238 results about "Tocopherol" patented technology

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a synthetic nicotine composition and a preparation method thereof. The nicotine buccal film agent disclosed by the invention is prepared from the following components in parts by weight: 2 to 4 parts of nicotine clathrate compound powder, 0.2 to 0.6 part of phosphatidic acid, 0.1 to 0.3 part of tannic acid, 0.1 to 0.2 part of sodium ascorbate, 0.04 to 0.06 part of tocopherol, 0.01 to 0.02 part of ethylene diamine tetraacetic acid, 2 to 4 parts of povidone and 40 to 80 parts of absolute ethyl alcohol. The synthesized nicotine composition prepared by the invention can effectively relieve the phenomenon that the faster the nicotine is released, the stronger the bitter taste is. Meanwhile, in a high-temperature and high-humidity environment, the stability of nicotine can be effectively maintained, and the oxidation half-life period of nicotine is prolonged.

The invention relates to the technical field of polymer compositions, and particularly discloses a degradable bio-based food packaging material and a preparation method thereof.The degradable bio-based food packaging material is prepared from polylactic acid, ITA esterified bacterial cellulose, CSL-ITA esterified bacterial cellulose, polycaprolactone glycol, acetyl tributyl citrate, a photoinitiator and tocopherol; the preparation method comprises the following steps: esterifying bacterial cellulose hydrogel with itaconic anhydride, grafting with sodium copper chlorophyllin, dehydrating with gradient ethanol, and drying with supercritical CO2 to obtain modified powder; according to the preparation method, the interfacial compatibility of the bacterial cellulose and the polylactic acid is enhanced through ITA esterification, the illumination antibacterial function is given by utilizing CSL grafting, the polycaprolactone glycol and the acetyl tributyl citrate are synergistically used for toughening and improving the brittleness, the photoinitiator is added, the photoinitiator is added for mixing, and ultraviolet crosslinking curing is performed after film forming. The tocopherol protects the stability of the antibacterial structure of the CSL, the water resistance is improved through photo-crosslinking, and the material is degradable and meets the food packaging requirement.

The invention discloses melogabalin besylate tablets and a preparation method thereof, a tablet core comprises melogabalin besylate, a filler, a disintegrating agent, a lubricant, a flow aid and a stabilizer, the disintegrating agent is sodium carboxymethyl starch, and the stabilizer is tocopherol and tartaric acid; on the basis of selecting sodium carboxymethyl starch as a disintegrating agent, the melogabalin besylate tablet of which the stability (especially the quality control of impurities I) is superior to that of a reference preparation is prepared by investigating the variety and the dosage of a stabilizing agent and selecting a specific stabilizing agent combination; the technical prejudice that the stability of calcium carboxymethyl cellulose is superior to that of sodium carboxymethyl starch in the prior art is overcome.

The invention relates to the technical field of rice bran processing, and discloses a rice bran degreasing and nutrition retention edible process synergistic treatment method which comprises the following steps: (a) in an NADES-aqueous solution medium, adding an immobilized catalyst A, and hydrolyzing ferulate bonds and phospholipids in rice bran at low temperature; (b) carrying out intermediate dehydration on the slurry obtained in the step (a) to reduce the water activity; (c) adding an immobilized catalyst B into the dehydrated slurry in the step (b), carrying out esterification reaction, and grafting free ferulic acid generated by hydrolysis to glyceride in situ; and (d) carrying out solid-liquid separation on the slurry obtained in the step (c) to obtain finished oil and finished powder. According to the method, an NADES medium is adopted to replace an organic solvent, the whole process is carried out at low temperature, degradation of heat-sensitive nutrient substances is avoided, and resource utilization of ferulic acid is achieved. The prepared functional rice bran oil is rich in feruloyl glyceride, total tocopherol and oryzanol, and is low in acid value and peroxide value.

This invention discloses a recombinant collagen liposome, its preparation method, and its application. The recombinant collagen liposome comprises 1-10 parts recombinant type XVII collagen, 2-15 parts soybean lecithin, 0.3-2 parts tocopherol, 0.5-7 parts antioxidant, 20-54 parts glycerol, and Dendrobium officinale enzymatic hydrolysate to a total weight of 100 parts. This invention improves the stability and transdermal absorption of recombinant type XVII collagen by encapsulating it in liposomes. The prepared recombinant collagen liposomes not only have a high encapsulation efficiency but also retain excellent barrier repair and anti-wrinkle effects after 8 weeks of storage, making them suitable for use in cosmetics.

They are prepared by a high energy method (e.g. by sonication) from: an oily solution of edible oils (e.g. high-oleic sunflower oil) as solvent, with melatonin (e.g. 100 μM) and edible fat-soluble antioxidant agents (e.g. 100 μM α-tocopherol), and an aqueous solution of edible water-soluble stabilizing agents (e.g. dextrin 1% w / v). These formulations, applied externally (e.g. by spraying) are useful for preharvest application and / or postharvest preservation of fruits or vegetables, particularly of stone fruits, and specifically of sweet cherries. In two varieties of sweet cherries and two varieties of plums, preservations with the formulations are significantly better than those reached with aqueous solutions of melatonin, or with a commercial formulation, or in the absence of treatment.

The invention discloses cosmetic oil with whitening, soothing and anti-aging effects and a preparation method of the cosmetic oil. The plant essential oil is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of sunflower seed oil, 0.01 to 0.05 part of lupinus albus seed extract, 0.0001 to 0.001 part of tocopherol, 0.01 to 0.05 part of rosemary leaf extract, 0.001 to 0.1 part of dimethyl methoxy benzodihydropyranol, 50 to 90 parts of caprylic / capric triglyceride, 0.01 to 0.2 part of ascorbyl tetraisopalmitate, 0.01 to 0.2 part of bisabolol, 5 to 20 parts of squalane, 2 to 8 parts of simmondsia chinensis seed oil, 5 to 15 parts of meadowfoam seed oil and 0.1 to 1 part of lavender oil. And 0.3-1 part of a centella asiatica extract. According to the cosmetic oil product provided by the invention, by optimizing the use of substances, the composition has triple effects of whitening, relieving and resisting aging, can meet multiple skin care requirements of consumers at the same time, and is wide in market application range.

The invention discloses a self-emulsifying adjuvant of a vaccine and a preparation method of the self-emulsifying adjuvant, and relates to the technical field of vaccine adjuvants. The adjuvant comprises an oil phase, an emulsifier and a freeze-drying protective agent, the oil phase comprises squalene and tocopherol, the emulsifier comprises polysorbate and a polyoxyethylene-polyoxypropylene block copolymer, and the freeze-drying protective agent comprises sugar and sugar alcohol. The preparation method comprises the following steps: emulsifying an oil phase and a water phase to form a nano-emulsion, and then freeze-drying to obtain freeze-dried powder. The adjuvant has the advantages of small particle size, uniform distribution, high stability, rapid reconstruction and the like, and can effectively maintain active components and improve the immune effect of vaccines.

The invention provides pet tear stain eye drops containing haematococcus pluvialis extract, the pH value of the eye drops is 6.8-7.2, the osmotic pressure is 280-320 mOsm / kg, the viscosity is 3-8 mPa.s (25 DEG C), and the eye drops comprise the following components in percentage by mass: 0.05-0.5% of haematococcus pluvialis astaxanthin extract (based on the astaxanthin content being greater than or equal to 5%), 0.05-0.5% of a pH regulator (based on the astaxanthin content being greater than or equal to 5%), and the balance of water. 1%-3% of an anti-inflammatory plant compound; 0.5%-1.2% of an isoosmotic adjusting agent; 0.2%-0.8% of a nano carrier stabilizer; 0.01%-0.1% of a pH buffer agent; compared with the prior art, the invention has the following beneficial effects: the corneal permeability of the astaxanthin is increased to 82% (measured by a Franz diffusion cell) through PLGA coating, and is increased by 5.5 times compared with the corneal permeability of the astaxanthin in a free state (15%); natural tocopherol is reserved through supercritical CO2 extraction (the content of the natural tocopherol is larger than or equal to 0.5% through HPLC detection), and the retention rate of the astaxanthin stored at 40 DEG C for 90 days is larger than or equal to 90% through Calendula quercitrin inhibits the expression of IL-6 (enzyme-linked immunosorbent assay (ELISA) detection is reduced by 76%), and chamomile bisabolol blocks a COX-2 pathway.

The invention discloses a qualitative and quantitative detection method for vitamin A and vitamin E in food. The qualitative and quantitative detection method comprises the following steps: step 1, pre-treating a sample and accurately adding an isotope internal standard: adding d6-alpha-tocopheryl acetate and d8-retinol acetate into the sample before saponification and preparing a blank matrix; 2, pre-treatment parameter QbD-DOE collaborative optimization, wherein a response surface method is adopted for conducting center composite design on the saponification temperature, time and BHT concentration, and the interaction effect of all the factors is analyzed to determine an optimal operation window; step 3, intelligently optimizing chromatography-mass spectrometry conditions and tuning parameters; step 4, constructing a matrix matching calibration curve and performing WLS quantitative analysis: performing gradient dilution on a standard substance by utilizing a blank matrix extracting solution, adding an isotope internal standard to prepare a 5-7-point matrix matching calibration curve, fitting the curve by adopting a weighted least square method, and verifying the correlation and intercept change of the calibration curve every day; and 5, multi-dimensional qualitative confirmation and intelligent diagnosis system operation.

The invention relates to an auxiliary lipid molecule containing a tocopherol structure, a lipid nanoparticle containing the auxiliary lipid molecule and application of the auxiliary lipid molecule. Specifically, the invention provides an auxiliary lipid molecule containing tocopherol and a derivative structure thereof as shown in a formula (1), a lipid nanoparticle containing the auxiliary lipid molecule, and a preparation method and application of the auxiliary lipid molecule. Compared with auxiliary lipid molecules conventionally used in the field, the lipid nanoparticles prepared from the auxiliary lipid molecules shown in the formula (1) can significantly improve the delivery efficiency and expression of nucleic acid. # imgabs0 #

The invention discloses a compound microorganism freeze-drying protective agent, a preparation method of the compound microorganism freeze-drying protective agent and a use method of the compound microorganism freeze-drying protective agent. Comprising the following raw materials in parts by weight: 0.03 part of disodium ethylene diamine tetraacetate, 5 to 15 parts of trehalose, 2 to 5 parts of sorbitol, 0.5 to 2 parts of ascorbic acid, 0.05 to 0.2 part of N-acetyl-L-cysteine, 0.1 to 0.5 part of polylactic acid-glycolic acid copolymer, 0.01 to 0.05 part of alpha-tocopherol and 1 to 3 parts of bentonite. The PLGA, the alpha-tocopherol and the NAC construct a three-stage synergistic anti-oxidation system from outside to inside: the PLGA is externally blocked, so that rapid consumption of an antioxidant is avoided, and slow release is realized; the alpha-tocopherol realizes oxidative damage repair of cell membranes; nAC maintains the internal reduction environment of cells, reduces oxidative stress and can regenerate alpha-tocopherol at the same time, and reutilization of resources is achieved.

Disclosed is a method of reducing fine lines or wrinkles on skin. The method can include applying a topical skin care composition to skin with fine lines or wrinkles. The composition can include lactobacillus ferment, ascorbyl glucoside, Terminalia ferdinandiana fruit extract, Helianthus annuus (Sunflower) seed extract, glycerin, Persea gratissima (avocado) oil, Butyrospermum parkii (shea) butter, coco-caprylate / caprate, Sclerotium gum, sodium benzoate, and tocopherol.

The present invention specifically relates to an anti-cracking and repairing composition containing artemisia annua and camellia seed oil, and its preparation and application, belonging to the technical field of cosmetics. The composition of the present invention is prepared by using allantoin, phenoxyethanol, ethylhexylglycerin, artemisia annua extract, urea, tocopherol, camellia seed oil, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, portulaca oleracea extract, taraxacum extract, grape seed oil, squalane, caprylic / capric triglyceride, bis(lauroyl glutamine) lysine sodium, glycerin, butanediol, carrageenan, sodium carboxymethyl cellulose and water. The cooperation among the raw materials enables the composition to have excellent anti-chapping, skin repairing and nursing, and anti-inflammatory and soothing effects, and at the same time has good stability and safety effects.

The present invention relates to an injectable pre-formulation comprising:a) at least one of a mono-, di- or tri-acyl lipid and / or a tocopherol;b) optionally at least one phospholipid;c) at least one biocompatible, organic solvent; andd) at least one prostacyclin analogue or a salt thereof;wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. Such compositions may additionally comprise polar co-solvents. Methods of treatment, particularly for management of pulmonary artery hypertension (PAH), severe PAH, Raynaud's disease, ischemia and related conditions are provided, as well as corresponding uses of the compositions. Administration devices comprising the formulations and kits comprising the devices are also provided.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention aims to provide a microbial feed additive for preventing zearalenone poisoning, which can obviously improve the reproductive performance and growth performance of livestock and poultry and enhance the immunity of animals. The composite microbial agent mainly comprises the following components in parts by weight: 1-5 parts of DL-alpha-tocopheryl acetate, 1-3 parts of superoxide dismutase (SOD), 5-10 parts of coated vitamin C and 82-93 parts of a bacillus subtilis microbial agent. 100 parts by weight of feed contains 0.005-0.01 part by weight of the feed additive disclosed by the invention. The embodiment 1 of the invention is preparation of bacillus subtilis for degrading ZEA, and the embodiment 2 of the invention is preparation of the microbial feed additive according to the content of the invention. The embodiment 3 is a detoxification experiment of the microbial feed additive on the ZEA in the young sow feed. An embodiment 3 verifies that the traditional Chinese medicine composition can well prevent the problems of reproductive disorder, low production capacity, reduced immunity and the like caused by ZEA poisoning of young sows.

The invention provides a whitening and spot-fading skin care composition and a preparation method thereof, and belongs to the technical field of whitening and skincare, and the composition comprises modified glabridin, a nicotinamide-tranexamic acid co-coating, an alhagi sparsifolia flower extract and an artemisia desertorum seed extract. The modified glabridin is obtained by modifying glabridin with tocopherol succinate, polyethylene glycol and artemisia desertorum seed gum. The nicotinamide-tranexamic acid co-coating is obtained by coating a mixture of nicotinamide and tranexamic acid with sodium alginate and chitosan hydrochloride. The alhagi sparsifolia extract is obtained by carrying out common enzymolysis on alhagi sparsifolia dry powder through compound enzyme and glucosidase and purifying through a mixed filler adsorption column, and the artemisia desertorum seed extract is obtained by fermenting artemisia desertorum seed powder through aspergillus oryzae, removing impurities through ADS-7 resin and purifying through a polyamide resin column. The effective components are prepared by adopting a special preparation and purification method and are matched according to a specific ratio for use, and the whitening effects of inhibiting tyrosinase, blocking melanin generation, scavenging free radicals and the like are achieved through multi-effect synergism.

The invention discloses an essence composition for promoting eyelash growth and a preparation method thereof.The essence composition comprises a phase A, a phase B, a phase C, a phase D and a phase E. The phase B comprises natural active extracts. The natural active extract comprises butyrospermum parkii butter, a matricaria chamomilla leaf extract, glycyrrhiza glabra, a centella asiatica extract, a rosemary leaf extract, tocopherol, a scutellaria baicalensis root extract, a tea leaf extract and a polygonum cuspidatum root extract in a mass ratio of (0.488985): (0.005): (0.0025): (0.0025): (0.0005): (0.0005): (0.000005): (0.000005): (0.000005). On the premise that safety and mildness are guaranteed, the eyelash density and length are remarkably improved through low-dosage active ingredients, and the safe and efficient requirements of daily eyelash nursing can be met.

The invention discloses a staphylococcus carnosus chromophore strengthening method based on regulation and control of exogenous additives and application of the staphylococcus carnosus chromophore strengthening method in salting dried fish. The staphylococcus carnosus chromophore strengthening method comprises the following steps: mixing a methemoglobin solution with broth, adding the exogenous additives, and constructing a simulation system; inoculating staphylococcus carnosus into the simulation system for culturing, and observing the color change of the simulation system; wherein the exogenous additive comprises one or more of L-arginine, tea polyphenol, ascorbic acid or tocopherol. One or more of L-arginine, tea polyphenols, ascorbic acid or tocopherol are used as exogenous additives for synergistic fermentation with staphylococcus carnosus, so that the redness value of the salted dried fish is remarkably increased.

The present invention refers to combinations, compositions and kits of parts having thymol, or an extract of plant belonging to the genus Thymus containing thymol, and a tocopherol as well as to their use in the prevention and / or treatment of ocular diseases or also for non-therapeutical purposes.

The present invention provides a gel composition and an oil-in-water composition that have a strong barrier function.　The gel composition comprises: one or more first compounds, which are represented by polyoxyethylene phytosterols; one or more second compounds, which are represented by polyethylene glycol distearate; one or more third compounds, which are represented by polyoxyethylene alkyl ethers; and one or more fourth compounds selected from the group consisting of ascorbic acid and salts thereof, ascorbic acid monoesters, ascorbic acid diesters, tocopherols and esters thereof, glycyrrhetinic acid and esters and salts thereof, and betamethasone and esters thereof.

To provide a sirolimus-containing powder granule formulation that ensures bioavailability and has improved stability. [Solution] A sirolimus-containing granular preparation containing sirolimus and tocopherol, but not containing hydroxypropylcellulose, and a method for producing a sirolimus-containing granular preparation, characterized by comprising the steps of (1) mixing a solution containing sirolimus and tocopherol with core particles that form the core of the granular preparation in the absence of hydroxypropylcellulose, and (2) drying the mixture obtained in step (1).

The invention discloses a fried crisp meat wrapping material and application thereof, and belongs to the technical field of food. The fried crisp meat wrapping material is prepared from the following raw materials in parts by weight: 80 parts of wheat flour, 20 parts of waxy corn starch, 150 parts of water, 0.75 part of xanthan gum and 0.05 part of tocopherol. The fried crispy meat prepared by the method disclosed by the invention has relatively low oil content, meanwhile, the quality of frying oil can be maintained to a certain extent in the frying process, and potential food safety hazards are reduced. The crispy meat shells fried with the wrapping material prepared by the method have better health attributes and better palatability, and based on the oxidation resistance of tocopherol in the shells, the crispy meat shells have important significance for maintaining body health and preventing diseases.

The present drinking therapy is intended to build, promote and maintain the intestinal microbiome (flora balance) and consists of a beverage having at least the following components: a herbal probiotic enzyme beverage (probiotic); necessary prebiotics of vitamins, mineral substances and trace elements are combined; the invention relates to natural nutritional oil rich in omega-3 fatty acid and tocopherol. These ingredients are processed into emulsions, whereby the resulting beverage can be drunk periodically, preferably daily, as part of drinking therapy.

To provide a technique for promoting assimilation of oligosaccharide such as HMO by enteric bacterium.SOLUTION: Provided is a composition in which a tocopherol is used as an active ingredient of the composition for promoting assimilation of oligosaccharide. The tocopherol includes one or more selected from the group consisting of β-tocopherol, γ-tocopherol and δ-tocopherol. The oligosaccharide to be assimilated is preferably human milk oligosaccharide. In the assimilation-promoting composition, the mass ratio (δ / β) of the content of δ-tocopherol to the content of β-tocopherol is preferably 5 or more, and the mass ratio (γ / δ) of the content of γ-tocopherol to the content of δ-tocopherol is preferably 8.8 or less.SELECTED DRAWING: None

The invention discloses an optimized formula of plant organic nano-selenium for activating an immune system, inhibiting cancer cell proliferation, preventing cancers, preventing tumors, resisting oxidation and resisting aging, and belongs to the technical field of functional food formulas. According to the formula, selenium-enriched yeast and dl-alpha-tocopheryl acetate are used as main materials, L-ascorbic acid can be selectively added, auxiliary materials such as microcrystalline cellulose and starch sodium octenylsuccinate are matched to prepare a capsule preparation, and the content of functional components in a single preparation is precisely controlled as follows: 90-100 micrograms of selenium and 40-50 mg of vitamin E, or 90-100 micrograms of selenium, 40-50 mg of vitamin E and 40 mg of vitamin C. According to the invention, synergistic interaction is realized through scientific proportioning of functional components, a fat-soluble and water-soluble dual anti-oxidation system is constructed, an organism immune system can be effectively activated, cancer cell proliferation can be inhibited, and meanwhile, the composition has multiple effects of preventing cancers, preventing tumors, resisting oxidation and resisting aging; the preparation method is simple and convenient in process, easy in parameter control and suitable for industrial large-scale production, the prepared preparation is high in active ingredient stability, excellent in bioavailability, high in safety and capable of being widely applied to preparation of related functional foods, and all raw materials are food-grade. The technical problems that an existing selenium compound formula is unreasonable in proportion, poor in efficacy synergy and poor in preparation performance are solved.

The invention discloses a method for determining tocopherol in hedyotis diffusa. According to the method, the content of the tocopherol in the hedyotis diffusa is measured by using liquid chromatography. According to the method, ethanol is used as an extracting solution, an ultrasonic method is adopted for extraction, and liquid chromatography is adopted for detection. Chromatographic conditions are as follows: a stationary phase is an Agilent C18 column, and a mobile phase is chromatographic grade methanol; the column temperature is 35 DEG C, and the flow velocity is 1ml / min; the detection wavelength is 295 nm; the sample size is 20 microliters. The method has the advantages of simple pretreatment, high efficiency, high analysis speed and high detection efficiency.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

To provide an external composition which contains tocopherol and / or a derivative thereof, isopropyl myristate, and N-methyl-2-pyrrolidone, and which suppresses separation of the contained components.SOLUTION: An external composition contains: (A) tocopherol and / or a derivative thereof; (B) isopropyl myristate; (C) N-methyl-2-pyrrolidone; and (D) menthol.SELECTED DRAWING: None