42 results about "Denervation" patented technology

Systems, devices, and methods described herein relate to catheter devices for therapy delivery in renal denervation applications. In some embodiments, a catheter includes a shaft having first and second sets of electrodes. In some embodiments, each electrode set can include electrodes that are spaced from one another by inter-electrode spacings and being spaced from one another by an inter-set spacing. In some embodiments, the inter-set spacing can be at least 50% greater than each inter-electrode spacing. In some embodiments, the first or second set of electrodes can include at least one basket electrode.

Methods, systems, devices, components, and apparatuses for renal denervation. The treatment component includes a first sensor configured to detect a first temperature or a first impedance. The treatment component includes a first energy delivery element configured to deliver energy to the vessel wall. The treatment component includes a processor. The processor is configured to determine a heart rate based on the first temperature or the first impedance. The processor is configured to determine that the heart rate is less than a threshold heart rate indicating a slowing of the heart rate. The processor is configured to control the first energy delivery element to regulate the delivery of energy to the vessel wall.

An example computing device includes a memory; and one or more processors coupled to the memory, the one or more processors being configured to: determine a baseline circadian pattern of blood pressure for a patient over a first period of time; determine a subsequent circadian pattern of blood pressure for the patient over a second period of time, the second period of time being after the first period of time; determine one or more differences between the subsequent circadian pattern and the baseline circadian pattern; determine, based on the one or more differences between the subsequent circadian pattern and the baseline circadian pattern, whether the patient is a candidate for denervation therapy; and output, responsive to determining whether the patient is a candidate for the denervation therapy, an indication of whether the patient is or is not a candidate for the denervation therapy.

An electrode apparatus for nerve denervation or modulation includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

An apparatus includes a processor configured to receive, via an ambulatory blood pressure monitor, ambulatory blood pressure data for a patient; retrieve, from an electronic health record database, patient data including at least one of demographic data, diagnostic data, or treatment data for the patient; and receive, via an electronic medication diary, medication compliance data for the patient. The processor is also configured to determine a suitability of the patient for a renal denervation treatment, wherein the determination is based on the patient data. The processor is also configured to output, to a display, a screen display based on the determination, wherein the screen display comprises at least one of a first indication of whether the patient is expected to respond to the renal denervation treatment; or a second indication of an expected level of responsiveness of the patient to the renal denervation treatment.

The present application relates to the technical field of rehabilitation medical parameter optimization, in particular to an optimization method for treating denervation atrophy based on 9% stretching parameters, which comprises the following steps: collecting muscle electrical signal time series data, muscle hardness elasticity data and joint activity angle range data of the denervation atrophy area; performing time-frequency domain joint feature decomposition on the muscle electrical signal time series data to obtain an electromyogram time-frequency feature map; and performing elastic modulus distribution reconstruction on the muscle hardness elasticity data to obtain a hardness distribution feature matrix. An improved particle swarm optimization algorithm based on population topology adjacency relationship is adopted to complete 9% stretching parameter dynamic optimization, so as to obtain an optimal stretching displacement amount and a stretching frequency, and then generate a treatment parameter sequence containing a stretching holding time, an intermittent time and a total treatment time length, thereby realizing individualized intelligent configuration of denervation atrophy rehabilitation treatment parameters.

Apparatus and methods for deactivating bronchial nerves extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits focused ultrasound so as to heat tissues throughout circular impact volume (13) as, for example, at least about 1 cm3 encompassing the bronchus to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual bronchial nerves.

An example control device for performing a denervation procedure on a patient includes a memory and processing circuitry coupled to the memory. The processing circuitry is configured to receive, from one or more sensors and prior to delivery of neuromodulation therapy via a neuromodulation catheter, pre-therapy sensor data. The pre-therapy sensor data includes one or more parameter measurements for a period of time prior to the delivery of the neuromodulation therapy. The processing circuitry is configured to determine, based on the pre-therapy sensor data, whether the delivery of neuromodulation therapy would cause a deviation, in which the deviation includes one or more patient parameters or device parameters exceeding one or more patient parameter thresholds or device parameter thresholds, and transmit an output based on the determination.

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.

A denervation system and method uses vasoconstriction response to stimulation to intraoperatively guide an interventional physician to understand therapy effectiveness. The denervation system and method involve receiving a first radiographic image of a blood vessel, receiving a second radiographic image of the blood vessel after treating and stimulating a target blood vessel site, and determining a first vasoconstriction metric based on the first radiographic image and the second radiographic image. The denervation system and method also involve receiving a third radiographic image and a fourth radiographic image of the blood vessel before and after stimulation of the target vascular site, respectively, prior to treating the target vascular site, and determining a second vasoconstriction metric based on the third radiographic image and the fourth radiographic image. The denervation system and method also involve outputting an indication of whether the treatment is complete based on the first vasoconstriction metric and / or the second vasoconstriction metric.

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least some of nerves on a tube in the body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements by using a gear ratio between two rack gears depending on a pitch circle diameter ratio between two pinion gears.

Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue.

A method for improving an ejection fraction of a patient in need thereof, including positioning a pulmonary artery manipulation device in a target blood vessel, within the pulmonary vasculature of the patient; and impairing the activity of at least one sympathetic nerve, nerve fiber or neuron, using the pulmonary artery manipulation device, to denervate the target blood vessel, thereby improving the ejection fraction of the patient.

The application provides a real-time feedback imaging system for assisting percutaneous renal denervation, comprising a catheter assembly, a controller connected with the catheter assembly and an imaging element connected with the controller; wherein the catheter assembly is used for ablating an ablation site in a patient's body and collecting information about the ablation site; the controller is used for determining the catheter position, the ablated site and the ablation times of the site according to the real-time acquired fluoroscopy image of the catheter moving in the renal artery, and determining the ablation effect according to the information about the ablation site; the application has the beneficial effect that based on the image processing system and the sensing system, the application can real-time feedback the progress of RDN on the imaging element, including the catheter position, the ablated site, the ablation times of the site and the ablation effect, etc., which provides convenience for the operation of the operator, thereby improving the safety and effectiveness of RDN.

Apparatus and methods for deactivating renal nerves extending along a renal artery of a mammalian subject to treat hypertension and related conditions. An ultrasonic transducer (30) is inserted into the renal artery (10) as, for example, by advancing the distal end of a catheter (18) bearing the transducer into the renal artery. The ultrasonic transducer emits unfocused ultrasound so as to heat tissues throughout a relatively large impact volume (11) as, for example, at least about 0.5 cm3 encompassing the renal artery to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual renal nerves.

Apparatus and methods for deactivating bronchial nerves extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits focused ultrasound so as to heat tissues throughout circular impact volume (13) as, for example, at least about 1 cm3 encompassing the bronchus to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual bronchial nerves.

Provided is a catheter including a shaft having a distal end and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue. The loop includes: a first film capable of bending to curl around the tissue; a plurality of electrodes disposed on the first film and arranged in parallel to each other with a predetermined distance; a sensor disposed at a position corresponding to a position between the plurality of electrodes.

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide coupled to the end of the electrode unit and configured to guide the electrode unit to be brought into contact with the tube in the body; an electrode guide driving unit configured to move the electrode guide in forward and backward directions; and an electrode driving unit configured to move the electrode guide in the forward and backward directions in conjunction with the electrode guide driving unit.

Systems and methods for performing a treatment procedure using a treatment device comprising electrodes by applying stimulation signals from the electrodes to a vascular wall; observing a physiological response to the stimulation signal; applying a therapy to the vessel wall; applying another stimulation signal from the electrodes to the blood vessel; and observing a second physiological response to the second stimulation signal. The therapy is successful when the second physiological response differs from the first physiological response by more than a threshold.

A system includes a processor circuit configured to receive an endovascular flow measurement obtained by an endovascular flow measurement positioned within a blood vessel of a patient. The system controls a nerve stimulation device to stimulate a nerve of the patient and receives an additional endovascular flow measurement while the nerve is stimulated. The processor circuit then performs a comparison of the two flow measurements received and provides an output based on the comparison.

The invention relates to a catheter for transvascular stimulation and denervation of a part of the autonomic nervous system of the human body, in particular for transvascular stimulation of the renal nerves or stimulation of the carotid body. The invention essentially consists of a catheter that allows both electrical neurostimulation of one or more regions of the autonomic nervous system around the artery for mapping the eye and denervation of the one or more mapped regions if the one or more mapped regions are targets of interest.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

An example computing system includes a memory and one or more processors coupled to the memory. The one or more processors obtain values for a plurality of patient parameters of a patient with hypertension that relate to a physiological condition of the patient. Before delivery of denervation therapy to the patient, the one or more processors determine, using a computational model, a predicted change in blood pressure of the patient if the denervation therapy is delivered based on the values of the plurality of patient parameters based on the values of the plurality of patient parameters. The one or more processors output, responsive to determining the predicted change in blood pressure of the patient, an indication associated with the predicted change in blood pressure of the patient.

The invention discloses an application of an ASIC3 inhibitor in preparation of a tumor treatment drug, and belongs to the technical field of biological medicines. The ASIC3 inhibitor is injected into the tumor to specifically block the tumor promoting effect of the mouse breast cancer sensory nerves, so that the solid tumor progress is inhibited. The application provides favorable support evidence for further development of a strategy of inhibiting tumors through a sensory nerve pathway, particularly in the aspect of safety, side effects caused by traditional tumor denervation are reduced, good enlightenment is provided for new use of old drugs of the marketed nervous system regulating drugs with good tolerance characteristics, and the application has broad application prospects. The method has important value and application potential.

A medical system includes a therapeutic fluid supply containing a therapeutic drug and a medical device in fluid communication with the therapeutic fluid supply. The medical device includes an expandable element and an injection tube coupled to the expandable element. The injection tube defines a port. The injection tube is in communication with the therapeutic fluid supply and configured to deliver the therapeutic drug through the port.

The present application relates to a kind of navigation system for renal artery denervation, navigation method, computer equipment, belong to surgical navigation technical field, solve the problem of insufficient two-dimensional perspective information in prior art, contrast propagation depends on experience.System includes three-dimensional blood vessel modeling module, for the three-dimensional reconstruction of the acquired CBCT projection sequence, obtain reconstruction body data, then gradually carry out three-dimensional blood vessel modeling, center line extraction, obtain the vascular topology skeleton, including blood vessel center line and multiple blood vessel nodes;Contrast propagation prediction module is used to obtain contrast agent injection point information, combined with vascular topology skeleton, carries out contrast agent propagation path prediction, generates corresponding contrast reachable area;Image mapping fusion module is used to fuse three-dimensional blood vessel surface model, contrast reachable area and the real-time perspective image obtained, generate fusion image.The present application realizes contrast propagation prediction, three-dimensional contrast path superposition, improves navigation accuracy, reduces contrast agent use.

The invention discloses a microneedle nerve conduit containing extracellular vesicles and also discloses a preparation method of the nerve conduit, and the preparation method comprises the following steps: selecting a healthy adult male mouse, making an incision in the hip of the mouse, and cutting off sciatic nerves at the far end of the ischial notch, then separating the gastrocnemius muscle tissue, and extracting acute denervation skeletal muscle source extracellular vesicles Mu-EVs from the tissue; the preparation method comprises the following steps: preparing a GelMA hydrogel pre-polymerization solution by using a methacrylated monomer and a photoinitiator, and adding Mu-EVs into the pre-polymerization solution to obtain Mu-EVs-containing GelMA hydrogel; preparing the hydrogel into a microneedle patch; and preparing the microneedle patch into the microneedle nerve conduit. According to the nerve conduit disclosed by the invention, through the synergistic effect of physical support and long-acting drug delivery of the conduit, the acute denervation skeletal muscle derived extracellular vesicles are continuously released, the metabolism of damaged neurons is activated, the regeneration of axons is accelerated, and the repair effect of peripheral nerve injury is improved.

A system and method of performing a treatment procedure, the method comprising: applying a neural denervation therapy to a wall of a blood vessel; monitoring impedance of tissue of the blood vessel; ending the application of the therapy; and displaying, on the user interface, an indication of the efficacy of the neural denervation therapy.