The present invention designs and synthesizes the ascorbyl
ester derivatives of the
aryl (ethanoic)
propanoic acid non-steroidal anti-inflammatory medicaments, such as
ibuprofen,
ketoprofen and
naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the
ibuprofen as the representative is a common
antipyretic analgesic medicament. The invention has remarkable
antipyretic and
analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the
elderly people, infants and children. The
aryl (ethanoic)
propanoic acid ascorbyl ester can be converted into ascorbyl
ester derivatives and the addition salts of the derivatives with pharmaceutical acid or pharmaceutical alkaline, which can improve the water
solubility thereof, facilitate intravenously administration, reduce the onset time, improve the
bioavailability, reduce the stimulation effect to
gastrointestinal tract, and enhance the penetrating capacity to hemato encephalic barrier, and can be used as a novel medicament to be applied for antiphlogistic, antipyresis, analgesia, treatment of
arthritis, dysmenorrheal,
multiple sclerosis, pneumonia
cystic fibrosis and patent
ductus arteriosus of premature infants, and prevention and treatment of cerebral apoplexy, hypoxic-
ischemic brain damage,
senile dementia and certain cancers.