97 results about "Denervation" patented technology

Systems, devices, and methods described herein relate to catheter devices for therapy delivery in renal denervation applications. In some embodiments, a catheter includes a shaft having first and second sets of electrodes. In some embodiments, each electrode set can include electrodes that are spaced from one another by inter-electrode spacings and being spaced from one another by an inter-set spacing. In some embodiments, the inter-set spacing can be at least 50% greater than each inter-electrode spacing. In some embodiments, the first or second set of electrodes can include at least one basket electrode.

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide coupled to the end of the electrode unit and configured to guide the electrode unit to be brought into contact with the tube in the body; an electrode guide driving unit configured to move the electrode guide in forward and backward directions; and an electrode driving unit configured to move the electrode guide in the forward and backward directions in conjunction with the electrode guide driving unit. The electrode driving unit includes a tensile force maintenance unit connected to one end of the electrode unit and configured to provide a tensile force to the electrode unit; and a moving unit that moves in the forward direction until the electrode guide is transitioned to a first state in a state where the moving unit is connected to the tensile force maintenance unit, and then is disconnected from the tensile force maintenance unit and further moves in the forward direction until the electrode guide is transitioned to a second state.

Systems, devices, and methods described herein relate to catheter devices for therapy delivery in renal denervation applications. In some embodiments, a catheter includes a shaft having first and second sets of electrodes. In some embodiments, each electrode set can include electrodes that are spaced from one another by inter-electrode spacings and being spaced from one another by an inter-set spacing. In some embodiments, the inter-set spacing can be at least 50% greater than each inter-electrode spacing. In some embodiments, the first or second set of electrodes can include at least one basket electrode.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

The present invention concerns selective renal denervation treatment of drug resistant hypertensive patients by correlating the patients' genetic panel by categorization and hierarchy according to patients' genetic variants within the functional genes for heart activity, for the renin-angiotensin aldosterone system, and for renal activity.

The present disclosure provides a method of performing and evaluating a treatment procedure, the method comprising: navigating a treatment device to a target tissue; transitioning the treatment device from a first linear configuration to a second deployed configuration such that a plurality of electrodes on the treatment device engage the target tissue; applying a pulse of neurostimulation energy having at least two phases to the target tissue via the plurality of electrodes, the neurostimulation energy comprising an anode phase and a cathode phase, where the phase of neurostimulation is switched from anode to cathode or from cathode to anode for each consecutive pulse; observing a physiological response to the nerve stimulation energy indicative of a nerve response; performing denervation on the nerves of the target tissue; and applying the neurostimulation energy to the target tissue, wherein less than a physiological response than a threshold indicates successful denervation of the nerves of the target tissue.

Described herein are systems and methods for performing and determining the effectiveness of a denervation procedure. Such systems include an excitation source, a controller, and a catheter including elements for delivering a first ablation therapy from a first longitudinal location along a biological lumen and for delivering a second ablation therapy from a second longitudinal location longitudinally spaced from the first longitudinal location. A sensing subsystem of the system senses neural activity from a third longitudinal location along the biological lumen and determines the effectiveness of at least one of the first or second ablation therapies.

Methods, systems, devices, components, and apparatuses for renal denervation. The treatment component includes a first sensor configured to detect a first temperature or a first impedance. The treatment component includes a first energy delivery element configured to deliver energy to the vessel wall. The treatment component includes a processor. The processor is configured to determine a heart rate based on the first temperature or the first impedance. The processor is configured to determine that the heart rate is less than a threshold heart rate indicating a slowing of the heart rate. The processor is configured to control the first energy delivery element to regulate the delivery of energy to the vessel wall.

A system for denervation of nerves of a blood vessel including a catheter for navigation within a blood vessel of a patient, the catheter including electrodes and configured to apply a therapy to nerves beyond a wall of the blood vessel, a therapy source in communication with a distal portion of the catheter, and a stimulation source configured to output a neural block stimulation signal to at least a first of the electrodes and configured to output a first low frequency stimulation signal to at least a second of the electrodes, wherein application of the neural block stimulation signal via the electrodes to the wall of a blood vessel generates a neural block in afferent sympathetic nerves proximate the wall of the blood vessel, and application of the low frequency stimulation triggers a response in efferent sympathetic nerves proximate the wall of the blood vessel.

In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.

An example computing device includes a memory; and one or more processors coupled to the memory, the one or more processors being configured to: determine a baseline circadian pattern of blood pressure for a patient over a first period of time; determine a subsequent circadian pattern of blood pressure for the patient over a second period of time, the second period of time being after the first period of time; determine one or more differences between the subsequent circadian pattern and the baseline circadian pattern; determine, based on the one or more differences between the subsequent circadian pattern and the baseline circadian pattern, whether the patient is a candidate for denervation therapy; and output, responsive to determining whether the patient is a candidate for the denervation therapy, an indication of whether the patient is or is not a candidate for the denervation therapy.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

A system and method for denervation of nerves of a blood vessel including a catheter for navigation within a blood vessel, the catheter comprising a therapeutic element configured to apply a therapy to nerves adjacent the blood vessel, a therapy source in communication with the therapeutic element and configured to generate therapeutic energy and output the therapeutic energy to the therapeutic element, and a computing device including a processor and memory, the memory storing therein instructions that, when executed, cause the processor to cause the therapy source to generate the therapeutic energy, determine a rate of change of temperature associated with the therapeutic element while the therapeutic element is outputting the therapeutic energy, and determine efficacy of the therapy based on a comparison of a power of the therapeutic energy output to the therapeutic element and a rate of change of a temperature associated with the therapeutic element.

An electrode apparatus for nerve denervation or modulation includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least part of nerves on a tube in a body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

A pulmonary treatment system for treating target tissue in an airway of a subject includes a catheter assembly including an ablation assembly or tip including an expandable member, at least one energy emitter, and a cooling member, where the ablation tip is configured to be positioned within the airway of the subject, a cooling member disposed between the at least one energy emitter and the target tissue such that expansion of the expandable member causes the at least one energy emitter and the cooling member to engage a wall of the airway, the cooling member configured to cool a portion of a surface of the wall of the airway to reduce damage to the airway disposed between the at least one energy emitter and the target tissue; and a control assembly including a display configured to depict a three-dimensional graph presenting an airway of the subject for pre-planning prior to the procedure and to track the ablation tip in real time during treatment of the target tissue.

A system and method can be used to denervate at least a portion of a bronchial tree. An energy emitter of an instrument is percutaneously delivered to a treatment site and outputs energy to damage nerve tissue of the bronchial tree. The denervation procedure can be performed without damaging non-targeted tissue. Minimally invasive methods can be used to open airways to improve lung function in subjects with COPD, asthma, or the like. Different sections of the bronchial tree can be denervated while leaving airways intact to reduce recovery times.

An electrode apparatus for denervation or modulation in vivo includes: a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least a part of nerves on a tube in a body; an electrode guide coupled to an end of the electrode unit and configured to guide the electrode unit to be brought into contact with the tube in the body; an electrode guide driving unit configured to move the electrode guide in forward and backward directions; and an electrode driving unit configured to move the electrode unit in the forward and backward directions in conjunction with the electrode guide driving unit. The electrode driving unit includes: a tensile force maintenance unit connected to one end of the electrode unit; and a moving unit that is connected to the tensile force maintenance unit and moves the tensile force maintenance unit in the forward and backward directions. The tensile force maintenance unit includes a lever that provides a tensile force to the electrode unit. The lever senses the tensile force with a sensor and is automatically driven in the forward and backward directions based on the sensed tensile force.

An apparatus includes a processor configured to receive, via an ambulatory blood pressure monitor, ambulatory blood pressure data for a patient; retrieve, from an electronic health record database, patient data including at least one of demographic data, diagnostic data, or treatment data for the patient; and receive, via an electronic medication diary, medication compliance data for the patient. The processor is also configured to determine a suitability of the patient for a renal denervation treatment, wherein the determination is based on the patient data. The processor is also configured to output, to a display, a screen display based on the determination, wherein the screen display comprises at least one of a first indication of whether the patient is expected to respond to the renal denervation treatment; or a second indication of an expected level of responsiveness of the patient to the renal denervation treatment.

A system and method for denervation of nerves of a blood vessel including a therapeutic device configured for navigation within a blood vessel of a patient, stimulation elements formed on the therapeutic device, a stimulation source in communication with the stimulation elements, a therapy source in communication with the therapeutic device; and a computing device to cause the stimulation source to generate a stimulations signal for application to a blood vessel wall via at least one of the plurality of stimulation elements, detect changes in blood flow through the blood vessel, cause the therapy source to generate a therapy for application the blood vessel wall, and compare a change in blood flow through the blood vessel to a threshold to determine whether the therapy has denervated nerves.

The present application relates to the technical field of rehabilitation medical parameter optimization, in particular to an optimization method for treating denervation atrophy based on 9% stretching parameters, which comprises the following steps: collecting muscle electrical signal time series data, muscle hardness elasticity data and joint activity angle range data of the denervation atrophy area; performing time-frequency domain joint feature decomposition on the muscle electrical signal time series data to obtain an electromyogram time-frequency feature map; and performing elastic modulus distribution reconstruction on the muscle hardness elasticity data to obtain a hardness distribution feature matrix. An improved particle swarm optimization algorithm based on population topology adjacency relationship is adopted to complete 9% stretching parameter dynamic optimization, so as to obtain an optimal stretching displacement amount and a stretching frequency, and then generate a treatment parameter sequence containing a stretching holding time, an intermittent time and a total treatment time length, thereby realizing individualized intelligent configuration of denervation atrophy rehabilitation treatment parameters.

A method for evaluating an outcome of renal denervation includes: acquiring first blood flow data from a first region in a renal blood vessel after a vasodilator injected into the first region is activated in a second region in the renal blood vessel; and acquiring second blood flow data from the first region after renal denervation is performed with a catheter for denervation.

Apparatus and methods for deactivating bronchial nerves extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits focused ultrasound so as to heat tissues throughout circular impact volume (13) as, for example, at least about 1 cm3 encompassing the bronchus to a temperature sufficient to inactivate nerve conduction but insufficient to cause rapid ablation or necrosis of the tissues. The treatment can be performed without locating or focusing on individual bronchial nerves.

A method of performing bronchial denervation of a bronchus having bronchial nerves along a portion thereof is provided. The method includes providing a cryoablation device having multiple electrodes capable of delivering electrical energy and measuring impedance. At least one bronchial nerve is stimulated with electrical energy. The electrical signals from the at least one bronchial nerve are recorded to provide a first value representative of nerve function. Cryogenic treatment energy is applied to form ice in the bronchus having a thickness to encapsulate the at least one bronchial nerve to cause a reduction in nerve function. The at least one bronchial nerve is restimulated with electrical energy. The electrical signals are recorded from the restimulated at least one bronchial nerve to provide a second value that represents diminished nerve function. The first value and the second value are compared to provide an assessment of the reduction in nerve function.

A method of performing a therapeutic procedure includes navigating a therapeutic device to a location adjacent to target tissue, determining a first flow parameter within a blood vessel adjacent to the target tissue, applying neurostimulation to the target tissue and obtaining first images of blood vessels distal of the target tissue, applying therapy to the target tissue, applying neurostimulation to the target tissue, determining a second flow parameter within the blood vessel adjacent to the target tissue, comparing the second flow parameter to a flow parameter criteria, applying neurostimulation to the target tissue and obtaining second images of the blood vessels distal of the target tissue, comparing the first images to the second images to determine a vasoconstriction metric, and applying therapy to the target tissue if it is determined that the vasoconstriction metric satisfies a vasoconstriction criteria.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

Provided is a catheter including a shaft having a distal end removably connected to a distal portion and a proximal end coupled to a holder; a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue; a loop control disposed on a butt of the holder and configured to deliver a mechanical bending force to the loop. The loop includes at least a portion made of a shape-memory alloy whose shape changes at a critical temperature. In a first mode, the loop is configured to curl around the tissue at a first curvature at a temperature below the critical temperature by the mechanical bending force. In a second mode, the loop is configured to curl around the tissue at a second curvature at a temperature above the critical temperature.

An example control device for performing a denervation procedure on a patient includes a memory and processing circuitry coupled to the memory. The processing circuitry is configured to receive, from one or more sensors and prior to delivery of neuromodulation therapy via a neuromodulation catheter, pre-therapy sensor data. The pre-therapy sensor data includes one or more parameter measurements for a period of time prior to the delivery of the neuromodulation therapy. The processing circuitry is configured to determine, based on the pre-therapy sensor data, whether the delivery of neuromodulation therapy would cause a deviation, in which the deviation includes one or more patient parameters or device parameters exceeding one or more patient parameter thresholds or device parameter thresholds, and transmit an output based on the determination.

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.