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2 results about "Thromboplastin" patented technology
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Thromboplastin (TPL) or thrombokinase is a mixture of both phospholipids and tissue factor found in plasma aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin. It is a complex enzyme that is found in brain, lung, and other tissues and especially in blood platelets and that functions in the conversion of prothrombin to thrombin in the clotting of blood.
The present invention relates to a method for producing thrombin from a thromboplastin source using a given BaSO4 reagent as an adsorbent for prothrombin, and a method for assessing the suitability of a given BaSO4 reagent for the preparation of thrombin. In at least one embodiment, the method comprises contacting a sample of the given BaSO4 reagent with a thromboplastin source to obtain BaSO4-adsorbed thromboplastin, and subsequently assessing the procoagulant activity of the BaSO4-adsorbed thromboplastin. In another embodiment, the method comprises the step of assessing the procoagulant activity relative to normal mammalian plasma.