Polymer drug carrier and method for preparing same
A technology of polymers and drugs, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of cumbersome purification, complex chemical reactions, and single functions, and achieve large tissue penetration, good biocompatibility, The effect of simple preparation method
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Embodiment 1
[0040] In this example, the polymer drug carrier is prepared by the following method, which includes the following steps:
[0041] 100mgPEG 2000 -DSPE was dispersed in 5mL methanol, stirred and dissolved, and the organic solvent was removed with a rotary evaporator to form a lipid film. A tris-HCl buffer solution with pH 8.5 was added to the lipid film to form a PEG-DSPE nanomicelle solution, wherein the concentration of the PEG-DSPE nanomicelle was 2 mg / mL.
[0042] 20 mg of dopamine hydrochloride was added to the above PEG-DSPE nanomicelle solution, and the reaction vessel was opened and stirred for 24 hours to obtain a polymer drug carrier with a core-shell structure.
Embodiment 2
[0044] 100mgPEG 2000 -DSPE was dispersed in 6mL aqueous solution, ultrasonically stirred until dissolved, and tris-HCl buffer solution was added to adjust the pH value to 8.5 to form a PEG-DSPE nanomicelle solution, and the concentration of PEG-DSPE nanomicelle was 15mg / mL.
[0045] Add 150 mg of dopamine hydrochloride to the above PEG-DSPE nanomicelle solution, stir and react for 12 hours under the condition that the opening of the reaction vessel is in convection with the outside air, to obtain a polymer drug carrier with a core-shell structure.
Embodiment 3
[0047] 100mgPEG 2000 -DSPE was dispersed in 10 mL of tris-HCl buffer solution with a concentration of 10 mmol / L to form a PEG-DSPE nanomicelle solution with a concentration of 10 mg / mL.
[0048] Add 10 mL of tris-HCl buffer solution (concentration 10 mmol / L, pH 8.0) dissolved with 150 mg of dopamine hydrochloride to the above-mentioned PEG-DSPE nanomicelle solution, stir and react for 48 h under the condition that the opening of the reaction vessel is in convection with the outside air, A polymeric drug carrier with a core-shell structure was obtained.
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