81 results about "Topical agents" patented technology

The invention discloses an adapalene external preparation and a preparation method thereof, and relates to the technical field of adapalene preparation preparation. The adapalene gel comprises the following raw materials in percentage by mass: 4.5-7.5% of adapalene, 3.5-8% of a gel base material, 2-4.5% of cellulose, 0.5-2% of a penetration enhancer, 18-25% of a water-retaining agent, 2-5% of a surfactant, a pH value regulator and the balance of water, the dosage of the pH value regulator is based on the standard that the pH value of the adapalene external preparation is regulated to 7-7.5; the gel base material comprises poloxamer or carbomer, and further comprises sa-hao seed gum, and the use amount of the sa-hao seed gum accounts for 25-35% of the total mass of the gel base material. According to the adapalene external preparation provided by the invention, the irritation of adapalene to the skin is basically eliminated by utilizing the effects of the gel base material consisting of poloxamer or carbomer and sa-hao seed gum and the surfactant; the adhesive has good cohesiveness and water-retaining property, can keep the affected part moist after being smeared, promotes medicine absorption, and avoids being wiped off or automatically falling off; the stability is improved, and the medicine slow release time is indirectly prolonged.

A new means of intradermal delivery of a useful component is provided. Disclosed are an external-use skin preparation composition comprising fine needlelike taurine crystals including a useful component in the crystals, and a method for producing a fine needlelike taurine crystal including a useful component in the crystal, the method comprising a step of growing a crystal in an environment in which an aqueous solution (A) containing taurine dissolved is mixed with or held in contact with a liquid substance (B) having low solubility of taurine, wherein the useful component is dissolved or dispersed in the aqueous solution (A) or the liquid substance (B), whereby the useful component is included in the crystal along with the growth of the crystal.

To provide a water-in-oil emulsion composition with superior moisturizing and protective effects for the purpose of alleviating and healing xerodermic conditions, and further to provide a dermatological topical agent that delivers a high healing effect in a short time.SOLUTION: An oil-in-water emulsion composition is prepared that contains human-type ceramides delivering a healing effect against xerodermic conditions in a short time, in addition to the moisturizing effect of heparinoids. The oil-in-water emulsion composition enables the production of a dermatological topical agent that delivers a high healing effect against xerodermic conditions in a short time, while overcoming the drawbacks of water-in-oil creams.SELECTED DRAWING: None

A fibrillin production promoter contains at least one pyrimidine nucleotide or precursor thereof as an active ingredient.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a minoxidil external preparation composition as well as a preparation method and application thereof. The invention provides a minoxidil external preparation composition. The minoxidil external preparation composition comprises minoxidil, finasteride, pharmaceutic adjuvants, organic acid, ethanol and water. By adding finasteride and pharmaceutic adjuvants, the treatment effect on alopecia is enhanced; by adding a proper amount of organic acid, the dissolution of minoxidil can be promoted in the absence of propylene glycol, so that the problem of replacing a propylene glycol solvent is solved. The minoxidil external composition prepared by the invention is stable, the treatment effect of the minoxidil external composition on alopecia is obviously higher than that of a solution only containing a minoxidil single component, and the minoxidil external composition does not contain a propylene glycol component, so that the occurrence of propylene glycol allergy is avoided. And the preparation method is simple, stable and good in reproducibility.

The present invention relates to a method for producing hyperoxygenated fatty acids (hereinafter HOFA), the method using an O2 concentrator with an atmospheric air flow rate entered of between 1 to 5 litres / minute, at room temperature and pressure, which is the main subject matter of the invention. The first subject matter of the invention, which is dependent on the main subject matter, are medicinal topical formulations using said HOFA as a carrier, and the second secondary subject matter is the method for producing topical agents for healing and / or preventing epidermis damage.

A topical agent for onychomycosis according to the present disclosure contains, as an active ingredient, at least one selected from the group consisting of compounds represented by formula (1) and salts thereof, and contains, as a solvent, any of the solvents indicated by solvents (a)-(g). Solvent (a): dibasic acid diester; solvent (b): lower alcohol and dibasic acid diester; solvent (c): lower alcohol and dimethyl sulfoxide; solvent (d): dimethyl sulfoxide and dibasic acid diester; solvent (e): lower alcohol, dimethyl sulfoxide, and dibasic acid diester; solvent (f): lower alcohol and glycol; and solvent (g): lower alcohol, glycol, and dibasic acid diester.

The invention relates to the substances benfo-oxythiamine and / or oxythiamine for use as the active ingredient of a topically administered medicament for the therapeutic treatment of patients with a disease of the body surface skin (cutis and subcutis) and / or one or more mucous membranes (mucosa) caused by viruses. The medicament is administered at a time when viral replication has already taken place and viral release from the host cell(s) is imminent.Benfo-oxythiamine and / or oxythiamine cause (I) a slowing or prevention of the spread mechanisms of the viruses, so that the viruses remain in their host cells after replication and cell damage in the patient organism (host organism) is reduced or prevented, and (II) an immune response against the viruses remaining in the cells, so that the patient's immune system is activated or reactivated to generate an effective immune response against the viruses.

The invention relates to (i) the prevention or treatment of a sleep disturbance, preferably in a patient having neuropathic pain; and / or (ii) the prevention or treatment of neuropathic pain in a patient having a sleep disturbance; and / or (iii) the prevention or treatment of neuropathic pain in a patient having been treated previously and / or being treated concomitantly with an analgesic medication for relief of neuropathic pain, preferably selected from antiepileptics, antidepressants and opioid analgesics, wherein the patient preferably has a sleep disturbance; in either cases by means of one or more high-concentration capsaicin and / or capsaicinoid topical dose units, preferably pharmaceutical patches, comprising capsaicin and / or capsaicinoid at a concentration of at least 2.5 wt.-%, relative to the total weight of dose unit.

To provide an external preparation that is well retained on a living body surface and is capable of increasing drug permeability.SOLUTION: The present invention provides an external preparation comprising a non-lamellar liquid crystal-forming lipid and a drug.SELECTED DRAWING: None

The present invention relates to a topical pharmaceutical composition of tyrosine kinase inhibitors for the prevention or treatment of posterior eye disease. The topical pharmaceutical composition of the present invention is useful to deliver a high concentration of an active pharmaceutical ingredient such as tyrosine kinase inhibitor in the posterior segment of the eye for example at a concentration of up to 10000 times higher than the IC50 value of the active pharmaceutical ingredient.

A method and a system are described herein for preparing a custom cosmetic formulation. The system includes a controller in electronic communication with an order management system, wherein the order management system stores user-specific data including data related to a custom cosmetic formulation and components thereof, a plurality of valves for receiving pressurized fluid, the plurality of valves in electronic communication with the controller; a plurality of dispensers, each having a valve for metering fluid in predetermined quantities, and each having a dispensing head having a nozzle, each nozzle comprising a nozzle tip on a distal end thereof, wherein the nozzle tips are arranged so as to dispense a fluid into an inlet of a product receptacle, the dispensers in electronic communication with a data port; a measuring device in electronic communication with the controller, the measuring device capable of capturing data related to dispensed fluids from each of the plurality of dispensers and transmitting the data to the controller; a barcode scanner for reading order-specific instructions; a user interface for operator communication with the order management system and with the controller; a plurality of fluid conduits for introducing fluid to the dispensers; a fluid delivery apparatus for delivery of components of a custom cosmetic component to the dispensers; and a pressure source for pressurizing fluid in the fluid delivery apparatus for delivery of fluid from the fluid delivery apparatus to the plurality of dispensers.

To provide a PARP1 inhibitor and its use.SOLUTION: PARP1 inhibitors and pharmaceutical compositions comprising such inhibitors are described herein. The subject compounds and compositions are useful for the treatment of cancer. The compounds described herein are administered to a subject in need thereof according to standard pharmaceutical practice, either alone or in combination with pharmaceutically acceptable carriers, excipients or diluents, in a pharmaceutical composition. In one embodiment, the compounds of the invention can be administered to an animal. The compounds can be administered orally or parenterally, including the intravenous, intramuscular, intraperitoneal, subcutaneous, rectal and topical routes of administration.SELECTED DRAWING: None

Systems and methods herein are developed which enable modification of an initial customized cosmetic product, wherein the initial customized cosmetic product is created based on an initial customized cosmetic product specification or an existing specification of a non-custom product. One such system for making a custom cosmetic product from an existing non-custom cosmetic product is configured to be capable of: characterizing a non-custom product with a known key comprised of at least one search component; providing user interaction to modify at least one of the at least one search components in this key to create a modified key; and using the modified key to produce custom product by evaluating a neighborhood of closest keys to determine manufacturing instructions. Further, a system to modify a custom product is configured to be capable of: specifying a custom cosmetic product by a known key comprised of at least one search component; providing user interaction to modify at least one search component in this key to create a modified key; and using the modified key to produce custom product by evaluating a neighborhood of closest keys to determine manufacturing instruction.

A method of enhancing the quality of a skin scar by topical application of an agent for improving scar quality is characterised in that said agent is pre-emptively applied to a potential surgical cutaneous site in advance of surgery, including surgery involving use of lasers. The topical agent may be a polyphenol, such as (-)-epigallocatechin-3-gallate (EGCG). Use of such a topical agent in advance of surgery leads to significant beneficial effects on dermal scarring by reducing mast cells, angiogenesis, skin thickness and simultaneously increasing elastin content. The topical agent may be applied directly or incorporated in a dressing, such as in a dermal patch comprising an adhesive silicone sheet, and can be worn both in the lead up to surgery and post-operatively.

To provide a skin topical agent composition containing a component highly effective in alleviating xerosis.SOLUTION: A skin topical agent composition comprises a heparin-like substance having a molecular weight distribution as determined by size-exclusion high-performance liquid chromatography at a measurement wavelength of 210 nm, the molecular weight distribution being as follows. (A) The proportion of components with a molecular weight of 20,000 or less is 35 to 70 mol%. (B) The proportion of components with a molecular weight exceeding 20,000 is 30 to 65 mol%.SELECTED DRAWING: Figure 1

Dermatological treatments and systems employing cooling, topicals, and / or abrasion are disclosed herein. The system can include a cold plate and a suspension assembly tip. The suspension assembly tip can be selectively coupleable to the cold plate. The suspension assembly tip can include a suspension tip and a suspension. The suspension tip can include a contact surface that can be contacted onto a patient's skin to provide a treatment. The suspension can couple to both the cold plate and to the suspension tip. The suspension can be thermally conductive so as to closely thermally couple the suspension tip to the cold plate, or the suspension tip can have a low thermal conductivity so as to not closely thermally coupled the suspension tip to the cold plate.

A skin treatment device is provided with a thermally modulated treatment head adapted for contact with a user or other subject's skin. The device includes one or more thermal elements adapted to modulate the temperature of the head, a power source adapted to provide current to the thermal elements, and a controller adapted to modulate the head temperature by controlling the current delivered to the thermal elements. A topical agent can be disposed between the treatment head and the subject's skin, where the temperature of the topical agent is modulated in response to the temperature thereof.

This product is a skin care glove made of a sheet of laminated nonwoven fabric and microfiber or nanofiber, and is formed by fusing the peripheral edges except for the wrist opening. The product is formed from a thin sheet that is translucent, and when worn on a hand that has been treated with a skin topical agent such as lotion, emulsion, or cream, it adheres closely to the skin, improving the fit and creating a transparent texture, as shown in the "Reference Photo Showing the Condition of Use." The product can be worn on either the left or right hand.

To develop a novel method for treatment of diseases leading to serious corneal and conjunctival epithelial damage resulting from functional impairment of corneal and conjunctival epithelial stem cells, including severe ocular surface disease attributable to chronic graft-versus-host disease.SOLUTION: The present invention provides a prophylactic or treatment agent for severe ocular surface disease for topical administration, comprising apocynin as an active ingredient.SELECTED DRAWING: None

The invention discloses a traditional Chinese medicine composition for treating lumbar disc herniation and sciatica. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: radix angelicae pubescentis, eucommia ulmoides, frankincense, myrrh and liquorice. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: herba cistanche, radix morindae officinalis, herba epimedii, fructus psoraleae, radix cyathulae, radix rehmanniae preparata, herba lycopodii, caulis spatholobi, cibotium barometz and herba pyrolae. The traditional Chinese medicine composition is further prepared from the following raw materials in parts by weight: rhizoma curculiginis, radix paeoniae alba, pawpaw, semen brassicae, semen cuscutae, rhizoma drynariae, oroxylum indicum, ivy gracilaria, obscured homalomena rhizome and rheum officinale. Compared with the prior art, the traditional Chinese medicine composition has the advantages that the compatibility is reasonable, when the traditional Chinese medicine composition is prepared into emplastrum and ointment, through external application and local medication, the medicine efficacy directly reaches the focus, the efficacy is concentrated, the symptoms of sciatica and lumbago can be rapidly eliminated, the lesion tissue of sciatica can be repaired, the root of neuralgia can be relieved, one-time curing is achieved, no toxic or side effect exists, and the traditional Chinese medicine composition is safe and reliable. The curative effect is obvious.

and salts thereof, and contains, as a solvent, any of the solvents indicated by solvents (a)-(g). Solvent (a): dibasic acid diester; solvent (b): lower alcohol and dibasic acid diester; solvent (c): lower alcohol and dimethyl sulfoxide; solvent (d): dimethyl sulfoxide and dibasic acid diester; solvent (e): lower alcohol, dimethyl sulfoxide, and dibasic acid diester; solvent (f): lower alcohol and glycol; and solvent (g): lower alcohol, glycol, and dibasic acid diester.

The purpose of the present invention is to develop a novel treatment method for diseases such as severe ocular surface diseases caused by chronic graft-versus-host disease, which cause severe corneal and conjunctival epithelial damage due to dysfunction of corneal and conjunctival epithelial stem cells. SOLUTION: The present invention provides a topically administered agent for preventing or treating severe ocular surface diseases, which contains apocynin as an active ingredient.

The invention discloses an emulsion type suppository practical for vaginal administration, and relates to the technical field of pharmaceutical preparations, the suppository is a solid at room temperature, and can be converted into a cream type preparation in situ under vaginal temperature and wetting conditions; the suppository is composed of active and pharmaceutically acceptable auxiliary materials, the auxiliary materials comprise structural lipid, an emulsifier, a gel matrix and a pH regulator, and a suppository body is softened at body temperature and mixed with body fluid to form a cream mixture easy to coat on the mucous membrane surface in situ. The transformation process avoids greasy feeling and local discomfort possibly brought by a traditional greasy suppository, and also eliminates the trouble that the prefabricated cream needs to be matched with a special administration device, so that the local medication experience of a patient is improved while the administration convenience is ensured. Besides, through reasonable selection of auxiliary materials, the cream formed through conversion can provide proper adhesion, and the retention time of the medicine at the action part can be prolonged.

A fibrillin production promoter contains at least one pyrimidine nucleotide or precursor thereof as an active ingredient.

It is an object of the present invention to provide a film-forming composition for skin (such as a film-type skin protectant or a film-type skin topical agent) that does not contain a lower monohydric alcohol such as ethanol or isopropanol, is excellent in quick-drying properties and water resistance, is less sticky, and is excellent in feeling of use. The present invention relates to a film-forming composition for skin which contains a specific acrylic polymer, a plasticizer and water and is substantially free of a lower monohydric alcohol such as ethanol or isopropanol. The composition of the present invention is extremely useful for treatment of chronic skin diseases (that is, skin diseases in which skin barrier function is deteriorated) represented by hand eczema, atopic dermatitis, and the like.

A method for analyzing the distribution of a component of a skin topical agent having permeated through the skin according to the present disclosure comprises: a first mapping step for bringing a skin topical agent containing a labeled component of interest into contact with the skin, and thereafter, preparing a tissue piece in a region including the stratum corneum of the skin, preparing slices that expose cross sections along the depth direction of the stratum corneum in the tissue piece, and mapping the distribution of ions detected from the slices using Nano-SIMS; a second mapping step for bringing the skin topical agent containing the labeled component of interest into contact with the skin, and thereafter, taking a sample from the skin by a tape-stripping method, and mapping the distribution of ions detected from the sample using the Nano-SIMS; and a determination step for determining the distribution of the labeled component of interest from the ion distribution obtained in the first mapping step and the ion distribution obtained in the second mapping step.

The invention relates to a traditional Chinese medicine extract with effects of clearing heat, diminishing swelling and relieving pain as well as a preparation method and application of the traditional Chinese medicine extract. The traditional Chinese medicine extract with the effects of clearing heat, diminishing swelling and relieving pain comprises geniposide, baicalin and berberine hydrochloride. The preparation raw materials comprise cortex phellodendri, radix scutellariae, fructus gardeniae and radix curcumae. The traditional Chinese medicine composition has the functions of clearing away heat and toxic materials, relieving swelling and pain, dispelling wind and eliminating dampness and promoting blood circulation to remove blood stasis, has strong and rapid anti-inflammatory, swelling and pain relieving effects, can rapidly relieve symptoms such as arthralgia, swelling and dysfunction caused by gouty arthritis, and effectively recovers the joint function; the compound can be used for preparing medicines for treating acute gouty arthritis. The medicine can be an external skin preparation such as emplastrum or gel, and is convenient to use.

Provided are a usage method for a topical agent composition and a topical agent composition that make it possible for an oil-soluble component of the topical agent composition to achieve effective penetration. According to the present invention, a usage method for a topical agent composition involves applying a topical agent composition that includes water and solubilized micelles that encapsulate an oil-soluble component in a surfactant to a body surface, applying energy to the body surface to which the topical agent composition has been applied from above the topical agent composition using a beauty apparatus, and allowing the solubilized micelles to penetrate in from the body surface.

This invention relates to a topical agent for preventing and treating poplar canker and its application method. The topical agent, by weight percentage, comprises the following ingredients: 0.1-0.2% pyraclostrobin; 1-3% wetting and dispersing agent; 0.2%-0.8% thickener; 2-4% antifreeze agent; 0.01%-0.3% micronutrient fertilizer; 0.1%-0.3% defoamer; and the balance being deionized water. Before application, first use a scraper to clean the ulcerated areas on the poplar branches and trunks, thoroughly scraping away the rotten tissue, extending 2-3 cm beyond the diseased area on both the upper and lower surfaces. Then, evenly and promptly apply the topical agent to the treated wound surface, cover it with breathable non-woven fabric, and then apply another layer of topical agent over the non-woven fabric, ensuring close adhesion to the branches and trunk. The topical agent of this invention is simple to use, highly effective, and can effectively control canker, reduce the impact on poplar growth, and achieve efficient prevention and treatment of poplar canker.