123 results about "Denervation" patented technology

To provide a device that can be used to treat pulmonary hypertension with pulmonary denervation.SOLUTION: A multi-pole synchronous pulmonary artery radiofrequency ablation catheter is provided. An adjustment apparatus is arranged on a control handle 2. A cavity is arranged in a catheter body 1. A lead wire, a temperature sensing wire and a pull wire are arranged in the cavity. One end of the catheter body is flexible and connected to an annular ring 4. Tension of the pull wire is adjusted through the adjustment apparatus to achieve radian control of the flexible end. A shape memory wire is arranged in the annular ring, and has one end extending to a tip of the annular ring, and the other end passing through a root of the annular ring and fixed on the flexible end of the catheter body. The annular ring is provided with an electrode group with each electrode 5 connected to the lead wire and temperature sensing wire. The lead wire and the temperature sensing wire go through the catheter body and are electrically connected to the control handle.SELECTED DRAWING: Figure 1

Systems, devices, and methods described herein relate to catheter devices for therapy delivery in renal denervation applications. In some embodiments, a catheter includes a shaft having first and second sets of electrodes. In some embodiments, each electrode set can include electrodes that are spaced from one another by inter-electrode spacings and being spaced from one another by an inter-set spacing. In some embodiments, the inter-set spacing can be at least 50% greater than each inter-electrode spacing. In some embodiments, the first or second set of electrodes can include at least one basket electrode.

The systems, devices, and methods described herein relate to catheter devices for therapeutic delivery in renal denervation applications. In some embodiments, the catheter includes a shaft having a first set of electrodes and a second set of electrodes, each of the first set of electrodes and the second set of electrodes including electrodes spaced apart from each other by an inter-electrode spacing and the first set of electrodes and the second set of electrodes spaced apart from each other by an inter-group spacing. In some embodiments, the inter-group spacing may be at least 50% greater than each inter-electrode spacing. In some embodiments, the first set of electrodes or the second set of electrodes may include at least one basket-shaped electrode.

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide coupled to the end of the electrode unit and configured to guide the electrode unit to be brought into contact with the tube in the body; an electrode guide driving unit configured to move the electrode guide in forward and backward directions; and an electrode driving unit configured to move the electrode guide in the forward and backward directions in conjunction with the electrode guide driving unit. The electrode driving unit includes a tensile force maintenance unit connected to one end of the electrode unit and configured to provide a tensile force to the electrode unit; and a moving unit that moves in the forward direction until the electrode guide is transitioned to a first state in a state where the moving unit is connected to the tensile force maintenance unit, and then is disconnected from the tensile force maintenance unit and further moves in the forward direction until the electrode guide is transitioned to a second state.

Provided herein are methods for decreasing Ataxin-2 mRNA expression. Such methods are useful to ameliorate symptoms of Ataxin-2 associated diseases. Such Ataxin-2 associated diseases include amyotrophic lateral sclerosis (ALS). Such symptoms include loss of motor function, reduced CMAP amplitude, denervation, and loss of motor neurons.

Systems, devices, and methods described herein relate to catheter devices for therapy delivery in renal denervation applications. In some embodiments, a catheter includes a shaft having first and second sets of electrodes. In some embodiments, each electrode set can include electrodes that are spaced from one another by inter-electrode spacings and being spaced from one another by an inter-set spacing. In some embodiments, the inter-set spacing can be at least 50% greater than each inter-electrode spacing. In some embodiments, the first or second set of electrodes can include at least one basket electrode.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

The present invention concerns selective renal denervation treatment of drug resistant hypertensive patients by correlating the patients' genetic panel by categorization and hierarchy according to patients' genetic variants within the functional genes for heart activity, for the renin-angiotensin aldosterone system, and for renal activity.

The present disclosure provides a method of performing and evaluating a treatment procedure, the method comprising: navigating a treatment device to a target tissue; transitioning the treatment device from a first linear configuration to a second deployed configuration such that a plurality of electrodes on the treatment device engage the target tissue; applying a pulse of neurostimulation energy having at least two phases to the target tissue via the plurality of electrodes, the neurostimulation energy comprising an anode phase and a cathode phase, where the phase of neurostimulation is switched from anode to cathode or from cathode to anode for each consecutive pulse; observing a physiological response to the nerve stimulation energy indicative of a nerve response; performing denervation on the nerves of the target tissue; and applying the neurostimulation energy to the target tissue, wherein less than a physiological response than a threshold indicates successful denervation of the nerves of the target tissue.

Described herein are systems and methods for performing and determining the effectiveness of a denervation procedure. Such systems include an excitation source, a controller, and a catheter including elements for delivering a first ablation therapy from a first longitudinal location along a biological lumen and for delivering a second ablation therapy from a second longitudinal location longitudinally spaced from the first longitudinal location. A sensing subsystem of the system senses neural activity from a third longitudinal location along the biological lumen and determines the effectiveness of at least one of the first or second ablation therapies.

Methods, systems, devices, components, and apparatuses for renal denervation. The treatment component includes a first sensor configured to detect a first temperature or a first impedance. The treatment component includes a first energy delivery element configured to deliver energy to the vessel wall. The treatment component includes a processor. The processor is configured to determine a heart rate based on the first temperature or the first impedance. The processor is configured to determine that the heart rate is less than a threshold heart rate indicating a slowing of the heart rate. The processor is configured to control the first energy delivery element to regulate the delivery of energy to the vessel wall.

A system for denervation of nerves of a blood vessel including a catheter for navigation within a blood vessel of a patient, the catheter including electrodes and configured to apply a therapy to nerves beyond a wall of the blood vessel, a therapy source in communication with a distal portion of the catheter, and a stimulation source configured to output a neural block stimulation signal to at least a first of the electrodes and configured to output a first low frequency stimulation signal to at least a second of the electrodes, wherein application of the neural block stimulation signal via the electrodes to the wall of a blood vessel generates a neural block in afferent sympathetic nerves proximate the wall of the blood vessel, and application of the low frequency stimulation triggers a response in efferent sympathetic nerves proximate the wall of the blood vessel.

In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.

The invention provides an application of GW8510 in preparation of a medicine for treating amyotrophy. Compared with the prior art, the invention provides a new application of the GW8510 in treating amyotrophy. Experimental research proves that the GW8510 administration can significantly recover the athletic ability of mice with amyotrophy, improve the cross-sectional area of the muscles of the mice and recover the activity of creatine kinase in serum of the mice, so that the phenotype of the amyotrophy of the mice and related biochemical indexes of the amyotrophy are improved; the GW8510 can be used for remarkably recovering cell amyotrophy related gene and protein expression, and improving amyotrophy phenotype through an MSTNPGC1 alpha NRF2 related pathway; the GW8510 can be used for remarkably recovering cell fibrosis and denervation related gene expression and improving fibrosis and denervation degrees in a muscle atrophy model.

An example computing device includes a memory; and one or more processors coupled to the memory, the one or more processors being configured to: determine a baseline circadian pattern of blood pressure for a patient over a first period of time; determine a subsequent circadian pattern of blood pressure for the patient over a second period of time, the second period of time being after the first period of time; determine one or more differences between the subsequent circadian pattern and the baseline circadian pattern; determine, based on the one or more differences between the subsequent circadian pattern and the baseline circadian pattern, whether the patient is a candidate for denervation therapy; and output, responsive to determining whether the patient is a candidate for the denervation therapy, an indication of whether the patient is or is not a candidate for the denervation therapy.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

An electrode device for wrapping a vessel in the body according to an embodiment of the present invention comprise an electrode part that surrounds the vessel and denervates or modulates at least some nerves of the vessel; and a guide part that guides movement of the electrode part, wherein the electrode part includes: a first layer that is bent in order for the electrode part to be wound around the vessel; a second layer that is placed on the first layer and is bent in order for the electrode part to be wound in close contact with the vessel; an electrode that is placed on the second layer and denervates or modulates at least some nerves of the vessel with energy from an energy source generator.

A system and method for denervation of nerves of a blood vessel including a catheter for navigation within a blood vessel, the catheter comprising a therapeutic element configured to apply a therapy to nerves adjacent the blood vessel, a therapy source in communication with the therapeutic element and configured to generate therapeutic energy and output the therapeutic energy to the therapeutic element, and a computing device including a processor and memory, the memory storing therein instructions that, when executed, cause the processor to cause the therapy source to generate the therapeutic energy, determine a rate of change of temperature associated with the therapeutic element while the therapeutic element is outputting the therapeutic energy, and determine efficacy of the therapy based on a comparison of a power of the therapeutic energy output to the therapeutic element and a rate of change of a temperature associated with the therapeutic element.

An electrode apparatus for nerve denervation or modulation includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

The present invention, in some embodiments thereof, relates to methods and / or apparatus for measuring the effectiveness of a renal denervation treatment. In some embodiments, a method for determining effectiveness of the denervation treatment comprises tracking at least one of arterial wall movement, arterial blood flow rate, arterial blood flow velocity, blood pressure and arterial diameter at one or more selected locations in the renal artery over time, and assessing the effectiveness of said renal denervation treatment according to results obtained by tracking.

A pulmonary treatment system for treating target tissue in an airway of a subject includes a catheter assembly including an ablation assembly or tip including an expandable member, at least one energy emitter, and a cooling member, where the ablation tip is configured to be positioned within the airway of the subject, a cooling member disposed between the at least one energy emitter and the target tissue such that expansion of the expandable member causes the at least one energy emitter and the cooling member to engage a wall of the airway, the cooling member configured to cool a portion of a surface of the wall of the airway to reduce damage to the airway disposed between the at least one energy emitter and the target tissue; and a control assembly including a display configured to depict a three-dimensional graph presenting an airway of the subject for pre-planning prior to the procedure and to track the ablation tip in real time during treatment of the target tissue.

A system and method can be used to denervate at least a portion of a bronchial tree. An energy emitter of an instrument is percutaneously delivered to a treatment site and outputs energy to damage nerve tissue of the bronchial tree. The denervation procedure can be performed without damaging non-targeted tissue. Minimally invasive methods can be used to open airways to improve lung function in subjects with COPD, asthma, or the like. Different sections of the bronchial tree can be denervated while leaving airways intact to reduce recovery times.

An electrode apparatus for denervation or modulation in vivo includes: a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least a part of nerves on a tube in a body; an electrode guide coupled to an end of the electrode unit and configured to guide the electrode unit to be brought into contact with the tube in the body; an electrode guide driving unit configured to move the electrode guide in forward and backward directions; and an electrode driving unit configured to move the electrode unit in the forward and backward directions in conjunction with the electrode guide driving unit. The electrode driving unit includes: a tensile force maintenance unit connected to one end of the electrode unit; and a moving unit that is connected to the tensile force maintenance unit and moves the tensile force maintenance unit in the forward and backward directions. The tensile force maintenance unit includes a lever that provides a tensile force to the electrode unit. The lever senses the tensile force with a sensor and is automatically driven in the forward and backward directions based on the sensed tensile force.

An apparatus includes a processor configured to receive, via an ambulatory blood pressure monitor, ambulatory blood pressure data for a patient; retrieve, from an electronic health record database, patient data including at least one of demographic data, diagnostic data, or treatment data for the patient; and receive, via an electronic medication diary, medication compliance data for the patient. The processor is also configured to determine a suitability of the patient for a renal denervation treatment, wherein the determination is based on the patient data. The processor is also configured to output, to a display, a screen display based on the determination, wherein the screen display comprises at least one of a first indication of whether the patient is expected to respond to the renal denervation treatment; or a second indication of an expected level of responsiveness of the patient to the renal denervation treatment.

A system and method for denervation of nerves of a blood vessel including a therapeutic device configured for navigation within a blood vessel of a patient, stimulation elements formed on the therapeutic device, a stimulation source in communication with the stimulation elements, a therapy source in communication with the therapeutic device; and a computing device to cause the stimulation source to generate a stimulations signal for application to a blood vessel wall via at least one of the plurality of stimulation elements, detect changes in blood flow through the blood vessel, cause the therapy source to generate a therapy for application the blood vessel wall, and compare a change in blood flow through the blood vessel to a threshold to determine whether the therapy has denervated nerves.

The present application relates to the technical field of rehabilitation medical parameter optimization, in particular to an optimization method for treating denervation atrophy based on 9% stretching parameters, which comprises the following steps: collecting muscle electrical signal time series data, muscle hardness elasticity data and joint activity angle range data of the denervation atrophy area; performing time-frequency domain joint feature decomposition on the muscle electrical signal time series data to obtain an electromyogram time-frequency feature map; and performing elastic modulus distribution reconstruction on the muscle hardness elasticity data to obtain a hardness distribution feature matrix. An improved particle swarm optimization algorithm based on population topology adjacency relationship is adopted to complete 9% stretching parameter dynamic optimization, so as to obtain an optimal stretching displacement amount and a stretching frequency, and then generate a treatment parameter sequence containing a stretching holding time, an intermittent time and a total treatment time length, thereby realizing individualized intelligent configuration of denervation atrophy rehabilitation treatment parameters.

A method for evaluating an outcome of renal denervation includes: acquiring first blood flow data from a first region in a renal blood vessel after a vasodilator injected into the first region is activated in a second region in the renal blood vessel; and acquiring second blood flow data from the first region after renal denervation is performed with a catheter for denervation.