67 results about "Nucleus" patented technology

The embodiment of the invention discloses an electrical stimulation parameter determination method, device and equipment, a medium and a medical system. The method comprises the following steps: acquiring a brain three-dimensional model corresponding to a target user of which the brain is implanted with at least one stimulation electrode; determining at least one electrode contact combination corresponding to the target nucleus simulation model according to the first spatial position information of the target nucleus simulation model and the second spatial position information of the electrode simulation model; determining at least one group of candidate electrical stimulation parameters of the electrode contact combination according to the electrode contact combination and a target nucleus simulation model; determining the total power consumption of the stimulator of the candidate electrical stimulation parameters according to a preset total power consumption quantitative model of the stimulator and the candidate electrical stimulation parameters; and determining at least one group of target recommended electrical stimulation parameters from the plurality of groups of candidate electrical stimulation parameters according to the total power consumption of the plurality of stimulators. According to the technical scheme, the effect of accurately screening the recommended electrical stimulation parameters with low energy consumption and efficient stimulation effect according to the electrical stimulation power consumption is achieved.

The invention discloses an environment-emotion gradient association memristive neural network circuit based on a TAP cell regulation mechanism. The environment-emotion gradient association memristive neural network circuit is composed of a hippocampus module and an amygdala kernel module. The hippocampus module comprises an environment recognition neuron module and an emotion generation neuron module; the environment recognition neuron module and the emotion generation neuron module are each composed of a weight regulation and control module adj based on a TAP cell regulation mechanism, an adder, a memristor, a resistor, an operational amplifier, a function module ABM1 and a sampling holder. Wherein the weight regulation and control module adj is composed of a voltage-controlled switch, a summator, a function module ABM2 and a function module ABM3. The almond kernel module is composed of a weight regulation and control module adj, a memristor, a resistor, an operational amplifier and a sampling holder. The provided circuit simulates the hippocampus and amygdala nucleus of the brain in structure, the regulation principle of TAP cells on neural stem cells is used for reference in a weight regulation mechanism, and bidirectional gradient associated memory of the environment and the emotion can be achieved.

A pathway planning apparatus includes a processor configured to plan a pathway for implanting an electrode lead into a brain of a patient, wherein the planned pathway satisfies the following condition: if the electrode lead is implanted into the brain of the patient according to the pathway, the electrode lead is capable of simultaneously making contact with an anterior limb of an internal capsule and a nucleus accumbens in one hemisphere of a brain of the patient. The pathway planned by the pathway planning apparatus enables the electrode lead to simultaneously deliver the electrical stimulation to the anterior limb of the internal capsule and the nucleus accumbens such that a combined electrical stimulation therapy is achieved, which has a better effect of treating diseases such as addictive behaviors, depressive disorders, and obsessive-compulsive disorders.

A method for generating magnetic resonance (MR) images of a kidney region or a brain of a subject using multinuclear magnetic resonance imaging MRI includes performing, using an MRI system, an Na-nuclei pulse sequence module to acquire a portion of a first set of MR data from the kidney or brain region of the subject and performing, using the MRI system, an H-nuclei pulse sequence module to acquire a portion of a second set of MR data from the kidney or brain region of the subject. The Na-nuclei pulse sequence module and the H-nuclei pulse sequence module may be repeated in an interleaved manner until acquisition of the first set of MR data and the second set of MR data are complete. The method further includes generating at least one Na-based image using the first set of MR data, generating at least one H-based image using the second set of MR data and displaying one or more of the at least one Na-based image and the at least one H-based image on a display.

Methods and apparatuses for detecting and metrics described herein, e.g., disc budge (e.g., beaking), nuclear tail, nucleus boundary and nucleus disruption score may be highly predictive and may be used as part of a patient treatment. In particular, described herein are methods and apparatuses for identifying from one or more images of a patient's spine, one or more of: a disc budge score (e.g., beaking score), nuclear tail score, nucleus boundary score and nucleus disruption score, and using this score to propose, or modify a patient treatment.

The invention belongs to the technical field of medicines, and particularly relates to an N-propyl-4-phenylindole derivative as well as a preparation method and application thereof. The structure of the N-propyl-4-phenylindole derivative is as shown in the specification. The compound takes an indole ring as a parent nucleus, a phenyl substituent is introduced to the fourth site of the parent nucleus, a flexible n-propyl connecting chain is connected to the first site of the parent nucleus, the hydrophobic interaction with a receptor is enhanced through 4-phenyl, the overall physicochemical properties of molecules are adjusted, diversified alkaline amino fragments are flexibly connected through an N-propyl chain, and the compound is obtained. And the N-propyl-4-phenylindole derivative is obtained. Through the unique structure, strong H3 receptor antagonistic activity and anticonvulsion effect are achieved, and meanwhile, the compound has good safety and central nervous system penetrability and is expected to be developed into a new generation of high-efficiency and low-toxicity antiepileptic drug.

The application discloses a high-channel clinical microelectrode array intelligent brain function positioning system and method, and belongs to the fields of electronic information and clinical disease diagnosis and treatment technologies. The system comprises a microelectrode array implanted in the brain, a signal processing and transmission unit and a signal identification unit. The microelectrode array adopts a multi-channel design, can synchronously detect neural electrophysiological signals and transmitter chemical signals of different depths and directions, and has a resolution of a single cell level. The signal processing and transmission unit is responsible for signal acquisition, amplification and transmission, and applies electrical stimulation; the signal identification unit performs real-time processing on the signals through a convolutional neural network algorithm, quickly identifies target nuclei, and realizes accurate positioning. The application can realize real-time monitoring of neural cell discharges and transmitter releases at different depths and different directions, and can realize rapid and accurate target positioning with the aid of advanced intelligent algorithms, thereby providing a more reliable basis for DBS surgery.

This utility model relates to medicine and can be used in neurosurgery. It is used as a means of accessing the intervertebral disc between the 5th lumbar and 1st sacral vertebrae at a 90-degree angle for laser vaporization. The utility model achieves the following technical results: 1. A minimally invasive, minimally invasive approach to the intervertebral disc at the L5-S1 level. 2. Allows to improve the effectiveness of treatment and achieve maximum pain relief in polysegmental lesions of intervertebral discs 3. Prior to this utility model, attempts were made to perform laser vaporization of the disc at the L5-S1 vertebral body level from anatomically inconvenient locations, which was accompanied by a long time interval, prolonged pain for the patient, the end of the electrode was not in the center of the nucleus pulposus, sometimes even on the cortical layer of the vertebral bodies, as a result of which the maximum effect of vaporization was not obtained, or aseptic inflammation of the bone tissue of the vertebrae was obtained. This utility model eliminates the above-mentioned issues, reducing vaporization time. The essence of this utility model is that, using this trocar and drilling stylet, we provide direct access to the L5-S1 intervertebral disc. Laser vaporization of this disc has not previously been performed due to its anatomical limitations.

The invention discloses an application of a preparation for inhibiting the interaction of SPP1 / CD44 in preparing a medicine for preventing and / or treating nucleus pulposus cell degeneration, and relates to a method for effectively improving the nucleus pulposus cell function and degeneration by inhibiting the interaction of SPP1 / CD44 and inhibiting the nucleus pulposus cell degeneration induced by M1 macrophages. Potential intervention mechanisms and targets are provided for clinical prevention and treatment of the intervertebral disc degenerative diseases, and important research significance and clinical application prospects are achieved.

The application carries out quantitative susceptibility mapping (QSM) reconstruction on original gradient echo data (GRE), then constructs an individual space standardization QSM brain template by using structural images, carries out linear and nonlinear registration processing on QSM images of all subjects and the brain template, so as to achieve the purpose of standardization processing of the QSM images; meanwhile, the structural images are automatically segmented, the gray matter and white matter masks obtained after segmentation are used to carry out matrix point multiplication on the QSM images, then the standardized QSM images are smoothed and corresponding smoothing compensation is carried out; in FSL, a general linear model is constructed, and voxel-level whole brain statistical analysis is carried out on the QSM images; the masks obtained after automatic nucleus segmentation are used to extract the susceptibility values of corresponding deep nuclei in the QSM images; the whole process does not need to manually draw the interested region, and the quantitative analysis of the susceptibility values based on voxels and based on the interested region can be automatically completed, and the repeatability, comparability and reliability are greatly improved.

This invention relates to the field of biomedical image processing technology, and discloses a method and system for quantitative analysis of hypothalamic immunofluorescence images. The method includes: performing spectral unmixing on multispectral fluorescence microscopy images based on a nonnegative matrix factorization algorithm to obtain a clean signal distribution map; using Gaussian Laplace filtering and watershed transform to achieve cell detection and segmentation; performing affine and B-spline registration between slice images and standard brain atlases to generate regions of interest masks for neural nuclei; using a local background adaptive correction strategy to perform fluorescence quantification and positive determination; and calculating Pearson correlation coefficient and Manders overlap coefficient to achieve colocalization analysis. The system includes a spectral unmixing module, a cell detection and segmentation module, an atlas registration and region recognition module, a fluorescence intensity quantification module, and a colocalization analysis and statistical output module.

To provide a separation and discrimination method of a nucleus pulposus precursor cell, and application thereof.SOLUTION: Provided is a separation and discrimination method of a nucleus pulposus precursor cell, where a large number of tissue blocks are divided from a nucleus pulposus tissue, and the tissue blocks are left to stand and cultured in a culture dish after performing hydrolysis by enzyme. When cells are formed into the partition blocks on a bottom of the culture dish, a nucleus pulposus precursor cell is screened from the partition blocks by using a specific embryonic stem cell gene (e.g., Nanog, Oct-4, SOX2). Further, the method can screen a nucleus pulposus precursor cell having moving performance and / or mesenchymal stem cell properties by using a specific protein and a gene marker, and further can screen a nucleus pulposus precursor cell having anti-inflammatory performance. Finally, disclosed is application used for producing a pharmaceutical composition treating lower back pain by using the nucleus pulposus precursor cell obtained by the method, and a new therapy strategy to lower back pain is provided.SELECTED DRAWING: Figure 6

Methods and apparatus for segmenting cell nuclei in medical images apply first and second trained machine learning algorithms. The first trained machine learning algorithm processes a medical image to provide center locations of cell nuclei depicted in the image. The second machine learning algorithm processes each of a plurality of patches of the image. Each of the patches correspond to one of the plurality of center locations. Processing each patch yields a nuclear boundary corresponding to the corresponding one of the center locations. The methods and apparatus allow associating individual pixels of the image with one or more than one nuclei and have been shown to be effective for instance segmentation of nuclei in clusters of overlapping cell nuclei.

The invention provides a social disorder animal model construction method based on a basal lateral amygdaloid nucleus-screen nucleus neural circuit and application thereof, and belongs to the technical field of animal model construction. The method comprises the following steps: injecting a viral vector carrying a photosensitive protein gene or a photosuppressive protein gene into amygdaloid nucleus on the outer side of an animal basal to express neurons of cholecystokinin or neurons of CaMKII alpha; embedding an optical fiber above the screen-shaped core; first light stimulation is applied through an optical fiber to activate nerve projection from amygdaloid nucleus on the outer side of the substrate to the screen nucleus, and a social disorder animal model is obtained; or applying a second photostimulus to inhibit the projection, resulting in a social disorder relief animal model. According to the invention, specific photogenetic regulation and control of the BLACCK +-CLA neural circuit is realized for the first time, social behaviors can be accurately regulated and controlled without interfering with movement and anxiety levels, and a reliable experimental tool is provided for mechanism research and drug screening of social obstacles.

The application relates to a stimulating coil for deep brain area nerve regulation, which is in an elliptical shape, has 6 turns, a short inner diameter of 5-15 mm, a long inner diameter of 15-40 mm, a wire width of 1.5 mm, a wire height of 1 mm, an axial spacing of 2 mm and a radial spacing of 1 mm. A transcranial magnetic stimulation system is electrically connected with two stimulating coils respectively. A transcranial magnetic stimulation method is used to symmetrically fix the two stimulating coils on the two sides of the head and make the stimulating coils close to the head; a power supply unit is used to rapidly discharge the two stimulating coils to induce a short strong pulse current in the stimulating coils and form a strong magnetic field of 1T-4T around the stimulating coils, so that the nucleus of the lamina and part of the hippocampus in the deep brain area are stimulated. The beneficial effect is that the stimulating effect on the deep brain area is excellent, especially in the aspect of accurately targeting specific brain areas, the nucleus of the lamina can be effectively stimulated, and part of the hippocampus can be touched.

This invention discloses a method, apparatus, device, medium, and medical system for determining brain surgical pathways. The method involves acquiring a brain structure model of a target user and at least one target point; determining the information transmission relationship between each nucleus sub-model and each neural fiber sub-model based on the brain structure model; determining multiple candidate surgical plans based on multiple preset path starting points, the target nucleus sub-model to which at least one target point belongs, and the information transmission relationship; evaluating the quality of each candidate surgical plan using a quantitative evaluation model based on at least one evaluation dimension, and determining the path quality attributes corresponding to each candidate surgical plan; determining at least one recommended surgical plan based on each path quality attribute; automatically generating multiple candidate paths that conform to neural conduction characteristics; and selecting the optimal plan through a quantitative evaluation model. This approach improves surgical accuracy while effectively reducing the risk of brain tissue damage and the complexity of surgical procedures.

The application relates to an intelligent diagnosis method for cervical cell atrophy levels, and relates to the problem that intelligent discrimination of cervical cell atrophy degrees is lacking in automatic pathological diagnosis technology. Cervical vaginal squamous epithelium is divided into surface layer cells, middle layer cells and basal layer cells, and ovarian estrogen affects the growth and maturity of the cells; a decrease in estrogen level can cause symptoms such as atrophic vaginitis and osteoporosis, which need to be treated in time; at present, squamous cell atrophy diagnosis is not clear enough, and there are few reports on atrophy degree diagnosis research, so it is of great significance to establish a systematic and intelligent diagnosis process for cervical cell atrophy degree discrimination. In order to improve the problem, the application provides an intelligent diagnosis method for cervical cell atrophy levels; the method first detects the surface layer cells, the middle layer cells and the basal layer cells by using a target detection model, then segments the cell nucleus of each layer of cells detected by using an instance segmentation model, and finally calculates the cell quantity ratio, the nucleus-cytoplasm ratio and the cell crowding degree index of each layer; the indexes are input into a random forest classification model to grade the atrophy degree; it is known through sufficient experimental verification that good effects are achieved in cervical cell atrophy degree discrimination. The application is applied to cervical cell atrophy degree discrimination.

This invention discloses a brain rehabilitation state recognition method based on multimodal image fusion, comprising: acquiring multimodal brain image data, performing preprocessing to form a standardized image set; constructing a dual-branch dynamic gated VM-UNet network to complete brain region functional partitioning and extract multimodal brain region features; constructing a dual-channel counterfactual generator for damage compensation to generate a surrogate reference and complete differential occlusion processing; extracting the functional energy regeneration phase of structural pathways based on the comparison between current features and the reference; jointly analyzing the closure relationship of the regeneration phase, identifying the compensatory support nucleus, and forming candidate recovery segments; performing multi-scale random stripping verification, reconstructing the closed stable domain, and outputting the brain rehabilitation state result. This invention achieves accurate differentiation and dynamic recognition of true brain function recovery and compensatory pseudo-improvement through fine multimodal image partitioning, counterfactual surrogate reference construction, and regeneration phase closure verification.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

The invention discloses application of arginine vasopressin in treatment of slow transit constipation, and relates to the technical field of medicines for treating slow transit constipation. The arginine vasopressin nose drop is found to have a very good treatment effect on slow transit constipation for the first time, and especially for loperamide-induced slow transit constipation, the arginine vasopressin nose drop can effectively promote intestinal tract movement and improve constipation symptoms. The arginine vasopressin is prepared into nose drops, can bypass a blood brain barrier to enter the brain, directly targets downstream nuclei of AVP neurons in a hypothalamic para-ventricular nucleus PVN nuclei, and intervenes treatment in the nerve center, and the effect is better. The discovery of the invention expands a new application for arginine vasopressin drugs, and also provides a new idea for development of constipation drugs.

An amyotrophic lateral sclerosis (ALS)-simulating model and a method for constructing the ALS-simulating model based on a caspase-4 (CASP4) gene are provideds. The method includes: (1) constructing a targeting fragment for knock-in of the CASP4 gene; (2) injecting gRNA, Cas9 mRNA, and the targeting fragment into a mouse zygote, culturing, and passaging to produce a hCASP4flox mouse with the CASP4 gene stably inherited; and (3) crossing the hCASP4flox mouse with a Cre driver mouse to produce a double-positive heterozygous mouse, which is a mouse model in which the CASP4 gene is specifically expressed in a nervous system. An ALS-simulating animal model is constructed based on a humanized CASP4 gene. The method can effectively avoid the mouse death caused by this apoptotic factor, and leads to an ALS-simulating mouse model in which TDP-43 fragments accumulate in the cytoplasm and TDP-43 is deleted in the nucleus.

The application discloses a rat robot speed and direction control method based on a mesencephalon-mesolimbic olfactory cortex loop. The application induces a rat robot to complete motion starting in a stationary state through adjustable micro-electric stimulation on a mesencephalon MLR motion area and a flocculus nucleus group, collects nerve signals of "speed cells" and "direction cells" in a mesolimbic olfactory cortex MEC nucleus area, adjusts a rat robot stimulation parameter instruction set, and realizes rat motion grading control. The CnF and PPN nucleus groups of the mesencephalon motion area are taken as speed regulation instruction input points, and the flocculus is taken as a direction regulation instruction input point, so as to establish a speed and direction grading regulation instruction model, and develop a new type of rat robot which can control motion speed and motion direction in real time. The application can be used for establishing a rat robot motion state grading regulation instruction set and exploring a rat motion nerve regulation mechanism.

To provide a novel compound and use thereof.SOLUTION: A compound is used that comprises: a nuclear translocation unit having the property of migrating into a nucleus of a cell; a functional unit having a specific structure; and a linker unit that links the nuclear translocation unit and the functional unit .SELECTED DRAWING: None

The invention discloses an interactive pupil light reflex teaching demonstration model and a working method thereof, and belongs to the technical field of medical education tools. The model comprises a demonstration light source, a photosensitive sensor, an adjustable pupil simulation mechanism, a neural pathway visualization assembly, a control circuit module and a man-machine interaction control interface, lED lamp strips and RGB lamp beads which are arranged along the optic nerve, the visual crossover, the visual beam, the midbrain apical anterior region, the para nucleus of the oculomotor nerve and the oculomotor nerve are controlled to be lightened in sequence, and an input channel, a central connection channel and an output channel of a neural signal are presented in a visual mode; meanwhile, the steering engine is driven to adjust the adjustable diaphragm structure, and dynamic contraction and expansion of pupils along with the change of light intensity are achieved. According to the invention, abstract physiological changes of pupils and neurotransmission pathways are converted into a visual, controllable and repeatable teaching demonstration process, and the system has the advantages of strong interactivity, good intuition, high safety and suitability for medical teaching and practical training.

The present application relates to the technical field of inhalation anesthetic antagonism, and particularly relates to the application of a corticotropin-releasing hormone receptor antagonist in the preparation of an inhalation anesthetic antagonist. The present application first discovers that the corticotropin-releasing hormone receptor of the dorsal raphe nucleus is a key target of the action of an inhalation anesthetic, and that the oculomotor nerve parvocellular nucleus-dorsal raphe nucleus neural loop mediates the effect of an inhalation anesthetic, and that a corticotropin-releasing hormone receptor antagonist can block the excitatory effect of urocortin on the neurons of the dorsal raphe nucleus, thereby weakening the effect of an inhalation anesthetic. The present application first applies a corticotropin-releasing hormone receptor antagonist in the preparation of an inhalation anesthetic antagonist, fills the technical gap in this field, is conducive to the rapid postoperative recovery of patients under general anesthesia, and has a broad application prospect.

An implant that can be implanted non-invasive or minimally-invasively into the sphenoid cavity of a subject for delivery of stimulation to deep brain reward circuit nodes of the brain and / or to drive hormonal release through stimulation of nuclei in the hippocampus or cells in the pituitary or nearby structures such as blood vessels. The implant is alternatively or additionally capable of sensing signals in the deep brain, and for powering deep-brain implants (i.e., devices placed in the brain that are difficult to power from the scalp due to distance).

The invention discloses an induction culture medium for inducing fibroblasts to transdifferentiate into nucleus pulposus cells and application of the induction culture medium, and belongs to the technical field of cytobiology and regenerative medicine. The induction culture medium comprises a basic culture medium and an induction composition, can be used for realizing 2D / 3D transdifferentiation of fibroblasts into nucleus pulposus cells, and meets the requirements of different application scenes. Meanwhile, the invention further provides an amplification culture medium, a technical system for forming a 3D (three-dimensional) organoid through amplification of the amplification culture medium is provided, and the method has important significance in promoting cell therapy of the intervertebral disc degenerative change.

The present application relates to the technical field of medicine, and particularly relates to a fusion protein and application thereof in preparation of a medicine for preventing and treating nervous system tumors. The fusion protein can specifically target lesion cells overexpressing AQP4 through AQP4 antibodies, deliver an effector fragment Apoptin into tumor cell nuclei to play a role, and specifically induce tumor cell apoptosis without damaging normal cells, and can be used for preventing and treating diseases caused by abnormal proliferation of nervous system cells. The present application further provides a medicine, and an active ingredient of the medicine comprises the fusion protein or the biomaterial.

The invention discloses a low-deviation multi-scale regional brain age prediction method based on adversarial training, and relates to the technical field of medical image analysis, artificial intelligence and neurodegenerative disease diagnosis. The method comprises the following steps: firstly, carrying out standardized preprocessing on T1 weighted structure MRI data, segmenting a brain region by using an AAL3 map, then constructing an adaptive 3D convolutional neural network, and introducing a gradient inversion layer to realize age group adversarial training so as to reduce systematic deviation; performing brain age prediction by adopting multiple regression models, further reducing residual deviation by a linear correction method, and finally performing statistical analysis to identify a regional accelerated aging mode of disease specificity. Experimental results show that the method effectively reduces the age-related deviation of 67.6% ROI, successfully identifies the significantly accelerated aging of the Parkinson's disease patient in left temporal medial gyrus, thalamus ventral lateral nucleus and brainstem monoaminergic nuclei, and provides important technical support for early diagnosis and progress monitoring of neurodegenerative diseases.

The present invention relates to a digital twin system in which a computational processor predicts a nucleus tractus solitarii (NTS)-based neuro-hemodynamic result, the digital twin system comprising: an encoding unit for converting a hemodynamic value (BPT) acquired at time T into a state of a normalized NTS latent space; a calculation unit for calculating a next latent state from the latent space state converted by the encoding unit by using an artificial neural network; and a decoding unit for re-converting, into an updated hemodynamic value (BPT+1), the next latent state calculated by a stimulus-based dynamics calculation unit.