The invention discloses a composite nutritional healthcare seasoning sauce or a sauce for being mixed with cooked rice. The sauce adopts camellia and olive oil (formed by mixing and blending camellia oil with olive oil), sardine, chicken meat, beef, mushroom and vegetables as main raw materials, adopts astaxanthin, edible salt, xylitol, oat beta-glucan, garlic, hot red pepper powder, pumpkin seeds, onion, chicken essence, Chinese prickly ash, ginger, peanuts, starch phosphate, nisin and lysozyme as auxiliary raw materials, and does not contain sugar or chemically synthesized antiseptics. The sauce contain rich kinds of nutrients, is rich in various amino acids, vitamins and mineral elements, and contain rich oleic acid, monounsaturated fatty acids, nucleic acid, taurine and other beneficial components, so the sauce contains rich nutrition, facilitates nutrient supplementation, and has the efficacy of preventing oxidation, preventing cardiovascular diseases and enhancing the immunity of human bodies, and has very substantial healthcare effects. The invention also provides a making method of the composite nutritional healthcare seasoning sauce.