27 results about "Caffeic acid" patented technology

The present application relates to the technical field of medicine, and particularly relates to a drug composition with a sequential synergistic repair effect and a preparation method and application thereof. The drug composition comprises liposome I encapsulating caffeic acid and liposome II encapsulating BH4; the liposome I is a ROS-responsive liposome, can specifically respond in a high ROS microenvironment, and then realize on-demand release of caffeic acid; meanwhile, the liposome II protects BH4 from entering cells to play a role, can effectively overcome the defects of difficult dissolution of caffeic acid and easy oxidation of caffeic acid and BH4, can improve the bioavailability of the two drugs, can realize sequential release of caffeic acid and BH4, and can play a synergistic treatment effect on different mechanisms of occurrence of radioactive skin damage, and provides a sequential synergistic repair strategy for clinic. The liposome I and the liposome II are both prepared by a thin film hydration method, and the operation is simple, the conditions are mild, the lipid film is uniformly formed, and the encapsulation rates of caffeic acid and BH4 are high.

A method for preparing silkworm pupa active peptide microcapsules and their applications are disclosed. In a microfluidic focusing droplet generation chip, an aqueous phase is injected into the chip through the main channel, and an oil phase is injected through two side channels. The resulting microdroplets are collected in the collecting phase to form microcapsules. The filter membrane has a pore size of 0.1-1 μm. The aqueous phase consists of sodium alginate and silkworm pupa protein peptides; the oil phase consists of one of mineral oil, soybean oil, silkworm pupa oil, corn oil, peanut oil, rapeseed oil, and lard; the collecting phase consists of caffeic acid-grafted chitosan and calcium chloride dissolved in acetic acid. By optimizing the formulation and process, droplets with good dispersibility in oil, uniform morphology and size, and good stability are prepared.

This invention relates to the field of adhesive technology, and discloses an environmentally friendly biomass-based underwater adhesive, its preparation method, and its applications. The adhesive is prepared by one-step melt copolymerization of three biomass raw materials: lipoic acid, caffeic acid, and cysteine. This system utilizes the ring-opening polymerization of lipoic acid to form a dynamic disulfide bond network providing cohesive force, the catechol groups of caffeic acid to provide various interfacial interactions with the substrate, and the thiol groups of cysteine ​​to simultaneously participate in network construction and inhibit catechol oxidation, thereby synergistically achieving high-strength and durable underwater adhesion. The adhesive achieves an underwater adhesion strength of up to 5.5 MPa on iron sheets, remains stable in various acid, alkali, and salt environments, and can be repeatedly recycled through hot melting. This invention uses entirely bio-based raw materials, employs a simple and non-toxic process, and is suitable for underwater remediation, marine engineering, and other fields.

This invention discloses a cultivation method for improving the drought resistance of sugar beet trees, belonging to the field of agricultural cultivation technology. Caffeic acid is sprayed onto both the front and back leaves of sugar beet trees in arid environments, and biochar is added to the cultivation soil. This invention achieves synergistic effects through the combined application of biochar and caffeic acid, using multi-target regulation. The improved water and nutrient supply provided by biochar provides a physiological basis for the antioxidant effect of caffeic acid, while the protection of photosynthetic structures by caffeic acid enhances the root system's utilization efficiency of the biochar-modified substrate, forming a positive feedback mechanism for multi-dimensional stress relief. The sugar beet cultivation method of this invention has proven to be highly effective in achieving high yield, high quality, and synergistic improvement in stress resistance.

Nanoparticle system comprising a metal, coated with polyethylene glycol (PEG), which is functionalized with a polyphenol-type organic acid, manufacturing procedure and use of said system. The present invention relates to a nanoparticle system comprising a metal selected from silver and gold, coated with polyethylene glycol (PEG), which is functionalized with a polyphenol-type organic acid selected from caffeic acid, gallic acid, and ferulic acid. The present invention also relates to a process for manufacturing said nanoparticle system and to the therapeutic and cosmetic use of said nanoparticle system.

The present application relates to the technical field of pharmaceutical compositions, and provides a composition for improving immune function, a preparation and a preparation method and application thereof, comprising: 25-40% of chlorogenic acid, 5-12% of luteolin, 10-20% of isochlorogenic acid A, 3-8% of caffeic acid, 0.5-1% of a targeting ligand, 2-5% of a microecological component, and 5-8% of a nano-carrier, and application of the composition in preparation of medicines, health products and functional foods for improving immune function, and a preparation method of the above-mentioned medicine preparation, comprising the following steps: preparing a core particle; coating the core particle with a sustained-release enteric coating to obtain a microcapsule particle; filling the microcapsule particle into a capsule shell to obtain an enteric capsule; coating the enteric capsule with a stomach-dissolving coating liquid to obtain a capsule preparation; and achieving the effect of improving the whole gastrointestinal immune function by rapidly targeting anti-inflammation in the stomach and continuously targeting regulation in the intestinal tract, and greatly improving the action efficiency and immune regulation effect of the preparation.

The present invention relates to a recombinant microorganism, preferably a recombinant yeast, capable of producing caffeic acid comprising a heterologous gene coding for an enzyme of the hydrolase family capable of breaking, preferably of hydrolyzing, the caffeoyl-shikimate bond to produce caffeic acid from caffeoyl-shikimate. Said microorganism, preferably said recombinant yeast, may also be capable of producing ferulic acid from the caffeic acid obtained. The present invention also relates to a method for producing caffeic acid and a method for producing caffeic acid and / or ferulic acid, using microorganisms, preferably yeasts, according to the invention. Finally, the invention also relates to the use of microorganisms, preferably yeasts, according to the invention to produce caffeic acid and / or ferulic acid.

This invention relates to a recombinant construct comprising: one or more TMV Ω enhancers; and a group of fluorescent factors configured to enable an organism or its tissues or cells to emit bioluminescence; the recombinant construct is configured to increase the biosynthetic content of caffeic acid in an organism or its tissues or cells, or to increase the bioluminescence intensity of an organism or its tissues or cells. This application, by introducing TMV Ω enhancers, achieves precise regulation of these two key genes, significantly improving bioluminescence intensity and solving the problems of poor targeting and limited synergistic effects of enhancer applications in existing technologies.

The application belongs to the technical field of antioxidant drug development, and discloses a caffeic acid derivative, a preparation method and application thereof. The caffeic acid derivative is a compound shown in formula 2 or a pharmaceutically acceptable salt thereof, and a solvate of the compound shown in formula 2 or the pharmaceutically acceptable salt thereof. The caffeic acid derivative is a novel compound, and the compounds are designed and successfully synthesized for the first time, and the structures thereof are characterized. The preparation method of the caffeic acid derivative is simple, convenient to operate, and capable of rapidly synthesizing the compounds. Research finds that the caffeic acid derivative has good antioxidant activity, and has a good application prospect in the treatment of oxidative stress.

The group of inventions relates to the field of processing oily raw material, and more particularly to a novel product in the form of a protein-sugar hydrolysate (PSH) obtained from sunflower meal, a method for producing same by enzymatic hydrolysis, and PSH-based food and feed products. The PSH contains 40-70% protein, 20-40% sugar, and at least 0.02% caffeic acid in free form or in bound form as part of chlorogenic acid isomer molecules. In addition, the PSH has a total branched-chain amino acid content of at least 30 g / kg of the final product (PSH), and an arginine content of at least 20 g / kg PSH. The resulting PSH does not contain antinutrients and serves as an excellent substitute for animal protein in food products and in diets for aquatic organisms, livestock and domestic pets. The claimed novel method is safe, environmentally-friendly, waste-free and allows flexibility in terms of the operations and ingredients used in the production process.

This invention belongs to the field of semiconductor photocatalysis technology, specifically relating to a modified Ti3C2 MXene / g-C3N4 composite photocatalytic material, its preparation method, and its applications. The preparation method innovatively modifies the surface of Ti3C2 MXene with caffeic acid to form a caffeic acid-carbon-coated Ti3C2 MXene coating, which is then further composited with g-C3N4. A binary or ternary molten salt system is used to construct the fluid reaction environment, while molten salt ions are used to etch and morphology-control the composite g-C3N4, aiming to improve the photogenerated charge separation efficiency and thus optimize the photocatalytic hydrogen production performance of the semiconductor material.

This invention provides a method for extracting active ingredients from *Erigeron breviscapus*, belonging to the field of pharmaceutical technology. Based on the differences in the physicochemical properties of the compounds, this invention first achieves preliminary separation of caffeic acid esters and scutellarin, followed by further purification and separation based on the properties of the two types of substances. Specifically, this invention uses ethanol-water solutions of different concentrations to extract caffeic acid esters stepwise, and uses macroporous and microporous resins for preliminary separation of the caffeic acid esters. Scutellarin is then preliminarily separated through acid-base treatment. Finally, high-purity scutellarin, 3,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, and scutellarin are obtained through reversed-phase industrial chromatography. This invention achieves the extraction and separation of multiple active ingredients from *Erigeron breviscapus*, and all solvents used in the extraction and separation process are recyclable, resulting in low cost.

A prenyltransferase capable of producing bakuchiol or its analogues from geranyl pyrophosphate (GPP) and cinnamic acid, coumaric acid, caffeic acid and / or ferulic acid is disclosed herein. Manipulated cells expressing a prenyltransferase capable of producing bakuchiol or its analogues, as well as methods of using the prenyltransferase and cells to produce bakuchiol or its analogues, are also disclosed herein.

The present application relates to a composition containing chlorogenic acid, caffeic acid, and quinic acid. The polyphenol-containing composition of the present application may be used for reducing an off-taste or off-flavor. In addition, the polyphenol-containing composition of the present application may be used as a preservative of a product, in particular an antioxidant or browning inhibitor of a product.

This invention discloses a chitosan-organic acid supramolecular ionic salt and its preparation method, belonging to the supramolecular field. The invention involves mixing chitosan with an organic acid (one or more of maleic acid, sorbic acid, ferulic acid, caffeic acid, cinnamic acid, and fumaric acid) and a solvent, followed by drying to obtain the chitosan-organic acid supramolecular ionic salt. The chitosan-organic acid supramolecular ionic salt prepared by this invention can improve the water solubility of chitosan and improve severely damaged hair, offering multiple functions such as repair and smoothing, making it suitable for hair care products. Furthermore, the preparation method is simple, requiring no catalyst or high temperature and pressure, making it suitable for industrial use.

This invention discloses a high thermal stability recycled PE pipe and its preparation method, belonging to the field of polymer material technology. The pipe is obtained by co-extrusion of three layers: an inner layer, a middle layer, and an outer layer. The inner layer comprises the following raw materials by weight: 70-85 parts PE100, 10-25 parts high-quality recycled PE, 2-3 parts caffeic acid-amylated POSS, and 0.3-0.5 parts crosslinking agent. The middle layer comprises the following raw materials by weight: 40-60 parts PE80, 35-55 parts recycled PE, 1-2 parts compatibilizer, 4-8 parts mercapto-modified carbon fiber, and 0.05-0.2 parts crosslinking agent. The outer layer comprises the following raw materials by weight: 60-80 parts PE80, 15-35 parts recycled PE, 4-6 parts kaolin-supported 2-vinylimidazole material, and 0.3-0.5 parts crosslinking agent. The pipe prepared by this invention possesses high thermal stability and excellent resistance to ultraviolet aging.

This invention relates to a luciferase variant having a 35-80 amino acid deletion near the N-terminus of the sequence shown in SEQ ID NO.:1; preferably, the deletion is 35-40, 40-45, or 55-60 amino acids near the N-terminus of the sequence shown in SEQ ID NO.:1; the luciferase variant is configured to increase the luminescence intensity or caffeic acid content of an organism or its tissues or cells. This invention solves the problems of low luminescence efficiency and poor signal stability of the FBP system in organisms. This application systematically designs N-terminal truncated LUZ sequences of different lengths to screen for mutants that improve the luminescence effect of organisms. These mutants can be combined with other elements to further enhance the luminescence intensity of organisms.

This invention discloses a concentrated tomato product that increases blood flow and its preparation method. On a dry basis, the product contains 3.0 g / 100g of cis-lycopene, 1.5 g / 100g of total phytosterols, and 0.8 g / 100g of total polyphenols. The phytosterols are composed of β-sitosterol and stigmasterol, and the polyphenols are composed of chlorogenic acid, caffeic acid, and ferulic acid. This invention maximizes the preservation of the tomato's nutritional components by screening high-lycopene tomato varieties and optimizing pretreatment, enzyme inactivation, and juicing process parameters. Simultaneously, by precisely adding exogenous phytosterols, polyphenol extracts, and synergistic components such as Omega-3 fatty acids and vitamin E, a multi-component synergistic system is constructed. The components work together synergistically to significantly enhance the product's function of increasing blood flow, effectively improving microcirculation, reducing blood viscosity, and providing protection for cardiovascular health.

This invention provides a *Phellinus linteus* polyketide synthase gene. SvPKS1 Applications in promoting bioluminescence in fungi or plants, the SvPKS1 The coding sequence is shown in SEQ ID NO.1, and the fungus is a caffeic acid-producing fungus. The application includes using transgenic technology to... SvPKS1 Other genes in the FBP fungal luminescence pathway ( nnH3H , nnLuz , nnCPH This invention discloses for the first time the *Phellinus linteus* polyketide synthase gene, which is co-expressed in fungi or plants to promote bioluminescence in fungi or plants. SvPKS1 With fungal luminescence pathway genes nnH3H , nnLuz , nnCPH Co-expression promotes bioluminescence in fungi or plants, providing a key candidate enzyme gene for promoting sustainable bioluminescence in fungi or plants.

The present application belongs to the technical field of traditional Chinese medicine analysis, and particularly relates to a construction method of a characteristic spectrum of a Radix et Rhizoma Aconiti Lateralis Praeparata throat clearing mixture and application thereof. The present application realizes a leap from single index control to overall quality evaluation. The present application first establishes a characteristic spectrum method special for the Radix et Rhizoma Aconiti Lateralis Praeparata throat clearing mixture, and breaks through the limitation of the prior art that only the content of a single component is determined. By simultaneously monitoring the consistency of five key characteristic peaks of chlorogenic acid, caffeic acid, scandenoside, gardenia glycoside and catechin and the overall spectrum, the material basis feeding condition and the proportioning stability of the monarch, minister, assistant and guide medicinal ingredients in the preparation can be comprehensively reflected, so that the overall quality and the uniformity of the curative effect of the product are more scientifically ensured.

This invention relates to the field of coating technology, and more specifically, to an exposed hydrophobic flame-retardant fireproof coating, comprising the following steps: preparation of caffeic acid-intercalated calcium aluminum lanthanum hydrotalcite, preparation of a water-resistant flame-retardant composite, preparation of modified sodium lignosulfonate, and preparation of the exposed hydrophobic flame-retardant fireproof coating. The water-resistant flame-retardant composite effectively utilizes the flame-retardant properties of the caffeic acid-intercalated calcium aluminum lanthanum hydrotalcite. During high-temperature combustion, the caffeic acid-intercalated calcium aluminum lanthanum hydrotalcite forms a dense composite char layer structure, effectively isolating heat and oxygen, thus improving the flame-retardant properties of the fireproof coating. Simultaneously, it also possesses good hydrophobic protective properties, enhancing the hydrophobic properties of the exposed hydrophobic flame-retardant fireproof coating. The modified sodium lignosulfonate effectively improves the UV resistance of the exposed hydrophobic flame-retardant fireproof coating, extending the coating's UV aging resistance life.

The present invention provides a nicotine modifier that improves the uniformity of nicotine release with each puff of a new type of tobacco product, comprising component A, which is at least one of tannic acid, proline, caffeic acid, and pyruvic acid, and component B, which is at least one of phosphoric acid and boric acid. Furthermore, the invention provides a concentrated slurry containing the nicotine modifier, a method for producing the same, a sheet produced by the concentrated slurry method using the concentrated slurry, and a new type of tobacco product containing the concentrated slurry sheet. With this nicotine modifier, the synergistic effect of component A and component B can induce and adjust the nicotine release behavior in tobacco tissue, thereby significantly improving the uniformity of nicotine release with each puff of the new type of tobacco product.

This application discloses a novel phenolic acid decarboxylase, its preparation method, and its applications, relating to the field of enzyme engineering technology. The novel enzyme was extracted from *Mycobacterium avium*, and its amino acid sequence is shown in SEQ ID NO: 3. This enzyme can efficiently catalyze the decarboxylation of hydroxycinnamic acid substrates such as ferulic acid, p-coumaric acid, caffeic acid, and sinapic acid to generate corresponding 4-vinylphenol compounds, with yields of 93.37%, 98.12%, 85.24%, and 11.21%, respectively. The catalytic activity against sinapic acid is significantly superior to most reported phenolic acid decarboxylases. Furthermore, under pH 8.5 and CO2 conditions, this enzyme can also reverse-catalyze the carboxylation reaction of 4-vinylphenol compounds to generate the corresponding hydroxycinnamic acid, with yields between 12% and 20%. It shows promising applications in the high-value utilization of lignin, food flavoring synthesis, and CO2 bioimmobilization.

This invention relates to the field of adhesive preparation technology, specifically to a weather-resistant and mildew-resistant MS adhesive and its preparation process. The process includes the following steps: preparing an antibacterial silane-terminated polyurethane resin, preparing a bio-based UV absorber, preparing light-stabilized capsules, and preparing the weather-resistant and mildew-resistant MS adhesive. This invention combines caffeic acid and ethylene carbonate to prepare a bio-based UV absorber. After fabricating polyester-silane hybrid microcapsules using the bio-based UV absorber as the core material, moisture-responsive slow release is achieved. Even if the wall material is completely degraded, the released BHBPE remains a solid polymer, not volatilizing, precipitating, or being lost due to diffusion within the sealant matrix. Finally, it is applied to silane-terminated polyurethane MS adhesive, providing both durable UV absorption and long-lasting antibacterial properties.

This invention relates to caffeic acid O-methyltransferase mutant A-23 and its applications, belonging to the fields of enzyme engineering and synthetic biology. To address the problem of low melatonin synthesis efficiency in existing technologies, this invention provides caffeic acid O-methyltransferase mutant A-23. Mutant A-23 is based on the parental caffeic acid O-methyltransferase shown in SEQ ID NO.2, with an arginine-histidine mutation at amino acid position 93. The caffeic acid O-methyltransferase mutant A-23 provided by this invention can catalyze the production of melatonin from N-acetyl-5-hydroxytryptamine in the presence of S-adenosylmethionine, and can be used for the enzymatic preparation and microbial fermentation production of melatonin.

The application provides a kind of nanocomposite, multifunctional antibacterial hydrogel and its preparation method and application, belong to the technical field of biomedical materials.The application mixes carbon nanotube and 1,3,5-tri (4-aminophenyl) benzene, carries out first reaction, then mixes with 2,5-dimethoxy benzene-1,4-dimethyl formaldehyde, acetic acid solution, carries out second reaction, after second reaction is finished, the precipitate is collected, the precipitate is washed, dried to obtain imine COF material;The imine COF material and the ethanol solution containing iron ions are mixed, ultrasonic, stirring, the precipitate is collected, the precipitate is washed, dried to obtain nanocomposite.Oxidized dextran solution is sequentially mixed with the nanocomposite, coffee acid grafted chitosan solution, and the multifunctional antibacterial hydrogel is obtained by gelation.The nanocomposite and the multifunctional antibacterial hydrogel can be used for synergistic killing of bacteria in infected wounds and regulation and repair of wound microenvironment.