122 results about "Lipid film" patented technology

An apparatus and method for the kinetic analysis of tear interference is disclosed. The apparatus includes a light source for illuminating a tear film of a cornea, an optical train for modifying the light before it reaches the cornea and after it is the carrier of an image from the cornea, an image recorder to record a series of images of the illuminated tear film, and an image output for providing the series of images to a display; the series of images illustrating a tear film dispersion pattern indicative of a tear stability condition. The method includes the steps of illuminating the film on a cornea of said eye with light, recording a series of images of the illuminated film, and outputting the series of images to a display. The series of images illustrating at least one of a lipid film spread and a tear film dispersion pattern indicative of a tear stability condition.

A lipid membrane is self-assembled and stabilized at a solid surface by depositing a lipid monolayer or a lipid multilayer on a substrate, otaining a supported lipid monolayer or a supported lipid multilayer; and in situ polymerizing the supported lipid monolayer or the supported lipid multilayer, thereby obtaining a polymerized membrane.

Disclosed is a bangosome injection of mitoxantrone or and its preparing technique. The injection comprises of mitoxantrone, phospholipid, cholesterol, anti oxidant additive, organic acid, alkali, sugar, buffer and water for injection, the preparing technique includes preparation of lipid film, packaging medicine, homogenization of bangosome, purifying or solidifying bangosome, constant volume, degerming, subpackage and reposition and so on. The has remarkable stability, high ratio of packaging medicine, low cost, few poisonous side-effect and simple preparing technique.

A process for the preparation of liposomes is described. The process includes the steps of formation of a lipid film on a ceramic filter, preferably an asymmetric ceramic filter, followed by hydration of the lipid film obtained. The liposomes thus formed are recovered. Multilamellar liposomes prepared by the process are also described.

The invention relates to a method for preparing silicon-dioxide microspheres with liposome embedded with quantum dots. The method includes the following steps: lipid material is dissolved in an organic solvent for being prepared to be a lipid film by rotary evaporation; the lipid film is added with a water solvent of the quantum dots for being prepared to be the liposome taking lipid as the film and the quantum dots as the core and with a grain size less than or equal to 10 Mum by a thin film dispersing method; the lipsome is added with tetraethyl orthosilicate to form silicon dioxide on the surface of the lipsome so as to obtain the silicon-dioxide microsphere with the liposome embedded with the quantum dots. The method has the advantages that: the silicon-dioxide microsphere with the liposome embedded with the quantum dots can decrease the toxicity of the quantum dots, increase the light signal intensity of every luminous point, and obtain microspheres with large quantity and different fuorescence spectra characteristics so as to play a part in biological high-flux detection. The quantum-dot microsphere of micron size is applicable to the cure of tumour artery embolism; and the quantum-dot silicon-dioxide microspheres with different grain sizes evenly arranging from nanometer to micron can be obtained by the method.

The invention discloses a nutrition-balanced protective agent of crops, which is generated mainly by raw materials in the following portions by weight: 0.5-2.5 portions of amino acid, 0.5-2.5 portions of potassium dihydrogen phosphate, 0.5-2.0 portions of carbamide, 1.5-3.0 portions of trace elements, 2-5 portions of lipid film and 200-1000 portions of water. In order to achieve much better effect, the protective agent of the invention is combined with disinsection and sterilization components such as avermectin or cypermethrin, etc., as well. The protective agent has balanced and comprehensive nutrition, high fertilizer effect, good protective property, safe application, low cost and convenient application; the invention has double effects of nutrition and protection and is easy to be absorbed by crops, and has unique effects especially on improving crop photosynthesis, strengthening crop stress resistance, guaranteeing blossoms to bear fruit, expanding fruit, improving the color, polish and plumpness of the fruit, improving quality, developing marketability, etc.

The invention discloses washing-free hand sterilizing gel and a preparation method thereof, and relates to the field of wash supplies. The washing-free hand sterilizing gel is prepared from, by weight, 0.1-2 parts of 2,4,4'-trichloro-2-hydroxyl-diphenyl ether, 0.1-3 parts of carbopol, 1-100 parts of 75% ethanol, 0.1-5 parts of glycerol, 1-10 parts of plant extracts, 0.01-0.5 part of triethanolamine and 1-30 parts of deionized water. The prepared washing-free hand sterilizing gel is a washing-free hand sterilizing product, and the washing mode of traditional hand cleaning and sterilizing is broken; multiple plant extracts are adopted to replace chemosynthetic skin conditioners and functional components, the gel is conducive to skin protection, and after the hands are sterilized, skin surface lipid films are protected to avoid loss of skin moisture.

The invention discloses a mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The mung bean fermentation broth comprises a wall-broken filtrate obtained after fermentation of mung bean sprouts via lactic acid bacteria, wherein the solid content of the filtrate is 1 to 20%. The invention also discloses a preparation method for the mung beanfermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The preparation method comprises the following steps: 1) germination of mung beans; 2) breeding of lactic acid bacteria; 3) liquid homogenization of mung bean sprouts, addition of milk and trace elements, steam sterilization and cooling; 4) inoculation of the lactic acid bacteria for fermentation; 5) high-pressure homogenization and wall breaking; 6) freeze concentration and coarse filtration; and 7) membrane filtration and degerming. According to the invention, mung bean seeds are subjected topreliminary germination at first and then to fermentation via lactic acid bacteria, and the obtained wall-broken filtrate is safe and free of any irritation during external application, and can substantially inhibit hyaluronidase, rapidly eliminate Bacillus acnes, reduce hyperpigmentation and inhibit the formation of acne scars.

The invention discloses a method for preparing liposome enveloped by catechin. The method sequentially comprises the following steps of: 1) mixing soya bean lecithin and cholesterol in a mass ratio of (1.5-6):1, and dissolving in a solvent I or dissolving soya bean lecithin in the solvent I; evaporating in water bath at the temperature of between 30 and 40 DEG C under reduced pressure for 10 to 30 minutes to form a layer of thin lipid membrane; 2) adding a solvent II into the thin lipid film to dissolve the thin lipid membrane, adding a phosphate buffer solution containing catechin, and uniformly mixing to form a stable single-phase system; and 3) decompressing the single-phase system and evaporating for 30 to 50 minutes to form water based suspension and thus obtaining the liposome enveloped by the catechin. The obtained liposome enveloped by the catechin can improve the oxidation resistance of catechin, so that the bioavailability of the catechin can be improved.

A means and method for preparing vesicles and freestanding two-dimensional assemblies using aqueous two-phase systems (ATPS) is described. The surface tension of the ATPS is sufficient to support the assembly of various types of particles, and provide the advantage of being biocompatible with DNA and other types of biological molecules that may be used in the assembly. Vesicles are formed by mixing chemically dissimilar compounds in appropriate concentrations and at a temperature sufficient to form a monophasic mixture. This mixture is then heated above the temperature at which the polymer mixture is monophasic, added to a lipid film, and allowed to hydrate at this elevated temperature.

The invention relates to a preparation method and application of a drug carrier. The preparation method comprises preparation of ZIF-M nanoparticles, preparation of ZIF-M@PVP / DMPC nanoparticles and preparation of ZIF-M@LIP nanoparticles. According to the invention, the main materials of the nanoparticles are ZIF-8 and lipidosome, and are low in toxicity, good in biocompatibility and good in degradation capacity, so that the problem of toxic residues in a chemical synthesis method is solved; the prepared nanoparticles have the advantages of high crystallinity, uniform particles and stable physical and chemical properties; reaction raw materials are cheap and easy to obtain, the preparation method is simple in process and high in operability, and production and application requirements can be further met; and when IR780 is embedded into the lipid shell of the nanoparticle, controllable release of the drug, namely pH and near-infrared NIR controlled release of the drug, can be realized.

The invention discloses a probiotics liposome and a preparation method thereof. The particle size of the probiotics liposome is (143.87+ / -10.58)-(161.53+ / -11.62)nm, and the encapsulation rate of probiotics in the probiotics liposome is 40-57.14%. The method includes steps: (1) preparing a lipid film; (2) preparing phosphate buffer solution; (3) dissolving probiotics into the phosphate buffer solution to form mixed solution 2, and preheating; (4) forming liposome suspension; (5) subjecting the liposome suspension to ultrasonic treatment, filtration and hydration to obtain the probiotics liposome. The probiotics liposome is prepared aiming at the problem of proneness to inactivation of probiotics in a digestion process of the human body, stability and activity of encapsulated probiotics in the human body are improved, the survival rate and setting quantity of probiotics in the intestinal tract are increased, and accordingly probiotic effects of probiotics can be truly achieved.

The invention discloses a bionic camellia extract-containing composition for repairing skin barrier and application of the composition. The composition is prepared from skin surface lipid film repairing components: squalene substances, fatty acid, triglyceride and cholesterol analogues; keratinocyte interstitial components: free fatty acid, ceramide and cholesterol analogues; synergistic interaction componentcomprises: a relieving and inflammation diminishing component, an anti-aging component, a whitening component and a skin penetrating agent; wherein the skin surface lipid film repairing and keratinocyte interstitial components are prepared from the camellia extract, camelina oil, oat kernel oil, squalane, phytosterol and ceramide 3. According to the composition for repairing the skin barrier, on the basis of the principle of the human skin barrier, keratinocyte interstitial components and skin surface lipid film repairing components which are similar to the human skin barrier in structure are subjected to bionic matching through a large number of formula tests and studies, the components in the skin barrier are safely simulated, and the complete and healthy epidermal barrier isremodeled.

The invention relates to a preparation method of a stem cell secreted factor flexible liposome. The preparation method comprises the steps that 0.100-0.150g of phospholipid, 0.020-0.030g of cholesterol, 0.2-0.3mg of vitamin E are dissolved by using 10ml of organic solvent, decompression and rotary evaporation are performed to remove the organic solvent and form a lipid film, a stem cell secreted factor solution is hydrated with the lipid film to form a stem cell secreted factor flexible liposome solution, the obtained stem cell secreted factor flexible liposome solution is subjected to homogenization treatment, and the stem cell secreted factor flexible liposome is obtained. The preparation method of the stem cell secreted factor flexible liposome effectively improves the retention time ofmesenchymal stem cell secreted factors, facilitates the adhesion and absorption of drugs and the skin, reduces stimulation and adverse effects, enhances the penetration ability to reach deep tissue,enhances the curative effects of secreted factors of mesenchymal stem cells, improves the utilization degree of the mesenchymal stem cells, and has no toxic side effects.

A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.

The invention discloses a pomegranate grafting method and belongs to the technical field of grafting. The pomegranate grafting method includes preparing land, dressing pomegranate seeds by a new lipid film and sowing; fertilizing pomegranate seedlings when pomegranate roots are 3-8 cm in diameter, cutting off top shoots of the pomegranate seedlings, and wrapping cuts by plastics; cutting positions of stock with bud eyes into 'W'-shaped cuts, cutting scions into W-shape fitted to the stock cuts, and inserting the scions into the cuts; spraying nutrient solution at the cut fitting positions of the stock, and then binding and fixing by film tapes but with buds of the scions exposed; finally managing in the final period. By the pomegranate grafting method, survival rate of scion grafting can be remarkably improved.

The invention discloses a moisturizing mild amino acid bath lotion and a preparation method thereof. A mild amino acid surfactant is taken as a foaming cleaner to reduce the irritation of the surfactant to skin and the damage to the natural lipid film of the skin, and the amino acid surfactant mainly comprises sodium cocoyl glycinate, cocoyl amidopropyl betaine and sodium lauroyl sarcosinate; a spirulina maxima extract and glycerin are adopted to moisten and maintain the skin, and at the same time, 1,3-propanediol is supplemented to form a smooth film on the skin to reduce the evaporation of water on the skin surface after bathing, at the same time, due to the slight film-forming property of 1,3-propanediol, the method can help spirulina maxima and glycerin to adsorb on the skin and increase the moistening and maintenance of the skin; and the moisturizing mild amino acid bath lotion has the effect of washing and protecting, and is helpful for improving or eliminating the symptoms of dry skin and pruritus.

The invention relates to the technical field of medicaments. The existing process for preparing particle preparations such as a lipid film comprises the step of dissolving a medicament into the oil for injection to form milky microspheres, so the prepared particle preparations have the defects of low medicament-loading amount, poor stability, large using amount of auxiliary materials and large toxic and side effect. The invention provides a method for preparing a freeze-drying particle preparation for injection, which comprises the following steps: firstly, dissolving water-insoluble medicinal powder into a volatile water-soluble organic solvent to form molecular medicinal solution, and then dispersing the molecular medicinal solution into the water for injection to form fluffy soft aggregate mixed suspension; and then adding a small amount of injection-grade auxiliary material such as dispersant and the like into the suspension, and obtaining the freeze-drying particle preparation for injection through a certain preparation process. The particle preparation prepared by the preparation method has the characteristics of small using amount of auxiliary materials, high medicament-loading amount, good stability, simple preparation process and the like. The preparation method of the invention has broad practicability, and basically can meet the preparation requirement of most water-insoluble powdery medicinal particle preparations.

The invention discloses a preparation method of a vegetable protein / gum arabic / lipid emulsified edible composite film, comprising the steps of: preparation of a vegetable protein isolate-gum Arabic (SPI-GA) cross-linking product, preparation of a SPI-GA lipid film forming solution, and preparation of a SPI-GA lipid film. The preparation method of the invention is simple and convenient to operate.On the one hand, a special process is used to conduct glycosylation chemical crosslinking on protein and polysaccharide for full combination, so that the mixed product is more stable, and the mechanical strength and other properties of the film are effectively improved, and on the other hand, by emulsification, lipid is directly introduced into the film forming solution formed by protein and polysaccharide, and then drying is carried out for film forming, so that the stable edible film having excellent hydrophobic properties is formed. The invention is of great significance to further researchand process optimization of composite edible films as a food packaging material.

The invention discloses a skin surface lipid film healing composition.The skin surface lipid film healing composition is prepared from, by mass, 0.1-1% of sodium hyaluronate, 0.2-4% of trehalose, 2-15% of glycerinum, 1-10% of at least one of shea butter and avocado butter, 0.1-0.5% of sodium polyacrylate and 69.5-96.6% of water.An experiment proves that the skin surface lipid film healing composition can effectively relieve symptoms such as redness, swollenness, heat pain, skin peeling and pruritus caused after beautifying means such as laser beautifying and chemical peeling are performed on skin, and is good in absorption effect; no emulsifying agent is added in gel, the skin surface lipid film healing composition belongs to a non-emulsification system, the sensitized risk is lowered, the preparation method is simple, the production period is short, the formula is simple, and the cost is low.

The invention discloses a method for preparing magnetic lipid ultrasonic microbubble contrast medium. The method comprises the following steps: preparing FeCl3 and FeCl2 solution and adding the solutions into a flask; dripping NH4OH under stirring condition so as to generate precipitation and curing; taking out and flushing the generated product until the pH value is 7; drying generated product to obtain the Fe3O4 magnetic nano particles; preparing the Fe3O4 dry powder into magnetic fluid; discarding the supernatant, suspending precipitation again in phosphate buffer and adding PEI to form PEI / Fe3O4 nano particles; mixing the PEI / Fe3O4 nano particles with pEGFP-C1 plasmid DNA for standing to obtain gene-loaded Fe3O4 magnetic nano particles; dissolving DSPC, DPPE and DPPA in an organic solvent in which the ratio of chloroform to isopropanol is 2:1; evaporating the solvent to leave a lipid film; preparing hydration solution from glucose and propylene glycol in a ratio of 4:1 and adding the hydration solution into the flask, and dispersing the hydration solution to obtain lipid suspension; adding 40 mg of PEG4000, heating the mixed suspension for dissolving; adding DNA / PEI / Fe3O4 and gelatin into the lipid suspension; adding 800.01 ml of Tween; replacing air above a penicillin bottle; and shaking the suspension to obtain the gene-loaded magnetic lipid ultrasonic microbubbles.

The invention discloses a nanometer lipid ultrasonic contrast agent and a preparation method thereof. According to the method, the nanometer lipid ultrasonic contrast agent which is small in particle size and can develop stably is prepared by adopting lipid film dispersion and mechanical oscillation methods, is good in outer shell crushing resistance, is difficult to crack under the condition of low mechanical index, is extremely low in solubility and diffusion rate in a solution, can perform microcirculation pouring well, can last longer time in blood, has favorable acoustic property and stability, can obviously enhance the heart, kidney, liver and tumor development by in-vivo radiography, and long in radiography time which is more than 30 minutes.

The invention provides skin-care makeup remover cream with a skin surface lipid film repairing function. The skin-care makeup remover cream is prepared from components of raw materials in percentage by weight as follows: 20%-55% of grease, 10%-30% of an emulsifier, 2%-10% of polyethylene, 1%-25% of polyalcohol and / or deionized water, 5%-15% of squalane, 2%-5% of a traditional Chinese medicine additive and 0.1%-0.2% of methylparaben or phenoxyethanol or imidazolidinyl urea, and the sum of percentages of all the components is 100%. The skin-care makeup remover cream is a water-containing system, has good skin feeling, is not sticky, is very refreshing and has a good cleaning effect on water-soluble dirt while compared with a whole-oil system, people don't feel tight in face after using the cream, and skin is protected. The product has a low melting point, is solid-state paste at the normal temperature and can rapidly form thin oil after a little cream is slightly applied to the skin and spread on the skin; besides, through matched use of squalane and the traditional Chinese medicine additive, the skin-care makeup remover cream can repair a skin surface lipid film, form a natural barrier on the skin surface, promote proliferation of skin basal cells and help repair damaged cells.

The invention discloses a pure natural makeup removal paste which is prepared from, by weight, 20-55% of vegetable fat, 10-35% of a surface active agent, 2-30% of solid wax, 0.1-5% of rosemary extract or tocopherol, 2-10% of sage essential oil, 3-6% of myrrh essential oil, 0.5-1% of carnation extract, 0.2-0.8% of citrus fruit extract and 0.2-0.6% of lotus extract, wherein the sum of the percentages of the compositions is 100%. The adopted natural vegetable fat contains no essence, synthetical pigment, preservative, mineral oil, mineral wax and other chemical raw materials harmful to human skin, and is safe, mild, free of stimulation and capable of nourishing skin while achieving makeup removal. In addition, by using the sage essential oil, the myrrh essential oil and the carnation extract in a cooperated mode, the good effects of repairing the skin surface lipid film, adjusting the skin balance value, promoting updating of damaged skin, thickening cuticle and replenishing and locking water are achieved. The invention further provides a preparation method of the makeup removal paste.

The invention discloses a plant moisturizing composition. The plant moisturizing composition comprises the following components in parts by weight: 1-3 parts of aloe extract, 1-3 parts of vitamin E, 2-5 parts of grape seed extract, 0.5-1 part of apple polyphenol and 0.3-1.2 parts of grape polyphenol. The plant moisturizing composition can resist free radicals, prevent destroy of collagenous fibers and elastic fibers, maintain inherent elasticity and tension of skin, improve a water evaporation preventing function of a skin surface lipid film and enhance a barrier function of a cuticular layer, so that water locking capability of the skin is greatly enhanced, and moisturizing and ant-aging functions are realized.

The invention discloses a novel composite nano preparation based on sonodynamic / immune combined therapy and a preparation method and application thereof, the novel composite nano preparation comprises a sound-sensitive agent, an immune activator, an active oxygen enhancing drug and liposome, the sound-sensitive agent and the active oxygen enhancing drug are entrapped in a liposome phospholipid bimolecular layer, and the immune activator is embedded on the lipidosome phospholipid bimolecular layer. The method comprises the following steps: (1) preparing a sound-sensitive agent, a cinnamyl aldehyde derivative, MPLA, a lecithin and DSPE-PEG5k into a solution; (2) evaporating out the solvent in the solution obtained in the step (1), and dispersing the drug-loaded lipid film in a buffer solution to obtain a drug-loaded liposome suspension; and (3) enabling the solution obtained in the step (2) to pass through a polycarbonate film to obtain the composite nano-liposome. The preparation can induce anti-tumor reaction, not only can prevent the development of in-situ solid tumors, but also can prevent the tumors from metastasis to far-end tissues. The composition is especially suitable for a combined treatment preparation of sonodynamic therapy and immunotherapy.

The invention belongs to the field of antibacterial drugs, and discloses a preparation method and application of a liposome composite material for light-controlled release of tungsten sulfide quantumdots and vancomycin. The material is called WS2QDs-Van@lipo for short, wherein WS2QDs are the tungsten sulfide quantum dots, Van is the vancomycin, and lipo is liposome. The preparation method comprises the following steps of firstly, dissolving dipalmitoyl phosphatidylcholine, cholesterol and distearoyl phosphatidylethanolamine-polyethylene glycol-hydroxyl in trichloromethane, and carrying out vacuum drying to generate a lipid film; then, adding the lipid film into PBS containing the WS2QDs and the Van, and performing hydrating to form a thin film; and finally, carrying out ultrasonic treatment after vortex oscillation, and carrying out centrifugal purification to obtain the WS2QDs-Van@lipo composite material. The material can be used as an antibacterial reagent, and can be accurately released at a target part through light control, so that the use amount of antibiotics and the systemic toxicity of organisms are reduced; and the material has a relatively good inhibition effect on theactivity of escherichia coli and vancomycin-resistant staphylococcus aureus, and can provide a safe and effective solution for treatment of refractory drug-resistant bacteria.

The invention belongs to the technical field of personal care products, and discloses a polypeptide flexible liposome, a preparation method and applications thereof. The preparation method comprises the following steps: (1) adding phospholipid, cholesterol, a membrane material softener and active polypeptide into an organic solvent, carrying out ultrasonic oscillation dissolving, placing the mixed solution into a rotary evaporation container, and carrying out rotary evaporation to remove the organic solvent so as to obtain a liposome solution, obtaining a layer of lipid film on the wall of the rotary evaporation container; (2) adding the water phase containing the surfactant into a rotary evaporation container, carrying out water bath constant-temperature stirring, and then carrying out ultrasonic treatment to enable a lipid film on the rotary evaporation container to completely fall off, so as to obtain a polypeptide flexible liposome primary emulsion; and (3) carrying out high-pressure homogenization treatment on the obtained polypeptide flexible liposome primary emulsion, and filtering the obtained homogenized solution by using a microfiltration membrane to remove impurities, thereby finally obtaining the polypeptide flexible liposome. The lipidosome is used for effectively encapsulating the polypeptide, so that the transdermal performance of the lipid vesicle is greatly improved, polypeptide molecules can enter the deeper layer of the skin to play a role, and the lipid vesicle can be applied to anti-wrinkle products.

The invention discloses high-penetrating cosmetic composition and a preparation method thereof and aims to provide composition which has small particle size, is easy to absorb by skin, has long-lasting and durable moisturizing effects, prevents skin drying and can reconstruct a skin surface lipid film. According to the technical scheme, the high-penetrating cosmetic composition is prepared from components in percentage by weight as follows: 5%-40% of an emulsifier phase, 3%-25% of an oil phase and the balance of a water phase; the emulsifier phase comprises components in percentage by weight of the high-penetrating cosmetic composition as follows: 1%-8% of an emulsifier, 3%-20% of polyol and 1%-12% water; the emulsifier mainly contains sodium dilauramidoglutamide lysine. The invention belongs to the technical field of cosmetics.