellent application prospect in the field of medicine and pharmacology.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Wearable flexible sensor with photothermal effect and antibacterial function
ActiveCN111000566AWith photothermal effectHas antibacterial functionFibre typesDiagnostic recording/measuringHuman bodyCarbon nanotube
The invention discloses a wearable flexible sensor which is a novel wearable sensor taking an acrylon-spandex interwoven fabric as a base material. After the surface of the base material is treated byusing a specific raw material, the base material is soaked in a carbon nanotube aqueous solution and a silver nitrate aqueous solution in sequence, and silver ions are reduced into elemental silver.The acrylon-spandex interwoven base material shows excellent conductivity, so that the sensor can be used for monitoring macroscopic (finger joints, wrist joints, elbow joints and knee joints) and microscopic motion (facial muscle, throat vibration and eyeball rotation) of a human body. The base material of the sensor is a common warp and weft interwoven woven fabric, and the sensor can be completely assembled on clothes worn by people in daily life to achieve real-time monitoring of daily life activities of the human body. Meanwhile, due to the fact that a large number of carbon nano tubes and silver particles are attached to the surface of the base material of the sensor, a photothermal effect can be generated after illumination, and an antibacterial function is achieved.
Owner:JIANGNAN UNIV +1
Construction, expression and application of tumor-targeted peptide F3 modified cowpea chlorotic mottle virus-like particles
InactiveCN108558990ADoes not affect self-assemblyNon-infectiousSsRNA viruses positive-senseAntibody mimetics/scaffoldsIodideTumor target
The invention provides a construction and application of tumor-targeted peptide F3 modified cowpea chlorotic mottle virus-like particles. The F3-CCMV virus-like particles are constructed by insertingthe tumor-targeted peptide F3 into CCMV capsid protein CP whose amino terminal 1-26 amino acid residues are knocked out. The F3-CCMV virus-like particles serve as targeted drug delivery carriers to encapsulate near-infrared dye IR780 iodide, thereby preparing F3-CCMV-IR780 nanoparticles; and the F3-CCMV virus-like particles is capable of targeting and recognizing tumor cells, killing the tumor cells by a photothermal effect, and exerting a biological immune-targeting therapeutic effect.
Owner:ECOLOGY INST SHANDONG ACAD OF SCI
Preparation method and application of mesoporous SiO2/MoS2 material
ActiveCN107512736ASimple preparation processImprove preparation efficiencyOrganic active ingredientsMaterial nanotechnologySilane couplingPolyethylene glycol
The invention provides a preparation method of a mesoporous SiO2 / MoS2 material. The preparation method comprises the following steps: step I, weighing mesoporous silicon dioxide, a sulfur source and a molybdenum source according to a given ratio; step II, ultrasonically dispersing the mesoporous silicon dioxide, the sulfur source and the molybdenum source in an ethanol aqueous solution, and obtaining uniform turbid solution; step III, rotating and centrifuging the uniform turbid solution under a vacuum condition, and obtaining precipitates; step IV, transferring the precipitates into a stainless steel reaction kettle, adding polyethylene glycol, sealing, and reacting to obtain a reaction product; step V, washing the reaction product by using a neovaricaine aqueous solution, then washing with distilled water, and obtaining mesoporous silicon dioxide loaded with MoS2; step VI, adding silane coupling agent into the ethanol solution with the mesoporous silicon dioxide loaded with the MoS2 under a water bath condition, stirring, reacting, and centrifuging to obtain the amino modified mesoporous SiO2 / MoS2 material; and step VII, dispersing the mesoporous SiO2 / MoS2 material into an aqueous solution, adding activated polyethylene glycol, reacting, and obtaining the completely modified stable mesoporous SiO2 / MoS2 material.
Owner:UNIV OF SHANGHAI FOR SCI & TECH +1
Method for chemical design of photothermal effect type self-healing hydrogel based on melanin
PendingCN110627975AWith photothermal effectSelf-healingMaterial nanotechnologyChemical designMelanin
The invention discloses a method for chemical design and preparation of nano-composite hydrogel with strong photothermal effect and self-repairing capability by melanin. Specifically, polydopamine type nanoparticles are prepared, also surface initiated atom transfer free radical polymerization technology is utilized, firstly an atom transfer free radical polymerization initiator (PDA@Br) is grafted on the surfaces of polydopamine type nanoparticles, then polydimethylaminoethyl methacrylate (PDMAEMA) is grafted on the surface of the polydopamine type nanoparticles, thereby achieving functionalmodification on the surfaces of the polydopamine type nanoparticles. The prepared polydopamine type nano-composite material (PDA@PDMAEMA) is implanted into a hydrogel to obtain the nano-composite hydrogel with strong photothermal effect and self-repairing performance.
Owner:LUDONG UNIVERSITY
X-ray pyrogenic composite nanoparticle
InactiveCN103230370ASimplify the linkProduce efficientlyEnergy modified materialsGranular deliveryRare earth ionsX-ray
The invention relates to an X-ray pyrogenic composite nanoparticle, which belongs to the technical field of medical inspection. The composite nanoparticle comprises an X-ray long-lasting phosphorescent particle core, a nanogold shell layer and an amino-modified silica shell layer, wherein the X-ray long-lasting phosphorescent particle core is wrapped in the nanogold shell layer, and the nanogold shell layer is wrapped in the amino-modified silica shell layer; and the X-ray long-lasting phosphorescent particle core is a rare-earth ion doped oxide, sulfide or oxysulfide nanoparticle, positive ions of oxide, sulfide or oxysulfide are metal ions and rare-earth ions, and doped ions are rare-earth ions. The X-ray pyrogenic composite nanoparticle disclosed by the invention has the beneficial effects that a micro dose of X-ray energy can be efficiently converted into heat energy which is enough to kill tumor cells, and after independent of X ray radiation, the production of heat energy has time continuity.
Owner:DALIAN MARITIME UNIVERSITY
Porous biological ceramic calcium silicate stent with photo-thermal function and preparation method thereof
InactiveCN109650865ALow reaction temperatureSimple molding processAdditive manufacturing apparatusCeramicwareCalcium silicateAlcohol
The invention relates to a porous biological ceramic calcium silicate stent with a photo-thermal function and a preparation method thereof. The preparation method of the stent comprises the followingsteps of 1, preparing a silicon resin-alcohol solution; 2, preparing an active additive / silicon resin printing slurry; 3, preparing a porous stent blank; 4, preparing the porous biological ceramic calcium silicate stent. Compared with the prior art, a polymer precursor method based on a silicon resin precursor has the advantages that in combination with a three-dimensional printing technology, theporous biological ceramic calcium silicate stent which contains carbon dots and achieves the photo-thermal treatment function is prepared, the internal structure of the stent is easy to control, andthe growth of new bones can be promoted; under illumination of infrared light, tumor cells can be killed, the growth of tumors is inhibited, and it is expected that a new strategy is provided for repairing treatment of bone damage after a clinical bone tumor operation.
Owner:UNIV OF SHANGHAI FOR SCI & TECH
Preparation method and application of rare earth ytterbium-holmium-dual-doped pyrochlore phase nanofiber
ActiveCN109913979ASimple manufacturing methodGood repeatabilityInorganic material artificial filamentsDispersityPyrochlore
The invention discloses a preparation method and application of a rare earth ytterbium-holmium-dual-doped pyrochlore phase nanofiber. The method comprises the steps that with dimethylformamide as a solvent, polyvinylpyrrolidone is added, a Taylor cone is formed through liquid drops under a static field, under the liquid surface tension and application force of an electric field, an electrospinningmethod is used for preparing a one-dimensional nano material, then through the processes of heat increase, heat preservation and cooling, organic matter is removed, and a cube pyrochlore phase one-dimensional nano material is prepared. The one-dimensional nanofiber has good dispersity in water and has good upconversion performance and a photo-thermal effect under irradiation of near-infrared light. The preparation method is simple, easy to implement and good in repeatability and can meet the batch production demand. The upconversion photo-thermal material base is an oxide, is good in chemicalstability, free of toxicity and low in price and is easily dispersed in water, and the demands of photo-thermal treatment and industrial production can be met. The preparation method is expected to play an important role in the field of treatment for serious diseases such as cancers and tumors.
Owner:SHAANXI UNIV OF SCI & TECH
Layered double-hydroxide nano drug-loaded compound and preparation and application thereof
ActiveCN110755617AIncrease loading capacityHas the ability to releaseDrug photocleavagePharmaceutical non-active ingredientsDrugCompound s
The invention relates to a layered double hydroxide nano drug-loaded compound and preparation and application thereof, wherein the compound is obtained by sequentially modifying Mn2+(superscript) mixed layered double hydroxide (MLDH) nanosheets with NH2-PEG-COOH and loading a heat shock protein inhibitor 17AAG. The method is mild in reaction conditions and easy to operate, and has an industrialized implementation prospect.
Owner:DONGHUA UNIV
Polypyrrole-graphene/polyurethane antifouling coating, its preparation method and application
ActiveCN113913100BAvoid stickingReduce penetrationAntifouling/underwater paintsPaints with biocidesCrack resistancePolypyrrole
The invention discloses a polypyrrole-graphene / polyurethane antifouling paint, a preparation method and application thereof, wherein the polypyrrole-graphene / polyurethane antifouling paint is composed of component A and component B; in parts by weight, A The components are mainly composed of the following raw materials: 500 parts of group-hydrolyzed polyurethane prepolymer, 25-50 parts of bentonite, 25-50 parts of titanium dioxide, 60-120 parts of zinc oxide, 15-30 parts of talc, polypyrrole-graphene 15-30 parts of nanofillers; by weight, component B is mainly composed of the following raw materials: 5-7 parts of leveling agent, 5-7 parts of defoamer, 6-15 parts of chain extender, 10 parts of silane coupling agent ‑25 parts, 1-2 parts of catalyst. The present invention is a two-component polyurethane coating, which has good adhesion, anti-collision and crack resistance, and can also improve antifouling performance and antifouling durability.
Owner:HARBIN ENG UNIV
ZIF-67/GO photocatalysis-photothermal composite film as well as preparation method and application thereof
ActiveCN111715287AIncrease profitWith photothermal effectWater/sewage treatment by irradiationWater treatment compoundsComposite filmMeth-
The invention discloses a preparation method of a ZIF-67 / GO photocatalysis-photothermal composite film, which comprises the following steps: a) adding graphene oxide into ultrapure water, and carryingout ultrasonic treatment to obtain a uniform solution of graphene oxide, i.e., a GO aqueous solution; b) carrying out suction filtration on the GO aqueous solution on a PTFE film, and drying at normal temperature to obtain a GO film; c) pouring a Co(NO3)<2>.6H2O solution into a culture dish filled with the GO film, keeping at 35-45 DEG C for 8-24 hours, pouring out the solution, and cleaning thefilm with methanol; pouring a 2-methylimidazole solution into a culture dish filled with the GO film soaked by the Co(NO3)<2>.6H2O solution, keeping the temperature at 35-45 DEG C for 8-24 hours, pouring out the solution, and cleaning the film with methanol; and finally, drying the film in a vacuum drying oven at 60 DEG C to obtain the ZIF-67 / GO photocatalysis-photothermal composite film. The preparation method of the ZIF-67 / GO photocatalysis-photothermal composite film is simple, the cost is relatively low, and the ZIF-67 / GO photocatalysis-photothermal composite film has excellent photocatalysis-photothermal synergistic performance. The composite film can be used for photocatalytic-photothermal synergistic catalytic reduction of metal ions.
Owner:SHANGHAI NORMAL UNIVERSITY
Carbon nanosphere-based diagnosis and treatment integrated composite material as well as preparation method and application thereof
PendingCN112807432ALuminousWith photothermal effectMaterial nanotechnologyPowder deliveryLanthanideNanoparti cles
The invention discloses a carbon nanosphere-based diagnosis and treatment integrated composite material. The composite material is characterized in that the composite material is formed by bonding a rare earth doped nanocrystalline scintillator on the surface of a carbon nanosphere, wherein the rare earth doped nanocrystalline scintillator is lanthanide-doped fluoride-based nanoparticles, and the carbon nanosphere and the rare earth doped nanocrystalline scintillator are combined through amido bonds. The composite material has the advantages of good stability, good biocompatibility, luminescence property under X-ray excitation, and photothermal effect under near-infrared light irradiation. The invention further discloses a preparation method of the composite material. The method has the advantages of high repeatability, easiness in industrialization and the like. The invention further discloses an application of the composite material in integration of X-ray excited fluorescence imaging and near-infrared photothermal therapy.
Owner:SHANGHAI UNIV
Method for preparing ytterbium-thulium-doped blue luminous pyrochlore-phase nanofiber and application of nanofiber
ActiveCN109943915AWith photothermal effectAvoid hydrolysisInorganic material artificial filamentsLuminescent compositionsPyrochloreCrystallinity
The invention discloses a method for preparing a rare-earth ytterbium-thulium-doped blue luminous pyrochlore-phase nanofiber and application of the nanofiber. The method comprises the steps of addingpolyvinylpyrrolidone into dimethyl formamide, preparing a one-dimensional nanofiber material under the acting force of liquid surface tension and an electric field, and then removing organic matter residues in the processes of heating, heat preservation and cooling to prepare the cubic pyrochlore-phase one-dimensional nanofiber with high crystallinity. The obtained one-dimensional nanofiber achieves blue up-conversion luminescence perceivable for eyes and has high dispersibility in water and a great photothermal effect under the irradiation of near-infrared light. The preparation method is simple, feasible and high in repeatability and can meet the requirement of industrial batch production. An up-conversion photothermal material matrix is an oxide which is high in chemical stability and free of toxin and is easily dispersed in water, and the demands of photo-thermal therapy can be met. The prepared one-dimensional pure pyrochlore-phase nano material is expected to play an important role in the treatment field of major diseases such as cancers and tumors.
Owner:SHAANXI UNIV OF SCI & TECH
Preparation method of super-hydrophobic coating with anti-icing/deicing function
ActiveCN114605855AExcellent light-to-heat conversion performanceStable photothermal effectWind energy generationCoatingsZinc Acetate DihydrateCarbon nanotube
The invention relates to a preparation method of a super-hydrophobic coating with an anti-icing / deicing function. The preparation method comprises the following steps: (1) synthesizing layered basic zinc acetate powder by a hydrothermal method; (2) modifying layered basic zinc acetate with polydopamine; (3) preparing an aluminum phosphate binder; (4) preparing an ethanol solution of the ball-milled carbon nanotubes; (5) uniformly mixing the substances in proportion and adding a water repellent agent; and (6) spraying to prepare the coating. The coating has the electrothermal effect, the photothermal effect, the super-hydrophobic performance and the acid and alkali resistance at the same time, and can be suitable for multiple environments. In the daytime, the coating is rapidly heated to remove ice (photo-thermal) under direct sunlight radiation, in the night, ice (electric heating) can be rapidly removed by loading small voltage at the two ends of the coating, during snowing, electric heating and photo-thermal work simultaneously, and electric energy consumption can be greatly reduced. In addition, when it rains, accumulated water on the super-hydrophobic surface quickly rolls away from the surface, and therefore the freezing area on the surface of the coating under the low-temperature condition can be effectively reduced.
Owner:NANCHANG UNIV
A kind of polydopamine nanodiagnostic agent and preparation method thereof
ActiveCN109364245BWith photothermal effectImprove hypoxiaEnergy modified materialsEchographic/ultrasound-imaging preparationsTumor therapySinglet oxygen
The invention discloses a polydopamine nanometer diagnosis and treatment preparation and a preparation method thereof. The nano-therapeutic agent uses mesoporous polydopamine as a carrier, and carries rhodium nanoparticles in the pores and surfaces of mesoporous polydopamine respectively through hydrothermal synthesis reaction, and then absorbs photosensitizer chlorin (Ce6) on polydopamine and polydopamine. The polydopamine nanometer therapeutic agent with good dispersion is obtained on the composite nanoparticle of rhodium. The invention utilizes the photothermal effect of the carrier mesoporous polydopamine and the rhodium nanoparticle itself to locally heat up the tumor site. Combined with the catalytic properties of rhodium nanoparticles, it catalyzes the decomposition of hydrogen peroxide in the tumor microenvironment to generate oxygen. Under the conditions of photosensitizer Ce6 and external laser, it can realize the generation of singlet oxygen and effectively kill cancer cells. At the same time, combined with the photoacoustic imaging properties of polydopamine, the purpose of photoacoustic imaging-guided photothermal therapy and photodynamic synergistic therapy can be realized, which is expected to improve the effect of tumor treatment and has good biocompatibility, which has the potential for clinical application.
Owner:SUN YAT SEN UNIV
A kind of layered double hydroxide nano drug-loaded complex and its preparation and application
ActiveCN110755617BWith photothermal effectIncrease loading capacityDrug photocleavagePharmaceutical non-active ingredientsHeat Shock Protein InhibitorMedicinal chemistry
Owner:DONGHUA UNIV
A photosensitive liposome carrying water-soluble drugs
ActiveCN103284951BControl the effect of heat therapyEffective damageEnergy modified materialsAntineoplastic agentsBiophysicsLiposome
The invention provides a photosensitive liposome carrying a water-soluble antitumor drug, which is composed of thermosensitive phospholipids, cholesterol, long-circulation materials and hollow gold nanoparticles. Absorption peak, the particle size distribution range of hollow gold nanoparticles is 20~100nm. In the present invention, a new photosensitive liposome is assembled by encapsulating water-soluble medicine and hollow gold nanoparticles in the thermosensitive liposome. Under the external near-infrared light, the encapsulated hollow gold nanoparticles produce photothermal therapy effect. At the same time, the photothermal effect is used to control the rapid and large-scale localized release of drugs from photosensitive liposomes, effectively damaging blood vessels or Kill tumor cells and play a role in chemotherapy. The drug-loaded liposome of the present invention realizes the therapeutic effect of synchronous photothermal and drug molecules, significantly improves the therapeutic effect on diseases such as tumors, and has clinical applicability and realistic therapeutic significance.
Owner:ZHEJIANG UNIV
Photothermoelectric detector based on platinum diselenide bismuth telluride and preparation method thereof
ActiveCN112563400ASimple structureMild preparation conditionsThermoelectric device with peltier/seeback effectThermoelectric device manufacture/treatmentPlatinumBismuth telluride
The invention discloses a photo-thermoelectric detector and a preparation method thereof, and relates to the field of photo-thermoelectric detectors based on platinum diselenide bismuth telluride, thephoto-thermoelectric detector comprises a bismuth telluride thermoelectric conversion layer and a photo-thermal conversion layer arranged on the thermoelectric conversion layer, and the photo-thermalconversion layer is made of platinum diselenide, The area of the photo-thermal conversion layer is smaller than that of the thermoelectric conversion layer, a first electrode is arranged on the photo-thermal conversion layer, a second electrode is arranged on the thermoelectric conversion layer, the photo-thermal conversion layer forms a temperature gradient with the thermoelectric conversion layer after being heated by illumination, and a potential difference is generated along the thickness direction. The problem that an existing semiconductor optical detector is difficult to consider bothbroadband and high responsivity is solved.
Owner:南京科耐激光技术有限公司
An integrated coating material with anti-ice and wave absorbing function, and preparation method and application thereof
ActiveCN113817094BHas superhydrophobic propertiesPrevent wettingPretreated surfacesRadiation-absorbing paintsEpoxyPolymer science
The invention relates to a coating material, in particular to an integrated coating material with anti-ice and wave absorbing functions, and a preparation method and application thereof. The present invention first provides a photocurable fluorinated epoxy resin, which can greatly reduce the surface free energy and improve the hydrophobicity of the material by introducing organic fluorine segments. The present invention also provides an integrated coating material system with anti-ice and wave absorbing functions, which comprises light-cured fluorinated epoxy resin, fluorinated Fe 3 O 4 Nanoparticles, photocuring initiators and organic solvents, this coating material system can realize the functional coupling of anti-icing and wave absorption, and has broad application prospects.
Owner:NAT INNOVATION INST OF DEFENSE TECH PLA ACAD OF MILITARY SCI
A kind of multifunctional nano drug composition and preparation method thereof
ActiveCN105233282BHigh drug loadingNarrow distributionOrganic active ingredientsEnergy modified materialsPorphyrinTumor therapy
The invention provides a multifunctional nano-drug combination and a preparation method thereof. The combination comprises a carrier and active ingredients loaded on the carrier, wherein the carrier is a polymer formed by mPEG-PLGA and / or PEG-PLGA and a porphyrin compound through covalent-bond connection, and the active ingredients include hydrophobic and hydrophilic drugs. Preferentially, the carrier and the active ingredients loaded on the carrier form particles with the nano size of 50-1000 nm. The multifunctional nano-drug combination has photo-thermal effect so that the treatment efficiency can be improved based on traditional chemotherapy in combination with photo-thermal therapy, and the multifunctional nano-drug combination can be applied to cancer therapy drugs.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
A kind of polymer drug carrier and preparation method thereof
ActiveCN105031656BHas photothermal therapeutic effectWith photothermal effectEnergy modified materialsPharmaceutical non-active ingredientsSide effectBiocompatibility Testing
The invention provides a polymer drug carrier and a method for preparing the same. The polymer drug carrier is provided with a core-shell structure, a core comprises polyethylene glycol-distearoyl phosphoethanolamine nano-micelle, and a shell comprises poly-dopamine. The method includes forming the nano-micelle from polyethylene glycol-distearoyl phosphoethanolamine; forming the poly-dopamine shell on the outside of the nano-micelle to obtain the polymer drug carrier. The polymer drug carrier and the method have the advantages that the core and the shell of the polymer drug carrier comprise biodegradable polymers, accordingly, the polymer drug carrier is good in biocompatibility, and few toxic and side effects can be realized; the particle size of the polymer drug carrier is smaller than 50nm, tumor gathering effects and photo-thermal therapy effects can be realized, and tumor cell killing effects can be realized after near-infrared light irradiates on the polymer drug carrier; drugs can be encapsulated by the nano-micelle of the polymer drug carrier, diversified drugs can be loaded under chemical modification effects of the poly-dopamine, and accordingly the polymer drug carrier has an excellent application prospect in the field of medicine and pharmacology.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
A kind of janus particle with chemotherapeutic/photothermal synergistic effect and preparation method thereof
ActiveCN108704133BIncrease loadWith photothermal effectPowder deliveryOrganic active ingredientsNanocarriersMesoporous silica
A Janus particle with chemotherapy / photothermal synergy and its preparation method, belonging to the field of biomedicine technology, can solve the technical problem that other materials are not easy to achieve multiple methods of combined treatment of cancer. The particle is gold-silica / mesoporous Silica Janus nanostructure, gold nanoparticles are in situ reduced on the surface of aminated mesoporous silica hemisphere by Pickering emulsion method, and different drugs are loaded on both ends. Aminated mesoporous silica Janus particles modified by gold nanoparticles are prepared by the Pickering emulsion method. The Janus particles of the present invention can simultaneously load two kinds of drugs, and can precisely control the ratio of the two kinds of drugs. The two kinds of drugs can pass pH, oxidation Reduction and other external signal stimuli respond to drug release, which solves the technical problem of drug burst release caused by existing drug nanocarriers.
Owner:SHANXI UNIV
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