229 results about "Topical agents" patented technology

Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and / or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The present invention relates to acne and rosacea compositions by a six-prong synergistic combination treatment strategy that includes (1) control of excess sebum production, (2) control of undesirable bacteria or mites, (3) control of inflammation, (4) enhanced desquamation of follicular infundibulum cells, (5) reduction of irritation from anti-acne or rosacea compositions themselves, and (6) enhancement of the topical bioavailability of anti-acne and rosacea compositions. This is achieved by a synergistic combination of commonly utilized topical anti-acne and rosacea ingredients with a topical bioavailability enhancement composition, which results in enhanced anti-acne and rosacea action from such ingredients. Moreover, additional inclusion of an anti-inflammatory composition, and also a vascular micro-circulation enhancement composition, further results in synergistic superior anti-acne and rosacea benefits from such compositions. The present invention discloses additional surprising synergistic combinations for the control of acne and rosacea that are suitable for a variety of delivery systems and packaging forms.

A method and apparatus for treatment of skin or other tissue, using a source of thermal, electromagnetic radiation, electrical current, ultrasonic, mechanical or other type of energy, to cause minimally-invasive thermally-mediated effects in skin or other tissue which stimulates a wound-healing response, in conjunction with topical agents or other wound healing compositions, for application on the skin or other tissue which accelerate collagenesis, such as in response to wound healing. The dosage and time period of application of the compositions are adjusted to prevent external or surface tissue damage.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

Various embodiments described herein promote accelerated healing of a wound. For example, in some embodiments, a gas emitter, such as an oxygen emitter, and a therapeutic agent, such as a zeolite, are positioned proximal to a wound. In some embodiments, the therapeutic agent is dispersed or contained in a substrate or pouch removably attached to the gas emitter. The therapeutic agent can be a topical agent configured to make contact with the wound during therapy.

Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and / or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The invention relates to a medical coating layer coated on the gasbag surface of a balloon pipe which can release the narrowing of blood vessel and reduce free radical damage after operation, belonging to the field of the medical instruments, which comprises 1% to 99% of medicine and 1% to 99% of medical carrier, wherein the medical comprises a single oxidation resisting medicine, or a mixture of a plurality of oxidation resisting medicines, or a mixture of a single or a plurality of oxidation resisting medicines with blood vessel narrowing resisting medicines; the medicines are evenly coated on the surface of the gasbag all together or layer by layer. The medical coating layer coated on the gasbag surface of a balloon pipe has the advantages that through local medication the damage to human cells and organizations after blood transfusion due to myocardial ischemia can be effectively released and reduced and the cardiac dysfunction can be finally cured.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-alpha-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

The present invention relates to pharmaceutical compositions of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle and / or to pharmaceutical compositions utilizing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle or as a solvent system in preparation of such pharmaceutical compositions. The pharmaceutical compositions of the present invention are safe, non-toxic, exhibits enhanced physical stability compared to conventional formulations containing such pharmaceutical actives and are suitable for use as injectables for intravenous and intramuscular administration, as well as for use as a preformed solution / liquid for filling in and preparation of capsules, tablets, nasal sprays, gargles, dermal applications, gels, topicals, liquid oral dosage forms and other dosage forms.

This invention relates to a method of treating otitis externa, and in particular otitis externa of fungal etiology, using topical medication, including antifungal agents such as itraconazole and miconazole, and optionally also including a second antifungal agent, which is formulated for topical application to the external ear canal, preferably as an ear drop in liquid form.

The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents / moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.

Systems and methods herein are developed which enable modification of an initial customized cosmetic product, wherein the initial customized cosmetic product is created based on an initial customized cosmetic product specification or an existing specification of a non-custom product. One such system and method for making a custom cosmetic product from an existing non-custom cosmetic product is configured to be capable of: characterizing a non-custom product with a known key comprised of at least one search component; providing user interaction to modify at least one of the at least one search components in this key to create a modified key; and using the modified key to produce custom product which may include determining manufacturing instructions. Such systems and methods may incorporate a custom or non-custom product attribute data base for providing product attribute data for modification and adjustment of the user search key using an adjustment service. Also incorporated herein are applications based on user interaction through two-dimensional complexion color maps derived using data associated with skin color, tone, morphology and / or biochemistry from a plurality of users.

The invention relates to a medical instrument field, in particular to a medicine coating layer of blood vessel support of degradation polymer with anti-coagulant phosphoric acid choline ingredient. The medicine coating layer is formed by 1 percent to 50 percent medicine and medicine carrier of 50 percent to 99 percent degradation polymer with anti-coagulant phosphoric acid choline ingredient. The medicine can choose individual oxidation resisting medicine, mixture of diverse oxidation resisting medicines, mixture of single or diverse blood vessel restenosis medicines, mixture of single or diverse oxidation resisting medicine and blood vessel restenosis medicine composition. The medicine carrier is a copolymer of three macromolecules of polylactic acid (PDLLA), polyethylene glyco and phosphoric acid choline. And the medicine and medical biological degradation polymer are coated uniformly on the surface of the blood vessel support by the mixing or stratification coating method. According to local medication, the thrombus incidence rate can be effectively eased and reduced, so that the restenosis of coronary artery can be finally cured.

The invention provides a Secnidazole vaginal effervescent tablet and its production method which comprises active constituent Secnidazole and effervescent tablet findings, wherein the Secnidazole amounts to 25-60% of the total weight.

The invention relates to a degradation blood vessel bracket drug coating layer, belonging to the technical field of medical instrument, which can depress late thrombosis incidence. The drug coating layer comprises the following materials: drug 1 to 50 percent and drug carrier 50 to 99 precent, which is characterized in that: the drug can be selected from a single antioxidation resisting drug, or mix of various antioxidation resisting drugs, or mix of a single or various anti-vascular restenosis drugs, or mix of a single or various antioxidation drugs and restenosis drugs. The drugs and medical bioceramics degradation polymer are uniformly coated on the surface of the blood vessel bracket adopting the mix or stratification method of application. The drug coating layer has the advantages of effectively relaxing and depressing late thrombosis incidence by local usage of medicine, and thus realizing the cure of coronary restenosis.

The present invention provides novel compositions which comprise sodium hypochlorite, sodium, chloride, both organic and inorganic trace minerals in hypertonic condition presented in the forms of a clear aqueous solution (low or high concentrations for further reconstitution with purified water to obtain the final ready-to-use solution), gel or salve, lotion, wet pad, wet foam, ointment, stick, and dry mixture solution, for local application for the purposes of cleansing, disinfecting and inhibiting infection and promoting the natural healing of conditions such as fresh cuts, surgical stitches, chronic (diabetic gangrene) and acute wounds, herpes zoster, athlete's foot, and bed sores, without the necessity for covering up the wounds with gauzes / plasters nor any concurrent use of topical medication. These compositions are also suitable for the treatment of conditions such as unpleasant body odor, acne and mixed bacterial infection in the ear.

Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The present invention relates to pharmaceutical compositions of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle and / or to pharmaceutical compositions utilizing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle or as a solvent system in preparation of such pharmaceutical compositions. The pharmaceutical compositions of the present invention are safe, non-toxic, exhibits enhanced physical stability compared to conventional formulations containing such pharmaceutical actives and are suitable for use as injectables for intravenous and intramuscular administration, as well as for use as a preformed solution / liquid for filling in and preparation of capsules, tablets, nasal sprays, gargles, dermal applications, gels, topicals, liquid oral dosage forms and other dosage forms.

Stable whiteness is provided by adding stabilizers to a topical anti-aging, anti-oxidant sunscreen or skin care formulation containing Tinosorb S and other optional ingredients, including CoQ10. The formulation will not stain clothing or other fabrics.

Method and apparatus are disclosed for applying a therapeutic amount of a non-systemic vasoconstrictor inside the uterus to control abnormal uterine bleeding. The abnormal bleeding can be due to excessive menstrual blood flow, bleeding from a surgical procedure, postpartum bleeding or any other acute or chronic condition. The vasoconstrictor includes topical agents such as an alpha-adrenergic agonist, for example oxymetazoline. The delivery system can include a catheter having means for retaining position of a distal portion within the uterus. A proximal portion can extend outside of the body for coupling to a vasoconstrictor source, or alternatively, the proximal portion can terminate within the vaginal canal and include a docking port for coupling to a source of vasoconstrictor that is inserted therein. In other embodiments, an applicator is disclosed that is positioned in fluid communication with the lumen of the cervix and allows application of a vasoconstrictor therein.

The present invention discloses an applicator system comprising a handle, and an applicator removably attached to the handle via an adaptor hole, where an adaptor nipple is centrally located on the applicator, the adaptor nipple being capable of removably connecting to the adaptor hole. An interchangeable topical agent applicator kit comprises an applicator, a handle, a screen, a spreader, and a lid. Further disclosed is a method for interchangeably reusing a topical applicator, comprising removing an applicator from a handle, cleaning the applicator, reattaching the applicator on the handle, and loading the applicator with a topical agent.

A method and a system are described herein for preparing a custom cosmetic formulation. The system includes a controller in electronic communication with an order management system, wherein the order management system stores user-specific data including data related to a custom cosmetic formulation and components thereof, a plurality of valves for receiving pressurized fluid, the plurality of valves in electronic communication with the controller; a plurality of dispensers, each having a valve for metering fluid in predetermined quantities, and each having a dispensing head having a nozzle, each nozzle comprising a nozzle tip on a distal end thereof, wherein the nozzle tips are arranged so as to dispense a fluid into an inlet of a product receptacle, the dispensers in electronic communication with a data port; a measuring device in electronic communication with the controller, the measuring device capable of capturing data related to dispensed fluids from each of the plurality of dispensers and transmitting the data to the controller; a barcode scanner for reading order-specific instructions; a user interface for operator communication with the order management system and with the controller; a plurality of fluid conduits for introducing fluid to the dispensers; a fluid delivery apparatus for delivery of components of a custom cosmetic component to the dispensers; and a pressure source for pressurizing fluid in the fluid delivery apparatus for delivery of fluid from the fluid delivery apparatus to the plurality of dispensers.

A method and apparatus for treatment of skin or other tissue, using a source of thermal, electromagnetic radiation, electrical current, ultrasonic, mechanical or other type of energy, to cause minimally-invasive thermally-mediated effects in skin or other tissue which stimulates a wound-healing response, in conjunction with topical agents or other wound healing compositions, for application on the skin or other tissue which accelerate collagenesis, such as in response to wound healing. The dosage and time period of application of the compositions are adjusted to prevent external or surface tissue damage.

The invention discloses traditional Chinese medicine preparations of an ointment, a suppository and a lotion containing pseudo-ginseng, rhubarb, rhizome of Chinese goldthread and cortex phellodendri and for treating hemorrhoid. The preparations comprise the medicines of pseudo-ginseng, rhubarb, rhizome of Chinese goldthread, cortex phellodendri, radix sophorae flavescentis, Radix sanguisorbae and menthol in a certain weight ratio. The medicines can be prepared into an ointment, a suppository and a lotion. The composition provided by the invention has the efficacies of clearing heat and removing dampness, relaxing bowels, dissipating binds, subsiding swelling, killing pain, stopping bleeding, dispersing blood stasis and promoting wound healing. The preparations are widely suitable for anal itching, eczema or constipation tenesmus caused by internal hemorrhoid bleeding, external hemorrhoid edema pain and mixed hemorrhoids, and unsmooth defecation, slow wound healing and edema pain discomfort after hemorrhoid operation, and have the advanategs of safety, effectiveness and no side effect. The invention adopts advanced ultrasonic extraction and ultrafine pulverization technologies in modern traditional Chinese medicine extraction, so that the preparations have high bioavailability and obvious treatment effect, and is a novel local medication for hemorrhoid.

An orally or topically administered composition capable of reducing inflammation in animals, preferably humans, suffering from inflammation, contains a therapeutically effective amount of a post-supercritical carbon dioxide alcoholic extract of ginger; therapeutically effective amounts of supercritical carbon dioxide extracts of rosemary, turmeric, oregano and ginger (preferably certified organic ginger); and therapeutically effective amounts of hydroalcoholic extracts of holy basil, turmeric, scutellariae baicalensis, rosemary, green tea, huzhang, Chinese goldthread, and barberry. The composition is preferably orally administered on a daily basis for at least about 4 weeks.