50 results about "Electro physiology" patented technology

This invention discloses a breathable, conductive hydrogel electrode, its preparation method, and its applications. The breathable, conductive hydrogel electrode comprises a porous fiber support structure and a hydrogel conductive network. The porous fiber support structure has a three-dimensional porous structure formed by interwoven porous fibers, each fiber possessing a three-dimensional interconnected channel structure formed by interconnected pores distributed on and within the porous fibers. The hydrogel conductive network is distributed on the surface and within the porous fiber support structure, forming a continuous ion conduction path within the electrode. The breathable, conductive hydrogel electrode provided by this invention has advantages such as high breathability, self-humidification, low impedance, and breathability, achieving high-fidelity, long-term acquisition of physiological signals such as electroencephalograms (EEG), electrocardiograms (ECG), and electromyograms (EMG). It can be widely used in electrophysiological signal monitoring, smart wearables, sleep analysis, and human-computer interaction.

A system includes an interface and a processor. The interface is configured to receive multiple electrophysiological (EP) signals from a tissue area along an ablation curve inside a cardiac chamber of a heart of a patient. The processor is configured to (i) generate local conduction vectors (LCVs) for the area based on the multiple EP signals, (ii) estimate a level of change between sets of LCVs along the ablation curve within the tissue area, and (iii) based on the level of change, identify a presence of a conduction gap in the ablation curve.#

A catheter system for use with a catheter with a distal assembly supporting a plurality of electrodes adapted to sense electrical signal in heart tissue and a force sensor configured to generate first contact signals representative of a contact force acting on the distal assembly. The system includes an ablation power generator configured to energize the plurality of electrodes, an impedance circuitry configured to generate second contact signals representative of the electrodes in contact with tissue, a processor configured to receive the first and second contact signals and generate switch signals in response thereto, and a switch circuitry configured to connect in response to the switch signals solely selected electrodes in contact with tissue to the ablation power generator in forming one or more composite electrodes.

An electrophysiological medical device includes a catheter, a magnetic positioning system, and a processing unit. The catheter is inserted into the human body. The magnetic positioning system includes a magnetic field generator and a magnetic sensor. The magnetic field generator generates a magnetic field, and the magnetic sensor moves with the catheter to detect first magnetic field information indicating the catheter's position within the body. The processing unit acquires the first magnetic field information from the magnetic positioning system and generates the catheter's original position information based on this information. The processing unit also acquires relevant information from a digital subtraction angiography (DSA) device that causes magnetic interference to the magnetic positioning system, corrects the catheter's original position information based on this information, and obtains and outputs the corrected position information of the catheter. This electrophysiological medical device can specifically address the impact of DSA equipment on the positioning accuracy of the magnetic positioning system, thereby improving positioning accuracy, avoiding the impact of low positioning accuracy on diagnosis and operation, and ultimately improving medical outcomes.

Systems, devices, and methods for treating drug-refractory epilepsy are disclosed. [Solution] In one embodiment, a method for treating epilepsy is disclosed, comprising detecting electrophysiological signals of a subject using a first electrode array coupled to a first intravascular carrier. The method further comprises analyzing the electrophysiological signals using a neuromodulator electrically coupled to the first electrode array, and stimulating a target site in the subject's body using a second electrode array coupled to a second intravascular carrier implanted in a portion of a body blood vessel above the base of the subject's skull.

An ablation catheter, having an annular distal end. The annular distal end includes an arc-shaped tail end catheter body. In the ablation catheter, a plurality of electrode pairs are arranged at intervals along the arc-shaped extending direction of the tail end catheter body. The plurality of electrode pairs are respectively wound on the tail end catheter body. Each electrode pair comprises two ring electrodes. Each ring electrode is wound on the tail end catheter body. According to the design of the electrode pairs, on the premise of ensuring the ablation effectiveness and safety, the diameter of the annular distal end is more convenient to adjust. Moreover, the electrode pairs are used for collecting electrophysiological signals more accurately, and the situation that the change determination of electrical signals is affected by the large distance between the electrodes is avoided.

This invention relates to an in vitro method for mapping the spatiotemporal electrophysiological dynamics and spatial transcriptional profiles of cells in a functional neuronal cell ensemble. This in vitro method includes simultaneously recording and analyzing spatial data of molecular activity and electrical network activity at the level down to individual cells using high-density electrobiosensors, spatial transcriptomics, optical imaging, and advanced computational strategies. The invention also relates to: methods for identifying the composition of a functional neuronal ensemble; methods for monitoring the spatiotemporal electrophysiological dynamics and transcriptional profiles of cells in a functional neuronal cell ensemble; methods for monitoring the cellular composition of a functional neuronal ensemble; methods for identifying compounds that influence spatial electrophysiological and transcriptional dynamics; and / or methods for identifying the cellular composition of a functional neuronal cell ensemble based on detected dynamics; and devices thereof. This invention allows for a better understanding of disease mechanisms, the identification of therapeutic targets, and the development of new drugs and treatment regimens.

This invention discloses a method and system for monitoring exercise fatigue based on multimodal biometric recognition, relating to the field of exercise health monitoring technology. The method includes: simultaneously acquiring surface electromyography (EMG), muscle thickness, and inertial data; decomposing EMG signals to reconstruct pure signals and artifacts, and generating reliability weights based on inertia; extracting electrophysiological features from EMG, constructing hysteresis loops from thickness and angle to extract mechanical features, and extracting emotional features from inertia; inputting the three types of features into an adversarial network to decouple and output pure fatigue features; inputting the data into a hidden Markov model to decode the current state and predict the next cycle; fusing the prediction vector, fatigue features, and weights, generating fused features via a graph network and self-attention, outputting a level and labeling the type. This invention solves the problems of dynamic changes in signal quality leading to fused weight mismatch, difficulty in distinguishing fatigue sources, lack of evolutionary prediction, and low cross-individual adaptation efficiency, achieving high-precision and interpretable real-time exercise fatigue monitoring.

An example method includes storing reconstructed electrophysiological data sets for at least two baseline time intervals and at least one modulation time interval. The electrophysiological data sets are representative of electrophysiological signals reconstructed at locations across a respective surface of interest within a patient's body based on non-invasively measured electrophysiological signals for respective time intervals. The modulation time interval can overlap with modulating an arrhythmia or arrhythmogenic activity. The method can also include computing dominant frequency maps from the electrophysiological signals reconstructed for at least two baseline data sets and the at least one modulation data set. The method can also include analyzing the dominant frequency maps to determine an indication of dominant frequency stability across at least a portion of the surface of interest.

The application relates to the field of electrophysiological catheters, and provides an electrophysiological catheter and an electrode assembly of the electrophysiological catheter. The electrode assembly of the electrophysiological catheter comprises a spline and a spline connecting seat, the spline is arranged on the distal end side of the spline connecting seat, the spline connecting seat comprises a first seat body and a second seat body, the second seat body is embedded in the first seat body, the distal end of the second seat body is exposed to the distal end of the first seat body, and the second seat body is rotatably arranged on the first seat body; a first sensor is arranged on the first seat body, the first sensor is non-coaxial with the second seat body, and the detectable signal of the first sensor comprises the spatial position of the first sensor relative to the rotation axis of the second seat body; and a second sensor is arranged on the second seat body, the second sensor is coaxially arranged with the second seat body, and the detectable signal of the second sensor comprises the rotation angle of the second seat body. The application mainly solves the problem of how to obtain the driving angle of a driving rod of an electrophysiological catheter.

The application discloses a Parkinson's disease freezing gait early prediction method based on electroencephalogram high-order phase characteristics. The method comprises the following steps: acquiring scalp electroencephalogram signals of multiple target brain regions of a user and performing pretreatment; applying a surface Laplace space filtering algorithm to the pretreated signals to suppress volume conduction effect; extracting multi-dimensional neuroelectrophysiological characteristics from the filtered signals in real time, wherein the characteristics at least include phase locking values of target brain region networks in frequency bands and phase-amplitude coupling strength indexes in target brain regions; inputting the multi-dimensional characteristics into a pre-trained machine learning prediction model to output a probability quantitative value of physical freezing gait of the user in future seconds. By introducing surface Laplace filtering and high-order cross-frequency coupling characteristics, the application effectively improves signal space resolution and specificity of prediction characteristics, realizes low-delay and high-accuracy early prediction, and can be used for wearable electroencephalogram devices.

This invention provides an electrophysiological signal acquisition device and method for aquatic shellfish, relating to the interdisciplinary fields of aquatic biology and neuroelectrophysiology. The device includes a display, an electrophysiological signal processor, conductive wires, a shielding cover, an experimental water tank, a sealing gasket, an inducer conduit, bioelectrodes, and an inducer injector. During electrophysiological signal acquisition, the test sample is placed in the experimental water tank, and an inducer is injected through the inducer conduit to create chemical stimulation. The bioelectrodes and the electrophysiological signal processor capture and process the bioelectrical signals generated by the sample in real time. This invention overcomes the difficulty of effectively and accurately acquiring electrophysiological signals from aquatic shellfish underwater, and has advantages such as simple structure, strong anti-interference ability, and easy operation.

At least some embodiments of the present disclosure is directed to a system for processing cardiac information. The system including a processing unit is configured to: receive one or more cardiac electrical signals from one or more electrodes disposed within a cardiac chamber, wherein the cardiac electrical signals are acquired over a cardiac beat; receive an indication of a measurement location corresponding to each of the cardiac electrical signals; analyze the one or more cardiac electrical signals to calculate a plurality of duty cycle values, the calculated duty cycle values corresponding to a plurality of pre-selected cycle length windows; and calculate an average duty cycle of the calculated duty cycle values over the plurality of pre-selected cycle length windows.

To provide a guiding sheath assembly.SOLUTION: A guiding sheath assembly has an elongated shaft, a control handle with a control knob, and a shuttle configured for translation in response to manipulation of the control knob. The assembly includes a puller wire extending along the shaft and responsive to translation of the shuttle to deflect the shaft. The puller wire has a stop at its proximal end, where a deflection sensor is affixed to stop a subject to compression to generate a signal in response to distortion between the first shuttle and the first stop. A catheter having a control handle and a control knob for manipulation of a deflection puller wire whose proximal end is affixed to a stop anchored in the control handle housing includes a strain gauge affixed to the stop configured to detect deformation resulting from actuation of the puller wire in deflecting the catheter shaft. A drip chamber is also provided.SELECTED DRAWING: Figure 1

A closed-loop microelectrode array for spinal cord nerve function repair based on 3D printing, its fabrication method, and its application are disclosed, solving the problems of signal interference, mechanical mismatch, and lack of closed-loop control in existing neuromodulation devices. The invention includes an electrode array base plate with several electrode supports mounted on it. The upper end face of the base plate serves as a mounting surface, and the electrode supports are densely arranged on this mounting surface. The end of each electrode support away from the base plate is an electrode group for direct contact with the spinal cord nerve. Each electrode support comprises, from the inside out, an electrophysiological recording microelectrode, a first dielectric layer, an inner ground microelectrode, a second dielectric layer, an electrical stimulation microelectrode, a third dielectric layer, an outer ground microelectrode, and a fourth dielectric layer. The upper end of the electrophysiological recording microelectrode, the first dielectric layer, the inner ground microelectrode, the second dielectric layer, the electrical stimulation microelectrode, the third dielectric layer, the outer ground microelectrode, and the fourth dielectric layer is the electrode group for direct contact with the spinal cord nerve.

This invention relates to the field of medical device technology, specifically to an intelligent energy control method and system for an electrosurgical energy platform. The method includes: real-time acquisition of multi-dimensional electrophysiological parameters at the tissue-electrode contact point during electrosurgical procedures, including tissue impedance, voltage, current, and phase difference; inputting the acquired multi-dimensional electrophysiological parameters into a pre-trained tissue type recognition model to identify the currently contacting tissue type and determine its corresponding energy safety threshold; dynamically calculating the optimal energy output parameters based on the identified tissue type and surgical operation mode; and real-time monitoring of tissue state changes, automatically adjusting energy output or triggering a safety protection mechanism when the tissue state reaches a preset critical value. This invention achieves adaptive intelligent control of the electrosurgical energy platform through a combination of multi-parameter fusion sensing and artificial intelligence algorithms, improving surgical safety and accuracy, reducing tissue thermal damage, and lowering the risk of surgical complications.

The utility model relates to an adjustable air bag type pelvic floor muscle biofeedback trainer, and particularly relates to the technical field of medical apparatus and instruments. The adjustable air bag type pelvic floor muscle biofeedback trainer is composed of a medical silica gel air bag, a pressure regulating module, a pressure sensor, a main control unit and a display terminal. The air bag is provided with annular convex textures and is divided into a proximal chamber and a distal chamber; the pressure regulating module is connected with a micro air pump and an electromagnetic valve through a tee joint; a silicon piezoresistive sensor is embedded in a double air guide pipe to detect pressure in real time; the main control unit drives an air path and processes data, which are transmitted to the display terminal through SPI or wireless communication. The pneumatic structure realizes biomechanical feedback in the mechanical domain, and through independent regulation and control of the double chambers, dynamic adaptation of the air bag and rapid pressure response, the training precision and adaptability are improved, the biofeedback mechanism is converted from the electrophysiological domain to the mechanical domain, the "detection-feedback-regulation" closed loop is realized through the pneumatic structure innovation, a high cost-effective solution is provided for the pelvic floor rehabilitation field, and the hardware cost is reduced.

In a described example, a method includes constructing a data structure including a representation of locations, within a given cardiac region, visited by a catheter during a build phase for a model of at least the given cardiac region. The method can also include receiving an electrogram associated with one or more first electrodes of the catheter at locations in a patient's heart and receiving an electrophysiological signal associated with second electrodes at respective substantially fixed locations relative to the patient's heart. The method can also include identifying, based on the electrogram and the electrophysiological signal, a cardiac region corresponding to a respective one or more of the locations of the one or more first electrodes in the patient's heart. On a graphical user interface, visual indicia can be displayed based on the identified cardiac region and the given cardiac region.

Provided by the present disclosure are a boundary element-based three-dimensional mapping method, system and apparatus, as well as a device and a medium. The method includes the following steps: acquiring a three-dimensional endocardium model, electrode potential data collected by an electrode probe in a cardiac chamber, and position data of the electrode probe collected by a three-dimensional spatial positioning system; performing boundary element discretization processing of the endocardium using a normal vector in geometric vector data, the position data and a preset electrostatic relationship of an intracardiac potential to determine a numerical relationship equation after boundary element discretization; solving an endocardial potential by inverse operation based on the numerical relationship equation, the position data and the electrode potential data; and determining an endocardial charge density on the endocardium according to the endocardial potential data and a preset charge density algorithm, and displaying the endocardial charge density in real time.

This invention relates to the field of electrophysiological catheter technology and is an algorithm for detecting the contact between electrophysiological catheters and tissues. It adopts a semi-supervised learning approach and uses a dynamic and relative numerical verification method. The input data is used as the training set and test set of the classification model. Known physical laws are used as the conditions for classifying the dataset, and the model parameters are continuously updated to train the classification model and achieve real-time contact detection.

The application relates to the technical field of electric massage, and discloses an acupoint positioning electric stimulation massage method and system based on a flexible electrode array, which comprises the following steps: pasting the flexible electrode array on a skin stimulation area, injecting a composite electric detection signal of superimposed low-frequency sine waves and high-frequency pulse sequences into the subcutaneous tissue through the electrode, collecting and extracting low-frequency impedance spectrum and high-frequency transient response waveform, determining the subcutaneous extracellular fluid resistance and fitting the capacitance charging and discharging time, combining into an acupoint electrophysiological characteristic vector, positioning the active acupoint to be stimulated through spatial clustering analysis, and then applying a biphasic asymmetric electric stimulation pulse according to the electric characteristics of the tissue, capturing an induced composite response signal in real time, fitting the density to obtain an action potential emission density trend, reducing the pulse repetition frequency and pulse width when the trend reaches a decay inflection point, and restoring the trend to a resting state level until the trend is restored to a resting state level; and the application can improve the effectiveness of electric stimulation massage.

An apparatus includes a catheter assembly for use in a medical procedure to conduct electrophysiological mapping. The catheter assembly includes a catheter having an end effector with a tip member. One or more insert-molded microelectrodes are located in the tip member of the end effector for conducting electrophysiological mapping. The insert-molded microelectrodes include a microelectrode and a composite that isolates the microelectrode from contact with the tip member.

The application discloses a non-invasive brain-computer interface multi-modal data acquisition and analysis method and system, wherein the method is executed by a central control system and comprises the following steps: step 1, a uniform synchronous acquisition instruction is sent to a plurality of electro-physiological signal collectors worn on the same subject; step 2, multi-dimensional multi-modal physiological data streams synchronously collected and returned by the plurality of electro-physiological signal collectors based on the synchronous acquisition instruction are received; step 3, time alignment processing is performed on the multi-dimensional multi-modal physiological data streams to generate a multi-modal data set with time stamp synchronization; and step 4, automatic analysis and marking are performed on the multi-modal data set with time stamp synchronization based on preset analysis rules to identify the space-time correlation between different modal physiological data. The application realizes high-precision multi-modal synchronous acquisition, visual operation, improves the repeatability of experiments and the comparability of data, and is convenient for popularization and application in scientific research and clinical scenes.

This invention discloses a closed-loop drug delivery method and system. The closed-loop drug delivery system includes an electrophysiological signal acquisition unit, a wearable main body, and a drug delivery component. A flexible substrate is deployed in the wearable main body; a control unit, a drug storage unit, and a driving unit are integrated on the flexible substrate. The method includes: acquiring electrophysiological signals from the patient's body surface and / or body through the electrophysiological signal acquisition unit; outputting a drug delivery command based on the electrophysiological signals through the control unit; obtaining a target dosage of drug from the drug storage unit based on the drug delivery command through the driving unit; and delivering the target dosage of drug to the drug delivery location through the drug delivery component. This solution solves the problems of existing drug delivery methods being highly dependent on medical personnel and difficult to accurately control the dosage. By acquiring the patient's electrophysiological signals and controlling drug delivery based on these signals, the dependence on medical personnel for disease treatment can be significantly reduced, and the accuracy of drug delivery timing and dosage can be improved.

The invention belongs to the technical field of electrophysiological catheters, and discloses a pulse ablation catheter. The pulse ablation catheter comprises an ablation component, the ablation component comprises an inner tube, a middle tube and an outer tube which are sequentially arranged from inside to outside, a core electrode is arranged at the far end of the inner tube, a mesh basket electrode is arranged at the far end of the middle tube, and the mesh basket electrode comprises a sheet-shaped conduction part and a plurality of arc-shaped insulation arms circumferentially arranged on the outer edge of the sheet-shaped conduction part at intervals. The near end of the arc-shaped insulation arm is connected with the middle tube, the sheet-shaped conduction part is located at the far end of the core electrode, the surface of the far end of the sheet-shaped conduction part is a conduction surface, the rest part is a non-conduction surface, a plurality of side branch rods are arranged in the circumferential direction of the far end of the outer tube at intervals, and the side branch rods extend outwards in the radial direction of the outer tube; and a plurality of side branch electrodes are arranged on each side branch rod. The device has multiple electrode distribution forms, the diversity of electric field distribution is improved, and the device is suitable for multiple application scenes; and the ablation depth is increased.

The application belongs to the technical field of electrophysiological detection, and relates to a high-throughput deep cortex electrode debugging, sterilization and intraoperative use device.The device comprises a transparent hole shell, a silica gel separation plate with a clamping groove and an ethylene oxide compatible hub module.Test results show that the transparent hole shell and the silica gel separation plate with the clamping groove completely fix the electrode, and can avoid the tip of the electrode from being accidentally touched with the shell or other parts during the whole process of debugging, transportation, sterilization or use.The device can directly perform ethylene oxide sterilization on the connection of each module of the electrode without opening the shell, and obviously saves the time for assembling the electrode modules and debugging during the operation.Using the ethylene oxide compatible hub module can quickly release the data line during the operation, and the data line is mechanically protected and electromagnetically shielded, and is suitable for the complex electromagnetic environment and mechanical environment in the operating room.