468results about How to "Reduce inflammation" patented technology

The invention discloses an anti-allergy soothing composition as well as a preparation method and cosmetics thereof. The anti-allergy soothing composition comprises the following components in percentage by mass: 2%-8% of a cactus extract, 1%-5% of a radix scutellariae root extract, 0.5%-3% of a Chinese herbaceous peony root extract, 2%-5% of a radix ophiopogonis root extract, 2%-5% of an oat bran extract, 40%-50% of butanediol and the balance of water. The composition has good anti-allergy and soothing effects, when the composition is applied to skin care products and cosmetics, the cosmetics can have the good anti-allergy and soothing effects, and the skin care products and the cosmetics can have good universality. Meanwhile, the preparation method of the anti-allergy soothing composition is simple and easy to implement and easy to popularize and use.

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention provides lactobacillus reuteri HNU872 and application of the lactobacillus reuteri HNU872 in preparation of intestinal inflammation related products. The invention discloses how the Lactobacillus reuteri HNU872 effectively alleviates the phenotype of DSS-induced mouse enteritis. The invention also discloses a preparation method of the Lactobacillus reuteri HNU872. Research results show that the Lactobacillus reuteri HNU872 can significantly relieve weight loss caused by enteritis, improve colon length, significantly improve the level of anti-inflammatory cytokines in serum and reduce the concentration of pro-inflammatory cytokines. In addition, the expression of the intestinal tight junction protein ZO-1 is obviously promoted. The lactobacillus reuteri HNU872 can regulate diversity and structure of intestinal microbiota of mice, inhibit enrichment of pathogenic bacteria and relieve inflammatory response. According to the invention, the action mechanism of the lactobacillus reuteri HNU872 in improving enteritis is clarified, and a solid scientific basis is provided for developing a microbial product based on probiotics as an alternative treatment strategy for ulcerative colitis.

The invention discloses carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops as well as a preparation method and application thereof, and relates to the technical field of eye drops and medical biogel. The carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops are prepared from tannic acid modified carboxymethyl chitosan and adipose tissue-derived stromal cell exosome freeze-dried powder, the carboxymethyl chitosan-hyaluronic acid-stem cell exosome eye drops provided by the invention can effectively treat xerophthalmia, and are stable in components, safe and reliable. The three components including the tannic acid modified carboxymethyl chitosan, the hyaluronic acid and the adipose tissue-derived stromal cell exosome coexist, so that the functions of all the components can be fully played, a synergistic effect is achieved, and a better treatment effect on xerophthalmia is achieved.

The invention provides an anti-hair loss composition containing cacumen biotae as well as a preparation method and application of the anti-hair loss composition, and belongs to the technical field of biological medicines. The anti-hair loss composition containing cacumen biotae comprises a cacumen biotae extract, a ginseng root extract, an eclipta prostrata extract, a polygonum multiflorum extract, a tea seed extract, a gleditsia sinensis extract, a mulberry bark extract, a cortex dictamni extract, a cnidium monnieri seed extract and a mint extract. All the components have a synergistic effect, and the shampoo has the effects of improving the greasy environment of scalp, preventing grease from blocking hair follicles, reducing the damage of inflammation to the hair follicles, inhibiting the activity of 5 alpha-reductase, improving the color and toughness of hair and the like, relieves alopecia seborrhoeica and achieves an anti-alopecia effect.

The invention relates to the technical field of daily chemical products, in particular to a scalp care composition and application thereof. From the perspective of scalp care, selenium disulfide and piroctone olamine salt are taken as bactericides and compounded with bactericidal and anti-dandruff components to form the organic and integrated anti-dandruff and scalp conditioning composition, and the composition has the effects of removing dandruff, relieving itching, soothing and controlling oil and can effectively relieve the problems of dry dandruff and fungal dandruff. The scalp care composition is added into the shampoo, serves as a main component of the multi-effect repairing and dandruff removing shampoo, can effectively solve the problems of oily dandruff, dry dandruff, scalp itching, scalp hair greasy, scalp sub-health and the like, and has the effects of reducing scalp inflammatory response, promoting updating of scalp cutin, inhibiting generation of scalp redundant sebum and the like; the nursing dimension is more comprehensive, and the application range is wider.

The invention belongs to the technical field of biological medicines, and particularly relates to a pyruvate preparation for treating asthma and a preparation method of the pyruvate preparation. The pyruvate preparation is prepared from the following components in parts by weight: 10 to 12 parts of pyruvate, 10 to 12 parts of sodium chloride, 0.5 to 1 part of citric acid and 500 parts of water for injection. The pH value of the pyruvate preparation is 6 to 7. The pyruvate preparation is used for daily management of asthma patients, the purpose of inhibiting asthma is achieved by controlling increase of the number of inflammatory cells such as eosinophilic granulocytes and reducing inflammatory reaction, the effect of the pyruvate preparation is close to that of similar hormone medicine dexamethasone, and the effect of the pyruvate preparation is improved while the treatment purpose is achieved. The dependence and side effects of patients on hormone drugs are reduced.

The invention belongs to the field of cosmetics, and discloses a composition with an anti-hair-loss effect and application thereof.The composition is prepared by mixing a cacumen biotae extract, a radix polygoni multiflori extract, an oil control factor and soybean milk fermentation liquor, and the anti-hair-loss effect of the cacumen biotae extract and the radix polygoni multiflori extract is further enhanced through the oil control factor and the soybean milk fermentation liquor; in addition, the invention further discloses a cosmetic which contains 1-10 wt% of the composition.

The invention discloses an effect of Collagen in relieving vomitoxin injury of bovine rumen epithelial cells by vitamin E, and belongs to the technical field of genetic engineering, the Collagen is COL1A1 protein, COL2A1 protein and COL5A1 protein; the amino acid sequence of the COL1A1 protein is as shown in SEQ ID NO. 19; the amino acid sequence of the COL2A1 protein is as shown in SEQ ID NO. 20; the amino acid sequence of the COL5A1 protein is as shown in SEQ ID NO. 21. According to the effect of Collagen in relieving bovine rumen epithelial cells damaged by vomitoxin through vitamin E, it is found that vitamin E can effectively protect the cell membrane integrity of the bovine rumen epithelial cells and can relieve cell viability decline, oxidative stress, immune and inflammatory reactions and the cell apoptosis rate caused by DON; vitamin E can promote ECM receptor effect and protein digestion and absorption ways by adjusting Collagen protein so as to protect rumen epithelial cells of dairy cows.

The invention provides milk exosome composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The milk exosome composite hydrogel provided by the invention is prepared from milk exosome, hyaluronic acid, epsilon-polylysine, 3-aminophenylboronic acid and tannic acid. The exosome is extracted from milk of a non-stem cell source; the molecular weight of the hyaluronic acid is 200 to 400 KDa. The invention provides a hydrogel carrier capable of loading a large amount of milk exosomes, and the hydrogel carrier can continuously release a large amount of milk exosomes and can give full play to the anti-oxidation and inflammation inhibition effects of the milk exosomes. In the aspect of wound healing, the milk exosome and the hydrogel carrier have a synergistic effect, so that the healing effect can be remarkably improved, and the healing period is shortened.

The invention relates to the technical field of medical apparatus and instruments, in particular to a scar rehabilitation therapeutic apparatus for realizing treatment based on AI evaluation analysis, which comprises a host, an AI evaluation system and a magnetic treatment component, and is characterized in that the host comprises a shell and an electric control system; the AI evaluation system comprises a data acquisition module and a treatment planning module; the data acquisition module is used for acquiring human body scar area information, the treatment planning module identifies data acquired by the data acquisition module, scar information is obtained after the data are identified and processed, and a scar rehabilitation treatment scheme is planned according to the scar information; the electric control system controls the magnetic treatment assembly to perform scar rehabilitation treatment according to the scar rehabilitation treatment scheme; the magnetic treatment assembly comprises a magnetic fixing device, a magnetic driving device and a magnetic patch; the magnetic patch is attached to a human body scar area, and the magnetic driving device executes a scar rehabilitation treatment scheme under the control of the electric control system, so that the magnetic patch rotates and moves.

The invention provides an application of a recombinant XVII type humanized collagen or a composition containing the recombinant XVII type humanized collagen in preparation of a preparation for preventing and / or treating lupus erythematosus, which can overcome the defect that more adverse reactions are generated in treatment in the existing scheme.

Compared with a porous microsphere in the prior art, the polymer material microsphere with the closed hollow structure is provided with the closed hollow structure or a gas chamber, the surface of the microsphere is smooth on the whole, and acute inflammatory reaction can be avoided. By adopting the microspheres prepared by the invention, the total material implantation amount can be reduced when the same regenerative stimulation point is implanted; and the preparation process is simple, and large-scale production is facilitated.

The invention relates to the technical field of abdominal wall adhesion materials induced by prevention and treatment of bacterial infection, and discloses an ionic liquid-based antibacterial-anti-inflammatory integrated bioactive nanoparticle with microwave sensitivity, a preparation method and application of the ionic liquid-based antibacterial-anti-inflammatory integrated bioactive nanoparticle. Then, the surfaces of the hollow nano particles are modified with bacteria specific targeting molecule 3-aminophenylboronic acid, and PBA-HPDA is formed; finally, chlorogenic acid and quaternary ammonium salt are combined according to a certain proportion to form ionic liquid (ILs) with a microwave heat effect, the ionic liquid (ILs) is wrapped in HPDA, and composite nanoparticles PBA-HPDA-CAQAC are formed. The nano particle material prepared by the invention has microwave heat effect and antibacterial and anti-inflammatory integrated biological activity, and has excellent bactericidal and anti-inflammatory effects.

The invention relates to the field of hair dyeing products, in particular to a low-irritation essential oil hair dye and a preparation method thereof. The invention relates to a low-irritation essential oil hair dye, which comprises a No.1 agent and a No.2 agent, the No.1 agent comprises a humectant, a hair coloring agent, an antioxidant, a chelating agent and a solvent A; a thickening agent A, an emulsifier A and a hair conditioner; a pH regulator A, and polydimethylsiloxane; the disinfectant is prepared from an aromatic A, polyquaternium-7, polyquaternium-10, argania spinosa kernel oil, a camellia extract, a ginger root extract and a preservative; the agent 2 comprises a solvent B, cetearyl trimethyl ammonium chloride, sodium stannate and a pH regulator B; a thickener B, an emulsifier B and mineral oil; a chelating agent C; and an oxidant. The hair dye provided by the invention can reduce irritation under the condition of ensuring the hair dyeing effect and relieve the frizz degree of dyed hair, and has a plurality of advantages.

The invention discloses an effect of an APOA gene in relieving vomitoxin injury of bovine liver cells by vitamin E, and relates to the technical field of the effect of vitamin E in relieving vomitoxin injury of bovine liver cells. The APOA gene refers to an APOA1 gene, an APOA2 gene and an APOA4 gene; the CDS sequence of the APOA1 gene is as shown in SEQ ID NO. 19; the CDS sequence of the APOA2 gene is as shown in SEQ ID NO. 20; the CDS sequence of the APOA4 gene is as shown in SEQ ID NO. 21; the effect is that the vitamin E regulates an APOA gene to be enriched to a cholesterol metabolic pathway. According to the effect of the APOA gene in relieving vomitoxin-caused cattle liver cells, it is found that the vitamin E can effectively protect the cell membrane integrity of the cattle liver cells and can relieve cell viability decline, oxidative stress, inflammatory response and cell apoptosis caused by vomitoxin; vitamin E regulates the cholesterol metabolic pathway by regulating the APOA gene level so as to play a role in protecting liver cells of dairy cows.

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.

The invention relates to a skin care composition containing perigord truffle and plant exosome and application of the skin care composition. The skin care composition containing perigord truffle and plant exosome comprises perigord truffle extract, chlorella exosome, malachite extract, fermentation product filtrate and soluble collagen. The fermentation product filtrate comprises any one or a combination of at least two of a Thermus thermophilus fermentation product, a lactobacillus / soybean milk fermentation product filtrate or a lactobacillus / mung bean seed extract / sodium glutamate fermentation product filtrate. The perigord truffle extract, the chlorella exosome, the malachite extract, the fermentation product filtrate and the soluble collagen are creatively combined to form the composition with the whitening, anti-allergy and anti-oxidation effects, and the composition has the effects of inhibiting melanin synthesis, relieving skin inflammation response, whitening skin, resisting allergy and resisting oxidation. And an unexpected synergistic effect is achieved in the aspects of oxidation resistance and aging resistance. The composition is mild in performance and free of irritation and toxic and side effects, and can be applied to cosmetic products more safely.

The invention provides a formula for treating rhinitis, and belongs to the technical field of traditional Chinese medicine, the formula for treating rhinitis is prepared from centipeda minima, schizonepeta spike, magnolia flower, cocklebur fruit, radix angelicae, rhizoma atractylodis, rhizoma acori graminei, cavalerie mosla herb, asarum, sal ammoniac, dried alum, musk, borneol and 50-degree white spirit according to specific parts by weight, and the preparation method comprises the following steps: firstly, removing impurities from part of the raw materials, and crushing into powder; when the traditional Chinese medicine is used, the liquid medicine is used for cleaning the nasal cavity and is repeated for 3-5 times, the formula has a good curative effect on diseases such as acute and chronic rhinitis, turbinate hypertrophy, nasal polyp, nasosinusitis and the like, clinical embodiments prove that the symptoms of a chronic rhinitis patient basically disappear after the chronic rhinitis patient is treated for 4 weeks, and the traditional Chinese medicine has a good curative effect. After a patient with nasosinusitis is treated for 6 weeks, inflammation is obviously absorbed, and after a patient with hypertrophy of nasal turbinates is treated for 8 weeks, ventilation basically returns to normal.

The invention relates to a composition with soothing and moisturizing effects and application of the composition. The composition comprises a piper nigrum extract, an oat kernel extract, schizophyllan and tranexamic acid. According to the invention, when the kava pepper extract, the oat kernel extract, the schizophyllan and the tranexamic acid are creatively combined for use, synergistic interaction can be realized in the aspects of soothing skin, moisturizing and repairing skin barrier, and the soothing and moisturizing effects of the product are further improved. The composition with the soothing and moisturizing effects has the specific effects of increasing the water content of the skin, calming and soothing the skin, improving the facial redness condition and reducing the inflammatory response, is very suitable for skin care products, and is mild, free of irritation and good in stability.

The invention discloses application of indobufen in preparation of a medicine for preventing and treating diseases induced by excessive ferroptosis, and particularly relates to the technical field of medicines. The invention relates to an application of indobufen in preparation of drugs for preventing and treating diseases induced by excessive ferroptosis by inhibiting ferroptosis. The indobufen is a ferroptosis inhibitor. The invention provides a new application of indobufen alone or in combination with other drugs in promoting wound healing. Cell and animal level experiments prove that the indobufen can inhibit the local ferroptosis level of the wound surface, so that the wound surface healing is obviously accelerated, and the indobufen has a good clinical application prospect.

The invention relates to a citric acid-based particle injection material as well as a preparation method and application thereof. The preparation method comprises the following steps: melting and heating citric acid and 1, 8-octylene glycol to form a POC prepolymer, dissolving the POC prepolymer with an organic solvent to obtain a dissolved solution, and slowly pouring the dissolved solution into ultrapure water for multiple times for purification to obtain a purified POC degradable prepolymer; and dissolving the POC degradable prepolymer with a solvent, adding inorganic salt particles, and carrying out a cross-linking reaction to obtain the POC injectable particle material. Medicines, active molecules, various metal ions and the like are loaded on POC in a physical compounding or chemical crosslinking mode, and the citric acid-based particle injection material is obtained. The citric acid-based biological material provided by the invention, as a novel medical beauty raw material and a related particle injection filler thereof, can effectively promote regeneration, proliferation, migration and chemotaxis of skin cells, promote the production of collagen and achieve a medical beauty effect. Meanwhile, the immune response of the organism can be activated, inflammation is reduced, the product after degradation is citric acid which can be metabolized randomly, and obvious immunogenicity and toxic and side effects are avoided.

The present invention proposes a Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof, which belong to the field of pharmaceutical technology. Ag-graphene oxide is adsorbed on in vitro proliferated γδT cells, a Chinese medicine fermentation product obtained by fermentation and extraction of Xanthium sibiricum, Astragalus, Poria, Magnolia officinalis, and Mentha is prepared, berberine and quercetin are prepared into eutectic powder, the three are mixed and added into water, probiotics, carboxymethyl chitosan, poloxamer 407 and poloxamer 188 are added, and mixed evenly to prepare a Chinese medicine composition for treating allergic rhinitis, which has a good effect of improving allergic rhinitis, adopts a method of combining traditional Chinese and Western medicine, reduces inflammatory response, enhances the immune function of patients, improves the clinical symptoms of patients with allergic rhinitis, reduces the long-term recurrence rate, reduces the use of drugs, improves the quality of life, and reduces the risk of developing asthma, and has broad application prospects.

The invention provides application of FBXO22 in diagnosis and treatment of a non-alcoholic fatty liver disease, discloses high expression of FBXO22 in the non-alcoholic fatty liver disease, and verifies that the process of the non-alcoholic fatty liver disease can be delayed, liver inflammation can be relieved and liver lipid accumulation can be slowed down by reducing the expression level of the FBXO22. The FBXO22 can be used for diagnosing and treating the non-alcoholic fatty liver disease and screening candidate drugs for the non-alcoholic fatty liver disease, and the FBXO22 can also be used for evaluating the drug effect and researching and revealing the pathogenesis of the non-alcoholic fatty liver disease. The invention has important significance for clinical research of the non-alcoholic fatty liver disease.

The invention relates to a multifunctional magnesium alloy coating with high biocompatibility and a preparation method and application thereof. Comprising the following steps: (1) carrying out surface treatment on a magnesium alloy substrate; (2) micro-arc oxidation treatment; (3) after preparing a coating solution, carrying out double-sided ultrasonic atomization spraying; and (4) drying, soaking and cleaning. According to the preparation method, a micro-arc oxidation treatment technology and a double-sided ultrasonic atomization spraying technology are combined for the first time, pores and cracks of the MAO coating serve as binding sites, effective loads are provided for the silk fibroin / nano-hydroxyapatite particle coating, the MAO coating and the SF / nHAp coating are fully combined, and the composite coating is prepared. According to the coating, the MAO coating and the SF / nHAp coating are combined for the first time, the defect of rapid degradation when the magnesium alloy serves as an in-vivo implant is effectively overcome, the corrosion resistance of the magnesium alloy is remarkably improved, the release rate of hydrogen after implantation is reduced, and rising of the pH value around the implant is slowed down.

The invention provides a synthesis method of a novel inhalable liposome and an application of the novel inhalable liposome in ARDS (arterial thrombosis syndrome) treatment, and the synthesis method comprises the following steps: firstly, mixing DSPE-PEG2K-TK-NHS and tocilizumab (TCZ: Tocilizumab) to form a lead compound DSPE-PEG2K-TK-TCZ; the preparation method comprises the following steps: dissolving DPPC, cholesterol, DSPE-TK-PEG2k and FG4592 in 5mL of chloroform, carrying out reduced pressure evaporation in a sample bottle to form a film, and adding 3mL of deionized water to prepare Lip-coated RF; and then stirring and incubating the DSPE-PEG2K-TK-TCZ and the Lip (at) RF, so as to form the Lip (at) RFT. As a functional nano-material with ultra-small size, good biocompatibility, excellent ROS removal capability and ROS responsive drug release, the nano-material is used for treating ARDS. The invention has the advantages that: the Lip-coated RFT relieves lung oxidative stress, inflammatory response, protein permeability and histological severity in the LPS-induced mouse ALI model. Therefore, Lip at RFT can be used as a new way for treating ARDS. Aerosol inhalation of Lip-coated RFT can effectively improve the severity of ARDS.

The invention provides a uric acid reducing composition containing fructus gardeniae and a preparation method of the uric acid reducing composition, and belongs to the technical field of medicines. The preparation method comprises the following steps: fermenting mulberry leaves, chicory, cape jasmine and kudzu vine roots through lactobacillus rhamnosus and bifidobacterium longum, separating probiotics from fermentation liquor, adding immobilized ionic liquid into the fermentation liquor, introducing carbon dioxide for adsorption, filtering, adding solids into ethanol, heating for desorption, concentrating to obtain an extract 1, precipitating filtrate with ethanol to obtain an extract 2, and carrying out freeze-drying to obtain the folium mori-chicory-cape jasmine extract. The preparation method comprises the following steps: embedding probiotics together with sodium alginate to prepare a uric acid-reducing embedding material, and uniformly mixing the uric acid-reducing embedding material with the extract 1, vitamin C and tea polyphenol to prepare the uric acid-reducing composition containing fructus gardeniae. The prepared uric acid reducing composition containing fructus gardeniae can promote uric acid excretion, inhibit sodium urate crystallization, improve the antioxidant effect, repair intestinal barriers, relieve inflammation, inhibit xanthine oxidase (XOD) activity and expression and reduce the blood uric acid level, has a good uric acid reducing effect and has a wide application prospect.

The invention discloses a soothing and moisturizing composition as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides a soothing and moisturizing composition. The soothing and moisturizing composition is prepared from the following components in parts by weight: 1 to 10 parts of chondrus crispus extract, 1 to 10 parts of water temple porphyra polysaccharide, 1 to 10 parts of crithmum maritimum extract, 0.05 to 2 parts of oligopeptide-1 and 0.05 to 2 parts of palmitoyl pentapeptide-4. The inventor discovers that when existing at the same time, the chondrus crispus extract, the laver polysaccharide, the crithmum maritimum extract, the oligopeptide-1 and the palmitoyl pentapeptide-4 can cooperate with one another and act together from multiple aspects, and the effects of multi-channel, deep moisturizing, soothing and skin barrier enhancing are better achieved.

The invention provides a skin care composition containing stem cell extract as well as a preparation method and application of the skin care composition, and belongs to the technical field of cosmetics. The method comprises the following steps: mixing and culturing the extracted urine-derived stem cells and pilose antler stem cells in a DMEM culture medium added with epidermal growth factors, cholera toxin, penicillin, streptomycin, transferrin, IL-2 and IL-15, then separating a culture solution to obtain mixed exosomes, mixed stem cells and extracellular matrixes, preparing the mixed stem cells into stem cell lipidosome, and preparing the stem cell lipidosome. Embedding the stem cell extract and the mixed exosome into titanium dioxide / silicon dioxide microspheres, adding into an extracellular matrix, and uniformly dispersing to obtain the skin care composition containing the stem cell extract. The skin care composition containing the stem cell extract prepared by the invention can obviously prolong the preservation period of stem cells and exosomes and improve the repair and improvement of the stem cells and the exosomes on skin, and the prepared composition has better effects of resisting aging, whitening, promoting skin elasticity, resisting wrinkles and the like, and has a wide application prospect.

The invention discloses a fibroblast exosome for repairing scars and a preparation method and application thereof, and relates to the technical field of biology, and the preparation method comprises the following steps: S1, taking fibroblasts, and carrying out adaptive culture on the fibroblasts in a complete culture medium for 24-30 hours; s2, after the adaptive culture is completed, replacing a new culture medium, culturing in a complete culture medium containing 10% of fetal calf serum until the fusion degree is 80%, carrying out digestion treatment by adopting 0.25% of pancreatin, centrifuging, collecting supernate, and carrying out ultracentrifugation extraction on the supernate to obtain a primary product of the fibroblast exosome; s3, carrying out transfection treatment on the primary product of the fibroblast exosome to obtain the fibroblast exosome for repairing scars; the prepared fiber-forming exosome can also influence the movement of epidermal and dermal cells by regulating the expression of related factors in a TGF-beta / Smad signal channel, and the regulating effect is mainly to promote scar-free healing of the skin, so that the generation of scars is reduced from the source.