252 results about "Caffeic acid" patented technology

The invention provides a metal polyphenol nanoparticle, a preparation method thereof and an application of the metal polyphenol nanoparticle in preparation of a medicine for treating acute lung injury, the metal polyphenol nanoparticle is formed by self-assembly of metal ions and polyphenol, the metal ions are selected from Mg < 2 + >, Zn < 2 + >, Mn < 2 + > or Cu < 2 + >, and the polyphenol is selected from Mg < 2 + >, Zn < 2 + >, Mn < 2 + > or Cu < 2 + >. The polyphenol is selected from epigallocatechin gallate (EGCG), caffeic acid (CA), chlorogenic acid (CGA), gallic acid (GA) and luteolin (LUT). The metal polyphenol nanoparticles are used for preparing a medicine for treating acute lung injury induced by sepsis, pneumonia, serious trauma or inhalation injury, and the medicine further comprises a pharmaceutically acceptable carrier. The metal polyphenol nanoparticles provided by the invention are simple in preparation process and high in biological safety, polyphenol and metal ions synergistically enhance the anti-inflammatory and antioxidant activity, and the metal polyphenol nanoparticles are superior to the single use of polyphenol or metal ions.

The invention discloses a gynecological antibacterial gel containing a carbomer component, and belongs to the technical field of gynecological nursing materials. The gel is prepared from 0.5 to 5 percent of plant extract microcapsules, 0.5 to 3 percent of carbomer, 2 to 10 percent of glycerol, 0.1 to 1.5 percent of triethanol and the balance of purified water. The plant extract microcapsule is prepared by compounding methacrylated silk fibroin and a caffeic acid hyaluronic acid graft, has temperature responsiveness, can improve the adhesive force on the surface of vaginal mucosa, and realizes slow release of the plant extract; the caffeic acid catechol hydroxyl is chelated with silver ions, a nano-silver monodisperse layer is formed on the surface of the microcapsule, and the antibacterial activity is improved. The composite plant extract can inhibit bacteria, repair mucous membranes and maintain the acidic microenvironment of the vagina. When the gel is prepared, the problem that the swelling efficiency of carbomer is low is solved through glycerol pre-grinding, and triethanolamine is added in three times to form a gradient cross-linked network. The problems that traditional gel is unstable in viscosity, poor in mucous membrane adhesiveness and prone to damaging vagina micro-ecology are solved, the antibacterial effect is good, and preservation is stable.

The invention relates to the technical field of fermentation of edible and medicinal fungi, and discloses a phellinus igniarius fermentation method capable of producing high-yield Hispidin and an application of the phellinus igniarius fermentation method. The phellinus igniarius fermentation method comprises the following steps: inoculating a phellinus igniarius strain into a culture medium containing a copper ion compound, and fermenting. The phellinus igniarius mycelium obtained by adopting the fermentation method is rich in Hispidin, and can be widely used for preparing related medicines and health foods for protecting liver, resisting tumors, resisting viruses, resisting oxidation, reducing uric acid and the like. In addition, the invention also discloses a high performance liquid chromatography detection method for analyzing the content of Hispidin, by adopting the method, the content of Hispidin and precursor substances (such as protocatechuic acid, protocatechualdehyde, caffeic acid, osmundone and the like) in the phellinus igniarius leavening and derivative products thereof as well as phellinus igniarius mycelia can be effectively analyzed, and the accuracy of Hispidin detection is favorably improved.

The invention discloses a construction method and an identification method of characteristic chromatograms of a senecio scandens medicinal material as well as decoction pieces, standard decoction and formula granules thereof, and relates to the technical field of traditional Chinese medicine identification. The construction method of the specific chromatogram comprises the following steps: extracting a to-be-detected sample with methanol to obtain a test solution; the method comprises the following steps: dissolving 5-caffeoylquinic acid, chlorogenic acid, caffeic acid, 4-caffeoylquinic acid, rutin, hyperoside, isoquercitrin and 4, 5-dicaffeoylquinic acid with methanol to obtain a reference solution; and a liquid chromatograph is adopted for determination. A chromatographic column of the liquid chromatograph takes phenyl-methyl polysiloxane as a stationary phase, acetonitrile as a mobile phase A and 0.05 vol%-0.3 vol% formic acid aqueous solution as a mobile phase B for gradient elution. The information of the characteristic chromatogram constructed by the method is rich, and the quality of the senecio scandens medicinal material, decoction pieces, standard decoction and formula granules can be quickly and comprehensively reflected.

Disclosed are modified Type 1 O-methyltransferases (OMTs) and methods of using such modified OMTs. In some forms of the modified OMTs, the amino acid corresponding to Phe337 of Sorghum bicolor stilbene OMT (SbSOMT) is substituted with a polar amino acid. In some forms of the modified OMTs, the amino acid corresponding to Asn323 of Sorghum bicolor caffeic acid OMT (SbCOMT) is substituted with a hydrophobic amino acid. In some forms of the modified OMTs, the amino acid corresponding to Ile144 of SbSOMT is substituted with a polar amino acid. In some forms of the modified OMTs, the amino acid corresponding to Asn128 of SbCOMT is substituted with a hydrophobic amino acid.

The invention belongs to the technical field of polymer synthetic materials, and particularly relates to bio-based MS resin and a preparation method thereof. The bio-based MS resin is a free radical copolymer of a methyl methacrylate monomer and a styrene monomer; the methyl methacrylate monomers comprise bio-based methyl methacrylate, isobornyl methacrylate and 3-pinane methacrylate, and the methyl methacrylate monomers comprise methyl methacrylate, isobornyl methacrylate and 3-pinane methacrylate; the styrene monomers comprise styrene and caffeic acid derivatives; based on 100% of the mass of the bio-based MS resin, the methacrylate monomer accounts for 30%; the molar ratio of caffeic acid derivatives to styrene in the styrene monomers is 1: (1-9). The synthesized bio-based MS resin has the characteristics of greenness and reproducibility, compared with petroleum-based MS resin, the performance of the MS resin can be regulated and controlled by designing a protecting group of a bio-based caffeic acid derivative so as to expand the application range of the MS resin, a specific functional group can be introduced to prepare a functional, advanced and high-performance polymer material, and the MS resin has a good market prospect.

The invention discloses a nano-drug material based on self-assembly of berberine and caffeic acid and a preparation method of the nano-drug material. The preparation method comprises the following steps: respectively dissolving berberine and caffeic acid in an organic solvent to prepare a berberine-organic solvent solution and a caffeic acid-organic solvent solution; adjusting the pH value of the caffeic acid-organic solvent solution to 7.0-7.5; adding the caffeic acid-organic solvent solution while stirring the berberine-organic solvent solution, uniformly mixing, adding the mixed solution into deionized water with the preheating temperature of 30-70 DEG C, and stirring at a constant temperature, so that the berberine and the caffeic acid are self-assembled to obtain a mixed solution; dialyzing the mixed solution to obtain a berberine and caffeic acid self-assembled solution; and performing vacuum freeze drying to obtain a target product. The nano-drug material disclosed by the invention is small in particle size, better in solubility and dissolution rate in different pH environments than berberine hydrochloride and caffeic acid eutectic, good in stability in an aqueous solution and environment-friendly in method.

The invention belongs to the field of quality analysis and control of traditional Chinese medicines, and discloses a method for determining the content of carpesium abrotanoides components, which comprises the following steps: by taking isochlorogenic acid A as an internal reference substance, calculating the content of chlorogenic acid, caffeic acid, galuteolin, 11 (13)-dehydroaxillary Ivalin, isochlorogenic acid C, 2, 3, 4, 5-tetramethyl-1, 3, 4, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5- According to the method, the content of 10 components of carabrone is rapidly and accurately detected according to the relative correction factors of 2, 3, 4, 5-tetracaffeoyl-D-glucaric acid, 2-deoxy-4-surface-gaillanin, carabrone and dellelactone, and the problem that the detection cost is high due to the fact that many reference substances are needed, are not easy to obtain and are high in price in carabrone content determination is solved.

The invention relates to a preparation method of a mixture of sorghum starch and caffeic acid. The preparation method is characterized by comprising the following steps: mixing water, sorghum starch and caffeic acid to prepare a sorghum starch-caffeic acid mixed solution; then carrying out microblog treatment on the sorghum starch-caffeic acid mixed solution; after the treatment is finished, cleaning with an ethanol solution to remove free caffeic acid components in a reaction system, and centrifuging to take white precipitate at the lower layer; and freeze-drying to obtain a mixture of sorghum starch and caffeic acid. The SS-CA compound provided by the invention has a more stable gel continuous phase in the aging process. At the same aging time point, the moisture distribution of the SS-CA composite system has a lower free water peak area proportion, and the moisture retention capability is improved.

The invention discloses a method for improving the self-luminous intensity of a plant, which is characterized in that an AroGL175Q gene or an RgTAL gene and a PtC3H gene or the AroGL175Q gene, the RgTAL gene and the PtC3H gene are expressed in a plant containing a fungus bioluminescence system FBP, so that a transgenic plant of which the caffeic acid content, the milk tree alkali content and the luminous intensity are obviously increased is obtained. According to the invention, through metabolic network optimization and transformation, phenylpropane metabolites required by middle and upper streams of a fungus bioluminescence pathway are increased, and synthesis of caffeic acid and milk tree alkali in plants is increased, so that bioluminescence enhancement is realized. The precursor supply bottleneck of a fungus bioluminescence system is broken through, and an innovative solution is provided for creating efficient self-luminous plants.

Methods, compositions and uses for inhibiting the growth in blood cancer cells in a patient with one or more of a caffeic acid phenpropyl ester (GL8) analogue selected from the group consisting of As26, J229, J91, LL27, LL23, HM7, As25, MT26, and J205. The blood cancer cells can be myeloma, lymphoma and leukemia cells. The methods, compositions and uses can be in conjunction with the use of an IMiD to treat a patient. The compositions can include a pharmaceutically acceptable carrier, adjuvant or vehicle, a pharmaceutically acceptable salt or dietary supplement.

The invention discloses an application of caffeic acid-O-methyltransferase in regulation and control of salt tolerance of rice. The overexpressed OsCOMT gene disclosed by the invention can remarkably improve the melatonin content and antioxidant level of rice seedlings, so that the tolerance of plants to salt stress is enhanced, and the plants can maintain normal growth under the condition of salt stress; the deletion of the gene OsCOMT leads to the increase of the sensitivity of seedling-stage rice to salt stress, and exogenous melatonin can recover the salt-sensitive phenotype of a mutant-knocked-out plant and improve the photosynthetic rate of the mutant-knocked-out plant. The OsCOMT gene and the encoding protein thereof have important theoretical and practical significance on research of a plant stress tolerance mechanism and improvement of stress tolerance and related traits of plants, can play an important role in plant stress tolerance gene engineering improvement, and are wide in application prospect.

The invention provides a method for preparing a polyvinyl alcohol flame-retardant film by using coffee shell carbon dots and application, and belongs to the technical field of composites.The method comprises the following steps that a coffee shell carbon dot solution and polyvinyl alcohol are mixed, heated in an oil bath and then cooled to the room temperature, the cooled coffee shell carbon dot-polyvinyl alcohol solution is subjected to tape casting to form a film, and the polyvinyl alcohol flame-retardant film is obtained. And drying to obtain the coffee shell carbon dot-based polyvinyl alcohol flame-retardant film. The coffee shells are used as the raw material to prepare the carbon dots, caffeic acid and chlorogenic acid in the coffee shells are mainly used, resource utilization of waste is achieved, the production cost of the flame-retardant film is reduced, and the prepared flame-retardant film is light, has certain mechanical strength and is suitable for various fields needing light flame-retardant materials. The flame retardant property is excellent, flame spreading can be effectively delayed or prevented, the safety of the material is improved, and the preparation method is simple and is more suitable for popularization and application.

The invention discloses a pH response type multifunctional hydrogel dressing and a preparation method and application thereof, and belongs to the field of medical hydrogel dressings, the pH response type antibacterial hydrogel provided by the invention comprises the following components: a gel matrix, a cross-linking agent and a natural antibacterial active component; firstly, a bond is formed through a Schiff base reaction, so that the gel can be responded and released in a wound acid environment; and then connecting natural active antibacterial drugs such as caffeic acid, tannic acid or luteolin through boric acid ester bonds to obtain the pH-responsive antibacterial hydrogel. The pH-responsive antibacterial hydrogel prepared by the invention has good absorption capacity, a porous structure, adjustable mechanical strength and biocompatibility, also has good antibacterial, anti-inflammatory and anti-oxidation effects, provides a simple and effective method for repairing chronic wounds, and has good application prospects.

The invention provides a fingerprint spectrum and multi-component content determination method of a calamus-far nerve calming mixture, and relates to the field of quality control of traditional Chinese medicines. 31 common peaks are calibrated by establishing a fingerprint spectrum, and 24 common peaks can clearly belong to polygala tenuifolia. Meanwhile, synchronous content determination of seven components including chlorogenic acid, caffeic acid, ferulic acid, liquiritin, 2, 3, 5, 4 '-tetrahydroxy stilbene-2-O-beta-D-glucoside, 3, 6'-dimustard acyl sucrose and rosmarinic acid is realized. The method is good in precision, high in repeatability and stable and reliable in result, the medicine quality can be comprehensively and accurately reflected and controlled, and powerful support is provided for guaranteeing the safety and effectiveness of the calamus-far Ningmind mixture.

The present invention provides A ceramide compound, comprising: a structure of general formula I or an enantiomer or diastereomer of general formula I:in which:R1 is selected from the condensation residues of ferulic acid, sinapic acid, abscisic acid, sotretinoin, tretinoin, fusidic acid, royal jelly acid, sorbic acid, caffeic acid or trans-cinnamic acid;R2 is selected from one of the following structures:—C15H29, —C15H31, —C15H27, —CHOHC14H27, —CHOHC14H29.The present disclosure also provides a ceramide compound containing conjugated carboxylic acid, preparation method therefor and application thereof. The invention reacts functional carboxylic acid with sphingosine base to obtain a class of ceramide compound with novel structure. The introduction of physiologically active molecular fragments of functional carboxylic acids into ceramides will enhance the original efficacy of this type of molecules and also improve the physical and chemical properties of ceramide compound. For example, improving the antioxidant properties of ceramide compound.

The invention discloses a recombinant bacterium for efficiently synthesizing caffeic acid as well as a construction method and application of the recombinant bacterium, and relates to the technical field of genetic engineering. It is found that fre, mdaB, hisP and gltL genes in tyrosine producing bacteria are specifically reduced or knocked out, then caffeic acid synthetic pathway enzyme expression vectors are transferred, the production capacity of caffeic acid of the strains can be remarkably improved, the production capacity can be improved by 11.5%-20.4% on the original basis, and when the tyrosine producing bacteria are applied to caffeic acid production, the yield of caffeic acid can be remarkably improved.

The invention discloses a construction method and application of a specific chromatogram of a Shanhaidan pharmaceutical preparation, and belongs to the technical field of traditional Chinese medicine detection. The method comprises the following steps: preparing a test solution by using a plurality of different batches of Shanhaidan medicinal preparations in combination with high performance liquid chromatography and mass spectrometry technologies; the preparation method comprises the following steps: preparing a single reference substance solution from uridine, tanshinol, daidzin, p-hydroxybenzoic acid, puerarin, caffeic acid, 3 '-hydroxy puerarin, physcion, calycosin-7-O-beta-D-glucoside, stilbene glucoside, rosmarinic acid, alkannic acid, formononin, salvianolic acid B, daidzein and calycosin-7-one; and respectively carrying out high performance liquid chromatography analysis on the test solution and the reference solution to obtain the characteristic chromatogram of the Shanhaidan pharmaceutical preparation. The method is simple and convenient to operate, high in precision, good in reproducibility and accurate and reliable in result. And at least 16 components can be identified at one time under the same chromatographic condition, so that the detection efficiency is remarkably improved, the time and the cost are saved, and the quality of the Shanhaidan pharmaceutical preparation is comprehensively and scientifically evaluated.

The invention discloses recombinant saccharomyces cerevisiae, a 11-seed oil fermentation product as well as a preparation method and application of the 11-seed oil fermentation product, and belongs to the technical field of synthetic biology and fermentation product preparation. According to the recombinant saccharomyces cerevisiae disclosed by the invention, a caffeic acid coenzyme A ligase 4CL coding gene, a chalcone isomerase CHI coding gene, a flavanone-3-hydroxylase F3H coding gene and a chalcone synthase CHS mutant coding gene are over-expressed, and the chalcone synthase CHS mutant is preferably Y69H / H71Y / Q161K. The preparation method of the 11-seed oil fermentation product comprises the following steps: fermenting a recombinant saccharomyces cerevisiae fermentation solution in the presence of a sophora flower bud extract and caffeic acid to obtain a first fermentation solution; fermenting the lactic acid bacteria fermentation liquor in the presence of 11 seed oil to obtain second fermentation liquor; and mixing the first fermentation liquid and the second fermentation liquid, continuing fermentation, and respectively collecting an oil phase and a water phase after fermentation is finished, so as to obtain a fermentation product. The product provided by the invention has multivitamin antioxidant activity.

The invention discloses an acylthiourea compound as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing an acyl isothiocyanate intermediate from caffeic acid serving as a raw material, protecting hydroxyl on a benzene ring of the raw material by using TBS, then reacting with primary amine to prepare an acylthiourea intermediate, and finally, removing the TBS protective agent under the action of TBAF, thereby obtaining the acylthiourea compound. Experiments show that the acylthiourea compound has a medicinal value, can be used for treating inflammatory bowel diseases, and can be applied to development of related drugs.

The invention relates to the field of wastewater treatment, in particular to a water quality conditioner added with improved humic acid and a preparation method of the water quality conditioner. The water quality conditioner added with the improved humic acid is obtained by compounding the improved humic acid and interface functionalized hematite nanocrystals; the improved humic acid is methacrylic acid grafted phenol modified humic acid; the interface functionalized hematite nanocrystals are selected from one of caffeic acid interface functionalized hematite nanocrystals and benzimidazole interface functionalized hematite nanocrystals. No toxic reducing agent or precious metal is used; caffeic acid and benzimidazole are degradable or low-toxicity small molecules, and the residual quantity is low; the final product is Cr (III) hydroxide or organic complex, can be further precipitated or recycled, and accords with the concept of green water treatment. All reaction preparation conditions are mild, and equipment requirements are low. The raw materials are wide in source, low in cost and suitable for industrial production.

The invention belongs to the technical field of organic synthesis and cosmetics, and particularly relates to a synthesis method of caffeoyl tripeptide-1. According to the invention, caffeic acid and tripeptide-1 are used as raw materials, and a condensation reaction is carried out under mild conditions through a specific activation strategy and a protective group technology to generate a target product. The method has the advantages of simple steps, mild reaction conditions, high total yield, good product purity and the like.

The present invention relates to a nanoparticle system comprising a metal selected from silver and gold, coated with polyethylene glycol (PEG) and functionalised with a polyphenol organic acid selected from caffeic acid, gallic acid and ferulic acid. The present invention also relates to a method for manufacturing said nanoparticle system and to the therapeutic and cosmetic use of said nanoparticle system.

The present application relates to the technical field of medicine, and particularly relates to a drug composition with a sequential synergistic repair effect and a preparation method and application thereof. The drug composition comprises liposome I encapsulating caffeic acid and liposome II encapsulating BH4; the liposome I is a ROS-responsive liposome, can specifically respond in a high ROS microenvironment, and then realize on-demand release of caffeic acid; meanwhile, the liposome II protects BH4 from entering cells to play a role, can effectively overcome the defects of difficult dissolution of caffeic acid and easy oxidation of caffeic acid and BH4, can improve the bioavailability of the two drugs, can realize sequential release of caffeic acid and BH4, and can play a synergistic treatment effect on different mechanisms of occurrence of radioactive skin damage, and provides a sequential synergistic repair strategy for clinic. The liposome I and the liposome II are both prepared by a thin film hydration method, and the operation is simple, the conditions are mild, the lipid film is uniformly formed, and the encapsulation rates of caffeic acid and BH4 are high.

The invention discloses polymer-based anti-crack concrete and a preparation method thereof, and relates to the technical field of concrete. When the polymer-based anti-crack concrete is prepared, caffeic acid and glycidyl methacrylate react to prepare a chain extender; the preparation method comprises the following steps: reacting isophorone diisocyanate with polyethylene glycol and a chain extender in sequence to prepare polyurethane, and then reacting with mercaptopropyltrimethoxysilane to prepare modified polyurethane; the preparation method comprises the following steps: reacting carboxylated cellulose nanofibers with 4-amino-2, 2, 6, 6-tetramethylpiperidine to prepare pre-modified nanocellulose, and reacting the pre-modified nanocellulose with isocyanate propyl triethoxy silane to prepare modified nanocellulose; uniformly mixing the fine aggregate, the coarse aggregate, cement, fly ash, the modified polyurethane, the modified nano cellulose, water, a water reducing agent and a defoaming agent, pouring into a mold, vibrating, standing, demolding and curing to obtain the polymer-based anti-crack concrete. The polymer-based anti-crack concrete prepared by the preparation method disclosed by the invention has good anti-crack and anti-aging properties.

The present application relates to a method for introducing an exogenous caffeic acid synthesis pathway to improve the light intensity of plants, and introducing TAL genes and P450 genes into plants to obtain a significant up-regulation effect of caffeic acid expression amount. This may be because the introduction of TAL genes and P450 genes promotes the deamination of L-DOPA, increases the accumulation amount of L-DOPA, and further effectively increases the caffeic acid expression amount in plants. Based on this pathway, the synthesis of luciferin in plants is increased to enhance the light intensity of plants.

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a construction method of a specific chromatogram of caulis clematidis armandii or derivative products thereof. The invention provides a construction method of a characteristic chromatogram of caulis clematidis armandii or a derivative product thereof, which comprises the following steps: by taking octadecylsilane chemically bonded silica as a filler and a mobile phase comprising a formic acid-containing aqueous solution and acetonitrile, carrying out a specific gradient elution procedure to obtain 22 common characteristic peaks, and realizing effective separation of the common characteristic peaks, so that the separation degree is good, and the accuracy is high. The obtained characteristic spectrum has more characteristic peaks and better baseline separation, and is easier to position and qualitatively analyze; the precision, the stability and the repeatability are relatively good; compared with the prior art, the method has the advantages that the characteristic peaks are more, six characteristic components including the straight clematis seed B, the lariciresinol, the secoisolariciresinol, the lariciresinol-4-O-beta-D-glucoside, the caffeic acid and the ferulic acid are identified, and a basis is provided for quality detection and content determination of the caulis clematidis armandii or derivative products of the caulis clematidis armandii.

A method for preparing silkworm pupa active peptide microcapsules and their applications are disclosed. In a microfluidic focusing droplet generation chip, an aqueous phase is injected into the chip through the main channel, and an oil phase is injected through two side channels. The resulting microdroplets are collected in the collecting phase to form microcapsules. The filter membrane has a pore size of 0.1-1 μm. The aqueous phase consists of sodium alginate and silkworm pupa protein peptides; the oil phase consists of one of mineral oil, soybean oil, silkworm pupa oil, corn oil, peanut oil, rapeseed oil, and lard; the collecting phase consists of caffeic acid-grafted chitosan and calcium chloride dissolved in acetic acid. By optimizing the formulation and process, droplets with good dispersibility in oil, uniform morphology and size, and good stability are prepared.

The present invention relates to tablet, capsule and ampoule formulations for oral and / or injectable use, said formulations comprising beta-D-mannuronic acid or alpha-L-guluronic acid or a mixture of beta-D-mannuronic acid and alpha-L-guluronic acid, their oligomers, or their pharmaceutically acceptable salts, the total amount of [beta]-D-mannuronic acid or [alpha]-L-guluronic acid or mixtures thereof, oligomers thereof, or pharmaceutically acceptable salts thereof is from 10% to 99.999% by weight, based on the total weight of the tablet or capsule formulation, or from 20% to 60% by weight, based on the total weight of the ampoule formulation; the tablet, capsule or ampoule formulation further comprises caffeic acid or a salt thereof, for example in powder form, in an amount preferably from 0.001 wt% to 1 wt%, more preferably from 0.01 wt% to 0.5 wt%, more preferably from 0.05 wt% to 0.3 wt%, based on the total weight of the tablet, capsule or ampoule formulation. Furthermore, the present invention relates to the oral and / or injectable use of tablet, capsule and ampoule formulations, preferably as supplements or medicaments, for use in methods for the treatment of neurodegenerative diseases, inflammatory responses, pain, cancer, aging, diabetes and / or heart diseases, as well as to methods of preparing such formulations.

This invention relates to the field of adhesive technology, and discloses an environmentally friendly biomass-based underwater adhesive, its preparation method, and its applications. The adhesive is prepared by one-step melt copolymerization of three biomass raw materials: lipoic acid, caffeic acid, and cysteine. This system utilizes the ring-opening polymerization of lipoic acid to form a dynamic disulfide bond network providing cohesive force, the catechol groups of caffeic acid to provide various interfacial interactions with the substrate, and the thiol groups of cysteine ​​to simultaneously participate in network construction and inhibit catechol oxidation, thereby synergistically achieving high-strength and durable underwater adhesion. The adhesive achieves an underwater adhesion strength of up to 5.5 MPa on iron sheets, remains stable in various acid, alkali, and salt environments, and can be repeatedly recycled through hot melting. This invention uses entirely bio-based raw materials, employs a simple and non-toxic process, and is suitable for underwater remediation, marine engineering, and other fields.