30results about How to "Reduce inflammation" patented technology

This invention discloses a micropeptide, its encoding nucleic acid, and its application in regulating inflammatory activation of microglia. The amino acid sequence of the micropeptide is shown in SEQ ID NO:3. Simultaneously, this invention discloses the nucleic acid encoding the micropeptide, which contains either the nucleotide sequence shown in SEQ ID NO:1 or the nucleotide sequence shown in SEQ ID NO:2, wherein SEQ ID NO:2 is a small open reading frame located within the sequence of SEQ ID NO:1. This invention validated the translational expression of the micropeptide in microglia by constructing an EGFP reporter gene fusion vector and a SUMO tag fusion expression vector. Functional experiments showed that under oxygen-glucose deprivation / reperfusion injury conditions, the micropeptide significantly inhibited inflammatory activation of microglia. This invention provides a new potential target and candidate drug for the treatment of neuroinflammatory diseases such as stroke.

The invention relates to nutritional compositions with Bifidobacterium breve and non-digestible oligosaccharides for use infants or toddlers for use in improving cognitive or behavioral performance or neuroinflammation.

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

This invention provides the application of *Bifidobacterium breve* in the preparation of products for treating gastric ulcers and gastric inflammation caused by *Helicobacter pylori*, belonging to the field of microbial technology. The *Bifidobacterium breve* NKU BB1-2 of this invention, with accession number GDMCC NO: 65956, can antagonize *Helicobacter pylori* colonization and alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori*. In vitro, *Bifidobacterium breve* NKU BB1-2 exhibits good antagonistic ability against *Helicobacter pylori*, significantly inhibiting its colonization and growth. Animal experiments show that *Bifidobacterium breve* NKU BB1-2 can alleviate the aggravation of gastric ulcers caused by *Helicobacter pylori* infection in vivo, manifested as reduced gastric mucosal damage, reduced gastric inflammation, and increased gastric pH. Furthermore, *Bifidobacterium breve* NKU BB1-2 can significantly enhance gastric microbial diversity, regulate and improve the gastric microbial structure, and assist in antagonizing and eradicating *Helicobacter pylori* infection.

An integrated eustachian tube sustained-release drainage device is provided with a drug-carryable, degradable and compressible elastic support, a drainage mechanism for draining liquid in the eustachian tube and a degradable connecting line, the drainage mechanism being fixed to the front end of the elastic support through the connecting line. The integrated eustachian tube drainage device can effectively drain the effusion and secretion in the eustachian tube, improve the ventilation and drainage conditions of the middle ear. The elastic support is composed of a degradable material and can carry drugs to continuously release the drugs, effectively treating diseases such as eustachian tube inflammation and reducing inflammatory reactions and promoting mucosal repair. Moreover, the degradable material of the elastic support reduces the long-term impact on the patient and reduces the risk of infection. The integrated eustachian tube drainage device can also be stably fixed in the eustachian tube, thereby improving the reliability of treatment.

This application discloses a hydrogel composition, its preparation method, and its applications, relating to the fields of regenerative medicine and biomedical materials technology. The hydrogel composition comprises o-nitrobenzyl alcohol-modified tetra-arm polyethylene glycol and methacrylated hyaluronic acid. The hydrogel composition provided in this application addresses the problems in related technologies that rely on tissue flaps or prostheses for repair, such as large trauma, easy foreign body reaction, asymmetrical shape, unnatural feel, and the inability of tissue engineering materials to be rapidly molded intraoperatively, requiring secondary surgery.

The application provides a preparation of gramicidin and an antibacterial hydrogel preparation of the gramicidin, and discloses medical uses of the gramicidin, and provides a recombinant gramicidin, heterologous expression of the gramicidin is realized by constructing a Pichia pastoris recombinant strain, and the antibacterial activity of the gramicidin is retained, and the method has the advantages of simplicity and rapidness. Meanwhile, the hydrogel preparation of the gramicidin provided by the application shows good potential for treating wound infection of a diabetic mouse, and has the performance of rapid adhesion and hemostasis, lays a foundation for development of a new antibacterial drug, and provides a new direction for treatment of chronic inflammatory wounds and open bleeding.

This invention belongs to the field of biomedical materials and relates to a method for preparing a multi-dynamically bonded hydrogel based on polysaccharides from the traditional Chinese medicine *Solanum nigrum* and its application. *Solanum nigrum* is initially extracted and precipitated with alcohol to obtain crude polysaccharides. The polysaccharides are then deproteinized using the Sevag method to obtain a crude polysaccharide solution. After dialysis and freeze-drying, crude polysaccharide is obtained. The crude product is separated and purified to obtain homogeneous polysaccharides. The homogeneous polysaccharide solution is reacted with sodium periodate solution in the dark, followed by dialysis, purification, and freeze-drying to obtain oxidized *Solanum nigrum* polysaccharide OBY. OBY is dissolved in boric acid solution to obtain solution A. Carboxymethyl chitosan is dissolved in polyvinyl alcohol solution to obtain solution B. After the solutions A and B have fully reacted, they are placed in a mold to obtain a multi-dynamically bonded hydrogel based on *Solanum nigrum* polysaccharides. This hydrogel can be applied to the preparation of drugs for chronic wound repair, providing a novel material system and application strategy for developing new wound dressings with excellent physicochemical properties, intelligent response characteristics, and active repair functions.

This invention discloses the application of psoralen in the preparation of FFA4 receptor agonists and drugs for FFA4 receptor-related diseases. Cellular experiments show that this compound is a concentration-dependent FFA4 agonist; animal experiments show that this compound has significant efficacy in a DSS-induced colitis model, reducing DSS-induced colonic shortening, improving weight loss, and alleviating splenic swelling. This compound can be used in the preparation of FFA4 agonists and in the prevention and treatment of FFA4-related diseases such as inflammatory bowel disease.

The application belongs to the technical field of biological nanomaterials, and particularly relates to a nano-enzyme material and a preparation method and application thereof. The application reacts dimethyl imidazole and metal salt in an aqueous solution to obtain a metal-dimethyl imidazole composite material solution, wherein the metal salt comprises copper salt and / or zinc salt; and reacts the metal-dimethyl imidazole composite material solution and tannic acid to obtain a nano-enzyme material. The nano-enzyme material provided by the application has excellent antioxidant enzyme-like catalytic activity and good biocompatibility, can effectively remove abnormally increased reactive oxygen species (ROS) in the process of myocardial infarction and myocardial ischemia-reperfusion injury, inhibit inflammatory response and myocardial cell apoptosis, improve the mitochondrial function state, thereby promoting the repair of damaged myocardial tissue and significantly improving the cardiac function, and provides a new technical solution for the treatment of myocardial infarction and related ischemic cardiovascular diseases.

Provided herein are methods and compositions for treating kidney-related disease conditions and complications, such as Berger's disease, and for preventing transplant rejection. For example, the present disclosure describes a method of improving function of a transplanted kidney in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds CD40 ligand.

This invention discloses a low-infection-risk detachable fixation wing and grooveless stop clamp hemodialysis catheter system, belonging to the field of medical device technology. This invention addresses two core pain points of existing long-term hemodialysis catheters: first, it redesigns the traditional one-piece fixation wing as a detachable structure, allowing for quick assembly and disassembly by external force without damaging the catheter, facilitating skin cleaning and reducing the risk of local infection and mechanical damage; second, it optimizes the separate stop clamp into a grooveless structure integrated with the connector, employing a full, smooth inner lumen to completely eliminate dead zones for bacterial residue, reducing catheter-related bloodstream infections at the source. This invention has a simple structure, strong clinical adaptability, and can be widely applied in the field of long-term hemodialysis treatment, demonstrating significant clinical application value.

The application provides medical uses of knocking down or inhibiting a circular RNA circ0030586, in particular, applications of a substance for knocking out or knocking down circ0030586 or a substance for inhibiting expression of circ0030586 in (A1)-(A2) as follows: (A1) preparing a drug for treating or assisting in treating a cardiovascular disease caused by endothelial dysfunction; (A2) preparing a drug for preventing or assisting in preventing a cardiovascular disease caused by endothelial dysfunction. In patients with atherosclerosis caused by endothelial dysfunction and cell and animal models related to atherosclerosis, it is found that inhibiting circ0030586 can delay the progression of atherosclerosis; the application provides a new target for diagnosis and treatment of atherosclerosis related vascular diseases caused by aging, and opens up a new direction for preparation of prevention and treatment drugs.

The present application belongs to the technical field of cosmetics or drugs, and particularly relates to a composition for treating gingivitis and application thereof. The composition is composed of shikonin acid and shikonin naphthoquinone, and the mass ratio of the shikonin acid to the shikonin naphthoquinone is 10-100:1. The present application has excellent effects in improving gingival bleeding and inhibiting alveolar bone absorption. The shikonin acid is prepared by high-pressure steam explosion combined with ethanol extraction, activated carbon decolorization and macroporous adsorption resin technology, and the shikonin naphthoquinone is prepared by supercritical CO2 extraction combined with molecular distillation technology. The preparation method is green, stable and controllable, the obtained active ingredient has high purity, and is suitable for industrial production. The composition of the present application is derived from natural plant ingredients, has high safety, can be prepared into various oral care dosage forms such as gels, toothpastes and mouthwashes, is used for the auxiliary treatment or daily care of gingivitis, and has good application prospect.

The application belongs to the technical field of bioengineering, and particularly relates to a Terminalia chebula Retz. fruit nano vesicle, a preparation method thereof and application of the nano vesicle in anti-skin aging products. In the application, a composite enzyme preparation containing ferulic acid esterase is used to perform enzymolysis on Terminalia chebula Retz. fruit raw materials, sodium alginate and a calcium chloride solution are added to the enzymolysis liquid after the enzymolysis, and the nano vesicle is subjected to precipitation treatment; finally, a sodium carbonate or sodium bicarbonate solution is used to treat the precipitate, the mixture is fully stirred, centrifuged, and the supernatant is collected to obtain a purified product of the Terminalia chebula Retz. fruit nano vesicle. The preparation method of the Terminalia chebula Retz. fruit nano vesicle provided by the application is efficient and low in cost, the nano vesicle obtained has a high miRNA content, animal experiments show that the nano vesicle can reduce the content of IL-6 inflammatory factors in the skin tissue of experimental animals, reduce the loss of collagen caused by ultraviolet rays, has significant anti-aging and light-aging alleviating effects, and can be applied to functional skin care products.

This invention relates to the field of medical device technology, and discloses a 3D-printed humeral prosthesis that preserves the shoulder joint. The prosthesis includes a prosthesis body, with a proximal end for connecting to the humeral head of the patient's own shoulder joint. The proximal end of the prosthesis body is ball-shaped, and a connection area is provided at the top of the proximal end, with multiple nail-like protrusions. The proximal end of the prosthesis body also has through-holes perpendicular to the connection area. The ball-shaped proximal end of the prosthesis body of this invention, with its connection area, connects to the humeral head of the patient's own shoulder joint, preserving the patient's own shoulder joint, maintaining the patient's natural range of motion and function, reducing damage to surrounding tissues, facilitating more natural movement and recovery of daily activities, and improving postoperative function. The ball-shaped connection has a large contact area, and the nail-like protrusion structure in the connection area of ​​the proximal end of the prosthesis body further increases the contact area, making the connection more stable; this contributes to the initial and long-term stability of the prosthesis implantation.

The present application relates to the field of microbial technology, and specifically discloses a lactobacillus plantarum DT55 and its application in preparing products with micro-plastic adsorption and removal functions.A new lactobacillus plantarum (Lactiplantibacillus plantarum) DT55 is developed, and the preservation number is GDMCC No:63623.The strain can adsorb micro-plastics, accelerate the discharge of plastics in the body, reduce the micro-plastic residues in the intestinal tract of mice, reduce the oxidative damage caused by micro-plastic accumulation, and reduce the inflammatory response caused by micro-plastics, and is expected to be developed into a probiotic product to protect human health.

The application discloses a new application of a substance increasing the content or activity of PARKIN in treating and / or preventing cardiovascular diseases. The application proves by transgenic and gene therapy means that increasing the content of PARKIN can significantly inhibit the activation of a cGAS-STING signal pathway and the downstream inflammatory response, thereby significantly improving the heart function, reducing the myocardial inflammatory response and myocardial fibrosis. The application provides a new drug target and treatment strategy for the prevention and treatment of cardiovascular diseases, and has important clinical application value.

The application relates to an application of a traditional Chinese medicine composition in a drug for chronic obstructive pulmonary disease, characterized in that the traditional Chinese medicine composition comprises the following components in parts: Magnolia officinalis 1-100 parts, Strychnos ignatii 1-100 parts, Toddalia asiatica 1-100 parts, Ephedra 1-100 parts, Amygdalus 1-100 parts, Notopterygium 1-100 parts, Zingiber officinale 1-100 parts, Pogostemonis 1-100 parts, Perilla 1-100 parts, Atractylodes 1-100 parts, Poria cocos 1-160 parts, Atractylodes macrocephala 1-120 parts, Gypsum fibrosum 1-100 parts, Fructus Crataegi 1-100 parts, Fructus Junci 1-100 parts, Fructus Hordei 1-100 parts, Lumbricus 1-100 parts, Radix et Rhizoma Veratri 1-100 parts, Herba Eupatorii Fortunei 1-100 parts, Semen Lepidii 1-100 parts and Semen Platycladi 1-100 parts.

本发明属于蜂花粉多糖分离的技术领域，具体涉及一种从蜂花粉中分离得到的低分子多糖及其提取工艺。采用微波辅助法提取粗多糖，再通过对荷花蜂花粉粗多糖进行Sevag法除蛋白后，采用DEAE‑52纤维素离子柱层析，得到纯化的低分子多糖LBPP‑1，其分子量为1625Da，主要由阿拉伯糖、盐酸氨基葡萄糖、半乳糖和葡萄糖组成，其结构中含有β‑构型糖苷键以及具有三螺旋结构，通过体外实验证明，荷花蜂花粉多糖具有清除DPPH、ABTS、羟基自由基的能力，且表现出较好的清除能力，此外，荷花蜂花粉多糖还可以抑制AAPH诱导的红细胞溶血，在细胞水平上表现出潜在的抗氧化能力。

Application of a multifunctional supramolecular nanoplatform drug: The application of a multifunctional supramolecular nanoplatform in the preparation of drugs for liver ischemia-reperfusion injury. The multifunctional supramolecular nanoplatform is a GalAC4A supramolecular carrier loaded with naringenin (NAR). The multifunctional supramolecular nanoplatform is prepared from naringenin (NAR), galactose (Gal), and CAC4A from azocalixarene. The multifunctional supramolecular nanoplatform is a NAR@GalAC4A nanocomposite. The multifunctional supramolecular nanoplatform achieves hepatocyte-specific targeting through desialyl glycoprotein receptor-mediated endocytosis. This invention proposes a novel "receptor recognition-hypoxia response-synergistic therapy" three-pronged design strategy, successfully constructing a GalAC4A supramolecular carrier loaded with naringenin (NAR) to form a NAR@GalAC4A nanocomposite.

The application relates to the technical field of skin care products, in particular to a preparation method and application of a pH-responsive core-shell composite enzyme composition; carboxymethyl chitosan is dissolved in deionized water, papain and keratinase are added, and stirring is carried out until the mixture is uniform to obtain an enzyme-containing solution; under stirring, the obtained solution is added dropwise into a sodium tripolyphosphate aqueous solution to generate an ionic gelation reaction and form an inner core microsphere loaded with the proteinase; superoxide dismutase is added into the inner core microsphere suspension to obtain a composite enzyme composition suspension; a stabilizer is added into the suspension, and freeze-drying is carried out to obtain a composite enzyme composition powder; the papain and the keratinase in the inner core synergistically decompose aged keratin; the SOD in the outer layer synchronously removes free radicals and relieves inflammatory reactions in the keratin metabolism process; the composition has precise pH response characteristics, can rapidly release active ingredients in the weak alkaline region of acne skin, slowly release the active ingredients in the healthy weak acidic skin region, and realizes targeted repair.

This invention discloses a method for preparing and applying right-handed molybdenum-doped carbon dots. The method involves using D-tartaric acid, ethylenediamine, and molybdenum salt as raw materials, followed by hydrothermal reaction, centrifugation, dialysis, and lyophilization to obtain D-Mo-CDs. These carbon quantum dots exhibit selective response to circularly polarized light; D-Mo-CDs are specifically activated under left-handed circularly polarized light irradiation, achieving a photothermal conversion efficiency of 51.2%, and possessing highly efficient reactive oxygen species generation capabilities, enabling photodynamic-photothermal synergistic antibacterial effects. This invention also discloses the application of these carbon quantum dots in the preparation of spatiotemporally precise antibacterial materials and in medical devices or dressings for treating bacterial infected wounds. This material exhibits high biocompatibility, significant in vitro antibacterial effects, and promotes wound healing in vivo, providing a novel integrated solution for the treatment of infected wounds.

This invention discloses a curcumin derivative with therapeutic effects on acute lung injury and its preparation method, comprising: dissolving curcumin in tetrahydrofuran, removing air from the reaction apparatus, and adding nitrogen to the reaction apparatus to fill it with nitrogen; then adding ethyl magnesium bromide and refluxing at a first preset temperature for 30 min; then adding succinic anhydride and refluxing at a second preset temperature for 4 h; stopping the reaction by adding water and adjusting the pH to 4 with hydrochloric acid; after extraction with ethyl acetate, purifying the upper layer using a preset method to obtain a yellow oily substance I-1; reacting curcumin succinate monoester I-1 with a 5% sodium bicarbonate solution, and evaporating the solvent to obtain curcumin succinate monoester sodium salt II. The raw material used in this invention has wide clinical applications and is safe and low in toxicity. The hydroxyl group of curcumin is combined with succinic anhydride through a Grignard reaction to form curcumin succinate monoester I-1, which is then reacted with sodium bicarbonate solution to obtain curcumin succinate monoester sodium salt II.

The present application belongs to the technical field of microneedle dressings, and relates to a gradient-adapted ROS-responsive exosome self-adaptive release microneedle dressing and a preparation method thereof. The microneedle dressing comprises a substrate layer and a microneedle body array on the substrate layer. The substrate layer and the microneedle body array are both ROS-responsive broken crosslinking gelatin / carboxymethyl chitosan composite hydrogels. The gelatin and carboxymethyl chitosan on the microneedle body are also connected with exosomes through ROS-responsive broken bonds. The crosslinking degree of the microneedle dressing decreases in a gradient from the substrate layer to the tip of the microneedle body. In the preparation, the substrate layer precursor and the microneedle body array precursor are prepared first, then the microneedle body array precursor and the substrate layer precursor are sequentially injected into the microneedle dressing mold, and finally the pre-cooled ROS-responsive broken crosslinking agent solution is injected into the microneedle dressing mold. After the crosslinking reaction, drying and demolding, the microneedle dressing is obtained. The microneedle dressing can realize precise ROS-responsive exosome release, and the preparation method is simple.

The application discloses application of L-phenylalanine in preparation of an intestinal inflammation treatment product, wherein the L-phenylalanine has a CAS number of 63-91-2, belongs to a natural amino acid, and has high safety; the product is a drug, a food or a feed additive; the application can treat inflammatory bowel disease, reduce intestinal inflammatory reactions, and promote intestinal mucosal repair and maintenance of intestinal mucosal barrier function, so that intestinal inflammation related clinical symptoms are improved.

The present application relates to a skin cell soothing and repairing composition containing artemisia and its preparation method and application, and belongs to the technical field of cosmetics. The present application finds that only by inhibiting the upstream anti-inflammatory pathway of the NF-kappa B pathway, the anti-inflammatory effect is limited, while inhibiting the NF-kappa B pathway, the downstream transmission chain is blocked, and the anti-inflammatory effect is significantly enhanced. Based on this, the present application inhibits the upstream anti-inflammatory pathway by artemisia extract and jasminum officinale extract, reduces the recruitment and infiltration of inflammatory cells, blocks the downstream transmission chain, and synergistically improves the anti-inflammatory effect. In addition, the present application cooperates oat kernel oil, jasmine flower oil and squalane, on the one hand, improves the solubility of fat-soluble active substances, on the other hand, participates in the repair, stabilization and optimization of the lipid structure of the skin cuticle, synchronously opens the skin fat-soluble channel, and more efficiently transports active substances, thereby realizing excellent soothing, repairing and stabilizing effects.

The application discloses a catheter material for varicose vein closure surgery and a preparation method thereof, and raw materials at least include 100-150 parts of a polymer base material, 10-15 parts of a lubricant and 3-8 parts of a coupling agent in terms of weight. The catheter material is corrosion resistant and has high compatibility with human bodies, can effectively prevent human body fluids and tissue fragments from adhering and immersing into the catheter material, thereby improving the use effect of the catheter material, can prevent the catheter from being touched with human tissues to cause damage, avoids damage to human tissues, can reduce discomfort and inflammatory reactions during use, and can meet the use requirements of clinical surgery.

The application discloses application of anti-IGFBP7 antibodies in treating skin diseases, belongs to the technical field of psoriasis treatment, and discloses application of anti-IGFBP7 antibodies in preparation of a medicament for treating psoriasis, wherein the medicament is used for reducing and treating psoriasis-like inflammation by inhibiting expression of IGFBP7 in blood vessels of skin of a psoriasis patient. After the anti-IGFBP7 antibodies are used, psoriasis inflammation is reduced, meanwhile, epidermal thickness of a psoriasis patient is reduced, erythema formation is inhibited, and the generation of scales is reduced. In protecting vascular barrier function and treating psoriasis, the anti-IGFBP7 antibodies have a good medicinal prospect.

This invention discloses a composition, cosmetic, and preparation method with dual whitening and skin-smoothing effects. The composition comprises acetyl glucosamine, ascorbic acid tetraisopalmitate, and adenosine compounds in a mass ratio of (0.1–5):(0.1–10):(0.01–7). It is applied in cosmetics. Compared with existing technologies, the components of this invention work synergistically, resulting in a mild and non-irritating composition with simple and clearly defined components, exhibiting excellent whitening and skin-smoothing functions.