229 results about "Chlorin" patented technology

The present invention provides methods of making porphyrins and related compounds such as chlorins by condensing suitable starting materials (e.g., a dipyrromethane-dicarbinol plus dipyrromethane) in a polar solvent in the presence of a Lewis acid. The reactions are preferably carried out in a manner that minimizes rearrangement of the reaction product.

The present invention involves an artificial nose having an array comprising at least a first dye and a second dye in combination and having a distinct spectral response to an analyte. In one embodiment, the first and second dyes are from the group comprising chemoresponsive dyes, and the second dye is distinct from the first dye. In one embodiment, the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phthalocyanine, and salen, or their metal complexes. In another embodiment, the second dye is selected from the group of dyes consisting of acid-base indicator dyes and solvatochromic dyes. The present invention is particularly useful in detecting metal ligating vapors. Further, the array of the present invention can be connected to a visual display device.

An artificial turf is disclosed having a base and a plurality of synthetic fibers attached to and extending upward from the base, the fibers comprising a chlorin-based organic colorant and the colorant reflects infrared radiation in the range of 700 to 1,100 nm.

A method is provided for selectively occluding neovascular vessels formed in the ocular fundus of an eye, which includes intravenously administering a mono-L-aspartyl chlorin compound to a patient; subsequently estimating an appropriate time point when the mono-L-aspartyl chlorin compound has decreased in its concentration or has been eliminated from the retinal normal vascular vessels of the patient but is still remaining at an appropriate concentration in the vascular walls of the neovascular vessels of the ocular fundus; irradiating a laser light at a 664 nm-wavelength which is initiated at the appropriate time; and using the irradiation of the laser light to target lesions comprising the neovascular vessels, at a controlled power.

A bromine-contained biocide used for public place and sewage treatment contains chlorine supplying agnet, bromide and stabilizer of bromine and chlorine in ratio of (50-85):(10-45):(5-15). Its advantages are long acting period, good corrosion inhibiting effect.

The invention discloses dihydroporphin (III) chelates having plant growth regulating activity and use thereof as plant growth regulators. The respective structures of the chelates are shown below. In the structures, R may be H, Na, K, CH3 or C2H5, and X may be Cl, OCOCH3 or OH. The dihydroporphin (III) chelates are formed by chelating pyropheophorbide, purpurin and dihydroporphin serving as main ligands and different acid radicals and hydroxy radicals as axial ligands (X) with trivalent ions of iron serving as a transitional metal. The dihydroporphin (III) chelates serving as plant growth regulators are safe, nontoxic and insusceptible to accumulation of residue; the activity of the dihydroporphin (III) chelates are high and the effect of the dihydroporphin (III) chelates are remarkable; and the dihydroporphin (III) chelates can improve the chlorophyll content in plants, promote rooting, and increase germination rate, resistance and yield.

This invention concerns compounds useful for the control of insects, especially useful for the control of aphids and other sucking insects. More specifically, the invention concerns compounds of the formula (I) Wherein X represents NO2, CN or COOR4; L represents a single bond or R1, S and L taken together represent a 5- or 6-membered ring; R1 represents, methyl or ethyl; R2 and R3 independently represent hydrogen, methyl, ethyl, fluorin, chlorin or bromine; n is an integer from 0-3.

The invention discloses a method for preparing a chiral cylopropyl acetenyl tertiary alcohol compound.The steps of the method are as follows: (a) cylopropyl ethylnen or other derivatives react with a chiral induction reagent, a chirality auxiliary reagent and zinc halide in an organic solvent under the action of an alkaline reagent so as to obtain a zinc complex; (b) addition reaction is carried out between the obtained zinc complex and 5-chlorin-2-amino trifluoro-benzophenone; (c) (S)-2-amino-5-chlorin-alpha-cylopropyl ethylnen-alpha-benzyl alcohol trifluoride is collected from reaction liquid. Compared with butyl lithium and diethylzinc, the alkaline reagent adopted in the invention is safer; in addition, the cheap zinc halide is used as a ligand, which greatly reduces the cost. Therefore, the method is suitable for industrial production.

Improved β,β′-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compounds are provided as photosensitizers. Pharmaceutical compositions and photodynamic therapy comprising them are also disclosed.

The present invention discloses method which prepares bleaching dissolved pulp using corn-straw, it slurries using the alkali mode of one boiling and three heating-up after impregnating corn-straw in alkaline solution. It includes the production steps: preparing raw materials, dipping, feeding, boiling, washing materials, beating, former classification, chlorin-alkalization, bleaching, acid treatment, washing in water, rear classification, coarsing pulp and preparing the products. The method can produces the corn-straw into high grade slurry used for preparing viscose fiber, the slurry boiled is easier to be bleached, and the method has simple technology and easy operation, it greatly reduces the heavy environmental pollution caused by the waste disposals of pulping waste liquid after pulping production.

This invention relates to a synthesizing technology for preparing tropisetron with chloro 1, 3-dimethyl-2-chlorin imidazoline as the condensation agent, in which, indole-3-formic acid is reacted with tropaic alcohol for 12-24h under room temperature then to be cooled, filtered and cleaned to get the objective product tropisetron, and the mol ration of the indole-3-formic acid, tropaic alcohol and chloro 1, 3-dimethyl-2-chlorin imidazoline for condensation reaction, and the option is 1:1-1.5:1-1.5.

The invention discloses a synthesis method for pyridone, and relates to the technical field of synthesis of a heterocyclic compound containing three heterocyclic rings one of which takes nitrogen and oxygen as the only one heteroatom. The synthesis method comprises the following steps: reacting tetrahydrofuran, ursol, triethylamine and 5-chlorin valeryl chloride which are taken as raw materials, and after the reaction, adding potassium tert-butoxide for reacting again, thereby obtaining a monomer 1 after reaction; reacting the monomer 1 with phosphorus pentachloride in a dichloromethane solvent, thereby obtaining a monomer 2 after reaction; reacting the monomer 2 with morpholine to obtain a final product I. The synthesis method has the advantages that the raw materials are cheap and easily available, and the reaction process is greatly shortened in comparison with that of the prior art, and the synthesis method is mild and safe in reaction conditions, good in reaction reproducibility, low in cost, and high in efficiency, and has simple and easy operations in the reaction.

This invention discloses a method for catalyzing alcohol acid esterification by using an ionic liquid. The ionic liquid A+B- is used as catalyst and solvent, wherein: A+ has the following structural formula, and R could be an alkyl group or alkene group with more than one carbons; B- is selected from the following negative ions: chlorin, bromine, iodine, acetate, sulfate radical, hydrogensulfate radical, phosphate radical, hydrogen phosphate radical, nitrate radical, tetrafluoroboric radical, hexafluorophosphoric radical, p-toluenesulfonic radical, and trifluoromethanesulfonic radical; the catalyst amount added is 0.01%-50% of the total mole of the alcohol and acid added, reaction temperature 20-140Deg C, normal pressure reaction time 0.5-12h.

The invention provides the reagent box checking the bacterial vaginal disease, it includes the dry chemic reacting setting, the diluent and the liquid showing the color; the reacting setting has three blind holes placed the reagent mat testing the chroma of excessive oxidation hydrogen, the chroma of the leucocyte ester enzyme and the active ability of the saliva acid enzyme; the regent mat testing the chroma of the excessive oxidation hydrogen is dipped in the enzyme solution containing the peroxide enzyme, the phosphate amoritizing liquid, the 4-amino antipyrine, the 3,5-double chlorine double hydroxide group dobesilate and the vitamin C and dried. The reagent mat testing the chroma of the leucocyte ester enzyme is dipped in the enzyme solution containing the 5 bromine-4 chlorin- 3 heteroauxing salt and the cane suger and is dried; the reagent mat testing the active ability of the saliva acid enzyme is dipped in the 5 bromine-4 chlorin-3 indloe nerve arginine salt, the acetic acid salt cushioning liquid and the fucose and is dried; the cushioning liquid is composed of the physiological brine and MES cushioning liquid; the liquid showing the color is the B solution fixing the purple. The entironment, the cleanliness of the procreating path of the checked and the condition of the bug inducing the bacterial vagina can be test at the same time; it has many merits such as the easy handling, the celerity and the cheap cost.

The invention discloses a method of preparing the pentafluoroethane (HFC-125), which adopts the hydrogen fluoride (HF) and the perchlorethylene (PCE) as the material, and takes two reactors and two steps of gas phase catalysis fluorination reaction. A first reactor fluorinates the PCE and synthesizes 2,2-dichlor-1,1,1-trifluoroethane(HCFC-123) and 2-chlorin-1,1,1,2-tetrafluorothane(HCFC-124), and the second reactor fluorinates HCFC-123 and HCFC-124 and synthesizes HFC-125. The unreacted PCE in the resultant flow of the first reactor is separated by a first distillation tower and then circulates to the first reactor; the HF, HCFC-126, HCFC-124, HFC-125 and HCL in the resultant flow of the first reactor and the second reactor are separated by a second distillation tower and a third distillation tower, and then the separated HF circulates to the first reactor and the second reactor, while the HCFC-123, the HCFC-124 and the HFC-134a circulate to the second reactor. The invention can prolong the service life of the catalyst and improve the one-way conversion of PCE as well as remarkably reduce the content of chloropentafluoroethane(CFC-115) in the desired product HFC-125.

The invention discloses mesophilous bacterial chlorin water dispersion granule agent in disinfectant, and belongs to the disinfectant technology in the plant protection field. The invention comprises the components that the raw material medicine mesophilous bacterial chlorin occupies 100 to 600 shares, auxiliary agent occupies 180 to 360 shares, carrier packing material occupies 250 to 600 shares, and binding agent occupies 10 to 150 shares. The ingredients are mixed proportionally, after being evenly mixed, the mixture is crushed to obtain the target powder, the target powder and the binding agent are evenly mixed, and the mesophilous bacterial chlorin water dispersion granule can be obtained through granulation, drying and screening. The invention overcomes the disadvantage of the wettable powder of the mesophilous bacterial chlorin, both the us-cost of the farmer and the environment pollution are reduced. The invention has the advantages that the content is high, the disintegration is quick, the dispersivity is good, the invention is advantageous for storage and transportation and the stability is good, the activeness is high, the efficiency is good, and the invention is secure.

The invention discloses a hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation. The preparation is only composed of albumin and hydrophobic dihydroporphin photosensitizer and is free of other cross-linking agents or auxiliary materials. The used hydrophobic dihydroporphin photosensitizer is simple in structure, free of hydroxyl, alkoxyl, amino group and the like, capable of improving water-soluble functional groups of the dihydroporphin photosensitizer and easy to synthesize. The invention further discloses a preparation method and application of the nanometer medicine pharmaceutic preparation.

The invention relates to the technical field of medicines and in particular relates to a novel chlorine photosensitizer-pyropheophorbide-a ether amino acid derivative, a preparation method thereof and an application to preparation of antitumor medicines. A chemical structure of the pyropheophorbide-a ether amino acid derivative is shown in a general formula (I) in the specification. The pyropheophorbide-a ether amino acid derivative has the advantages of high efficiency, low toxicity and the like, and can be used for preparing new medicines for photodynamic therapy of cancers, medicines for photodynamic therapy of benign vascular diseases, such as age-related macular degeneration and nevus flammeus and medicines for photodynamic therapy of condyloma acuminate.

The present invention relates to herbicide composition of monosulfuron ester compound as well as its application, which is compounded with two-element or three-element from herbicide monosulfuron ester or its natrium salt (0.1 to 90 percent) as main active component, and other herbicide (0.1 to 85 percent) of ethyl carboxylic fluorine grass ether, Starane, thifensulfuron-methyl, tribenuron-methyl, 2,4D as well as its ramification, Prometrex prometryn, acetochlor, atrazine, triallate, metolachlor, bensulfuron-methyl or 2 armour 4 chlorin natrium etc., and the herbicide composition can be made into breast oil, wettable powder, soluble powder, water emulsion, microemulsion agent, aqua, suspending agent, microcapsule agent or water disperse particle agent by adding proper amount auxiliary agent and carrier accepted in agriculture. The composition can be used to prevent single and double cotyledon weed in wheat, corn and millet field.

The invention provides an anoxia-responsive nano drug carrier and a preparation method and application thereof. The nano drug comprises a hydrophobic seed core and an amphiphilic shell, wherein the hydrophobic seed core comprises chlorin e 6 and tirazamine, and the amphiphilic shell is hydrophilic macromolecular hyaluronic acid modified by hydrophobic molecule 2-nitroimidazole, the hydrophobic seed core and the amphiphilic shell form a non-conjugated position relationship by hydrophilic and hydrophobic forces. According to the preparation method, the nano drug is finally successfully preparedby optimizing the preparation process, the particle size of the product is moderate and controllable, the nano drug is irradiated by laser for photodynamic treatment, oxygen is consumed, and hydrophobic molecules 2-nitroimidazole is transformed into hydrophilic molecules 2-aminoimidazole under the anoxic condition, and the nano drug is dissolved, the drug release is achieved, the chemotherapy toxicity of the chemotherapeutic drug tirazamine is activated under the anoxic condition, the combined treatment is synergistic, cancer cells are effectively killed, the application prospect is wide and the market value is huge.

The method discloses a low-temperature catalytic combustion eliminating catalyst of volatile chloro aryl hydrocarbons, the catalyst is mainly composed of an alumina support modified by alkaline-earth metal, and loaded rare earth oxide and transition metallic oxide thereof; wherein the alkaline-earth metallic oxide includes magnesium oxide and barium oxide, the transition metallic oxide include one or more kinds of copper oxide, ferric oxide, vanadium pentoxide, manganese oxide, cobalt oxide and tungsten oxide, and the rare earth oxide is one or more kinds of lanthana oxide, cerium oxide, neodymium oxide and gadolinium oxide. The catalyst has high catalytic activity and no by-product generation, does not cause secondary pollution, and has strong anti-chlorin poisoning capacity and long catalyst life, and is particularly suitable for low-temperature catalytic combustion for removing halogen-contained organic compounds, especially for removing volatile chloro aryl hydrocarbon pollutants.

The invention discloses a polydopamine nano diagnosis and treatment preparation and a preparation method thereof. The nano diagnosis and treatment agent is prepared by the following steps: taking mesoporous polydopamine as a carrier, respectively supporting rhodium nanoparticles in the hole and on the surface of the mesoporous polydopamine by virtue of a hydrothermal synthesis reaction, and adsorbing a photosensitizer dihydroporphin (Ce6) onto the polydopamine and rhodium nanoparticles, thereby obtaining the polydopamine nano diagnosis and treatment agent with excellent dispersion property. Byutilizing photothermal effects of the carrier mesoporous polydopamine and the rhodium nanoparticles, the temperature of the tumor site is locally raised. By combining with catalytic characteristics of the rhodium nanoparticles, hydrogen peroxide in a tumor microenvironment is catalyzed to decompose so as to produce oxygen, and aims of producing singlet oxygen and effectively killing cancer cellsare achieved under the conditions of the photosensitizer Ce6 and applied laser. Meanwhile, by combining with photoacoustic imaging characteristics of the polydopamine, the aim of guiding photothermaltherapy and photodynamic synergistic therapy by photoacoustic imaging can be achieved, and the tumor treatment effect is expected to be improved. Moreover, the polydopamine nano diagnosis and treatment agent is excellent in biocompatibility, and has clinical application potential.

The invention discloses a preparation method of 2-chloro-4-amido-6,7-dimethoxy quinazoline. The preparation method comprises the following steps: 3,4-dimethoxy benzaldehyde is taken as an initial raw material, then the following reactions are sequentially carried out: oxidizing reaction between the 3,4-dimethoxy benzaldehyde and oxydol, nitration reaction between the 3,4-dimethoxy benzaldehyde and nitric acid, reduction reaction of the 3,4-dimethoxy benzaldehyde and hydrogen ion obtained by iron powder and hydrochloric acid, reaction between the 3,4-dimethoxy benzaldehyde and sodium cyanate, chlorination reaction between the 3,4-dimethoxy benzaldehyde and phosphorus oxychloride, ammoniation reaction between the 3,4-dimethoxy benzaldehyde and ammonia liquor, etc., then the 2-chloro-4-amido-6,7-dimethoxy quinazoline is obtained. The synthetic method takes the commercialized 3,4-dimethoxy benzaldehyde as the initial raw material, and potassium permanganate is not used in the oxidizing reaction process, organic solvents (glacial acetic acid, DMF) are not used in the refining process, the noxious solvent N, N-amino dimethylbenzene or the organic solvent N, N-dimethyl formamide with high boiling point is not used in the chlorination process, so the use amounts of the organic solvents and the phosphorus oxychloride are reduced, thus reducing the production cost, simplifying the production process, protecting the health of operators, reducing 'three wastes' pollution, protecting the environment and greatly improving the reaction yield and the production efficiency.

Chlorin compounds and compositions useful in photodynamic therapy for treating ophtalmic, cardiovascular, skin, and cancer or malignant diseases.

The invention relates to a method for preparing 2-chlorin-3-amideo-4-picolyl. The invention has the practical proposal to solve the technical problems that acetone, sodium methoxide, formic ether are adopted as the raw materials during synthesizing the 2-chlorin-3-amideo-4-picolyl. After the seven steps including sodium salt, condensation, addition, cyclization, chlorination, hydrolysis and Hofmann degradation, the total output rate of the reaction is larger than 18.4 percent, and the product purity is above 99.7 percent.

The invention discloses a preparing method of (R)-6-hydroxyl group-8-chlorin octoic acid carbethoxyl in biological catalysis technical domain, which comprises the following steps: sieving lipase with better stereoselectivity; optimizing a series of inversion conditions of enzyme resolution such as rotator speed of shaker, reaction temperature, reaction pH, bottom matter density and addition of surface activator or organic co-solvent; setting optical purity of product at 93. 8% and receiving ratio at 46. 7%; utilizing solubility difference of 6-hydroxyl group-8-chlorin octoic acid carbethoxyl and 6-hydroxyl group-8-chlorin octoic acid under different pH; proceeding primary separation for the product; getting the rough product with content of (R)-6-hydroxyl group-8-chlorin octoic acid carbethoxyl at 83. 4% and extraction receive rate at 92. 4%. This invention provides a new approach for (R)-lipoic acid preparation.

The invention relates to a method for preparing 3-abietylamine-2-hydroxypropyltrimethylammonium chloride, in particular to a method for preparing a cationic active agent with an abietylamine structure in respect of surface active agent in the filed of chemical processing of forest products. The method comprises the steps: at temperature lower than 10 DEG C to 150 DEG C, an acid binding agent combined by sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, potassium bicarbonate, potassium hydroxide, sodium hydroxide, triethylamine, tripropyl amine and tributylamine is carried on a solid composed on a carrier consisting of aluminum oxide, silica gel and active carbon to serve as a catalyst and directly catalyze abietylamine to react with a quaternization reagent composed of epoxypropyl trimethyl ammonium chloride and 3-chlorin-2-hydroxypropyltrimethylammonium chloride for 1h to 50h; then centrifugation or filtering, desolution at normal pressure or pressure reduced and recrytallization of a compound solvent are carried out, thus obtaining a wet material of the 3-abietylamine-2-hydroxypropyltrimethylammonium chloride; the wet material is dried for 1.0h to 48.0h at temperature of 10 DEG C to 120 DEG C at a vacuum degree of 0.01MPa to 0.1MPa; and a 3-abietylamine-2-hydroxypropyltrimethylammonium chloride product with mass content higher than 90 percent is obtained.

The invention discloses a preparing method of 2, 3-dichloro-5-trifluoro metyl group pyridine as new type pesticide intermediate, which comprises the following steps: refluxing organic solvent; chlorinating 2, 3-dichloro-5-metyl group pyridine; stripping organic solvent; crystallizing; centrifuging; hot-dissolving chlorinated material; fluoriding; distilling steam; separating; rectifying. This invention possesses simple craft and easy to operate, which can get high purity product with purity not less than 98% and receiving ratio at about 85%.

The invention relates to a chlorin and artesunate compound with photosensitive and sound-sensitive activity as well as a preparation method and an application of the compound and belongs to the technical field of chemical medicines. The chlorin and artesunate compound with photosensitive and sound-sensitive activity has different degrees of inhibition effects on human hepatoma cells Hep G2 in in-vitro anti-tumor activity evaluation. The photoactivity and ultrasonic activity are both higher than that of chlorin e6 and artesunate which are used as positive controls. The compound can be used for preparing a photosensitizer and a sound-sensitive agent in photodynamic therapy and sonodynamic therapy methods for tumor therapy.