Patents
Literature
52 results about "Anticoagulation Treatment" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Anticoagulation Therapy. Your healthcare provider may have prescribed an anticoagulant, also known as a “blood thinner” medication, such as Warfarin (Coumadin®), to treat or prevent a serious blood clot condition. A healthcare provider referral is required for Anticoagulation Therapy.
Thrombolysis and chronic anticoagulation therapy
InactiveUS7308303B2Sufficient amountAvoid the needElectrocardiographyMedical devicesDiseaseLife quality
Thrombolytic and / or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and / or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
Owner:BOSTON SCI NEUROMODULATION CORP
Method for extracting modified plasma protein powder and bioactive peptide for enriching blood from pig blood
InactiveCN101766251ANo pollution in the processLow costProtein composition from bloodAnimal proteins working-upFiltrationBlood plasma
The invention discloses a method for extracting modified plasma protein powder and bioactive peptide for enriching blood from pig blood, comprising the following steps of: taking fresh and healthy pig blood as a raw material; carrying out anticoagulation treatment, centrifuging and separation on the fresh and healthy pig blood to obtain a blood cell and blood plasma; carrying out high-pressure cutting and wall breaking, complex enzyme hydrolysis and flashing and deodorizing process treatment on the blood cell to obtain enzymolysis liquid; carrying out rough filtration, fine filtration, condensation treatment and spray drying to obtain the bioactive peptide for enriching the blood; and carrying out modification treatment on the separated blood plasma to obtain the plasma protein powder. The invention has the following advantages that: 1. the production cost is low and no pollution to the environment is generated; 2. the average molecular weight of small peptide of the produced bioactive peptide for enriching the blood is not more than 10,000Dalton, the content of free amino acid is not more than 15.0percent and the protein of the plasma protein powder is not less than 90.0 percent; 3. the water content of the produced modified plasma protein is not more than 5.0 percent, the viscosity (5 percent solution) is not less than 2.0 mpa.s and the content of the protein is not less than 90.0 percent; and 4. the process method saves time and energy, has simple operation and fully utilizes pig blood resources.
Owner:天津市食品工业生产力促进中心
Method for preparing liquid porcellanite APTT reagent
ActiveCN101526538AImprove stabilityImprove compatibilityBiological testingSystemic lupus erythematosusPorcellanite
The invention relates to a method for preparing a liquid porcellanite activating partial thromboplastin (APTT) reagent. The reagent is mainly used for monitoring coagulation factor deficiency of endogenous coagulation systems and carrying out screening test of related inhibitors, and used for detecting coagulation factors, heparin anticoagulation treatment and lupus anticoagulation substances as the current main means. Taking porcellanite as an activating agent, the method improves the sensitivity to the coagulation factors; a novel stable system solves the problem of keeping the stability of the reagent at a liquid state; and the method has the advantages of high sensitivity, convenient use, small experimental error, strong stability, good compatibility, low cost and the like.
Owner:SHANGHAI LONG ISLAND BIOTEC CO LTD
Nanometer silver antimicrobial deodorizing silk stockings
InactiveCN101161136AIncrease dissolved oxygenImprove microcirculationFibre treatmentPanty-hoseBillionthFar infrared
The aim of the present invention is to provide a health silk stockings produced using nanometer silver antibiotic material. The solution of the present invention is that to obtain nanometer stage silver particle (1 nanometer is equal to billionth meter) combining electrical arc method and mechnical rubbing method, then to implement antioxidation and anticoagulation treatment to the particles, at last to prepare nanometer silver antibiotic solution. To dip in the silk stockings in the nanometer silver antibiotic solution which temperature is 80 to 95 DEG C for 24 to 48 hours, then to take out and airing as well as iron out, so that the health silk stockings of the present invention is made. The silk stockings of the present invention has strong antibiotic effect, moreover, it is ventilating and flexible which ensure feet to be dry, the antibiotic effect is durable, also it has the deodorization effect, as well as release anion and far infrared energy, so it is a health silk stockings with complete function.
Owner:SHENGHONG GRP CO LTD
Method for extracting superoxide dismutase (SOD) from porcine blood red cells
The invention relates to a method for extracting superoxide dismutase (SOD) from porcine blood red cells, in the method, anticoagulation treatment is adopted for preventing blood coagulation and breaking of blood cells. Colloid mill breaking and low-temperature swelling are adopted for releasing matters dissolved in the blood cells to the maximum extent so as to get hemolysate. Thermal change is performed on the hemolysate twice for removing impurities, removing hemoglobin and a large number of impurity proteins so as to get SOD crude enzyme liquid, and ultrafiltration concentration, gradient elution, dialysis, salt removal and freeze-drying are further performed on the SOD crude enzyme liquid so as to get an SOD product. The method is simple to operate and easy to master; furthermore, by adopting the method, the product quality can be effectively improved, the production cost can be reduced, the production cycle can be shortened, the production efficiency can be improved, and the method is applicable to industrialized production.
Owner:HEILONGJIANG BAODI MEAT FOOD
Method for extracting hemin and globin from animal blood
InactiveCN102659791AReduce manufacturing costImprove qualityOrganic chemistryHydrolasesHeminImpurity
The invention relates to a method for extracting hemin and globin by the use of leech protease with animal blood as a raw material. The method comprises the following main steps of: 1, carrying out middle-temperature extraction to prepare leech protease for later use; 2, taking fresh animal blood, carrying out anticoagulation treatment, centrifuging and collecting hemoglobin cells; 3, adding one time of pure water, carrying out ultrasonic treatment and breaking cells; 4, filtering through a screen mesh, leaving a filtrate, and adjusting pH value; 5, adding leech protease for enzymatic hydrolysis; 6, adjusting pH value of an enzymatic hydrolysis liquid and carrying out centrifugal separation; and 7, washing a sediment which has undergone centrifugation, carrying out dehydrolysis and drying to obtain hemin; letting a supernatant which has undergone centrifugation pass through a microfiltration membrane to remove impurities, using a nanofiltration membrane for concentration, and carrying out dehydrolysis and drying on a concentrate to obtain globin. According to the invention, animal blood resources are fully utilized and the leech extract product is used as an enzyme preparation to produce hemin and globin with high added values. The technology is simple and easy to operate, the production cost is low, and the method is suitable for industrial production.
Owner:武汉普赛特膜技术循环利用有限公司
Preparation method of compound vaccinium bracteatum leaf juice duck blood tofu
InactiveCN107865326ADelicious and fragrantEdible functionality increasedFood scienceMedicineAnticoagulation Treatment
The present invention discloses a preparation method of compound vaccinium bracteatum leaf juice duck blood tofu. The preparation method comprises the following steps: vaccinium bracteatum leaf juiceis added into duck blood after an anticoagulation treatment to prepare compound duck blood, the compound duck blood is coagulated and the coagulated duck blood is cured to obtain the duck blood tofu;wherein a volume ratio of the vaccinium bracteatum leaf juice to the duck blood is 1:(3.5-5). The preparation method can cover the smell of the duck blood tofu, also can have certain anti-oxidation, anti-decay and anti-micro-organism effects, and prolongs shelf life of the duck blood tofu. At the same time, the produced duck blood tofu is uniform in color and luster, and smooth in cutting surfaces.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Special flavor pork skin paste and production method thereof
ActiveCN102845733AReduce hardnessSuitable for productionFood preparationBiotechnologyNutritive values
The invention relates to special flavor pork skin paste and a production method thereof and belongs to food processing technologies. Fresh pork skin or thawy quickly-frozen pork skin is subjected to cleaning, rinsing, impurity removal, peculiar smell removal and particle adjustment and then is subjected to softening and anticoagulation treatment. An appropriate amount of vegetable oil, soybean paste or flour paste and aromatic seasoning are added into softened and anti-coagulated pork skin, and paste type seasoning having special flavor and smooth and mellow taste is produced through flavor enhancing and cooking treatment. The production method changes the situation that existing pork skin only can be used in solid foods and chemical materials, improves the ductility and the spreadability of pork skin foods, enables products to be easily absorbed, enables the nutritive value to be improved and enables the seasoning to be delicious and tasty.
Owner:JILIN AGRICULTURAL UNIV
Anticoagulant for prolonging external hemolymph cell life and its application method
InactiveCN1411818AIncrease contentReduce contentMammal material medical ingredientsDead animal preservationMedicineHemolymph
Each 100 ml of blood anticoagulant contains trisodium citrate 3.31-3.32g, citric acid 0.01-0.05g, glucose 2.45-3.37g and the rest is water. The tests show that after the external blood is undergone the process of anticoagulation treatment it can prolong the stroage life of lymphocyte to 48-72 hr. from original 4-6 hr. Said invention also provides its application method.
Owner:SHANGHAI BLOOD CENT
Medical care interaction system for preventing and treating venous thromboembolism of inpatients
PendingCN110556186AReduce morbidityReduce the incidence of fatal VTEMedical communicationHealthcare resources and facilitiesInteraction systemsPrevention intervention
The invention discloses a medical care interaction system for preventing and treating venous thromboembolism of inpatients. The system is composed of a patient scoring system, a patient risk estimation system, a patient prevention intervention operation system, a patient informed agreement signing system and a background data capturing system. The patient scoring system outputs data to the patientrisk estimation system; the patient risk estimation system outputs data to the patient prevention intervention operation system, the patient prevention intervention operation system receives the dataand then presents the data to a doctor, the output end of the patient prevention intervention operation system is connected with the input end of the patient informed agreement signing system, and the background data capture system captures nursing evaluation information and doctor intervention information. The VTE morbidity of inpatients is effectively reduced, the important indexes such as theVTE risk assessment rate, the preventive measure implementation rate, the ratio of implementing anticoagulation treatment on the inpatients, the VTE detection rate and the hospital related lethal VTEoccurrence rate are focused on, and the social benefits and economic benefits of VTE prevention and treatment are remarkably improved.
Owner:田红燕
Preparation method for producing pig haemocyte active small peptide powder through one-step method
InactiveCN105859874AImprove hydrolysis efficiencySimple processHaemoglobins/myoglobinsPeptide preparation methodsDiseaseHemolysis
The invention relates to a preparation method for producing pig haemocyte active small peptide powder through a one-step method. The preparation method mainly comprises the steps of collecting fresh pig blood subjected to anticoagulation treatment, conducting centrifugal separation to obtain haemocyte liquid, conducting hemolysis, enzymolysis and centrifugation to obtain enzymatic hydrolysate, conducting ultrafiltration membrane filtration and nanofiltration membrane concentration on the enzymatic hydrolysate, and then conducting spray drying, so that the pig haemocyte active small peptide powder is obtained. According to the preparation method, efficient endo protease is selected, the one-step method is adopted, the ultrafiltration membrane and nanofiltration membrane separation technology is combined, the process procedure is simple, the production cycle is short, production efficiency is high, cost is low, and the preparation method is suitable for large-scale industrialized production. In the prepared pig haemocyte active small peptide powder, the content of active small peptide (with the relative molecular weight ranging from 180 Da to 1000 Da) reaches 75% or above, the content of organic hemin (heme iron) reaches 0.2% or above, the content of ash is lower than 5.0%, and the content of free amino acid is lower than 11%. The product can promote growth of animals and enhance immunity and disease resistance of animals and is a novel functional protein feed raw material.
Owner:陈石良
Novel process for extracting superoxide dismutase SOD from animal blood cell liquid
The invention discloses a novel process for extracting superoxide dismutase SOD from animal blood cell liquid. The process mainly comprises the following steps of: after carrying out anticoagulation treatment on animal fresh blood, centrifuging and separating blood cells; carrying out hemolysis, thermally denaturing, super-filtering and concentrating, and then carrying out fractional precipitation by acetone to obtain a rough product of the SOD; subjecting the rough product of the SOD to chromatographic purification, and then freezing and drying to obtain a competitive product of the SOD. In the process provided by the invention, chloroform ethanol is abandoned and transitional metal salt which is any one of copper salt, zinc salt and manganese salt in the process of thermally denaturing is not added; a ultra-filtering and concentrating process is further introduced on the base and the use amount of the acetone in the process of carrying out the fractional precipitation by acetone is extremely small. The novel process for extracting the SOD guarantees the activity of the traditional SOD to the maximum extent, has the advantages of simplicity in operation and low cost and is suitable for large-scale industrial production.
Owner:天津宝迪农业科技股份有限公司
Blood state analysis device, blood state analysis system, blood state analysis method, and storage device
A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.
Owner:SONY CORP
Processing method of flavored sheep/goat lung crisp chips
The invention discloses a processing method of flavored sheep / goat lung crisp chips. Through anticoagulation treatment, bloodstain in blood vessels of sheep / goat lung is effectively eliminated, the color of the sheep / goat lung is maintained to be bright, the putrid and deteriorated process of the sheep / goat lung is alleviated, and blood smell is eliminated; through technologies of alkaline washingand kneading, ultrasonic vibration, rinsing and dehydration and the like, endocrine substances and metabolism dirt of lung tracheas are thoroughly eliminated, sheep / goat odor is removed to the maximum extent, and peculiar smell of the sheep / goat lung is reduced; and unique flavor of steamed eel in black bean sauce is creatively used as seasoning, and the flavor feature of the sheep / goat lung crisp chips is improved. According to the processing method disclosed by the invention, on the base of creating a washing technology and reinforcing sheep / goat odor eliminating effects, the unique flavorof the steamed eel in black bean sauce is utilized as the seasoning, so that the sheep / goat odor is better covered, the individual flavor feature of the sheep / goat lung crisp chips is increased, new snack foods in great demand namely the sheep lung crisp chips are created, and high-value development of sheep / goat entrails is realized.
Owner:JIESHOU JINGHUA TECH INFORMATION CONSULTING SERVICE CO LTD
Blood state analysis device, blood state analysis system, blood state analysis method, and storage device
A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.
Owner:SONY CORP
Blood condition analysis device, blood condition analysis system, blood condition analysis method, and blood condition analysis program for causing computer to implement the method
ActiveUS20170023597A1Simple and highly accurate evaluationBiological testingMaterial impedancePlateletAnticoagulant
To provide a technology that allows for simple and highly accurate evaluation of the condition of blood.Provided is a blood condition analysis device, for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment canceling agents, coagulation activators, anticoagulants, platelet activators, and antiplatelet agents, the device including a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and / or hemoglobin content of the blood sample.
Owner:SONY CORP
Blood state analysis device, blood state analysis system, blood state analysis method, and storage device
A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood samlple comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample.For instance, such device (1) allows to correct blood clotting time resutls with respect to concentrations of an anti-coagulant drug present in the blood sample.
Owner:SONY CORP
Kit for detecting functions of coagulation and platelets of heparin-added blood samples and application thereof
PendingCN107746804ATimely point-of-care coagulation assessmentAccurate point-of-care coagulation assessmentBioreactor/fermenter combinationsBiological substance pretreatmentsDiseaseThrombus
The invention provides a kit for detecting functions of coagulation and platelets of heparin-added blood samples and application thereof and relates to the technical field of medical apparatus and instruments. The detection kit comprises a reagent cup and a detection probe, wherein glass beads and a stirring rod are arranged in the reagent cup; the reagent cup also comprises a cup lid; the reagentcup is tightly bonded with the cup lid; a groove is formed in the center of the cup lid and is used for mounting the detection probe; heparinase I is arranged in the reagent cup. The detection kit takes the glass beads as activators, is capable of detecting the functions of coagulation and platelets of heparin-added blood samples through an in-vitro coagulation activating method, has great significance to early discovery of the risk of thrombosis of patients, guidance of anticoagulation treatment and component blood transfusion, and diagnosis and treatment of platelet-related diseases, and iscapable of making up the defects of detection of the functions of coagulation and platelets of the heparin-added human blood in the in-vitro study field at present.
Owner:世纪亿康(天津)医疗科技发展有限公司
Small-cavity surgical robot with anti-blocking mechanism
The invention provides a small-cavity surgical robot with an anti-blocking mechanism, and relates to the technical field of surgical robotics.The small-cavity surgical robot comprises a mechanical arm, an operation platform is rotationally installed on the mechanical arm, an operation instrument used for conducting an operation on a patient is arranged on the operation platform, and a fixing frame is fixedly installed on the operation platform; a circular space between the inner pipe and the outer pipe is divided into two independent areas, the two independent areas are matched with the two connecting pipelines on the outer pipe and the connected micro peristaltic pump, and therefore the inner pipe and the outer pipe can be separated into two independent areas. By means of the design, normal saline and a low-concentration heparin solution can be conveyed respectively, the washing requirement in a conventional operation is met, anticoagulation treatment can be provided for an operation scene with the high blood coagulation risk, the application range of the surgical robot is greatly widened, surgical operation is more targeted and flexible, and the surgical robot is suitable for being popularized and used. And individual differences of different patients can be effectively handled.
Owner:SUN YAT SEN UNIV
Processing method of pigeon blood bean curd
The invention discloses a processing method of pigeon blood tofu. The content of protein peptide and the absorbable utilization degree of protein in a pigeon blood tofu finished product are improved. The method comprises the following steps: (1) anticoagulant treatment: adding an anticoagulant into fresh pigeon blood, and uniformly mixing; (2) extracting the pigeon blood protein: adjusting the pH value of the anticoagulant pigeon blood to the isoelectric point of the pigeon blood protein, centrifuging, and collecting the precipitate to obtain the pigeon blood protein; (3) pre-digestion treatment: carrying out enzymolysis pre-digestion treatment on the pigeon blood protein by using pepsin and trypsin in sequence; (4) making pigeon blood bean curds: adding guar gum, carrageenan, calcium chloride and water into the pre-digested pigeon blood protein, performing reflux treatment by using a colloid mill, and then heating gel to obtain the pigeon blood bean curds; (5) inoculating and fermenting: inoculating debaryomyces hansenii suspension into the pigeon blood tofu, and fermenting; and sterilizing the fermented pigeon blood tofu with steam, and cooling to obtain the pigeon blood tofu product.
Owner:SERICULTURAL &AGRI FOOD RESEARCH INSTITUTE GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES +3
Application of circulating tfpi-2 (tissue factor pathway inhibitor 2) in the assessment of atrial fibrillation and anticoagulation therapy
PendingCN113302497ADisease diagnosisBiological testingAnti coagulationTissue factor pathway inhibitor
The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of TFPI-2 in a sample from the subject, and comparing the amount of TFPI-2 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for assessing anticoagulation therapy and to methods for predicting the risk of stroke of a subject. Said methods are based on the determination of the amount of TFPI-2 in a sample from the subject.
Owner:F HOFFMANN LA ROCHE & CO AG +2
Platelet extraction method
PendingCN112831467ASolve the technical problem of low recovery rateIncrease acquisition rateCell dissociation methodsBlood/immune system cellsWhole blood unitsPlatelets blood
The invention discloses a platelet extraction method which comprises the following steps: carrying out at least two-stage centrifugal treatment on a whole blood sample subjected to anticoagulation treatment, and extracting platelets from an upper plasma layer obtained after each centrifugal treatment, mixing an upper platelet-deficient plasma layer separated after the last centrifugal treatment with a lower blood cell layer separated after the first centrifugal treatment to prepare a whole blood sample again, performing centrifugal treatment on the newly prepared whole blood sample, extracting platelets from the separated upper platelet-rich plasma layer again to obtain the platelet-rich plasma, and mixing and collecting all extracted platelets. The platelet extraction method disclosed by the invention has the advantages of simplicity in operation, high platelet acquisition rate and high acquisition number of large platelets.
Owner:SICHUAN CANCER HOSPITAL
Special flavor pork skin paste and production method thereof
ActiveCN102845733BReduce hardnessSuitable for productionFood preparationBiotechnologyNutritive values
The invention relates to special flavor pork skin paste and a production method thereof and belongs to food processing technologies. Fresh pork skin or thawy quickly-frozen pork skin is subjected to cleaning, rinsing, impurity removal, peculiar smell removal and particle adjustment and then is subjected to softening and anticoagulation treatment. An appropriate amount of vegetable oil, soybean paste or flour paste and aromatic seasoning are added into softened and anti-coagulated pork skin, and paste type seasoning having special flavor and smooth and mellow taste is produced through flavor enhancing and cooking treatment. The production method changes the situation that existing pork skin only can be used in solid foods and chemical materials, improves the ductility and the spreadability of pork skin foods, enables products to be easily absorbed, enables the nutritive value to be improved and enables the seasoning to be delicious and tasty.
Owner:JILIN AGRICULTURAL UNIV
Method for screening left atrial appendage thrombus by using multi-mode ultrasonic technology
PendingCN121221168ABlood flow measurement devicesOrgan movement/changes detectionEsophageal ultrasoundThrombus
The invention provides a method for screening left atrial appendage thrombus by using a multi-mode ultrasonic technology, and relates to the technical field of medical ultrasonic diagnosis. According to the method for screening the left atrial appendage thrombus by using the multi-mode ultrasonic technology, through a layered screening process of noninvasive primary screening, precise secondary screening and comprehensive judgment, the technical advantages of four complementary modes of transthoracic ultrasound (TTE), transesophageal ultrasound (TEE), ultrasonic contrast (CEUS) and shear wave elastography (SWE) are integrated, primary risk stratification is completed by using noninvasive TTE, and secondary risk stratification is completed by using noninvasive TTE; tEE is combined with CEUS and SWE to achieve multi-dimensional evaluation of the structure, the blood flow and the hardness of the thrombus for high-risk groups, and finally accurate detection and stability evaluation of the thrombus are achieved based on the judgment standard of multi-modal data fusion. According to the method, the detection rate of the left auricle thrombus can be remarkably increased, the unnecessary invasive operation risk is reduced, meanwhile, thrombus stability basis is provided for formulating a clinical anticoagulation treatment scheme, and the method is suitable for conventional screening of thrombus high-risk groups such as atrial fibrillation and the like.
Owner:CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL HAINAN HOSPITAL
Model for predicting rivaroxaban anticoagulation bleeding risk and application thereof
PendingCN114863989AThe result is accurate and reliableQuick checkMedical simulationHealth-index calculationAnticoagulation TreatmentRivaroxaban
The invention discloses a model for predicting the anti-coagulation bleeding risk of rivaroxaban and application of the model, and belongs to the technical field of biological detection. The model comprises a data input unit, an assignment unit, a curative effect prediction unit and a report output unit for two independent risk factors of a CYP3A4 genotype and a clinical bleeding history of a detected object, and a Camp is formed according to the units; b, the scoring system is used for counting according to the total score of 3, if Camp; the score B is less than or equal to 1, and rivaroxaban can be used as a blood coagulation factor X inhibitor for anticoagulation treatment; if Camp; the score B is greater than or equal to 2, and warfarin can be selected for anticoagulation treatment. The model can be used for guiding a clinician to accurately select a blood coagulation factor X inhibitor, a rivaroxaban bleeding risk prediction result is accurate and reliable, and a balance can be obtained between anticoagulation benefit and bleeding risk.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Heme preparation method adopting enzyme method
The invention discloses a heme preparation method adopting an enzyme method, and relates to the technical field of biological preparation, and the heme preparation method comprises the following steps: S1, taking animal blood and blood powder, carrying out anticoagulation treatment and centrifugal separation to obtain red blood cells, and carrying out cell breaking treatment on the red blood cells to release hemoglobin to obtain a hemoglobin solution; s2, mixing the obtained hemoglobin solution with protease, and carrying out enzymolysis reaction for 1-5 hours under the conditions that the pH value is 3.0-5.0 and the temperature is 20-40 DEG C, so that hemoglobin is subjected to enzymolysis to release heme, and an enzymolysis reaction solution is obtained; s3, precipitating, centrifuging, washing and drying the obtained enzymolysis reaction liquid to obtain a heme product. According to the preparation method of the heme, key links such as raw material pretreatment, enzymolysis reaction and product separation and purification are finely regulated and controlled, so that the heme preparation efficiency and the product quality are remarkably improved, the erythrocyte separation effect is effectively improved, and the release efficiency and the enzymolysis stability of the heme are enhanced.
Owner:JIANGSU MEIKE BIOTECHNOLOGY CO LTD +1
PH-viscosity dual-response fluorescent probe, preparation method and application
The invention provides a PH-viscosity dual-response fluorescent probe, a preparation method and application, belongs to the technical field of fluorescent probes, and is technically characterized in that the structural formula of a probe molecule is shown in the specification. By optimizing a fluorescent skeleton and hydrophilic modification and calibrating pH / viscosity response mapping, the application can be used for rapidly screening a blood coagulation function, evaluating an anticoagulation treatment effect or researching and developing a portable thrombus detection device.
Owner:NANJING STOMATOLOGICAL HOSPITAL
Method for extracting hemin and globin from animal blood
InactiveCN102659791BReduce manufacturing costImprove qualityOrganic chemistryHydrolasesHeminImpurity
Owner:武汉普赛特膜技术循环利用有限公司
A Chinese medicine composition and its application in treating pulmonary thromboembolism
The present invention discloses a traditional Chinese medicine composition and its use in treating pulmonary thromboembolism. The traditional Chinese medicine composition is prepared from the following raw materials: raw astragalus, whole angelica, herb agrimony, notoginseng powder, madder, red peony root, and dried tangerine peel. The traditional Chinese medicine composition of the present invention utilizes the inherent characteristics of each component raw material, rationally formulates the formula, and scientifically proportions the formula to achieve optimal synergistic efficacy. The traditional Chinese medicine composition has a definite therapeutic effect and has a good effect of reducing the incidence of bleeding during the anticoagulation process in patients with pulmonary thromboembolism. It also has low toxicity and high safety, and can improve the efficacy of anticoagulation treatment for pulmonary thromboembolism. The present invention makes up for the current shortage of traditional Chinese medicine prescriptions for pulmonary thromboembolism, and has the characteristics of a wide source of raw materials, a high safety factor, a small dosage, and a dosage form that meets clinical needs.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL
Preparation method of sheep peripheral blood lymphocyte transfer factor solution and injection
PendingCN114853870ARealize batch cultivationIncrease productionCell dissociation methodsPeptide/protein ingredientsWhite blood cellMicrofiltration membrane
The invention provides a preparation method of a sheep peripheral blood lymphocyte transfer factor solution, which comprises the following steps: collecting fresh sheep blood, carrying out anticoagulation treatment, and carrying out cell sedimentation and separation; collecting a lymphocyte layer, and diluting the collected lymphocytes with Hank's liquid to prepare a lymphocyte seed suspension for later use; performing cell suspension culture on the lymphocyte seed suspension to obtain lymphocyte liquid; the lymphocyte fluid is subjected to cell disruption, the disrupted cells are filtered and ultra-filtered through a microfiltration membrane and an ultra-filtration membrane respectively, and ultra-filtrate is the obtained transfer factor solution; the invention also provides an injection which is prepared by performing sterile filtration on a transfer factor solution and then adding mannitol and normal saline. According to the method, sheep leukocytes are used as a culture medium, a cell suspension culture process is adopted for enlarged culture, the prepared transfer factor solution, namely the injection, can be suitable for large-scale production, and the yield is greatly improved.
Owner:商丘美兰生物工程有限公司