67 results about "Denervation" patented technology

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide coupled to the end of the electrode unit and configured to guide the electrode unit to be brought into contact with the tube in the body; an electrode guide driving unit configured to move the electrode guide in forward and backward directions; and an electrode driving unit configured to move the electrode guide in the forward and backward directions in conjunction with the electrode guide driving unit. The electrode driving unit includes a tensile force maintenance unit connected to one end of the electrode unit and configured to provide a tensile force to the electrode unit; and a moving unit that moves in the forward direction until the electrode guide is transitioned to a first state in a state where the moving unit is connected to the tensile force maintenance unit, and then is disconnected from the tensile force maintenance unit and further moves in the forward direction until the electrode guide is transitioned to a second state.

Systems, devices, and methods described herein relate to catheter devices for therapy delivery in renal denervation applications. In some embodiments, a catheter includes a shaft having first and second sets of electrodes. In some embodiments, each electrode set can include electrodes that are spaced from one another by inter-electrode spacings and being spaced from one another by an inter-set spacing. In some embodiments, the inter-set spacing can be at least 50% greater than each inter-electrode spacing. In some embodiments, the first or second set of electrodes can include at least one basket electrode.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

Methods, systems, devices, components, and apparatuses for renal denervation. The treatment component includes a first sensor configured to detect a first temperature or a first impedance. The treatment component includes a first energy delivery element configured to deliver energy to the vessel wall. The treatment component includes a processor. The processor is configured to determine a heart rate based on the first temperature or the first impedance. The processor is configured to determine that the heart rate is less than a threshold heart rate indicating a slowing of the heart rate. The processor is configured to control the first energy delivery element to regulate the delivery of energy to the vessel wall.

A system for denervation of nerves of a blood vessel including a catheter for navigation within a blood vessel of a patient, the catheter including electrodes and configured to apply a therapy to nerves beyond a wall of the blood vessel, a therapy source in communication with a distal portion of the catheter, and a stimulation source configured to output a neural block stimulation signal to at least a first of the electrodes and configured to output a first low frequency stimulation signal to at least a second of the electrodes, wherein application of the neural block stimulation signal via the electrodes to the wall of a blood vessel generates a neural block in afferent sympathetic nerves proximate the wall of the blood vessel, and application of the low frequency stimulation triggers a response in efferent sympathetic nerves proximate the wall of the blood vessel.

In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.

An example computing device includes a memory; and one or more processors coupled to the memory, the one or more processors being configured to: determine a baseline circadian pattern of blood pressure for a patient over a first period of time; determine a subsequent circadian pattern of blood pressure for the patient over a second period of time, the second period of time being after the first period of time; determine one or more differences between the subsequent circadian pattern and the baseline circadian pattern; determine, based on the one or more differences between the subsequent circadian pattern and the baseline circadian pattern, whether the patient is a candidate for denervation therapy; and output, responsive to determining whether the patient is a candidate for the denervation therapy, an indication of whether the patient is or is not a candidate for the denervation therapy.

A system and method for denervation of nerves of a blood vessel including a catheter for navigation within a blood vessel, the catheter comprising a therapeutic element configured to apply a therapy to nerves adjacent the blood vessel, a therapy source in communication with the therapeutic element and configured to generate therapeutic energy and output the therapeutic energy to the therapeutic element, and a computing device including a processor and memory, the memory storing therein instructions that, when executed, cause the processor to cause the therapy source to generate the therapeutic energy, determine a rate of change of temperature associated with the therapeutic element while the therapeutic element is outputting the therapeutic energy, and determine efficacy of the therapy based on a comparison of a power of the therapeutic energy output to the therapeutic element and a rate of change of a temperature associated with the therapeutic element.

An electrode apparatus for nerve denervation or modulation includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

A pulmonary treatment system for treating target tissue in an airway of a subject includes a catheter assembly including an ablation assembly or tip including an expandable member, at least one energy emitter, and a cooling member, where the ablation tip is configured to be positioned within the airway of the subject, a cooling member disposed between the at least one energy emitter and the target tissue such that expansion of the expandable member causes the at least one energy emitter and the cooling member to engage a wall of the airway, the cooling member configured to cool a portion of a surface of the wall of the airway to reduce damage to the airway disposed between the at least one energy emitter and the target tissue; and a control assembly including a display configured to depict a three-dimensional graph presenting an airway of the subject for pre-planning prior to the procedure and to track the ablation tip in real time during treatment of the target tissue.

An apparatus includes a processor configured to receive, via an ambulatory blood pressure monitor, ambulatory blood pressure data for a patient; retrieve, from an electronic health record database, patient data including at least one of demographic data, diagnostic data, or treatment data for the patient; and receive, via an electronic medication diary, medication compliance data for the patient. The processor is also configured to determine a suitability of the patient for a renal denervation treatment, wherein the determination is based on the patient data. The processor is also configured to output, to a display, a screen display based on the determination, wherein the screen display comprises at least one of a first indication of whether the patient is expected to respond to the renal denervation treatment; or a second indication of an expected level of responsiveness of the patient to the renal denervation treatment.

A system and method for denervation of nerves of a blood vessel including a therapeutic device configured for navigation within a blood vessel of a patient, stimulation elements formed on the therapeutic device, a stimulation source in communication with the stimulation elements, a therapy source in communication with the therapeutic device; and a computing device to cause the stimulation source to generate a stimulations signal for application to a blood vessel wall via at least one of the plurality of stimulation elements, detect changes in blood flow through the blood vessel, cause the therapy source to generate a therapy for application the blood vessel wall, and compare a change in blood flow through the blood vessel to a threshold to determine whether the therapy has denervated nerves.

The present application relates to the technical field of rehabilitation medical parameter optimization, in particular to an optimization method for treating denervation atrophy based on 9% stretching parameters, which comprises the following steps: collecting muscle electrical signal time series data, muscle hardness elasticity data and joint activity angle range data of the denervation atrophy area; performing time-frequency domain joint feature decomposition on the muscle electrical signal time series data to obtain an electromyogram time-frequency feature map; and performing elastic modulus distribution reconstruction on the muscle hardness elasticity data to obtain a hardness distribution feature matrix. An improved particle swarm optimization algorithm based on population topology adjacency relationship is adopted to complete 9% stretching parameter dynamic optimization, so as to obtain an optimal stretching displacement amount and a stretching frequency, and then generate a treatment parameter sequence containing a stretching holding time, an intermittent time and a total treatment time length, thereby realizing individualized intelligent configuration of denervation atrophy rehabilitation treatment parameters.

Apparatus and methods for deactivating bronchial nerves extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits focused ultrasound so as to heat tissues throughout circular impact volume (13) as, for example, at least about 1 cm3 encompassing the bronchus to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual bronchial nerves.

A method of performing bronchial denervation of a bronchus having bronchial nerves along a portion thereof is provided. The method includes providing a cryoablation device having multiple electrodes capable of delivering electrical energy and measuring impedance. At least one bronchial nerve is stimulated with electrical energy. The electrical signals from the at least one bronchial nerve are recorded to provide a first value representative of nerve function. Cryogenic treatment energy is applied to form ice in the bronchus having a thickness to encapsulate the at least one bronchial nerve to cause a reduction in nerve function. The at least one bronchial nerve is restimulated with electrical energy. The electrical signals are recorded from the restimulated at least one bronchial nerve to provide a second value that represents diminished nerve function. The first value and the second value are compared to provide an assessment of the reduction in nerve function.

A method of performing a therapeutic procedure includes navigating a therapeutic device to a location adjacent to target tissue, determining a first flow parameter within a blood vessel adjacent to the target tissue, applying neurostimulation to the target tissue and obtaining first images of blood vessels distal of the target tissue, applying therapy to the target tissue, applying neurostimulation to the target tissue, determining a second flow parameter within the blood vessel adjacent to the target tissue, comparing the second flow parameter to a flow parameter criteria, applying neurostimulation to the target tissue and obtaining second images of the blood vessels distal of the target tissue, comparing the first images to the second images to determine a vasoconstriction metric, and applying therapy to the target tissue if it is determined that the vasoconstriction metric satisfies a vasoconstriction criteria.

An example control device for performing a denervation procedure on a patient includes a memory and processing circuitry coupled to the memory. The processing circuitry is configured to receive, from one or more sensors and prior to delivery of neuromodulation therapy via a neuromodulation catheter, pre-therapy sensor data. The pre-therapy sensor data includes one or more parameter measurements for a period of time prior to the delivery of the neuromodulation therapy. The processing circuitry is configured to determine, based on the pre-therapy sensor data, whether the delivery of neuromodulation therapy would cause a deviation, in which the deviation includes one or more patient parameters or device parameters exceeding one or more patient parameter thresholds or device parameter thresholds, and transmit an output based on the determination.

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.

A denervation system and method uses vasoconstriction response to stimulation to intraoperatively guide an interventional physician to understand therapy effectiveness. The denervation system and method involve receiving a first radiographic image of a blood vessel, receiving a second radiographic image of the blood vessel after treating and stimulating a target blood vessel site, and determining a first vasoconstriction metric based on the first radiographic image and the second radiographic image. The denervation system and method also involve receiving a third radiographic image and a fourth radiographic image of the blood vessel before and after stimulation of the target vascular site, respectively, prior to treating the target vascular site, and determining a second vasoconstriction metric based on the third radiographic image and the fourth radiographic image. The denervation system and method also involve outputting an indication of whether the treatment is complete based on the first vasoconstriction metric and / or the second vasoconstriction metric.

A system and method for denervation of nerves of a blood vessel including a catheter including a plurality of electrodes and configured to apply a therapy to nerves beyond a wall of the blood vessel, a therapy source in communication with a distal portion of the catheter, a stimulation source configured to output a neural block stimulation signal to at least one electrode, the stimulation source in electrical communication with the at least one electrode, and wherein application of the neural block stimulation signal an electrode to a wall of the blood vessel generates a neural block in nerves proximate the wall of the blood vessel, and a detector configured to detect a change in vascular tone of the blood vessel, wherein a change in vascular tone following application of the neural block stimulation signal indicates that the electrodes are located proximate sympathetic nerves.

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least some of nerves on a tube in the body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements by using a gear ratio between two rack gears depending on a pitch circle diameter ratio between two pinion gears.

Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue.

A method of performing and assessing a therapeutic procedure includes navigating a therapeutic device to target tissue, transitioning the therapeutic device from a first, linear configuration to a second, deployed configuration such that a plurality of electrodes on the therapeutic device are in engagement with the target tissue, applying pulses of neurostimulation energy having at least two phases to target tissue via the plurality of electrodes, the neurostimulation energy including an anodal phase and a cathodal phase, wherein a phase of the neurostimulation is switched from anodal to cathodal or cathodal to anodal for each successive pulse, observing a physiological response to the neurostimulation energy indicative of a neural response, denervating the nerves of the target tissue, and applying the neurostimulation energy to the target tissue, wherein a physiological response less than a threshold is indicative of a successful denervation of the nerves of the target tissue.

A system and method for denervation of nerves of a blood vessel including a first catheter configured for navigation within a blood vessel of a patient, the catheter having a first plurality of electrodes for applying stimulation and therapy to nerves adjacent the blood vessel, a second catheter configured for navigation within the blood vessel of a patient, the second catheter having a second plurality of electrodes for detecting a signal emitted by nerves to which stimulation has been applied, a stimulation source in electrical communication with the first plurality of electrodes and configured to output a stimulation signal to the first plurality of electrodes of the first catheter, and a computing device including a memory and a processor, the memory storing instructions that when executed, cause the processor to receive the signal detected by the second plurality of electrodes and determine an evoked compound action potential (ECAP) value.

Provided herein are methods for decreasing Ataxin-2 mRNA expression. Such methods are useful to ameliorate symptoms of Ataxin-2 associated diseases. Such Ataxin-2 associated diseases include amyotrophic lateral sclerosis (ALS). Such symptoms include loss of motor function, reduced CMAP amplitude, denervation, and loss of motor neurons.

A method for improving an ejection fraction of a patient in need thereof, including positioning a pulmonary artery manipulation device in a target blood vessel, within the pulmonary vasculature of the patient; and impairing the activity of at least one sympathetic nerve, nerve fiber or neuron, using the pulmonary artery manipulation device, to denervate the target blood vessel, thereby improving the ejection fraction of the patient.

The application provides a real-time feedback imaging system for assisting percutaneous renal denervation, comprising a catheter assembly, a controller connected with the catheter assembly and an imaging element connected with the controller; wherein the catheter assembly is used for ablating an ablation site in a patient's body and collecting information about the ablation site; the controller is used for determining the catheter position, the ablated site and the ablation times of the site according to the real-time acquired fluoroscopy image of the catheter moving in the renal artery, and determining the ablation effect according to the information about the ablation site; the application has the beneficial effect that based on the image processing system and the sensing system, the application can real-time feedback the progress of RDN on the imaging element, including the catheter position, the ablated site, the ablation times of the site and the ablation effect, etc., which provides convenience for the operation of the operator, thereby improving the safety and effectiveness of RDN.

Apparatus and methods for deactivating renal nerves extending along a renal artery of a mammalian subject to treat hypertension and related conditions. An ultrasonic transducer (30) is inserted into the renal artery (10) as, for example, by advancing the distal end of a catheter (18) bearing the transducer into the renal artery. The ultrasonic transducer emits unfocused ultrasound so as to heat tissues throughout a relatively large impact volume (11) as, for example, at least about 0.5 cm3 encompassing the renal artery to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual renal nerves.