855 results about "Candida albicans" patented technology

The present invention relates to nanosilver-containing antibacterial and antifungal granules ("NAGs"). The NAGs have longlasting inhibitory effect on a broad-spectrum of bacteria and fungi, which include, but are not limited to, Escherichia coli, Methicillin resistant Staphylococcus aureus, Chlamydia trachomatis, Providencia stuartii, Vibrio vulnificus, Pneumobacillus, Nitrate-negative bacillus, Staphylococcus aureus, Candida albicans, Bacillus cloacae, Bacillus allantoides, Morgan's bacillus (Salmonella morgani), Pseudomonas maltophila, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Bacillus subtilis, Bacillus foecalis alkaligenes, Streptococcus hemolyticus B, Citrobacter, and Salmonella paratyphi C. The NAGs contain ground stalk marrow of the plant Juncus effusus L. which has been dispersed with nanosilver particles. The nanosilver particles are about 1-100 nm in diameter. Each of the nanosilver particles contain a metallic silver core which is surrounded by silver oxide. The present invention also provides a process for making the NAGs. The NAGs can be used in a variety of healthcare and industrial products. Examples of the healthcare products include, but are not limited to, ointments or lotions to treat skin trauma, soaking solutions or cleansing solutions for dental or women hygiene, medications for treating gastrointestinal bacteria infections, sexual related diseases, and eye diseases. Examples of industrial products include, but are not limited to, food preservatives, water disinfectants, paper disinfectants, construction filling materials (to prevent mold formation).

α-MSH and other amino acid sequences derived from α-MSH were determined to have antimicrobial influences, including against two major and representative cutaneous and mucosal pathogens; Staphylococcus aureus and Candida albicans, Pharmaceutical compositions useful as antimicrobial agents, including for use in reducing the viability of microbes, reducing the germination of yeasts, killing microbes without reducing the killing of microbes by human neutrophils, for treating inflammation in which there is microbial infection without reducing microbial killing, and for increasing the accumulation of cAMP in microbes are disclosed. The antimicrobial agent is selected from the group consisting of one or more peptides including the amino acid sequence KPV, one or more peptides including the amino acid sequence MEHFRWG, or a biologically functional equivalent of any of the foregoing. The most effective of the peprides were those bearing the C-terminal amino acid sequence of α-MSH. i.e., α-MSH (1-13), (6-13), and (11-13).

A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.

The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such a mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

The invention discloses a polylactic acid antibacterial nanofiber membrane and a preparation method thereof, which belong to the technical field of functional spinning. An antibacterial agent is added into polylactic acid, and an electrostatic spinning technology is adopted to prepare the polylactic acid antibacterial nanofiber membrane with high antibacterial activity. The antibacterial agent in the fiber membrane is triclocarban (TCC). The nanofiber membrane comprises 95 or 94 mass percent of polylactic acid and 5 or 6 mass percent of antibacterial activity TCC. The obtained antibacterial fiber membrane can inhibit over 93 percent of staphylococcus aureus, escherichia coli and candida albicans. The antibacterial fiber membrane can be applied to the fields of daily use, spinning, industry and medicaments.

The invention relates to a test paper tape which can be used in the gynecological multiprogramming dry-chemistry joint detection. The test paper tape provided by the utility model comprises a dry-chemistry multiprogramming detection test paper tape which consists of a plastic substrate tape and various solidified regent blocks, and sample diluent. The dry regent blocks include combinations formed by increasing or decreasing at least three or more regent blocks of a Ph test regent block, a lactic acid regent block, a hydrogen peroxide concentration regent block, a leukocyte esterase concentration regent block, a neuraminidase activity regent block, an amine test regent block, a proline aminopeptidase substrate reagent block, an oxidase substrate reagent block, a N-acetylamine hexosidase substrate reagent block, a trichomonas specific protease substrate hydrolysis reagent block. the gynecological multiprogramming dry-chemistry joint detection test paper test provided by the utility model can detect Ph, lactic acid, hydrogen peroxide, leukocyte esterase, neuraminidase, amine test, proline aminopeptidase, oxidase, N-acetylamine hexosidase and trichomonas specific protease which are contained in leucorrhea sample at the same time, and can accurately reflect the microorganism environment of a women reproductive tract, the cleanness of leucorrhea secretion and the conditions of Candida albicans, trichomonas, gonococcus and the pathogens of bacterial vaginosis, thereby making the gynecological trichomonas detection more comprehensive; besides, the test paper tape provided by the utility model can be used easily and conveniently, and results can be obtained quickly. If the test paper tape is used together with a gynecological dry-chemistry analyzer, the operation can become easier and the result can be obtained more quickly.

The invention relates to toothpaste containing dencichine, which is characterized in that the toothpaste is prepared by adding arasaponin and dencichine into a toothpaste matrix, wherein the weight percent of the arasaponin is 0.2-1.2% and the weight percent of the dencichine is 0.01-1.0%. The toothpaste according to the invention can kill pyococcus, candida albicans, staphylococcus aureus, anaerobic bacteria and other pathogens which can cause gingivitis, periodontitis, canker sores, halitosis, ngival hamorrhage, caries and other symptoms in the oral cavity and eliminate the peculiar smell in the oral cavity. The effective rate for the gingivitis and the ngival hamorrhage achieves 94.6%; and the effective rate for the canker sores achieves 89%, and the efficacy is significant. The toothpaste has no toxicity or side effects, is safe to use and can prevent drug resistance. The toothpaste has significant efficacy for the gingivitis, the ngival hamorrhage, the canker sores and the like. The hemostatic effect of the toothpaste is well promoted. Sanchi extract and the dencichine are simultaneously used in the toothpaste, thereby enabling the effects of relieving pain and preventing thegingivitis, the ngival hamorrhage and the pain of the toothpaste to be more significant.

The invention provides a polyhexamethylene guanidine propionate disinfectant and a preparation method thereof. The polyhexamethylene guanidine propionate disinfectant is a hydrophilic solution prepared by the following steps: adding polyhexamethylene guanidine propionate, citric acid and surfactant to water and uniformly stirring the mixture at normal temperature. The polyhexamethylene guanidine propionate disinfectant has the advantages of broad spectrum of disinfection, quick results, long-time disinfection capability, high safety, non-toxicity, environmental protection, high stability, easy application, quick infiltration and volatilization, no coloration, easy cleaning, and the like. The polyhexamethylene guanidine propionate disinfectant has strong sterilization functions for colon bacillus, staphylococcus aureus, candida albicans, and the like with two-year effective periods. The polyhexamethylene guanidine propionate disinfectant can be used for disinfection of skins, wound surfaces, hands, air, departments of gynecology and urology, drinking water, and the like, thereby being a novel and ideal disinfectant.

The invention provides a plant bacteriostatic composition and application thereof in cosmetics. The plant bacteriostatic composition is obtained by compounding a licorice extract, a honeysuckle extract and a Mangnolia officinalis extract. The plant bacteriostatic composition has good bacteriostatic effect and particularly has a synergistic effect of inhibiting escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and aspergillus niger. The plant bacteriostatic composition can be applied to skin-care and washing cosmetics, reduces the adding amount of original preservatives and enables a product to have both antibacterial and anti-inflammatory effects.

The invention provides an oral antibacterial composition containing nisin and polylysine. According to the composition, the growth of oral pathogenic bacteria such as porphyromonas gingivalis, actinobacillus actinomycetemcomitans, streptococcus mutans, lactic acid bacillus, staphylococcus aureus and candida albicans can be effectively inhibited, and tooth decay, gingivitis, periodontitis, ozostomia and the like can be prevented; the composition can be prepared into toothpaste, mouth wash, refreshing and tasting chips and chewing gum which are used for preventing and treating oral diseases. Meanwhile, the invention provides a preparation method of the compositions such as the toothpaste, the mouth wash, the refreshing and tasting chips and the chewing gum. The oral antibacterial composition prepared through the method can prevent and treat various oral diseases and has no toxic and side effect and allergy or stimulation phenomenon on a human body.

The invention discloses an antiviral and antibiotic fiber, and a preparation method and an application thereof. The surface of the fiber is grafted with a monomer with a cationic functional group. The preparation method comprises the following steps: preprocessing a raw material fiber to improve the hydrophilic performance of the raw material fiber, fully infiltrating the preprocessed fiber in a grafting liquid containing a cationic functional group monomer, and carrying out an irradiation grafting reaction to obtain the antiviral and antibiotic fiber. The raw material fiber used by the preparation method can be a chemical fiber or natural fiber. Each of the anti-influenza virus rate and the anti-adenovirus rate of the antiviral and antibiotic fiber prepared in the invention is higher than 90%, and each of the anti-Staphylococcus aureus rate, the anti-Escherichia coli rate and the anti-Candida albicans rate of the antiviral and antibiotic fiber is higher than 96%. The antiviral and antibiotic fiber can be processed to form yarns, fabrics, nonwoven fabrics, nets and felts applied in medical, environmentally-friendly or/and personnel hygiene articles according to different uses.

The invention provides a silk hemp cellulose fiber and a preparation method thereof. The cellulose fiber is 1.8-2.5cN/dtex in dry breaking strength, is 0.9-1.6cN/dtex in wet breaking strength, is 16-24% in dry breaking elongation, is less than or equal to 12mg/100g in residual sulfur content, is more than or equal to 90% in staphylococcus aureus antibacterial rate, is more than or equal to 90.0% in escherichia coli antibacterial rate, and is more than or equal to 80.0% in candida albicans suppression ratio. The preparation method of the silk hemp cellulose fiber comprises the steps of preparing a hemp pulp viscose spinning solution, preparing a protein dispersing emulsion, preparing a hemp pulp protein modified spinning solution, spinning and aftertreatment. The silk hemp cellulose fiber has the smooth and soft hand feeling, feels like hemp, has the smooth zigzagged cross section like the hollow cross section of a natural hemp material, is environmentally-friendly and has the good wearability and textile processability, and besides, a protein material is uniformly dispersed inside the fiber, and therefore, the silk hemp cellulose fiber can resist multiple washing and cannot shed off.

The antifungal and cancer cell growth inhibitory activities of 1-(3′,4′,5′-trimethoxyphenyl)-2-nitro-ethylene (TMPN) were examined. TMPN was fungicidal for the majority of 132 reference strains and clinical isolates tested, including those resistant to fluconazole, ketoconazole, amphotericin B or flucytosine. Minimum fungicidal concentration/minimum inhibitory concentration (MFC/MIC) ratios were ≦2 for 96% of Cryptococcus neoformans clinical isolates and 71% of Candida albicans clinical isolates. TMPN was fungicidal for a variety of other basidiomycetes, endomycetes and hyphomycetes, and its activity was unaffected by alterations in media pH. TMPN was slightly cytotoxic for murine and human cancer cell lines (GI₅₀=1-4 μg/ml), and weakly inhibited mammalian tubulin polymerization (IC₅₀=0.60 μg/ml). TMPN may also be used as a biochemical probe for tubulin and fungal dimorphism studies.

The invention provides viscose fiber containing a radix isatidis extract. According to the viscose fiber, the content of radix isatidis microcapsules is 9.1%-9.79%, the dry fracture strength of the fiber is 2.70cN/dtex-2.75cN/dtex, the wet fracture strength of the fiber is 1.70cN/dtex-1.75cN/dtex, the elongation at break of the fiber is 22%-23%, the antibacterial rate of the fiber to staphylococcus aureus is 99.0%-99.8%, the antibacterial rate of the fiber to Candida albicans is 96.6-98.8%, the antibacterial rate of the fiber to typhoid bacillus is 97.2%-99.1%, and the fiber has very strong effects of inhibiting and killing influenza A virus and influenza B virus. The invention further provides a preparation method of the viscose fiber containing the radix isatidis extract. The preparation method comprises a step of modifying the radix isatidis microcapsules. According to the preparation method, the loss of the radix isatidis microcapsules in the preparation process of the fiber is reduced, the dismantling backwashing rate of a coagulating bath filter is reduced, and the distribution uniformity of the radix isatidis microcapsules in the fiber is increased.

A chitosan anti-bacterium finishing method of cashmere and wool fabric is a finishing method that uses the chitosan with low molecular weight as a finishing agent, epoxy chloropropane as a cross linker, lye as a curing agent, acetic liquor as a neutralizing agent, and goes through washing wool fabric, finishing (chitosan degradation liquor: MW 2000 to 10000 g/mol, 3 to 30cps, dosage: 5 to 20 percent of the weight of fabric; the cross linker is made from epoxy chloropropane, of which the dosage: is 0.05 to 0.50 percent of the chitosan finishing agent), through steps of washing of lye (0.1 to 1 percent of NaOH liquor), neutralization (0.5 to 2 percent of acetum) and drying (10 to 20 min under 70 to 90 DEG C). The fabric has good antibacterium property and after 50 times of washing, the bacteriostasis ratios are that: golden brown staphylococcus is 93.2 to 99.9 percent; colon bacillus is 72.4 to 92.4 percent; Candida albicans is 86.3 to 99.8 percent, moreover, the fabric is washable and has good fastness which can reach Grade four after 5o times of washing.

The invention provides a foam dressing containing a composite silver-zinc antibacterial material and a preparation method of the foam dressing. The foam dressing containing the composite silver-zinc antibacterial material comprises polyurethane foaming plastic and the composite silver-zinc antibacterial material, wherein the composite silver-zinc antibacterial material is adhered to the inside of the polyurethane foaming plastic, comprises the following raw materials in content: nano silver, nano zinc and a nano inorganic carrier; and the composite silver-zinc antibacterial material contains the following raw materials in percentage by mass: 10%-20% of silver and 20%-40% of zinc. The composite silver-zinc antibacterial material is dispersed into the foam dressing in a manner of foam molding or ultrasonic dipping together with foam. The foam dressing containing the composite silver-zinc antibacterial material is capable of effectively absorbing diffusate of the wound surface, and effectively inhibiting growth and breeding of staphylococcus aureus, pseudomonas aeruginosa and candida albicans.

The invention discloses antibacterial soap which is characterized by comprising the following raw material components: 5-15% of coconut oil, 10-20% of palm oil, 3-10% of olive oil, 15-30% of beef tallow, 5-15% of sodium hydroxide, 2-8% of liquorice water extract, 1-3% of sodium dodecyl benzene sulfonate and 3-8% of titanium dioxide. The antibacterial soap obtained in the invention can be directlyapplied to the skin to effectively eliminate and kill bacteria on the skin and can resist staphylococcus aureus, Pseudomonas aeruginosa, escherichia coli and Candida albicans simultaneously.

The invention provides a weissella cibaria XHR1 and applications thereof and a weissella cibaria XHR1 containing pickled vegetable. The preparation of the pickled vegetable is implemented through the steps of adding a culture solution of weissella cibaria XHR1 and bacterial powder of lactobacillus plantarum CICC 20764 into a pickled vegetable fermentation starting solution for pickling vegetables, so that the final concentration of weissella cibaria XHR1 is 10<6>-10<7> cfu/mL eventually, and then the final concentration of lactobacillus plantarum CICC 2076 is 10<5>-10<6> CFU/mL; and then, adding vegetables into the pickled vegetable fermentation starting solution, and carrying out vegetable pickling according to a traditional vegetable fermentation process, so that the pickled vegetable disclosed by the invention is obtained finally. According to the invention, prebiotic lactobacillus for inhibiting the growth of Candida albicans is applied to the fermentation of Sichuan pickled vegetables, so that the consumer group is wider, and the micro ecological level of alimentary canals of wide consumers can be improved, thereby inhibiting Candida albicans diseases from the perspective of public health.

The invention relates to marine streptomyces S187 having broad-spectrum antibacterial activity, belonging to the microbiological actinomycetes field. The marine streptomyces S187 is separated from a sea mud sample at a depth of 20 meters underwater in coastal waters. Primary screening through an agar block method proves that the bacterial strain has very strong antibacterial activity to Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger; the result of fermentation liquid secondary screening confirms good activity for antagonizing the Escherichia coli, the Staphylococcus aureus and the Bacillus subtilis. The analysis for 16S rDNA shows that the only actinomycetes having the homology as high as 99 percent with the marine streptomyces S187 is the salt lake bacterial strain Streptomyces chungwhensis (DSM41483) separated by Korean scholars, but the bacterial strain is separated from the sea mud sample for the first time. I type polyketide synthase (PKSI) is successfully amplified out from the streptomyces S187, which indicates that the streptomyces S187 has the potential ability of generating polyketide.

The invention discloses a cow leather mat with an anti-bacterial function. The cow leather mat is characterized in that a grain side and a flesh side of the cow leather mat simultaneously comprises a nano-silver and isothiazolinone antibacterial agent; the inhibition zone of the nano-silver and isothiazolinone antibacterial agent to staphylococcus aureus, colon bacillus, bacillus subtilis, Aspergillus niger, blue mould, hair mould, cryptococcus neoformans, candida albicans is 43.28 to 68.84mm; the dry wipe resistance level is 4 to 5 level or 5 level; the wet wipe resistance level is 3 to 4 level or 4 level; and folding resistance fastness is 1 level. The invention also discloses a preparation method of the cow leather mat. The cow leather mat not only has good inhibit function to bacterium and fungus, but also has durable antibacterial property; the preparation method is skillful, the only thing to do is to add antibacterial treatment after a middle layer is coated, additional investment cannot be increased, the process is simple to operate, and the cow leather mat is applicable to industrial application.