7 results about "Chlorin" patented technology

The application provides a method for monitoring lipid oxidation tendency, and belongs to the technical field of fluorescent probe detection. The method utilizes the fluorescence characteristics of a BODIPY molecular probe, and through selecting a molecular probe with a specific structure, directional reaction occurs between the BODIPY molecular probe and oxygen free radicals generated by lipid oxidation at a specific pH value. The conjugated system of the BODIPY molecular probe is destroyed, the half-chlorin structure is broken, and the fluorescence color changes from red to blue-green. According to the change of the fluorescence color before and after the reaction, the visualization monitoring of the lipid oxidation tendency and spatial distribution is realized through fluorescence imaging.

This invention discloses a method and apparatus for preparing dihydroporphyrin supramolecular assemblies, belonging to the field of functional nanomaterials technology. By designing a Y+S composite microfluidic chip, this invention utilizes Dean's vortex induced by an S-shaped flow channel to precisely control the nucleation and growth kinetics of Ce6 molecules, achieving the directional preparation of nanospherical Ce6 supramolecular assemblies. Simultaneously, it ensures that the assemblies have a narrow particle size distribution (PDI < 0.1), completely solving the problems of large morphological heterogeneity and poor controllability in traditional methods, and providing technical support for the standardized preparation of Ce6-based nanodelivery systems.

The invention discloses a colloid self-assembly crystal monolayer film with photodynamic and immunoregulation functions, a preparation method and application, the colloid self-assembly crystal monolayer film (BCCe6) is composed of SiO2-MnO2 particles and PSC-Ce6 particles, and a photosensitizer is chlorin e6. The diameter of the SiO2 particles is 4 to 6 m, and the diameter of the PSC particles is 300 to 500 nm; the density of the SiO2-MnO2 particles is 2.19 to 2.65 g / cm < 3 >, and the density of the carboxylated polystyrene particles modified by the photosensitizer is 0.96 to 1.05 g / cm < 3 >; the surface structure of the colloid self-assembly crystal monolayer film is a regular hexagonal close-packed structure, and the depth of a groove is 300-900 nm. The colloidal self-assembly crystal single-layer film can slowly release Mn < 2 + > ions and release ROS under the stimulation of near-infrared light, and efficient sterilization and macrophage phenotype rapid conversion are achieved through the cooperation of a surface physical structure and a chemical effect. The colloidal self-assembled crystal monolayer film is placed on a bacterial infected wound, and is removed after being irradiated by infrared light for 5-10 minutes, so that the healing of the wound can be accelerated.

The present invention describes methods for obtaining functionalized polymeric surfaces (MPn-PSm) from polymers or copolymers with appropriate functionalizations (X), which can be a halogen of a leaving group, such as polyvinyl chloride (MP1) and (chloromethyl) polystyrene-Merrifield (MP2), and curcumin photosensitizers (PS1), meso-tetra(aryl) porphyrins, chlorins or bacteriochlorins halogenated and functionalized with nucleophilic groups (PS2), in particular including P2 of the type meso-imidazoyl-porphyrins, chlorins or bacteriochlorins (PS3). The structures of all the photosensitizers in the present application incorporate a functional group (Y), which is a OH, SH or NH 2 nucleophile. The application also describes the covalent bonding process of the photosensitizers PS1-PS3 to the functional polymeric materials MP1-MP2 by means of a nucleophilic substitution reaction to prepare the MPn-Psm products. The formed products prevent microbial proliferation, which can cause the serious infections that are one of the main causes of death in patients using these devices.

The present invention relates to chlorin e6 analogs and pharmaceutically acceptable salts thereof, and compositions comprising chlorin w6 analogs and pharmaceutically acceptable salts thereof. The chlorin e6 analogs and pharmaceutically acceptable salts thereof are suitable for use in photodynamic therapy, cytoluminescence therapy, and photodynamic diagnosis, for example, for the treatment or detection of tumors or antiviral treatment. The present invention also relates to the use of chlorin e6 analogs and pharmaceutically acceptable salts thereof in the manufacture of phototherapeutic or photodiagnostic agents, and to methods of photodynamic therapy, cytoluminescence therapy, or photodynamic diagnosis, for example, for the treatment or detection of tumors or antiviral treatment. [Formula 1] TIFF2025539865000117.tif70159

The application discloses a reversible coordination type rare earth nanocrystal-organic dye, which comprises a rare earth nanocrystal and a chlorin dye, and the chlorin dye forms reversible coordination with the rare earth nanocrystal on the surface of the rare earth nanocrystal, wherein the chlorin dye has the structure shown in formula I: wherein R is halogen or a group * indicates a bonding position. The reversible coordination type rare earth nanocrystal-organic dye can form reversible coordination, the structure of the organic dye is not damaged, continuous detection can be carried out, the sensitivity of detection is high, and the anti-interference capability is strong. The application further discloses a preparation method of the reversible coordination type rare earth nanocrystal-organic dye, a luminescent probe, application of the luminescent probe in biological detection, and a method for detecting gastric juice pH by using the luminescent probe.

The application discloses a kind of no excitation small molecule photosensitizer drug and preparation method and application, belong to clinical metastatic cancer treatment drug technical field, solve the defects of PDT itself in prior art, it has the technical problems such as low efficiency, weak targeting, large side effect in deep tissue metastatic tumor treatment.The no excitation small molecule photosensitizer drug provided by the application is that photosensitizer molecules are connected in single molecule by covalent coupling method with energy donor and acceptor, synthesizes intramolecular CRET chemiluminescence imaging treatment probe, energy acceptor is photosensitizer, energy donor is peroxysuccinate compound or its derivative;Energy acceptor photosensitizer is chlorin photosensitizer, photosensitizer P is near-infrared photosensitizer chlorin Cy7, peroxysuccinate group C is oxalyl chloride ethyl ester, and the specific reaction is that Cy7 and oxalyl chloride ethyl ester are connected by esterification covalent reaction, to prepare photosensitizer molecular drug Cy7-EOM based on intramolecular CRET, realize effective photodynamic therapy to deep tissue metastatic tumor.