Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

96results about How to "Inhibition release" patented technology

Flame-retardant nylon material and preparation method thereof

The invention discloses a flame-retardant nylon material which comprises 50-70 parts of PA (polyamide), 1-5 parts of a toughening agent, 3-5 parts of a P-series flame retardant, 3-5 parts of an N-series flame retardant and 10-20 parts of a modified polysilsesquioxane flame retardant, and the modified polysilsesquioxane flame retardant is prepared from raw materials including silsesquioxane A, a compound B and a catalyst in an alkaline environment. The silsesquioxane A comprises at least one epoxy group D, and the compound B contains a phosphorus element P and a nitrogen element N and at least comprises a halogen end group X. The flame-retardant nylon material provided by the invention is excellent in flame retardant property and dielectric property, has good processability and mechanical property, greatly improves the anti-cracking property and anti-dripping effect of the flame-retardant nylon material, and is safe and environment-friendly.
Owner:SHENZHEN WOER HEAT SHRINKABLE MATERIAL

Gas supply device, bottleneck combination valve and hydrogen storage bottle group

The utility model relates to the technical field of hydrogen storage equipment, in particular to a gas supply device, a bottleneck combination valve and a hydrogen storage bottle group. The air supply device comprises an air supply pipeline, a valve seat, an air supply one-way valve, an overflowing protection valve and a filtering mechanism. The valve seat, the air supply one-way valve, the overflowing protection valve and the filtering mechanism are all arranged in the air supply pipeline; the air supply one-way valve is used for making contact with the valve seat and sealing the air supply pipeline when bearing preset pressure difference larger than the first direction. The overflowing protection valve is used for making contact with the valve seat and sealing the air supply pipeline when bearing the preset pressure difference larger than the second direction. By arranging the gas supply one-way valve, in the hydrogen filling process, high-pressure hydrogen is prevented from passing through the high-pressure electromagnetic valve, and then the influence of temperature and flutter on the service life of the high-pressure electromagnetic valve in the filling process is avoided; when the downstream pipeline of the bottle opening combination valve is broken and the flow is increased abnormally, the gas supply pipeline is closed through the overflowing protection valve, and abnormal discharge is avoided.
Owner:BEIJING TIANMA INTELLIGENT CONTROL TECHNOLOGY CO LTD +1

Difunctional electrocatalyst, preparation method thereof and hydrogen production method

The invention provides a bifunctional electrocatalyst, a preparation method thereof and a hydrogen production method, and relates to the field of catalysts. The bifunctional electrocatalyst comprises a conductive substrate and a core-shell type nano array structure vertically growing on the surface of the conductive substrate, a core in the core-shell type nano array structure comprises a tungsten-doped nickel-iron layered bimetal hydroxide nanosheet array, and a shell comprises cobalt phosphide. The bifunctional electrocatalyst shows excellent catalytic performance and stability in oxygen evolution and hydrogen evolution reactions, and has important application value in the field of electrocatalytic water decomposition.
Owner:ZHENGZHOU UNIV

Rotary adjustable curling iron

ActiveCN224268550UAchieve precise rotation controlquality improvementCurling devicesCurlingGear wheel
The utility model relates to the technical field of hairdressing equipment, in particular to a rotary adjustable hair curling rod which comprises a shell, a hair curling assembly, a rotary shifting piece and an upper limiting block. The gear set of the rotary base is meshed with the driven gear, and the second gear teeth of the rotary shifting piece are meshed with the gear set, so that accurate rotation control over the curling iron is achieved, the curling angle and the curling direction can be adjusted more flexibly and stably, the curling effect and the user experience are improved, and the practicability is high. The heating piece is guided through the first moving guide rail and the second moving guide rail, the stability and accuracy of the heating piece in the hair curling process are guaranteed, the problems that a traditional hair curling rod is uneven in heating and unsmooth in hair curling are solved, the hair curling quality is effectively improved, and the upper limiting block and the top cover improve the structural stability of the hair curling rod and improve the hair curling efficiency. And in addition, the use safety is improved, the heating piece is prevented from accidentally falling off or shifting, and safer and more reliable use experience is provided for a user.
Owner:深圳玖柒创欣科技有限公司

A compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method

ActiveCN118141855BImprove adhesionImprove liquidityPowder deliveryAntiviralsPowder InhalerSulfated polysaccharides
This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.
Owner:AFFILIATED HOSPITAL OF ZUNYI UNIV

Self-assembled hydrogels based on natural product catechins, their preparation methods and applications

ActiveCN117046406BInhibition releasegood anti-inflammatory activity
This invention discloses a self-assembled hydrogel based on the natural product catechin, its preparation method, and its application, relating to the field of pharmaceutical preparation technology. The invention includes the following steps: 1) dissolving catechin in a water-soluble medium; 2) heating the water-soluble medium until dissolved; 3) cooling to room temperature to obtain a catechin self-assembled hydrogel. The innovation of this invention lies in the discovery that the active substance catechin (levorotatory isomer, dextrorotatory isomer, and a mixture of the two isomers) can be induced to self-assemble into a hydrogel through heating and cooling. In the above hydrogel, the catechin self-assembles into nanofibers. Compared to free catechin, the catechin self-assembled hydrogel can more significantly inhibit LPS-induced RAW264.7NO release, exhibiting good anti-inflammatory activity.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

An unmanned vehicle for carbonizing crop straw

A vehicle for processing crop straw carbonization includes a vehicle body (1) and a walking mechanism (2). The vehicle body (1) is characterized in that: a stubble-cutting blade shaft (5) is horizontally mounted on a mounting frame (3) at the front of the vehicle body (1), a spiral roller pick-up device (6) is mounted on the mounting frame (3) and located at the rear of the stubble-cutting blade shaft (5), a crusher (8) is mounted at the rear of the spiral roller pick-up device (6), and the outlet at the lower end of the crusher (8) is connected to a hopper (10) located above via a conveying device (9). A carbonization reactor (12) is installed below the hopper (10), and a carbon collection box (14) is installed below the carbonization reactor (12). The present application has a reasonable structure, which allows the crushed straw material to be carbonized under the high temperature in the carbonization reactor, preventing it from being released into the atmosphere in the form of carbon dioxide, reducing carbon emissions. Moreover, the carbonized material can be returned to the field to improve the soil and enhance soil fertility, thus enabling large-scale processing of crop straw.
Owner:HUBEI INSTITUTE OF FINE ARTS

An endogenous polypeptide, its preparation method and application

ActiveCN122145604Bmeet safety requirementsavoid signal interference
This invention discloses an endogenous polypeptide, its preparation method, and its application. The structural formula of the polypeptide is shown in Formula (I): R1-(AA1)m-AA2-AA3-(AA4)n-R2, Formula (I); wherein, m is independently 2 or 3; n is independently 1, 2, or 3; AA1 is independently K, R, or H; AA2 is independently I or W; AA3 is independently I or W; AA4 is independently K, R, or H; R1 is any one of -H, Y, LY, PLY, or LLY; R2 is any one of -OH, L, LL, E, EL, EW, W, EH, or EHL. While retaining its targeted antioxidant and anti-inflammatory functions, the polypeptide has removed the domain with high affinity for heparin, thereby avoiding signal interference and potential biosafety risks that may be caused by full-length PF4, and meeting the safety requirements for cosmetic ingredients.
Owner:ZHEJIANG JINGLI BIOTECHNOLOGY CO LTD +2

A traditional Chinese medicine extract with antibacterial, anti-inflammatory and antipyretic effects, and an active ingredient self-assembled nanomaterial and application thereof

The application discloses a traditional Chinese medicine extract with antibacterial, anti-inflammatory and antipyretic effects and an active component self-assembled nanomaterial of the traditional Chinese medicine extract and application, wherein the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of inhibiting bacteria and relieving inflammation and can be used for treating atopic dermatitis. The in-vitro bacteriostatic experiment and animal experiment results verify that the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of resisting bacteria and inflammation and can effectively treat atopic dermatitis.
Owner:CHINA PHARM UNIV

Targeting nanoparticle for treating acute respiratory distress syndrome as well as preparation method and application thereof

PendingCN121987593AInhibit inflammationHigh enrichment efficiencyOrganic active ingredientsRespiratory disorderLipid filmBiocompatibility
The invention relates to the technical field of bioengineering, in particular to a targeting nanoparticle for treating acute respiratory distress syndrome as well as a preparation method and application of the targeting nanoparticle. Comprising the following steps: (1) combining MP peptide with DSPE-PEG2000-MAL through a maleimide-mercaptan reaction, dialyzing the obtained conjugate, washing, and freeze-drying, so as to obtain a DSPE-PEG2000-MP conjugate; and (2) mixing the conjugate, lipid, a pharmaceutical preparation and a solvent, removing the solvent to obtain a lipid film, hydrating the lipid film, and performing membrane extrusion to obtain the nanoparticles. The invention not only provides a novel efficient and safe ARDS treatment scheme, but also provides an innovative mode for the design of a nano-drug delivery system based on cell mediation. And due to the dual targeting capability, excellent anti-inflammatory efficiency and good biocompatibility, the nano-material has a wide prospect in clinical application.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

Production method of calcium carbonate and calcium carbonate production device

The present invention provides a production method of calcium carbonate whereby carbon dioxide is fixed as calcium carbonate by a safe and simple method. The production method of calcium carbonate disclosed herein includes the following steps. Step (S 1) of preparing a slurry including calcium hydroxide, and step (S2) of precipitating calcium carbonate by generating fine bubbles including carbon dioxide from a fine bubble generator that is provided with a porous section having micropores, and supplying the carbon dioxide into the slurry including the calcium hydroxide in a container configured to prevent carbon dioxide from being released into the atmosphere. Here, the fine bubble generator supplies carbon dioxide so that a flow rate of carbon dioxide is 40 to 2500 ml / min per 1 mol of the calcium hydroxide.
Owner:NORITAKE CO LTD

Application of light-driven organic semiconductor nano motor in preparation of products for promoting differentiation of neural stem cells

PendingCN121971432Apromote directed differentiationStable photoresponsivenessOrganic active ingredientsNervous disorderNanomotorDirected differentiation
The invention relates to the technical field of biomedicine, and discloses an application of a light-driven organic semiconductor nano motor in preparation of a product for promoting differentiation of neural stem cells, and the organic semiconductor nano motor is obtained by carrying out surface treatment on poly (3-hexylthiophene) through lauryl sodium sulfate and normal propyl alcohol. In-vivo experiments find that in-situ injection of the P3HT nanomotor in a subventricular region (V-SVZ) of a mouse can maintain stable photoresponse performance under visible light irradiation, and can promote directional differentiation of neural stem cells to a neural pedigree (rather than glial cells). In addition, the organic semiconductor nano motor has good cytocompatibility and systemic biological safety, and has a good application prospect in the field of nerve regeneration medicine.
Owner:SUN YAT SEN UNIV

Pharmaceutical composition for inhibiting tumor drug resistance and application thereof

The invention discloses a pharmaceutical composition for inhibiting tumor drug resistance and application thereof. The pharmaceutical composition comprises an exosome inhibitor, nintedanib and gemcitabine, the exosome inhibitor, the nintedanib and the gemcitabine are used in a combined manner, so that the cell viability of the CTS can be remarkably reduced, and the proportion of apoptotic cells in the CTS can be remarkably increased; the pharmaceutical composition interferes with the mutual transformation process between normal fibroblasts and CAFs, and inhibits secretion and release of EVs and reduces formation of new CAFs while restoring the CAFs existing in TME to normal fibroblasts, thereby successfully reversing the drug resistance of tumors.
Owner:浙江迈镝生物科技有限公司

Stabilizer for free DNA in blood and application thereof

The invention relates to the field of blood detection reagents, in particular to a blood free DNA stabilizer and application thereof. Every 100 ml of the blood free DNA stabilizer comprises 0.5-5 g of a buffer agent, 2-20 g of an aldehyde fixing agent, 15-20 g of an anticoagulant, 10-50 g of a cell stabilizer, 2.5-12.5 g of a nuclease inhibitor, and the balance of ultrapure water. The pH value of the blood free DNA stabilizer is 6.8 to 7.8; the cell stabilizer is selected from one or two or more than two of polysucrose-50, polysucrose-70, polysucrose-400, polyethylene glycol-4000, polyethylene glycol-6000, polyethylene glycol-8000 and glycine betaine. Preferably, the cell stabilizer is selected from polysucrose-70, and every 100 ml of the blood free DNA stabilizer contains 10 g of polysucrose-70. The stabilizer provided by the invention is low in toxicity and low in cost, and can maintain free DNA stability and inhibit blood cell genome release at normal temperature for 10 days, so that the storage cost and the transportation cost of a blood sample are effectively reduced, and the detection accuracy of the blood free DNA is improved.
Owner:INOZAN (JIANGSU) BIOTECHNOLOGY CO LTD

Scalp repair composition containing epidermis repair polysaccharide and saccharomycetes lysate

The invention relates to the technical field of daily chemical products and cosmetics, in particular to a scalp repair composition containing epidermis repair polysaccharide and saccharomycetes lysate. The skin repairing composition is prepared from the following raw materials in percentage by mass: 1 to 5 percent of skin repairing polysaccharide; 1%-5% of a yeast lysate; 1%-10% of PEG-5 (Polyethylene Glycol) glycerate triisostearate; and the balance of cosmetically acceptable matrix. The polysaccharide is mannan which is obtained by fermenting Paenibacillus sp.1538, and the weight-average molecular weight of the mannan is 6.15 * 10 < 6 > Da. The specific ultra-high molecular weight polysaccharide is compounded with the saccharomyces cerevisiae extract, and the low-irritation PEG-5 glycerate triisostearate is introduced, so that the compatibility problem that the high molecular weight polysaccharide is easy to flocculate is effectively solved. The composition can form a film immediately, deeply resist inflammation, relieve and repair a physical barrier of scalp, has an excellent synergistic effect, and solves the problem of scalp chemical stimulation injury caused by a traditional surfactant from the source.
Owner:GUANGDONG WANGXIANGBAOCHENG IND CO LTD

Printing ink adhesive force testing machine

The utility model belongs to the technical field of printing ink adhesion testing, and discloses a printing ink adhesion testing machine which is used for testing the printing ink adhesion of a plate printed with printing ink and comprises a roller, the roller is in a hollow sealed shell shape, a strip-shaped groove is formed in the peripheral wall of the upper end of the roller, the strip-shaped groove and the roller are coaxially arranged, and the strip-shaped groove is in through connection with the interior of the roller; a rotating roller and a wind-up roller which are rotationally connected are arranged in the roller, the rotating roller and the wind-up roller are coaxially arranged with the roller, and the rotating roller is fixedly sleeved with an adhesive tape roll; the adhesive tape at the free end of the adhesive tape roll extends out of the roller from one side of the strip-shaped groove, extends to the other side of the strip-shaped groove along the outer peripheral wall of the lower end of the roller and extends into the roller, and the adhesive tape at the free end of the adhesive tape roll is fixed to the peripheral wall of the winding roller; the winding roller is rotated, the winding roller drives the adhesive tape to be wound, the adhesive tape pulls the adhesive tape roll to be released, and the purpose of conveniently replacing the adhesive tape on the peripheral wall of the outer side of the roller is achieved.
Owner:SHANGHAI MEIYIKE INK CHEM CO LTD

Soothing gel composition and preparation method thereof

PendingCN121971349ACovering full cycle needsRelieve sensitivity symptomsCosmetic preparationsToilet preparationsActive agentSurface-active agents
The invention discloses a soothing gel composition and a preparation method thereof, and belongs to the technical field of gel. The soothing gel composition comprises the following components based on the total mass of the soothing gel composition: 8.5000% of a humectant; 5.9000% of a skin conditioning agent; 2.0000% of a surface active agent; 0.5300% of a thickening agent; 0.2000% of an astringent; 0.0800% of a preservative; 0.0500% of a repairing agent; 0.0003% of a coloring agent; 0.1130% of a soothing factor; 82.6267% of a solvent; the soothing factor is prepared from an abelmoschus esculentus flower extract, aloe barbadensis leaf juice, a scenedesmus sibiricus extract, a kalimeris crassifolia extract and sclerotium gum; the soothing effect of the soothing gel composition is improved through the synergistic interaction effect of the mallow flower extract, the aloe barbadensis leaf juice, the scenedesmus western extract, the kalimeris crassifolia extract and the sclerotium rolfsii gum.
Owner:GUANGZHOU HENGFANG BIOTECHNOLOGY CO LTD

Corrosion-resistant LED lamp

ActiveCN224743383Ulow mechanical strengthInhibition release
The utility model discloses a kind of corrosion-resistant LED lamps, including lamp shell, the lamp shell is equipped with inner chamber, the inner chamber is equipped with LED lamp pearl, the surface of lamp shell is equipped with protective layer, the protective layer includes the several protective pieces one of longitudinally arranged and the several protective pieces two of transversely arranged, the rear end of protective piece two and the front side of corresponding protective piece one are abutted;It also includes the metal edging strip of detachable connection with protective layer, metal edging strip is set to flexible metal material of bendable, the metal edging strip is connected and fixed with protective piece two and protective piece one of adjacent protective piece two;Protective layer is designed as detachable module, when local damage, can be replaced alone, reduce maintenance cost;When protective layer is damaged, humidity sensor detects humidity signal and passes to controller, controller identifies when higher than preset value, control buzzer to sound, to remind user.
Owner:WENZHOU DADI LIGHTING TECH

A method for preparing a flame-retardant epoxy resin containing a recyclable flame retardant and its application.

This invention discloses a method for preparing a flame-retardant epoxy resin containing a recyclable flame retardant and its application. The method for preparing the flame retardant includes: preparing a manganese cobalt oxide flame retardant through the co-precipitation of manganese and cobalt ions followed by calcination. This invention synthesizes a manganese cobalt oxide flame retardant via a co-precipitation method and uses it as a filler in epoxy resin, curing it to obtain a green, halogen-free, environmentally friendly flame-retardant epoxy resin. It does not pollute the environment during pyrolysis or combustion and can effectively catalyze the conversion of harmful gases generated during combustion, which is beneficial to environmental protection and sustainable development. It has excellent flame-retardant properties, greatly reducing the release of heat, smoke, and harmful gases during epoxy resin combustion, significantly enhancing its fire safety. Furthermore, it enables efficient recovery of the flame retardant from the epoxy resin, with a recovery rate of up to 90.0%, achieving high-quality resource utilization.
Owner:QUANGANG PETROCHEM RES INST OF FUJIAN NORMAL UNIV

A method for preparing biochar from fly ash under alkaline treatment

The application provides a method for preparing biochar from fly ash under alkali treatment, which comprises the following steps: adding fly ash and corn straw into an alkaline solution, and fully reacting to obtain a mixture of fly ash and corn straw after alkali treatment; and calcining the mixture to obtain biochar. In the process of converting biomass into biochar, the aromatic ring structure is greatly increased, a dense structure is formed on the surface of the biochar, the influence of external conditions on the biochar itself is reduced and prevented, thereby inhibiting the oxidation, decomposition and release of carbon molecules, and the thermal stability and chemical stability of the biochar are improved.
Owner:CHINA UNIV OF MINING & TECH (BEIJING)

Formaldehyde-free flame-retardant solid wood composite floor and modified lignin-based flame-retardant adhesive

This invention provides a formaldehyde-free flame-retardant solid wood composite flooring and a modified lignin-based flame-retardant adhesive. The flame-retardant adhesive comprises 20-30 parts by weight of ethanol lignin, 20-30 parts by weight of hydroxide, 10-20 parts by weight of phytate, 30-60 parts by weight of crosslinking agent, 30-50 parts by weight of high-temperature soybean meal powder, and 0.1-0.2 parts by weight of tackifier. The invention also provides a preparation method. First, amino-rich hydroxide and phytate are grafted onto ethanol lignin to obtain hydroxide / phytate ethanol lignin. Next, the obtained hydroxide / phytate ethanol lignin is mixed with the crosslinking agent and high-temperature soybean meal powder. Finally, the tackifier is added, and the mixture is mechanically stirred to prepare the modified lignin-based flame-retardant adhesive. The flame-retardant adhesive provided by this invention is formaldehyde-free, exhibits excellent flame-retardant properties, good coating performance, good water resistance, and great application potential.
Owner:ZHEJIANG SHENGHUA YUNFENG GREENEO

Sofa cushions and sofas

ActiveCN224698920UImprove the cushioning effectNo shaking feeling
This utility model discloses a sofa cushion and a sofa, belonging to the field of home furnishings. In order to reduce the wobbling sensation produced by traditional sofa cushions during use, the sofa cushion includes an internal structure (1), an internal sealing layer (2), a shaping layer (3), and a fabric layer (4) that are stacked and connected sequentially from the inside to the outside. The internal structure (1) contains a down tube layer (11) and a sponge structure (12) stacked and connected vertically. The down tube layer (11) contains multiple down tubes (111) arranged in the left-right direction and extending in the front-back direction. The sofa cushion uses a combination of down tube layers and sponge, which can greatly reduce the "wobbling sensation" and prevent the "sinking sensation" after sitting for a long time, thus improving the user's comfort.
Owner:BEIJING HAOKAN USEFUL DESIGN CO LTD

Sulfide solid electrolyte, method for manufacturing the same, positive electrode sheet, battery, and power using device

The application belongs to the technical field of batteries, and particularly relates to a sulfide solid electrolyte, a preparation method thereof, a positive electrode sheet, a battery and a power utilization device. The sulfide solid electrolyte comprises a compound shown in formula 1: Li 7+3y‑x P 1‑y Zn y S 6‑x Cl x‑2y Br 2y Formula 1 wherein, 1
Owner:CHINA AUTOMOTIVE BATTERY RES INST CO LTD

A dressing for the treatment of atopic dermatitis and a method of making and using the same

This invention discloses a dressing for treating atopic dermatitis, its preparation method, and its application, relating to the field of medical materials technology. The dressing for treating atopic dermatitis is composed of PH powder and Que@CD nanoparticles. The technical solution provided by this invention utilizes amino-rich ε-polylysine and NHS ester-modified hyaluronic acid for rapid cross-linking via an amidation reaction in a moist environment, forming a three-dimensional gel network encapsulating Que@CD nanoparticles. Utilizing the water solubility of Que@CD, quercetin can be rapidly released to relieve itching. Simultaneously, it exerts anti-inflammatory and antioxidant effects by scavenging excess reactive oxygen species, alleviating oxidative stress, regulating the immune microenvironment, and inhibiting the release of inflammatory factors. Therefore, the dressing proposed in this invention possesses in-situ gelling properties and drug burst release capability, enabling it to closely adhere to irregular skin wounds and comprehensively exert antioxidant, anti-inflammatory, and immunomodulatory effects.
Owner:SHENZHEN NANSHAN DISTRICT PEOPLES HOSPITAL

A composition for soothing dry, itchy, red baby skin and uses thereof

PendingCN122272444ASoothes symptoms of dry itching and rednessbalance microecologyInflammatory factorsVegetable oil
This invention provides a composition for soothing dry, itchy, and red skin in infants and children, and its application. The composition comprises 1-8% plant oil, 5-12% moisturizer, and 0.1-0.5% soothing ingredients. The plant oil contains ≥1% shea butter. Through the synergistic effect of the compound plant oil, moisturizer, and soothing ingredients, and with oat β-glucan modified by acetylation, the permeability and skin affinity are improved. The preparation employs a segmented emulsification and homogenization process, controlling the oil droplet size to 0.2-0.4 μm, and low-temperature compounding preserves the active ingredients. This composition achieves multiple benefits, including rapid soothing of dryness, itching, and redness, repair of the skin barrier structure, and balance of the skin microecology. Experimental verification shows that this composition has a significant inhibitory effect on inflammatory factors, is gentle and non-irritating, and can provide comprehensive protection for the delicate skin of infants and children.
Owner:广州丽新生物科技有限公司 +2

Use of isoflavones

PendingCN122075471Aclearly targetedSignificant activity in vivo and in vitroOrganic active ingredientsAntipyreticInflammatory factorsDisease
This invention relates to the field of biomedical technology, and more particularly to the application of an isoflavone compound, specifically Corylifol A, in the preparation of drugs for the prevention and / or treatment of inflammatory diseases. When used to prepare drugs for the prevention and / or treatment of inflammatory diseases, this isoflavone compound can directly bind to the IκBα protein and specifically inhibit its phosphorylation, thereby blocking the phosphorylation and nuclear translocation of the NF-κB p65 subunit, ultimately inhibiting the overactivation of the NF-κB signaling pathway. Furthermore, the isoflavone compound can significantly reduce the mortality rate of lipopolysaccharide-induced septicemia in mice, inhibit the levels of inflammatory factors in serum and lung tissue, and effectively alleviate LPS-induced acute lung injury in mice. Simultaneously, when the isoflavone compound is controlled within an effective concentration range, it exhibits no significant cytotoxicity to mouse peritoneal macrophages and can significantly inhibit the production and release of lipopolysaccharide-induced inflammatory factors IL-1β, TNF-α, and IL-6.
Owner:SHENZHEN UNIV

A cell extracellular vesicle derived from sophora flavescens and a preparation method and application thereof

PendingCN122503298Agood treatment effectImprove lipid accumulation
This invention discloses an extracellular vesicle derived from Sophora flavescens, its preparation method, and its application. It belongs to the field of biomedical technology. The extracellular vesicles derived from Sophora flavescens are obtained by isolating extracellular vesicles (SF-EVs) from the roots of Sophora flavescens. These vesicles have a particle size of 100-200 nm and contain proteins, lipids, high abundance of miR6300, and various alkaloids. This invention also provides a method for preparing the extracellular vesicles and further provides their application in the preparation of drugs for treating metabolic-associated steatohepatitis (MASH). In vitro and in vivo experiments have demonstrated that SF-EVs can significantly improve lipid accumulation, inflammatory response, and oxidative stress in MASH, with an overall therapeutic effect superior to an equivalent dose of total alkaloids from Sophora flavescens. Through protein / RNA knockout, transcriptome sequencing, and mechanism verification, miR6300 was found to be a key effector of SF-EVs in its anti-MASH effect, and it exerts a synergistic therapeutic effect by dually targeting CYP2B6 (improving lipid metabolism) and CXCL10 (inhibiting inflammation).
Owner:YUNNAN UNIVERSITY OF CHINESE MEDICINE

A high-efficiency breeding method for triploid ruditapes philippinarum based on asynchronous acquisition of sperm and egg and early induction

PendingCN122681054Aimprove consistencySolve the problem of fertilization out of sync
The present application relates to the technical field of polyploid breeding of shellfish, and specifically discloses a high-efficiency breeding method for triploid Ruditapes philippinarum based on asynchronous acquisition of sperm and egg and early induction. The method comprises the following steps: identifying and separating male and female parent shellfish before inducing parturition; allowing female parent shellfish to naturally release eggs; dissecting male parent shellfish to obtain sperm; artificially mixing and fertilizing; adding cytochalasin B to inhibit the release of the second polar body when the first polar body release rate of the fertilized egg reaches 30%-40%; and washing and hatching to obtain triploid larvae. The present application realizes controllable starting time of fertilization by asynchronous acquisition of sperm and egg, and has a triploid induction rate as high as 92.90% and a standard deviation of only ±1.60% in combination with an early induction window, and has the advantages of stable operation, good repeatability and suitability for large-scale production, thereby providing a reliable technical solution for the genetic improvement and sustainable development of the Ruditapes philippinarum industry.
Owner:YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI

An injection preparation of anti-lilrb4 monoclonal antibody

The present application relates to the field of biological medicine, and specifically provides an anti-LILRB4 monoclonal antibody injection preparation, which comprises an anti-LILRB4 monoclonal antibody, a buffer salt, a protein protective agent, and a surfactant, wherein the pH of the injection preparation is 5.5-6.5. The injection preparation provided by the present application provides a good storage environment for the anti-LILRB4 monoclonal antibody through the synergistic interaction of different contents of the buffer salt, the protein protective agent, and the surfactant, and guarantees the biological activity of the anti-LILRB4 monoclonal antibody. The anti-LILRB4 monoclonal antibody can effectively inhibit the combination of the LILRB4 antigen and its ligand complex, thereby blocking the interaction with the ligand ApoE complex, preventing the activation of the downstream NF-kappa B signal pathway and the release of ARG1, preventing the inhibition of T cell proliferation and the promotion of tissue infiltration, and can be used for treating cancer.
Owner:BEIJING DONGFANG BIOTECH CO LTD

Fermented plant drink for improving immunity and method for preparing the same

PendingCN122604009AImprove the level of productionpromote growth and reproduction
The present application relates to the technical field of plant drinks, and particularly relates to a fermented plant drink for improving immunity and a preparation method thereof. The preparation raw material of the plant drink comprises the following components in parts by weight: fermented plant pulp 100-150 parts, fig pectin 2-4 parts; the preparation raw material of the fermented plant pulp comprises the following components in parts by weight: apple 10-15 parts, sea buckthorn 8-12 parts, lemon 4-6 parts, roxburgh rose 5-10 parts, white orchid 4-6 parts, jujube 3-5 parts, sophora flower bud 1-2 parts. The fermented plant drink prepared by the present application has good sensory effect, can effectively eliminate free radicals and improve immunity.
Owner:SHANXI FUNCTIONAL FOOD RES INST OF SHANXI AGRI UNIV