367 results about "Tocopherol" patented technology

The invention belongs to the field of biological fermentation synthetic medicines, and particularly relates to tocopherol glucoside and a preparation process thereof. The synthesis method comprises the following steps: (1) preparing an enzyme catalyst; (2) carrying out enzymatic conversion reaction; (3) purifying ion resin; (4) removing impurities; the synthesis process provided by the invention is simple in route and strong in operability, the prepared tocopherol glucoside is high in purity, the total yield of the product is greater than 30%, and the purity is greater than 95.0%.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a synthetic nicotine composition and a preparation method thereof. The nicotine buccal film agent disclosed by the invention is prepared from the following components in parts by weight: 2 to 4 parts of nicotine clathrate compound powder, 0.2 to 0.6 part of phosphatidic acid, 0.1 to 0.3 part of tannic acid, 0.1 to 0.2 part of sodium ascorbate, 0.04 to 0.06 part of tocopherol, 0.01 to 0.02 part of ethylene diamine tetraacetic acid, 2 to 4 parts of povidone and 40 to 80 parts of absolute ethyl alcohol. The synthesized nicotine composition prepared by the invention can effectively relieve the phenomenon that the faster the nicotine is released, the stronger the bitter taste is. Meanwhile, in a high-temperature and high-humidity environment, the stability of nicotine can be effectively maintained, and the oxidation half-life period of nicotine is prolonged.

The invention discloses a camellia nitidissima flower extract-containing anti-pollution acne-sensitive skin repairing composition and application thereof, and relates to the technical field of cosmetics. The invention provides a camellia nitidissima flower extract-containing anti-pollution acne-sensitive skin repairing composition. The camellia nitidissima flower extract-containing anti-pollution acne-sensitive skin repairing composition is prepared from the following components in parts by weight: 1 to 5 parts of camellia nitidissima flower extract, 1 to 5 parts of seaweed oligosaccharide, 0.01 to 1 part of o-cymene-5-ol and 0.01 to 1 part of tocopherol retinoate. According to the anti-pollution acne-sensitive skin repairing composition containing the camellia nitidissima flower extract, four components including the camellia nitidissima flower extract, the seaweed oligosaccharide, the o-cymene-5-ol and the tocopherol retinoate in proper parts by weight are selected to cooperate with one another, so that the composition has better anti-pollution and antibacterial effects and has very good acne removing, repairing and soothing effects.

The invention relates to the field of food processing, and discloses a processing method for debitterizing and deodorizing linseed oil and efficiently retaining antioxidant nutrient linol and grease processed thereof.The method comprises the steps that 1, the linseed oil and a debitterizing agent are mixed to obtain debitterized linseed oil; (2) sequentially carrying out steam quenching and tempering treatment and deodorization treatment on the linseed oil to obtain deodorized linseed oil; wherein the temperature of the deodorization treatment is 45-100 DEG C higher than that of the water vapor quenching and tempering treatment. According to the method, bitter and fishy substances in the linseed oil can be efficiently removed, meanwhile, the loss of alpha-linolenic acid, linolenol (containing tocopherol, PC-8 and polyphenol) and sterol in the linseed oil is reduced, the retention rate of the alpha-linolenic acid, linolenol and sterol in the linseed oil is increased, and then the quality of the linseed oil is improved.

The invention discloses a serum-free culture medium for in-vitro proliferation of poultry muscle stem cells and application of the serum-free culture medium, and belongs to the technical field of cell engineering, a basic serum-free culture medium is DMEM-F12, a complete serum culture medium is a mixture of DMEM-F12 added with 10% of fetal calf serum and 1% of mycillin, and the volume ratio of a culture medium supplement to the basic culture medium is 1: 1000; the serum-free culture medium contains a supplement; the supplement comprises the following compositions: insulin, transferrin, fibroblast growth factor 2, epidermal growth factor, catalase, ethanolamine, vitamin B12, linoleic acid, linolenic acid, retinol acetate, tocopherol, L-alanine, L-proline, sodium selenite, sodium pyruvate, reduced glutathione, berberine hydrochloride and analogues thereof.

Methods are described for measuring the amount of one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample.

The invention relates to the technical field of polymer compositions, and particularly discloses a degradable bio-based food packaging material and a preparation method thereof.The degradable bio-based food packaging material is prepared from polylactic acid, ITA esterified bacterial cellulose, CSL-ITA esterified bacterial cellulose, polycaprolactone glycol, acetyl tributyl citrate, a photoinitiator and tocopherol; the preparation method comprises the following steps: esterifying bacterial cellulose hydrogel with itaconic anhydride, grafting with sodium copper chlorophyllin, dehydrating with gradient ethanol, and drying with supercritical CO2 to obtain modified powder; according to the preparation method, the interfacial compatibility of the bacterial cellulose and the polylactic acid is enhanced through ITA esterification, the illumination antibacterial function is given by utilizing CSL grafting, the polycaprolactone glycol and the acetyl tributyl citrate are synergistically used for toughening and improving the brittleness, the photoinitiator is added, the photoinitiator is added for mixing, and ultraviolet crosslinking curing is performed after film forming. The tocopherol protects the stability of the antibacterial structure of the CSL, the water resistance is improved through photo-crosslinking, and the material is degradable and meets the food packaging requirement.

The invention discloses melogabalin besylate tablets and a preparation method thereof, a tablet core comprises melogabalin besylate, a filler, a disintegrating agent, a lubricant, a flow aid and a stabilizer, the disintegrating agent is sodium carboxymethyl starch, and the stabilizer is tocopherol and tartaric acid; on the basis of selecting sodium carboxymethyl starch as a disintegrating agent, the melogabalin besylate tablet of which the stability (especially the quality control of impurities I) is superior to that of a reference preparation is prepared by investigating the variety and the dosage of a stabilizing agent and selecting a specific stabilizing agent combination; the technical prejudice that the stability of calcium carboxymethyl cellulose is superior to that of sodium carboxymethyl starch in the prior art is overcome.

The invention discloses a glucosyltransferase and a preparation method and application of a mutant of the glucosyltransferase. The amino acid sequence of the glucosyltransferase comprises a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The glucosyltransferase and the mutant thereof can efficiently catalyze the generation of the tocopherol glucoside, the enzyme activity can reach 0.34 U / mg, a new way of synthesizing the tocopherol glucoside by a biological method is developed, the glucosyltransferase and the mutant thereof can be widely applied to the fields of medicines, cosmetics and the like, the industrial production of tocopherol derivatives is promoted, and the production cost is reduced. The requirements of the market on high bioavailability and high stability tocopherol derivatives are met, and the technical progress and industrial upgrading of related industries are promoted.

The invention discloses a preparation method of a squalene and tocopherol composition microcapsule, and relates to the technical field of microcapsule preparation, and the preparation method is characterized by comprising the following steps: squalene, tocopherol and an emulsifier form a core material emulsion, Arabic gum, modified corn starch and maltodextrin are compounded to obtain a wall material emulsion, and the wall material emulsion is prepared into the squalene and tocopherol composition microcapsule. Uniformly mixing the core material emulsion and the wall material emulsion, and performing a spray drying process to obtain the squalene and tocopherol composition microcapsule. The obtained microcapsule has good thermal stability and antioxidant activity, and can well protect active components.

The invention discloses an anti-aging composition containing PQQ and a preparation method of the anti-aging composition, and belongs to the field of medicines or health food, the anti-aging composition comprises PQQ, an antioxidant, collagen, hyaluronic acid and a plant extract, and the content of PQQ is 0.1-5%; 1%-10% of collagen; 0.05%-2% of hyaluronic acid; the antioxidant comprises the following components in percentage by weight: 0.5%-5% of vitamin C, 0.1%-3% of alpha-tocopherol and 0.05%-2% of beta-carotene; the composition contains PQQ and various antioxidants such as vitamin C, alpha-tocopherol, beta-carotene, coenzyme Q10 and glutathione, and the components have a synergistic effect, so that free radicals can be effectively removed, oxidative damage can be reduced, and cell aging can be delayed; most of the components in the composition are natural substances or are widely applied to the fields of food and health care products, the safety is high, and the quality and safety of the product can be ensured through the steps of strict preparation process control, accurate component dissolving method, pH value adjustment, filtration and the like.

The invention relates to the technical field of rice bran processing, and discloses a rice bran degreasing and nutrition retention edible process synergistic treatment method which comprises the following steps: (a) in an NADES-aqueous solution medium, adding an immobilized catalyst A, and hydrolyzing ferulate bonds and phospholipids in rice bran at low temperature; (b) carrying out intermediate dehydration on the slurry obtained in the step (a) to reduce the water activity; (c) adding an immobilized catalyst B into the dehydrated slurry in the step (b), carrying out esterification reaction, and grafting free ferulic acid generated by hydrolysis to glyceride in situ; and (d) carrying out solid-liquid separation on the slurry obtained in the step (c) to obtain finished oil and finished powder. According to the method, an NADES medium is adopted to replace an organic solvent, the whole process is carried out at low temperature, degradation of heat-sensitive nutrient substances is avoided, and resource utilization of ferulic acid is achieved. The prepared functional rice bran oil is rich in feruloyl glyceride, total tocopherol and oryzanol, and is low in acid value and peroxide value.

This invention discloses a recombinant collagen liposome, its preparation method, and its application. The recombinant collagen liposome comprises 1-10 parts recombinant type XVII collagen, 2-15 parts soybean lecithin, 0.3-2 parts tocopherol, 0.5-7 parts antioxidant, 20-54 parts glycerol, and Dendrobium officinale enzymatic hydrolysate to a total weight of 100 parts. This invention improves the stability and transdermal absorption of recombinant type XVII collagen by encapsulating it in liposomes. The prepared recombinant collagen liposomes not only have a high encapsulation efficiency but also retain excellent barrier repair and anti-wrinkle effects after 8 weeks of storage, making them suitable for use in cosmetics.

They are prepared by a high energy method (e.g. by sonication) from: an oily solution of edible oils (e.g. high-oleic sunflower oil) as solvent, with melatonin (e.g. 100 μM) and edible fat-soluble antioxidant agents (e.g. 100 μM α-tocopherol), and an aqueous solution of edible water-soluble stabilizing agents (e.g. dextrin 1% w / v). These formulations, applied externally (e.g. by spraying) are useful for preharvest application and / or postharvest preservation of fruits or vegetables, particularly of stone fruits, and specifically of sweet cherries. In two varieties of sweet cherries and two varieties of plums, preservations with the formulations are significantly better than those reached with aqueous solutions of melatonin, or with a commercial formulation, or in the absence of treatment.

The invention relates to a method for extracting two tocopherol derivatives A and B from epimedium sagittatum and application of the two tocopherol derivatives A and B, which can effectively solve the problem of preparing the tocopherol derivatives A and B from the epimedium sagittatum and realizing the application of the tocopherol derivatives A and B in preparing anti-breast tumor drugs, and the method comprises the following steps: crushing the overground part of the epimedium sagittatum, carrying out reflux extraction with ethanol, carrying out reduced pressure recovery to obtain an extract, extracting, and carrying out chromatographic separation to obtain the two tocopherol derivatives A and B; and carrying out gradient elution, reduced-pressure recovery, thin-layer point plate detection, merging, purification, collection of fractions within retention time, and drying to obtain the product. The raw materials are rich, the preparation method is easy to operate, the obtained product is good in quality and good in use effect, the pharmaceutical composition can be effectively used for treating breast cancer, application in preparation of anti-breast cancer drugs is achieved, the medicinal value and commercial value of epimedium sagittatum are developed, and the pharmaceutical composition has remarkable economic and social benefits.

The invention discloses a freeze-dried human rabies vaccine and a preparation method thereof, and belongs to the technical field of viral vaccines. The method comprises the following steps: (1) cell culture; (2) virus inoculation; (3) harvesting viruses; (4) concentration and purification: clarifying the harvested virus liquid through a filter, carrying out ultrafiltration concentration through an ultrafiltration membrane to obtain a concentrated solution, and purifying by adopting a column chromatography to obtain a chromatographic solution; (5) preparing a stock solution: inactivating and hydrolyzing the chromatographic solution to obtain a virus inactivation solution, and adding human serum albumin into the virus inactivation solution to obtain the stock solution; (6) preparing a semi-finished product: diluting with a stabilizer to prepare the semi-finished product, wherein the stabilizer comprises the following raw materials: human serum albumin, araboxylan, L-arginine hydrochloride, casein phosphopeptides, alpha-tocopherol nicotinate, a solvent and the like; and (7) preparing a finished product. The rabies vaccine disclosed by the invention is excellent in quality and stable in immune efficacy, and liquid is clear after redissolution.

The invention discloses cosmetic oil with whitening, soothing and anti-aging effects and a preparation method of the cosmetic oil. The plant essential oil is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of sunflower seed oil, 0.01 to 0.05 part of lupinus albus seed extract, 0.0001 to 0.001 part of tocopherol, 0.01 to 0.05 part of rosemary leaf extract, 0.001 to 0.1 part of dimethyl methoxy benzodihydropyranol, 50 to 90 parts of caprylic / capric triglyceride, 0.01 to 0.2 part of ascorbyl tetraisopalmitate, 0.01 to 0.2 part of bisabolol, 5 to 20 parts of squalane, 2 to 8 parts of simmondsia chinensis seed oil, 5 to 15 parts of meadowfoam seed oil and 0.1 to 1 part of lavender oil. And 0.3-1 part of a centella asiatica extract. According to the cosmetic oil product provided by the invention, by optimizing the use of substances, the composition has triple effects of whitening, relieving and resisting aging, can meet multiple skin care requirements of consumers at the same time, and is wide in market application range.

The invention discloses a self-emulsifying adjuvant of a vaccine and a preparation method of the self-emulsifying adjuvant, and relates to the technical field of vaccine adjuvants. The adjuvant comprises an oil phase, an emulsifier and a freeze-drying protective agent, the oil phase comprises squalene and tocopherol, the emulsifier comprises polysorbate and a polyoxyethylene-polyoxypropylene block copolymer, and the freeze-drying protective agent comprises sugar and sugar alcohol. The preparation method comprises the following steps: emulsifying an oil phase and a water phase to form a nano-emulsion, and then freeze-drying to obtain freeze-dried powder. The adjuvant has the advantages of small particle size, uniform distribution, high stability, rapid reconstruction and the like, and can effectively maintain active components and improve the immune effect of vaccines.

The invention provides pet tear stain eye drops containing haematococcus pluvialis extract, the pH value of the eye drops is 6.8-7.2, the osmotic pressure is 280-320 mOsm / kg, the viscosity is 3-8 mPa.s (25 DEG C), and the eye drops comprise the following components in percentage by mass: 0.05-0.5% of haematococcus pluvialis astaxanthin extract (based on the astaxanthin content being greater than or equal to 5%), 0.05-0.5% of a pH regulator (based on the astaxanthin content being greater than or equal to 5%), and the balance of water. 1%-3% of an anti-inflammatory plant compound; 0.5%-1.2% of an isoosmotic adjusting agent; 0.2%-0.8% of a nano carrier stabilizer; 0.01%-0.1% of a pH buffer agent; compared with the prior art, the invention has the following beneficial effects: the corneal permeability of the astaxanthin is increased to 82% (measured by a Franz diffusion cell) through PLGA coating, and is increased by 5.5 times compared with the corneal permeability of the astaxanthin in a free state (15%); natural tocopherol is reserved through supercritical CO2 extraction (the content of the natural tocopherol is larger than or equal to 0.5% through HPLC detection), and the retention rate of the astaxanthin stored at 40 DEG C for 90 days is larger than or equal to 90% through Calendula quercitrin inhibits the expression of IL-6 (enzyme-linked immunosorbent assay (ELISA) detection is reduced by 76%), and chamomile bisabolol blocks a COX-2 pathway.

The invention relates to a compound feed capable of improving summer high-temperature resistance of haliotis diversicolor and a preparation method of the compound feed, and belongs to the field of aquatic feed. The compound feed disclosed by the invention is prepared from the following raw materials: dl-alpha-tocopherol and selenium-enriched yeast. The green disc abalone compound feed comprises the following basic components: fish meal, soybean meal, vital gluten, high gluten flour, fish oil, soybean lecithin, composite vitamins, composite minerals, beer yeast, kelp powder, vitamin C, choline chloride, sodium alginate, monocalcium phosphate, ethoxyquin and microcrystalline cellulose. Dl-alpha-tocopherol and selenium-enriched yeast are added as additives on the basis of the basic raw materials. The invention further provides a preparation method of the green disc abalone oversummer feed. The prepared finished feed can reduce the accumulative death rate of the green disc abalone in the summer culture period, and solves the problem of safe summer crossing of the green disc abalone.

The invention discloses a qualitative and quantitative detection method for vitamin A and vitamin E in food. The qualitative and quantitative detection method comprises the following steps: step 1, pre-treating a sample and accurately adding an isotope internal standard: adding d6-alpha-tocopheryl acetate and d8-retinol acetate into the sample before saponification and preparing a blank matrix; 2, pre-treatment parameter QbD-DOE collaborative optimization, wherein a response surface method is adopted for conducting center composite design on the saponification temperature, time and BHT concentration, and the interaction effect of all the factors is analyzed to determine an optimal operation window; step 3, intelligently optimizing chromatography-mass spectrometry conditions and tuning parameters; step 4, constructing a matrix matching calibration curve and performing WLS quantitative analysis: performing gradient dilution on a standard substance by utilizing a blank matrix extracting solution, adding an isotope internal standard to prepare a 5-7-point matrix matching calibration curve, fitting the curve by adopting a weighted least square method, and verifying the correlation and intercept change of the calibration curve every day; and 5, multi-dimensional qualitative confirmation and intelligent diagnosis system operation.

The invention belongs to the technical field of food processing and food additives, and discloses capsanthin nano-emulsion, jelly and a preparation method thereof. The preparation method of the capsanthin nano-emulsion comprises the following steps: adding capsanthin and DL-alpha-tocopherol into an emulsifier solution, stirring and dissolving to obtain an oil phase solution; ascorbic acid is added into water to be stirred and dissolved uniformly, and a water-phase solution is obtained; the oil phase solution and the water phase solution are fully mixed and then subjected to ultrasonic treatment, and the capsanthin nano-emulsion is obtained. And adding the nano emulsion into a jelly solution to obtain the paprika red pigment jelly. The preparation method is simple to operate, the raw materials are easy to obtain, the cost is low, the solubility, the light stability, the heat stability and the metal ion stability of the capsanthin in emulsion and jelly can be remarkably improved, degradation and fading of the capsanthin due to light, heat and metal ions can be effectively inhibited, and the capsanthin has a good application prospect in the food industry and related fields.

The invention relates to an auxiliary lipid molecule containing a tocopherol structure, a lipid nanoparticle containing the auxiliary lipid molecule and application of the auxiliary lipid molecule. Specifically, the invention provides an auxiliary lipid molecule containing tocopherol and a derivative structure thereof as shown in a formula (1), a lipid nanoparticle containing the auxiliary lipid molecule, and a preparation method and application of the auxiliary lipid molecule. Compared with auxiliary lipid molecules conventionally used in the field, the lipid nanoparticles prepared from the auxiliary lipid molecules shown in the formula (1) can significantly improve the delivery efficiency and expression of nucleic acid. # imgabs0 #

The invention discloses a compound microorganism freeze-drying protective agent, a preparation method of the compound microorganism freeze-drying protective agent and a use method of the compound microorganism freeze-drying protective agent. Comprising the following raw materials in parts by weight: 0.03 part of disodium ethylene diamine tetraacetate, 5 to 15 parts of trehalose, 2 to 5 parts of sorbitol, 0.5 to 2 parts of ascorbic acid, 0.05 to 0.2 part of N-acetyl-L-cysteine, 0.1 to 0.5 part of polylactic acid-glycolic acid copolymer, 0.01 to 0.05 part of alpha-tocopherol and 1 to 3 parts of bentonite. The PLGA, the alpha-tocopherol and the NAC construct a three-stage synergistic anti-oxidation system from outside to inside: the PLGA is externally blocked, so that rapid consumption of an antioxidant is avoided, and slow release is realized; the alpha-tocopherol realizes oxidative damage repair of cell membranes; nAC maintains the internal reduction environment of cells, reduces oxidative stress and can regenerate alpha-tocopherol at the same time, and reutilization of resources is achieved.

Disclosed is a method of reducing fine lines or wrinkles on skin. The method can include applying a topical skin care composition to skin with fine lines or wrinkles. The composition can include lactobacillus ferment, ascorbyl glucoside, Terminalia ferdinandiana fruit extract, Helianthus annuus (Sunflower) seed extract, glycerin, Persea gratissima (avocado) oil, Butyrospermum parkii (shea) butter, coco-caprylate / caprate, Sclerotium gum, sodium benzoate, and tocopherol.

The invention discloses repairing nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. Comprising the following components in percentage by weight: 1.0 to 5.0 percent of an emulsifier, 1.0 to 5.0 percent of squalane, 2.0 to 10.0 percent of an emollient, 3.0 to 10.0 percent of glycerol, 3.0 to 10.0 percent of butanediol, 0.5 to 3.0 percent of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 3.0 percent of a vetiver root extract, 0.5 to 3.0 percent of a codium tomentosum mixture, 0.5 to 3.0 percent of sodium stearoyl glutamate, 0.1 to 1.0 percent of trihydroxy palmitamide hydroxypropyl myristyl ether, 0.1 to 1.0 percent of xiangyan, 0.1 to 1.0 percent of rape sterols, 0.1 to 1.0 percent of safflower oleosome and the balance of water. The skin care product is prepared from the following components in percentage by weight: 0.1 to 1.0 percent of 5HA hyaluronic acid, 0.05 to 0.5 percent of sickle pod hematoxylon bark extract, 0.05 to 0.5 percent of cornflower extract, 0.1 to 1.0 percent of tocopherol, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.03 to 0.1 percent of essence, 0.5 to 2.0 percent of preservative and the balance of deionized water, wherein the total percentage is 100 percent. The nano-emulsion prepared by the invention can help the absorption of active matter components, improve the problems of skin dryness, roughness, desquamation, sensitivity and the like, enhance the water locking capacity of the skin and repair the skin barrier.

The present invention specifically relates to an anti-cracking and repairing composition containing artemisia annua and camellia seed oil, and its preparation and application, belonging to the technical field of cosmetics. The composition of the present invention is prepared by using allantoin, phenoxyethanol, ethylhexylglycerin, artemisia annua extract, urea, tocopherol, camellia seed oil, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, portulaca oleracea extract, taraxacum extract, grape seed oil, squalane, caprylic / capric triglyceride, bis(lauroyl glutamine) lysine sodium, glycerin, butanediol, carrageenan, sodium carboxymethyl cellulose and water. The cooperation among the raw materials enables the composition to have excellent anti-chapping, skin repairing and nursing, and anti-inflammatory and soothing effects, and at the same time has good stability and safety effects.

The present invention relates to an injectable pre-formulation comprising:a) at least one of a mono-, di- or tri-acyl lipid and / or a tocopherol;b) optionally at least one phospholipid;c) at least one biocompatible, organic solvent; andd) at least one prostacyclin analogue or a salt thereof;wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. Such compositions may additionally comprise polar co-solvents. Methods of treatment, particularly for management of pulmonary artery hypertension (PAH), severe PAH, Raynaud's disease, ischemia and related conditions are provided, as well as corresponding uses of the compositions. Administration devices comprising the formulations and kits comprising the devices are also provided.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention aims to provide a microbial feed additive for preventing zearalenone poisoning, which can obviously improve the reproductive performance and growth performance of livestock and poultry and enhance the immunity of animals. The composite microbial agent mainly comprises the following components in parts by weight: 1-5 parts of DL-alpha-tocopheryl acetate, 1-3 parts of superoxide dismutase (SOD), 5-10 parts of coated vitamin C and 82-93 parts of a bacillus subtilis microbial agent. 100 parts by weight of feed contains 0.005-0.01 part by weight of the feed additive disclosed by the invention. The embodiment 1 of the invention is preparation of bacillus subtilis for degrading ZEA, and the embodiment 2 of the invention is preparation of the microbial feed additive according to the content of the invention. The embodiment 3 is a detoxification experiment of the microbial feed additive on the ZEA in the young sow feed. An embodiment 3 verifies that the traditional Chinese medicine composition can well prevent the problems of reproductive disorder, low production capacity, reduced immunity and the like caused by ZEA poisoning of young sows.