94results about How to "Reduce inflammation" patented technology

This invention relates to the field of biopharmaceutical technology, providing a self-assembled peptide-rhein conjugate, its formulation, preparation method, and applications. The MMP-9-responsive self-assembled peptide-rhein conjugate of this invention, with the sequence Rhein-GFFPLGLAGACE, can respond to abnormally activated MMP-9 in atherosclerotic plaques, self-assembling in situ into a stable nanofiber structure at the lesion site. The rhein in this conjugate exhibits significant anti-inflammatory and antioxidant functions, but its water solubility and oral bioavailability are low. These are significantly improved after conjugation with the peptide, achieving targeted delivery and prolonging retention time. The introduction of the tripeptide ACE, which mimics the function of glutathione, further enhances the conjugate's ability to resist oxidative stress. Furthermore, this conjugate exhibits excellent anti-inflammatory and antioxidant effects, scavenging ROS, inhibiting inflammatory pathways, regulating macrophage phenotype, and inhibiting apoptosis, providing a new strategy for the treatment of atherosclerosis.

The invention belongs to the technical field of exosome preparation, and discloses a plant exosome with an anti-acne effect and a preparation method and application of the plant exosome with the anti-acne effect. According to the application, an integrated technical route of microbial regulation and induction, complexing-agent-free green extraction and synergistic acne resistance is established: a microbial strain spore suspension is used as a biological inducer, a plant active precursor is released by dynamic countercurrent of ethanol, and PEG / CaCl2 residues are completely eradicated through physical separation in the whole process; finally, the microorganism-induced plant exosome with high yield, high activity and high safety is obtained.

The invention discloses a composition with an anti-aging effect and a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition is prepared by compounding a traditional Chinese medicine active component, a moisturizing and permeation promoting component and a repairing and anti-aging auxiliary component, and the traditional Chinese medicine active component is composed of three zymolytes and three fermentation extracts which are respectively prepared from six medicinal and edible traditional Chinese medicine raw materials through differentiated composite enzymolysis and probiotic anaerobic fermentation processes. The problems that traditional Chinese medicine extracts are low in transdermal absorption rate, poor in bioavailability and insufficient in cosmetic system stability are solved, active ingredients are small-molecularized through process optimization, a multi-target synergistic anti-aging system is formed by matching with functional components, the anti-aging and repairing composition has excellent anti-aging and repairing effects, physical and chemical stability and skin safety, and the anti-aging and repairing composition has a good application prospect. The composition is suitable for various skin types and can be widely applied to preparation of anti-aging repair cosmetics.

This invention discloses a micropeptide, its encoding nucleic acid, and its application in regulating inflammatory activation of microglia. The amino acid sequence of the micropeptide is shown in SEQ ID NO:3. Simultaneously, this invention discloses the nucleic acid encoding the micropeptide, which contains either the nucleotide sequence shown in SEQ ID NO:1 or the nucleotide sequence shown in SEQ ID NO:2, wherein SEQ ID NO:2 is a small open reading frame located within the sequence of SEQ ID NO:1. This invention validated the translational expression of the micropeptide in microglia by constructing an EGFP reporter gene fusion vector and a SUMO tag fusion expression vector. Functional experiments showed that under oxygen-glucose deprivation / reperfusion injury conditions, the micropeptide significantly inhibited inflammatory activation of microglia. This invention provides a new potential target and candidate drug for the treatment of neuroinflammatory diseases such as stroke.

The invention relates to nutritional compositions with Bifidobacterium breve and non-digestible oligosaccharides for use infants or toddlers for use in improving cognitive or behavioral performance or neuroinflammation.

The application belongs to the technical field of biotechnology, and particularly relates to a pharmaceutical composition containing exosomes and application thereof. The pharmaceutical composition containing exosomes comprises stem cell exosomes, recombinant IGFBP7 protein and baeckea fruitin B; the amino acid sequence of the recombinant IGFBP7 protein is shown as SEQ ID NO:1. Test results show that the combination of umbilical cord mesenchymal stem cell exosomes, baeckea fruitin B and recombinant IGFBP7 protein can stimulate hair follicle stem cells, prolong the initial stage of hair growth of hair follicles, and thus effectively improve the hair loss of patients.

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

The present application relates to the field of medical or cosmetic formulations, the field of biopharmaceutical manufacturing technology and the field of preparation manufacturing technology, and in particular to a cosmetic composition, a preparation method and application thereof.The cosmetic composition comprises an active ingredient; the active ingredient comprises a chloranthus specious extract and a rhizoma corydalis extract; and the weight ratio of the chloranthus specious extract and the rhizoma corydalis extract is 0.6:1-1:1.The chloranthus specious extract and the rhizoma corydalis extract in the cosmetic composition provided by the present application are synergistic with each other, and have excellent soothing and repairing effects.

This invention provides the application of *Bifidobacterium breve* in the preparation of products for treating gastric ulcers and gastric inflammation caused by *Helicobacter pylori*, belonging to the field of microbial technology. The *Bifidobacterium breve* NKU BB1-2 of this invention, with accession number GDMCC NO: 65956, can antagonize *Helicobacter pylori* colonization and alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori*. In vitro, *Bifidobacterium breve* NKU BB1-2 exhibits good antagonistic ability against *Helicobacter pylori*, significantly inhibiting its colonization and growth. Animal experiments show that *Bifidobacterium breve* NKU BB1-2 can alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori* infection in vivo, manifested as reduced gastric mucosal damage, reduced gastric inflammation, and increased gastric pH. Furthermore, *Bifidobacterium breve* NKU BB1-2 can significantly enhance gastric microbial diversity, regulate and improve the gastric microbial structure, and assist in antagonizing and eradicating *Helicobacter pylori* infection.

The utility model relates to medical rehabilitation equipment technical field especially, a kind of hot compress device for facial paralysis treatment, including hollow face bag etc.;Hollow face bag is provided with multiple through holes, and hollow face bag is fixedly connected with multiple groups of first wide band and second wide band, and first wide band and second wide band are used to fix device on patient's face, and the top of hollow face bag is fixedly connected with medicine storage bag, and medicine storage bag is communicated with hollow face bag by connecting pipe, and the bottom of hollow face bag is provided with liquid outlet. The utility model injects the medicine liquid of heating into medicine storage bag, and the medicine liquid flows and diffuses to each part of hollow face bag by connecting pipe, then hollow face bag is fixed on patient's face, and the heat of medicine liquid is used to help improve facial blood flow, reduce inflammation, relax tense facial muscle, relieve pain and stiffness, provide an effective and convenient hot compress treatment means for facial paralysis patient, help to promote the recovery of facial nerve function.

The application discloses an intestinal micro-needle anastomosis stent with an antibacterial function and a preparation method and application thereof, which can effectively physically isolate an anastomotic stoma from intestinal contents, provides a relatively clean local environment for healing of the anastomotic stoma, and further reduces tension at the anastomotic stoma by fixing the micro-needle anastomosis stent at the anastomotic stoma, so that anastomotic leakage caused by excessive tension is avoided; a micro-needle layer on a surface of the stent can realize in-situ long-acting slow release of berberine hydrochloride (BBH) on a superficial layer of the anastomotic stoma, so that drug utilization of the BBH is improved, and occurrence of initial inflammation of the anastomotic stoma is effectively reduced, and healing of the anastomotic stoma is better regulated. Animal experiment results prove that implantation of the micro-needle anastomosis stent can effectively reduce inflammatory cell infiltration of local tissues, reduce anastomotic arrangement, and regulate smooth healing of the anastomotic stoma.

The utility model discloses a kind of capsule packaging tip type catheters, catheter has distal end, proximal end and catheter body, catheter body is made of biocompatible elastic material, catheter body includes at least one substantially parallelly arranged flow cavity and at least one inflation cavity for multiple capsules to flow and supply capsule filling, the distal end of catheter body is catheter tip, fixed balloon is set in the catheter tip, the catheter tip is also provided with the support balloon of packaging its tip, by the injection or inflation of inflation cavity for flowing with balloon, fixed balloon and support balloon are filled in turn, reach the purpose of making catheter fixed in suitable position and catheter tip packaging.This catheter is set by packaging support balloon outside catheter tip in distal end on the basis of existing single-balloon catheter, when support balloon is filled, make tip volume swell, hide catheter tip, avoid the irritation and damage of catheter tip to inner wall in prior art.

An integrated eustachian tube sustained-release drainage device is provided with a drug-carryable, degradable and compressible elastic support, a drainage mechanism for draining liquid in the eustachian tube and a degradable connecting line, the drainage mechanism being fixed to the front end of the elastic support through the connecting line. The integrated eustachian tube drainage device can effectively drain the effusion and secretion in the eustachian tube, improve the ventilation and drainage conditions of the middle ear. The elastic support is composed of a degradable material and can carry drugs to continuously release the drugs, effectively treating diseases such as eustachian tube inflammation and reducing inflammatory reactions and promoting mucosal repair. Moreover, the degradable material of the elastic support reduces the long-term impact on the patient and reduces the risk of infection. The integrated eustachian tube drainage device can also be stably fixed in the eustachian tube, thereby improving the reliability of treatment.

This invention discloses the application of VGLL4 in metabolic-associated fatty liver disease (MAFLD), relating to the field of biomedical technology. This invention is the first to discover that the molecular VGLL4 can be used to construct a novel MAFLD animal model with a complete pathological phenotype and clearly defined targets. This model exhibits typical phenotypes, including hepatic steatosis, insulin resistance, inflammatory response, and progression to steatohepatitis (MASH), without requiring a high-fat diet or chemical stimulation. By targeting the VGLL4-TEAD4 interaction or Pdk4, the aforementioned pathological phenotypes can be reversed. This invention provides a novel MAFLD model and intervention strategy, laying the foundation for further clinical trials and drug development.

The invention discloses a preparation method of a traditional Chinese medicine composition for treating skin tinea, allergic dermatitis and acne, and relates to the field of pharmaceutical preparations, the extraction rate of gallic acid and ethyl gallate contained in total tannin in fructus chebulae flesh, fructus terminaliae billericae flesh and fructus chebulae immaturus is improved through an enzymolysis method, and the transfer rate of effective components of quercetin is improved through a boiling granulation technology; therefore, the effect of treating psoriasis of the composition is improved. By adopting a boiling granulation technology, the technical problems of long preparation period and high cost in the prior art are solved. The release speed of aloe in intestinal tracts is controlled by adopting a slow release technology, and the upper and lower limit content range of barbaloin is controlled to reduce the occurrence rate of adverse reactions of the composition. Meanwhile, butyl hydroxy anisd (BHA), butylated hydroxytoluene (BHT) and a citric acid system are adopted, so that the problems of PEO skeleton degradation, out-of-control drug release behavior and insufficient main drug stability of the barbaloin-PEO sustained release preparation are solved.

This invention relates to the field of biomedical technology, specifically to the application of the MSR1 gene in the regulation of necrosis and apoptosis of dendritic cells (DCs) in sepsis. This application reduces DC necrosis and apoptosis during sepsis by knocking out the MSR1 gene, providing a novel therapeutic target for sepsis.

The invention belongs to the technical field of biological medicine, and particularly relates to a preparation method of a probiotic hydrogel material and application of the probiotic hydrogel material in treatment of acute radioactive intestinal injury. In order to solve the clinical key problem of radioactive intestinal injury, a novel biological material TG-CCS-coated DY802 of thiolated synchronously modified chitosan hydrogel TG-CCS loaded with'localized high-response 'lactobacillus salivarius DY802 is constructed. The synthesis process of the material is synergistic and time-saving, has excellent biological safety and tumor inhibition experiment performance, and can comprehensively repair four barriers of the intestinal tract: ROS is removed, and tight junction protein is protected to repair the physical barrier; forming a hydrogel protective layer to reinforce the chemical barrier; the flora diversity is improved, and the prebiotic effect is exerted to repair the biological barrier; the sphingomyelin metabolism and ceramide abundance are regulated and controlled, the abnormal infiltration of NK cells is inhibited, and the immune barrier is remodeled. Therefore, the probiotic hydrogel material disclosed by the invention is clear in treatment mechanism and remarkable in clinical transformation potential and application value.

This application discloses a composition containing palmitoyl tripeptide-5, a skin care product, and its uses. The composition containing palmitoyl tripeptide-5 comprises acetyl tripeptide-30 citrulline and palmitoyl tripeptide-5 in a mass ratio of (1.5-2):2. The composition containing palmitoyl tripeptide-5 can protect the skin through the synergistic effect of acetyl tripeptide-30 citrulline and palmitoyl tripeptide-5.

This application discloses a hydrogel composition, its preparation method, and its applications, relating to the fields of regenerative medicine and biomedical materials technology. The hydrogel composition comprises o-nitrobenzyl alcohol-modified tetra-arm polyethylene glycol and methacrylated hyaluronic acid. The hydrogel composition provided in this application addresses the problems in related technologies that rely on tissue flaps or prostheses for repair, such as large trauma, easy foreign body reaction, asymmetrical shape, unnatural feel, and the inability of tissue engineering materials to be rapidly molded intraoperatively, requiring secondary surgery.

This invention belongs to the field of toothpaste technology, specifically relating to a compound honeysuckle herbal toothpaste for treating oral ulcers and dental caries, and its preparation method. The toothpaste contains the following ingredients: honeysuckle extract, angelica dahurica extract, bletilla striata extract, licorice extract, cellulose gum, sorbitol, sodium monofluorophosphate, sodium benzoate, hydrated silica, sodium lauryl sulfate, sodium saccharin, and deionized water. The preparation process includes ultrafine grinding, two water extractions, low-temperature concentration, and graded filtration to prepare the herbal extracts, which are then mixed and homogenized with a matrix to obtain a stable gel paste. This process improves the extraction of beneficial components from the herbal extracts and achieves synergistic effects on multiple targets. This novel formulation has been demonstrated in rat oral ulcer experiments to significantly reduce ulcer diameter, accelerate healing, and reduce irritation. It has a mild and safe effect on the oral mucosa and is suitable for daily care in people prone to oral ulcers and those with sensitive mouths. This invention has a scientifically formulated, stable, and effective formula with promising application prospects.

The application provides a preparation of gramicidin and an antibacterial hydrogel preparation of the gramicidin, and discloses medical uses of the gramicidin, and provides a recombinant gramicidin, heterologous expression of the gramicidin is realized by constructing a Pichia pastoris recombinant strain, and the antibacterial activity of the gramicidin is retained, and the method has the advantages of simplicity and rapidness. Meanwhile, the hydrogel preparation of the gramicidin provided by the application shows good potential for treating wound infection of a diabetic mouse, and has the performance of rapid adhesion and hemostasis, lays a foundation for development of a new antibacterial drug, and provides a new direction for treatment of chronic inflammatory wounds and open bleeding.

The invention relates to the technical field of nursing materials, and discloses eye washing liquid for relieving eye fatigue and a preparation method thereof.The eye washing liquid is prepared from trehalose, taurine, sodium gualenate, sodium hyaluronate, ergothioneine, vitamin B12, vitamin B6, xanthophyll, mint, a humectant, a bacteriostatic agent, a chelating agent, a pH regulator and deionized water. Through the synergistic effect of the first synergistic composition and the second synergistic composition, retina cell injury induced by blue light can be effectively repaired, the repairing effect is superior to that of simple addition of a single component, blue light oxidative injury is repaired through a multi-target synergistic mechanism, a three-layer structure of a tear film lipid layer, a water layer and a mucoprotein layer can be reconstructed, and the repairing effect is good. According to the present invention, the tearable film stability is significantly improved, the excellent protection and repair effect is provided, the compatibility of the components is good, the product stability is high, and the multiple effects of ocular surface cleaning, asthenopia relieving, conjunctival congestion reducing and blue light oxidation damage preventing are provided.

The invention discloses application of serum alpha-non-red blood cell ghost protein 1 in preparation of drugs for diagnosing heart light chain amyloidosis diseases, and belongs to the technical field of biological medicines. The serum SPTAN1 protein is used for preparing the medicine for diagnosing the heart light-chain amyloidosis disease, the medicine is limited to be an enzyme linked immunosorbent assay kit, and the kit comprises an antibody of the SPTAN1 protein and further comprises a pre-coated plate, a standard substance, a coating buffer solution, a sample diluent, a confining liquid, horse radish peroxidase, an eluent and a color developing agent. The concentration of the SPTAN1 protein in the serum is measured through an enzyme linked immunosorbent assay kit, and early diagnosis of the heart AL amyloidosis disease is carried out. The invention provides a novel, efficient and sensitive biomarker, namely the serum SPTAN1 protein, early diagnosis of heart AL amyloidosis is realized by detecting the concentration of the SPTAN1 protein in serum, and the serum SPTAN1 protein has an important clinical application prospect.

The application discloses an artificial blood vessel joint and a preparation method thereof. The blood vessel joint adopts a carbon-based material as a base body, a double-layer composite coating with PyC and Ag-doped DLC and an Ag-doped DLC coating are prepared on the inner wall and the outer wall respectively, and the blood vessel joint is obtained; the inner wall of the blood vessel joint is smooth and compact, which is beneficial to blood circulation; the outer wall is a porous Ag-doped DLC coating, which is beneficial to biological fixation with tissues; the Ag-doped DLC coating endows the blood vessel joint with good antibacterial property, reduces inflammation, and can improve the adverse reaction of the human body caused by friction and powder loss after the blood vessel joint is implanted into the human body.

The invention discloses a traditional Chinese medicine composition for treating intestinal tract diseases, which is prepared from the following traditional Chinese medicines in parts by weight: 8-15 parts of selfheal, 20-40 parts of nacre mother of pearl, 5-10 parts of radix bupleuri, 3-8 parts of fried fructus aurantii, 3-8 parts of rhizoma cyperi, 6-12 parts of inula flower and 5-9 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition can be used for pertinently treating liver and gall stagnated heat, stomach qi reversal type bile reflux gastritis or gastroesophageal reflux disease, has the specific treatment effects of relieving inflammation, inhibiting local tissue angiogenesis and preventing precancerous lesions and / or canceration, and has good clinical significance.

This invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, its preparation method, combined drugs, and applications. The traditional Chinese medicine composition for treating ulcerative colitis of this invention is made from the following raw materials in parts by weight: Astragalus membranaceus 13-26 parts, Lonicera japonica 10-20 parts, Sargentodoxa cuneata 10-20 parts, Prunus mume 8-16 parts, Agrimonia pilosa 8-16 parts, Allium macrostemon 6-12 parts, Platycodon grandiflorus 6-12 parts, Coptis chinensis 3-6 parts, and Panax notoginseng powder 1-3 parts. An animal model of ulcerative colitis was constructed using DSS induction, and the results showed that the traditional Chinese medicine composition of this invention has a certain therapeutic effect on ulcerative colitis. Clinical studies showed that the traditional Chinese medicine composition of this invention, used in combination with mesalazine enteric-coated tablets, can reduce the modified Mayo score and serum inflammatory markers in patients with active ulcerative colitis, improve colonic mucosal inflammation and gastrointestinal symptoms, and effectively treat active ulcerative colitis of the damp-heat type.

This invention belongs to the field of biomedical materials and relates to a method for preparing a multi-dynamically bonded hydrogel based on polysaccharides from the traditional Chinese medicine *Solanum nigrum* and its application. *Solanum nigrum* is initially extracted and precipitated with alcohol to obtain crude polysaccharides. The polysaccharides are then deproteinized using the Sevag method to obtain a crude polysaccharide solution. After dialysis and freeze-drying, crude polysaccharide is obtained. The crude product is separated and purified to obtain homogeneous polysaccharides. The homogeneous polysaccharide solution is reacted with sodium periodate solution in the dark, followed by dialysis, purification, and freeze-drying to obtain oxidized *Solanum nigrum* polysaccharide OBY. OBY is dissolved in boric acid solution to obtain solution A. Carboxymethyl chitosan is dissolved in polyvinyl alcohol solution to obtain solution B. After the solutions A and B have fully reacted, they are placed in a mold to obtain a multi-dynamically bonded hydrogel based on *Solanum nigrum* polysaccharides. This hydrogel can be applied to the preparation of drugs for chronic wound repair, providing a novel material system and application strategy for developing new wound dressings with excellent physicochemical properties, intelligent response characteristics, and active repair functions.

This invention discloses the application of psoralen in the preparation of FFA4 receptor agonists and drugs for FFA4 receptor-related diseases. Cellular experiments show that this compound is a concentration-dependent FFA4 agonist; animal experiments show that this compound has significant efficacy in a DSS-induced colitis model, reducing DSS-induced colonic shortening, improving weight loss, and alleviating splenic swelling. This compound can be used in the preparation of FFA4 agonists and in the prevention and treatment of FFA4-related diseases such as inflammatory bowel disease.

The invention discloses application of a Reg4 gene in treatment of metabolism-related fatty liver, and relates to the technical field of biomedicine. The Reg4 gene is applied to the aspect of treating obesity and metabolism-related fatty liver; according to the application, by increasing expression of the Reg4 gene, liver lipid deposition, liver cell ballooning and inflammatory infiltration related to the metabolism-related fatty liver are inhibited; the application is realized by inhibiting the processes of de novo synthesis of fat in the liver, liver lipid uptake and fatty acid beta oxidation. The step of inhibiting the de novo synthesis of fat in the liver comprises the step of inhibiting the expression of genes of acetyl coenzyme A carboxylase 1, fatty acid synthase and / or stearoyl coenzyme A desaturase 1. The invention definitely proves that the Reg4 gene has an obvious effect of improving obesity and metabolism-related fatty liver, and can relieve hepatic fatty degeneration and inflammation.

The application discloses a furan coumarin compound and a preparation method and application thereof, and the molecular formula of the furan coumarin compound is C 21 H 20 O6; the furan coumarin compound can reduce the inflammatory reaction of RAW264.7 macrophages induced by lipopolysaccharide (LPS), can reduce the NO production of RAW264.7 macrophages induced by LPS, and can significantly inhibit the production of inflammatory factors such as TNF-alpha, interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta).