3 results about "Chlorin" patented technology

The application provides a method for monitoring lipid oxidation tendency, and belongs to the technical field of fluorescent probe detection. The method utilizes the fluorescence characteristics of a BODIPY molecular probe, and through selecting a molecular probe with a specific structure, directional reaction occurs between the BODIPY molecular probe and oxygen free radicals generated by lipid oxidation at a specific pH value. The conjugated system of the BODIPY molecular probe is destroyed, the half-chlorin structure is broken, and the fluorescence color changes from red to blue-green. According to the change of the fluorescence color before and after the reaction, the visualization monitoring of the lipid oxidation tendency and spatial distribution is realized through fluorescence imaging.

This invention discloses a method and apparatus for preparing dihydroporphyrin supramolecular assemblies, belonging to the field of functional nanomaterials technology. By designing a Y+S composite microfluidic chip, this invention utilizes Dean's vortex induced by an S-shaped flow channel to precisely control the nucleation and growth kinetics of Ce6 molecules, achieving the directional preparation of nanospherical Ce6 supramolecular assemblies. Simultaneously, it ensures that the assemblies have a narrow particle size distribution (PDI < 0.1), completely solving the problems of large morphological heterogeneity and poor controllability in traditional methods, and providing technical support for the standardized preparation of Ce6-based nanodelivery systems.

The invention discloses a colloid self-assembly crystal monolayer film with photodynamic and immunoregulation functions, a preparation method and application, the colloid self-assembly crystal monolayer film (BCCe6) is composed of SiO2-MnO2 particles and PSC-Ce6 particles, and a photosensitizer is chlorin e6. The diameter of the SiO2 particles is 4 to 6 m, and the diameter of the PSC particles is 300 to 500 nm; the density of the SiO2-MnO2 particles is 2.19 to 2.65 g / cm < 3 >, and the density of the carboxylated polystyrene particles modified by the photosensitizer is 0.96 to 1.05 g / cm < 3 >; the surface structure of the colloid self-assembly crystal monolayer film is a regular hexagonal close-packed structure, and the depth of a groove is 300-900 nm. The colloidal self-assembly crystal single-layer film can slowly release Mn < 2 + > ions and release ROS under the stimulation of near-infrared light, and efficient sterilization and macrophage phenotype rapid conversion are achieved through the cooperation of a surface physical structure and a chemical effect. The colloidal self-assembled crystal monolayer film is placed on a bacterial infected wound, and is removed after being irradiated by infrared light for 5-10 minutes, so that the healing of the wound can be accelerated.