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149 results about "Candida albicans" patented technology
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Candida albicans is an opportunistic pathogenic yeast that is a common member of the human gut flora. It can also survive outside the human body. It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults. It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions. It is one of the few species of the genus Candida that causes the human infection candidiasis, which results from an overgrowth of the fungus. Candidiasis is for example often observed in HIV-infected patients. C. albicans is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue. C. albicans, C. tropicalis, C. parapsilosis, and C. glabrata are together responsible for 50–90% of all cases of candidiasis in humans. A mortality rate of 40% has been reported for patients with systemic candidiasis due to C. albicans. By one estimate, invasive candidiasis contracted in a hospital causes 2,800 to 11,200 deaths yearly in the US. Nevertheless, these numbers may not truly reflect the true extent of damage this organism causes, given new studies indicating that C. albicans can cross the blood brain barrier.
Stachyose composition for promoting micro-ecological regulation of lactobacillus and application of stachyose composition
The invention relates to the field of biotechnology and female health care, in particular to a stachyose composition for promoting micro-ecological regulation of lactobacillus and application of the stachyose composition, and the composition comprises stachyose and pharmaceutically acceptable auxiliary materials. The stachyose is used as prebiotics to selectively promote proliferation and colonization of the lactobacillus crispatus, the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can promote proliferation of the lactobacillus crispatus, the lactobacillus crispatus is one or more of the lactobacillus crispatus, the lactobacillus plantarum and the lactobacillus acidophilus, and the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can inhibit gardnerella and candida albicans. The stachyose composition disclosed by the invention is in the form of slow-release gel and bath foam; the composition can be used for treating or preventing bacterial vaginitis, colpitis mycotica and related symptoms, has the advantages of no antibiotics, no drug resistance, high safety and the like, and is suitable for the fields of vagina local nursing and micro-ecological regulation.
Owner:FOHOW HEALTH PROD CO LTD
Secondary metabolite of fennel endophytic fungus fusarium oxysporum as well as preparation method and application of secondary metabolite
PendingCN120698958AOrganic active ingredientsAntibacterial agentsSecondary metaboliteBacillus cereus
The invention belongs to the field of plant endophytic fungus secondary metabolites, particularly relates to a secondary metabolite of fennel endophytic fungus fusarium oxysporum as well as a preparation method and application thereof, and provides a fennel endophytic fungus secondary metabolite with structures as shown in compounds 1-8. Wherein the compound 2 and the compound 7 have inhibitory activity on staphylococcus aureus, escherichia coli, bacillus cereus, bacillus subtilis, candida albicans and shigella, and have a certain inhibitory effect on cervical cancer Hela cell strains.
Owner:KUNMING UNIV OF SCI & TECH
Paenibacillus polymyxa B01 and application thereof
The invention relates to a Paenibacillus polymyxa strain B01 and application of the Paenibacillus polymyxa strain B01, and belongs to the technical field of microorganisms. The paenibacillus polymyxa B01 disclosed by the invention is preserved in the Guangdong Microbial Culture Collection Center, and the preservation number of the paenibacillus polymyxa B01 is GDMCC NO.66594. The strain is obtained by separation, purification and screening from a soil sample, and tests show that the strain has excellent pH and high temperature tolerance; antibacterial active substances generated by fermentation of the bacillus subtilis have a relatively good antibacterial effect on escherichia coli, pseudomonas aeruginosa, pseudomonas putida, staphylococcus aureus, candida albicans, aspergillus brazilis, propionibacterium acnes and malassezia; and the antibacterial active substance has excellent heat resistance, cold resistance, illumination stability, pH stability and preservative effect, belongs to a mild low-irritation raw material, can be used for preparing daily chemical products and medicines, and has wide application prospects and important conversion research values.
Owner:GUANGZHOU AIZHUO BIOTECHNOLOGY CO LTD
Polymer antibacterial artificial leather and preparation method thereof
PendingCN121848783AAntifouling/underwater paintsSynthetic resin layered productsPolymer sciencePolyether polyurethane
The invention discloses macromolecular antibacterial artificial leather and a preparation method thereof, and relates to the technical field of artificial leather preparation. The preparation method comprises the following steps: preparing zinc-loaded silicon dioxide with amino grafted on the surface and quaternized polyether polyurethane containing an epoxy group, mixing the zinc-loaded silicon dioxide and the quaternized polyether polyurethane to prepare antibacterial protection slurry, and bonding the zinc-loaded silicon dioxide and the quaternized polyether polyurethane through ring-opening reaction of the amino and the epoxy group during curing to form a cross-linked network, so as to obtain the antibacterial protection layer with antibacterial property, flexibility and wear resistance; zinc ions have an obvious inhibiting effect on bacteria such as gram-positive bacteria and gram-negative bacteria and fungi such as candida albicans, quaternary ammonium salt has an obvious inhibiting effect on influenza viruses, and the zinc ions and the quaternary ammonium salt have a synergistic effect, so that the antibacterial range of the artificial leather is wider, the inhibiting force on germs is stronger, and the antibacterial property of the artificial leather is further improved.
Owner:KUNMING PUPI ECONOMIC & TRADE CO LTD
A sanitary pad containing traditional Chinese medicine composition condensate explosive beads and a preparation process thereof
The present application relates to the technical field of nursing pad, in particular to a sanitary pad containing traditional Chinese medicine composition condensation fragrance burst beads and a preparation process thereof.The sanitary pad comprises, from bottom to top, an anti-sticking paper, a waterproof layer, an absorption layer, a composite layer and an anti-sticking paper; the composite layer is obtained by placing the traditional Chinese medicine composition condensation fragrance burst beads on the first fabric layer, covering the second fabric layer, and then bonding.The traditional Chinese medicine composition in the sanitary pad can effectively inhibit Candida albicans, Escherichia coli and Staphylococcus aureus; the essential oil added in the burst fragrance condensation beads can provide a pleasant fragrance, making the sanitary pad emit fragrance, and when prepared into a nursing pad, it can effectively cover the odor of the female genital area, and also improve the antibacterial effect of the sanitary pad, resulting in lower genital itching and odor.The sanitary pad can give the user a genital area without odor and itching, which is beneficial to the physiological health of women.
Owner:GUANGZHOU ZHONGLE INT BIOTECHNOLOGY CO LTD
Lactobacillus acidophilus FMM01 with effects of improving contractility of pelvic floor muscles and repairing mucous membranes and application of lactobacillus acidophilus FMM01
The invention discloses a lactobacillus acidophilus FMM01 with the effects of improving the contractility of pelvic floor muscles and repairing mucous membranes and application of the lactobacillus acidophilus FMM01, the lactobacillus acidophilus FMM01 is preserved in the China Center for Type Culture Collection, the preservation date is January 9, 2024, and the preservation number is CCTCC NO: M2024052. The lactobacillus acidophilus FMM01 has the advantages of self-adaption, high acid resistance, strong mucous membrane adhesiveness and no irritation to vaginal mucosa. The lyophilized powder is high in activity and excellent in stability; experimental results show that the lactobacillus acidophilus FMM01 can effectively inhibit bacteria, and especially can effectively inhibit enterobacter cloacae, vibrio parahaemolyticus and / or candida albicans. Besides, the lactobacillus acidophilus FMM01 can improve vaginal relaxation, improve pelvic floor muscle contractility and / or recover vaginal mucosa functions, can promote recovery of healthy florae after mixed vaginitis antibiotic / hormone treatment, improves the treatment effect of mixed vaginitis, and remarkably reduces the recurrence rate of mixed vaginitis.
Owner:JIANGSU KERONG BIOPHARMACEUTICAL CO LTD
Traditional Chinese medicine composition ointment for treating bacterial fungal infection and dermatitis and preparation method thereof
The invention belongs to the technical field of pharmacy, and mainly relates to a traditional Chinese medicine composition ointment for treating bacterial fungal infection and dermatitis and a preparation method thereof. The traditional Chinese medicinal materials such as the sophora flavescens, the blackberry lily, the cortex dictamni, the gallnut, the fructus cnidii, the aloe, the cortex pseudolaricis, the fructus kochiae, the cortex phellodendri, the typhonium giganteum, the radix stemonae, the hedyotis diffusa, the spina gleditsiae and the rhizoma smilacis glabrae which are subjected to biological fermentation can inhibit the growth of fungi and also can relieve itching and relieve swelling; the traditional Chinese medicine has small side effects; ti / ZIF-8 is also added, so that the antibacterial effect is more obvious; the traditional Chinese medicine composition can be used for treating acute and chronic dermatitis, eczema, dermatophytosis, tinea manuum, foot sweat, fungal infection, skin itch, papule, plaque papule, erythroderma and intractable skin stubborn dermatitis caused by various bacteria and fungi, red swelling and itching caused by mosquito bite, and inhibiting candida albicans, staphylococcus aureus and the like. In general, the method has a very wide application prospect in the field.
Owner:QINGFENG CHAIN FOOD BIOTECHNOLOGY (JILIN) CO LTD
Penicillium decumbens strain C01 and application thereof
The present application relates to a strain of Penicillium decumbens (P. Penicillium decumbens ) C01 and its application, and belongs to the field of microbial technology. The Penicillium decumbens C01 disclosed by the present application has been preserved in the Guangdong Microbial Digital Culture Collection Center, and its preservation number is GDMCC NO.66456. The strain is isolated, purified and screened from a soil sample collected in the garden area of Guangzhou South China Botanical Garden. Tests show that the bacteriostatic active substance produced by fermentation of the strain has good bacteriostatic effect on Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Propionibacterium acnes, Candida albicans and Pseudomonas aeruginosa. Moreover, the bacteriostatic active substance has high-temperature resistance and excellent preservative effect, and can be used as a bacteriostatic and preservative raw material, applied in the fields of food, health care products or daily chemical products, and has broad application prospect and important transformation research value.
Owner:GUANGZHOU AIZHUO BIOTECHNOLOGY CO LTD
Lactobacillus plantarum PB12 and PB14 and use thereof in preventing or treating inflammation of the vagina in women
The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.
Owner:ZHEJIANG WEIYUAN BIOTECHNOLOGY CO LTD
Application of leonurine in preparation of antibacterial product
PendingCN121129824AOrganic active ingredientsCosmetic preparationsBiotechnologyMethicillin resistance
The invention relates to the field of modern pharmacy of traditional Chinese medicines, and discloses application of leonurine in preparation of antibacterial products. According to the invention, the in-vitro antibacterial activity of leonurine is detected by an agar dilution method and a broth trace dilution method. The result shows that the leonurine can inhibit the proliferation of a staphylococcus aureus standard strain, and also has an inhibiting effect on most of methicillin-sensitive staphylococcus aureus, methicillin-resistant staphylococcus aureus and methicillin-resistant coagulase-negative staphylococcus which are obtained by clinical separation; meanwhile, the leonurine can inhibit proliferation of a malassezia standard strain and a clinical isolated strain, also has an inhibiting effect on most of ketoconazole drug-resistant candida and ketoconazole dose dependence-sensitive candida obtained through clinical isolation, and can be used for preparing antibacterial pharmaceutical compositions and skin care products.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
Use of compound HEX and / or compound POM-HEX in medicine for the prevention and / or treatment of fungal infections
The application provides an application of a compound HEX and / or a compound POM-HEX in medicine for preventing and / or treating fungal infection, and belongs to the technical field of medicine. In vitro experiments show that POM-HEX alone has inhibiting effects on candida and cryptococcus, and when combined with fluconazole, the antifungal activity can be significantly improved, and the drug-resistant strains can restore the sensitivity to fluconazole. The organ bacterial load experiment in mice in vivo proves that POM-HEX can stably exert the drug efficacy in the organism. In addition, the IC 50 value of the metabolic product HEX of POM-HEX for inhibiting the Eno1 enzyme activity of Candida albicans is 1 / 30 of the IC 50 of HEX for inhibiting the Eno1 enzyme activity of human. The application discloses that the HEX and / or the compound have strong antifungal activity and high selectivity for the target point Eno1, provides a new idea for antifungal treatment, the drug combination can reduce the drug dosage, reduce the toxic and side effects, and solves the problem of fungal drug resistance.
Owner:TONGJI UNIV
Highly antibacterial carbon dots, preparation process and application of highly antibacterial carbon dots in vaginal gel
The invention belongs to the field of preparation of high-antibacterial carbon dots, and discloses a high-antibacterial carbon dot, a preparation process and application of the high-antibacterial carbon dot in vaginal gel. The prepared carbon dots are prepared by adopting physical shearing and ultrasonic synergistic pretreatment, then cooperating with microwave gradient energy crushing and stripping, and then performing centrifugation, dialysis purification and vacuum freeze drying, the damage of oxidation or acid treatment to a graphite structure is avoided in the whole process, and the carbon dots have excellent antibacterial and antiviral performance, can effectively inactivate various pathogenic microorganisms, and have good application prospects. Comprise herpes simplex virus, human papilloma virus HPV16, staphylococcus aureus, candida albicans and the like. The invention also optimizes application conditions, is suitable for developing efficient and safe vagina antibacterial gel products, and provides an innovative solution for preventing and treating gynecological infection.
Owner:ENYUAN TECH WUXI CO LTD
Plantain fruit extract and uses thereof
This invention relates to the field of plant extract application technology, particularly to banana fruit extract and its applications. This invention reveals that banana fruit extract exhibits excellent performance in relieving inflammation, anti-oxidation, scavenging free radicals, delaying cell aging, inhibiting viruses and bacteria (inactivating HPV, Staphylococcus aureus, Candida albicans, Escherichia coli, and Propionibacterium acnes), reducing infection, promoting cell regeneration and repair, promoting collagen synthesis, enhancing elasticity and firmness, and acting as a plant-derived immunomodulator. Furthermore, it serves as a natural, intelligent transdermal carrier. Safe and non-irritating, this extraction method has shown excellent application value in high-value plants such as saffron, rose, Dendrobium officinale, ginseng, and Ganoderma lucidum. It provides a comprehensive solution for skin from defense to regeneration, offering a regulatory-compliant natural solution for functional skincare.
Owner:GUANGXI XIUPEI KELING BIOTECHNOLOGY CO LTD
Candida albicans specificity detection kit and application thereof
The invention discloses a Candida albicans specificity detection kit and application thereof, the kit comprises a nanoprobe, the nanoprobe takes a gold nanostar as a substrate, and the surface of the substrate is modified with Raman probe molecules and a Candida albicans specificity aptamer. The kit has high sensitivity, specificity, reproducibility, uniformity and stability, Raman spectrum can be collected through portable Raman spectrum equipment, the kit can be used for analyzing trace Candida albicans in a sample, and the detection limit is 1.14-1.21 CFU / mL. Compared with the traditional method, the detection method of the kit has the advantages of simple pretreatment process, short detection time, simplicity in operation and the like, obviously reduces the time and economic cost, and is more suitable for on-site rapid detection of candida albicans.
Owner:ZHEJIANG UNIV OF TECH
Polypeptide for treating rhinitis as well as preparation method and application thereof
The invention relates to a polypeptide for treating rhinitis as well as a preparation method and application thereof, and belongs to the technical field of biology. Natural active small molecule polypeptides are extracted from white tea plants, and the polypeptides are safe and non-toxic to cells and have remarkable bacteriostasis and sterilization effects on rhinitis pathogenic bacteria such as staphylococcus aureus, pseudomonas aeruginosa, candida albicans and aspergillus niger; in addition, in a guinea pig in-vivo test, symptoms of allergic rhinitis and inflammatory factors such as IgE, IL6 and IFN-gamma can be remarkably improved, and the treatment effect is superior to or equivalent to that of a positive control group. The white tea polypeptide disclosed by the invention has a remarkable effect of treating rhinitis, provides a novel, safe and efficient treatment choice for rhinitis patients, and has important scientific value and clinical application prospect.
Owner:HANGZHOU RED CROSS HOSPITAL (ZHEJIANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE & WESTERN MEDICINE)
Use of propionibacterium freudenreichii ssp. shermanii in the preparation of a product for improving constipation and depressive mood
The application belongs to the technical field of microorganisms, and provides application of Propionibacterium freudenreichii subsp. shermanii in preparation of products for improving constipation and depression, wherein the Propionibacterium freudenreichii subsp. shermanii NHNK-616 is preserved in the China Center for Type Culture Collection on July 1, 2024, and the preservation number is CCTCC NO: M 20241429. The inventors find that NHNK-616 has the functions of promoting 5-HT secretion, up-regulating intestinal aquaporin and brain-derived neurotrophic factor genes, metabolically producing gamma-aminobutyric acid, inhibiting growth of Candida albicans, inhibiting hypha formation of Candida albicans, combining with hypha of Candida albicans, and up-regulating expression of intestinal defensin and mucin genes, and therefore can be used for preparing products for improving constipation and depression.
Owner:QINGDAO NOVO NUOKANG BIOTECHNOLOGY CO LTD
Short-chain antibacterial peptide with anti-candida albicans activity and application thereof
The application provides a short-chain antibacterial peptide with anti-candida albicans activity and application thereof, and belongs to the application field of peptide antibiotics. The antibacterial peptide is a derivative peptide Pm-2W obtained by modification of an antibacterial peptide from Hainan Rana spinosa; the derivative peptide Pm-2W is obtained by modification of the antibacterial peptide; the Pm-2W has high anti-candida albicans activity; the Pm-2W has anti-candida albicans biofilm activity, is not prone to inducing drug resistance, has high stability and low hemolytic toxicity, and can be applied to preparation of drugs or bacteriostatic agents for treating candida albicans infection, and has good application prospect.
Owner:HAINAN UNIV
A plant composition with antibacterial properties, its preparation method and application
This invention relates to the field of antibacterial product technology, specifically to a plant composition with antibacterial effects, its preparation method, and its application. The plant composition, by weight, comprises the following raw material components: 2-6 parts of Lophatherum gracile, 2-5 parts of Rhodomyrtus tomentosa, 1-5 parts of Phellodendron amurense, and 2-8 parts of Podocarpus macrophyllus. The plant composition of this invention has the advantages of good efficacy and no side effects in inhibiting Staphylococcus aureus, Escherichia coli, Candida albicans, Malassezia furfur, and Propionibacterium acnes.
Owner:珠海远大美业生物科技有限公司 +1
Artemisia sieversiana volatile oil and use thereof in preparing antifungal bacteriostatic product
The application belongs to the technical field of natural plant extracts and application, and particularly relates to azafran volatile oil and application thereof in preparation of antifungal bacteriostatic products. In the application, the azafran is soaked in water and then distilled to obtain azafran volatile oil. The obtained azafran volatile oil shows good bacteriostasis, especially in inhibiting fungal strains such as Candida albicans, Malassezia furfur, Trichophyton mentagrophytes and Propionibacterium acnes. The application develops a new use of azafran volatile oil in preparation of antifungal bacteriostatic products.
Owner:QINGDAO UNIV OF SCI & TECH +1
Chonglingdan carbon dots and preparation method and application thereof
The application discloses a kind of smelly danchang dots and preparation method and application, belong to medical technical field.The preparation method of smelly danchang dot includes: smelly danchang fine powder is dispersed in distilled water, and is stirred pyrolysis on heating table;Pyrolysis product is diluted with distilled water, and supernatant is obtained by centrifugation, filter membrane filtration, dialysis, freeze-drying, to obtain carbon dot.The average particle size of obtained carbon dot is 4.51±1.04nm.The smelly danchang dot prepared in the application shows strong inhibitory activity to a variety of gram-positive bacteria (such as listeria, methicillin-resistant staphylococcus aureus MRSA) and fungi (such as Candida albicans), especially to clinically tricky drug-resistant strains, such as vancomycin-resistant enterococci (VRE) and MRSA effective, can be applied to the preparation of antibacterial drugs, antibacterial dressing, disinfectant or preservative, with the advantages of wide raw material source, simple preparation method, low cost, environment-friendly and the like.
Owner:YUNNAN UNIVERSITY OF CHINESE MEDICINE +1
Pharmaceutical composition for preventing, alleviating, or treating candidiasis, comprising methoxy-apo-enterobactin-based compound as active ingredient
PCT designated stageWO2026127339A1Organic active ingredientsCosmetic preparationsAntifungalBULK ACTIVE INGREDIENT
The present invention relates to a pharmaceutical composition for preventing, alleviating, or treating candidiasis, the composition comprising a methoxy-apo-enterobactin-based compound as an active ingredient, wherein the compound is isolated from a strain of the genus Streptomyces (Streptomyces sp.) and was found to have antifungal activity against Candida albicans and an inhibitory effect on ECE1 gene expression as well as the effect of reducing subcutaneous infection in an in vivo candidiasis model, and thus can be effectively used in related industries.
Owner:UNIVERSITY INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY +1
Application of tetrahydrothieno [2, 3-c] pyridine compound and derivative thereof
The invention belongs to the technical field of medicines, and particularly relates to application of a tetrahydrothieno [2, 3-c] pyridine compound and a derivative of the tetrahydrothieno [2, 3-c] pyridine compound. The compound provided by the invention has a structure as shown in a formula I, wherein R1 and R2 are independently selected from hydrogen and substituted or unsubstituted C1-C4 alkyl; and R3 is independently selected from a substituted or unsubstituted five-membered aromatic heterocyclic ring. The anti-candida albicans activity of the tetrahydrothieno [2, 3-c] pyridine compound and the pharmaceutically available salt provided by the invention is found for the first time, and the tetrahydrothieno [2, 3-c] pyridine compound and the pharmaceutically available salt can be used for clinically treating fungi such as candida albicans, and can effectively solve the problem of fungus drug resistance.
![Application of tetrahydrothieno [2, 3-c] pyridine compound and derivative thereof](https://images-eureka.patsnap.com/patent_img/2709df4f-8551-4555-a819-180ba8efa4c6/CN121129842A.png "Application of tetrahydrothieno [2, 3-c] pyridine compound and derivative thereof")
Owner:MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Application of itaconic acid derivatives in the preparation of drugs for treating candidemia
PendingCN122272557AReduce pathological damageReduce fungal colonizationInflammatory factorsTherapeutic effect
This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Propionibacterium sp. nhnk-621 and use thereof in the preparation of products for improving constipation and improving memory
The application belongs to the technical field of microorganisms, and discloses a propionic acid-producing propionic acid bacteria NHNK-621 and application of the propionic acid bacteria in preparation of products for improving constipation and memory, the bacteria strain has been preserved in the China Center for Type Culture Collection on November 25, 2024, and the number is CCTCC NO: M 20242631. The propionic acid bacteria NHNK-621 provided by the application has the functions of promoting 5-HT secretion, up-regulating intestinal aquaporin and brain-derived neurotrophic factor genes, metabolically producing gamma-aminobutyric acid, inhibiting growth of Candida albicans, inhibiting hypha formation of Candida albicans, combining with hypha of Candida albicans, up-regulating intestinal defensin and mucin gene expression, in addition, the bacterial biofilm can increase the colonization ability to intestinal epithelial cells, and can be used for preparing products for improving constipation and memory.
Owner:QINGDAO NOVO NUOKANG BIOTECHNOLOGY CO LTD
Preparation method of monoclonal antibody for detecting trichophyton rubrum and application of monoclonal antibody in fungal skin disease detection
PendingCN121449739AGenetically modified cellsBiological material analysisMalasseziaDermatology department
The invention discloses a preparation method of a monoclonal antibody for detecting trichophyton rubrum and application of the monoclonal antibody in fungal skin disease detection, and belongs to the field of biological medicine. The monoclonal antibody provided by the invention only has specific reaction with trichophyton rubrum, and has no cross reaction with common fungi such as trichophyton mentagrophytes, epidermophyton flocculent, candida albicans, malassezia and the like and normal flora of a human body, so that a false positive result is effectively avoided. Based on the double-antibody sandwich principle, the detection sensitivity can reach 200 pg / mL level, trace trichophyton rubrum in a clinical sample can be detected, and the positive rate is obviously higher than that of direct microscopic examination. The whole detection process can be completed within 15-20 min and is far faster than fungus culture for several weeks, a rapid diagnosis basis can be provided for doctors, and early treatment is facilitated. The kit provided by the invention has standardized operation steps, does not need complex instruments and special training, and is suitable for popularization and use in clinical laboratories of hospitals at all levels, outpatient clinics of dermatology and even basic medical institutions.
Owner:HOSPITAL OF DERMATOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES +1
Application of leuconostoc mesenteroides subsp. Mesenteroides in improvement of constipation and depression
The invention discloses application of leuconostoc mesenteroides subsp. Mesenteroides in improvement of constipation and depression, and belongs to the technical field of marine microorganisms. The invention discloses a leuconostoc mesenteroides subsp. Mesenteroides NHNK-613, which is preserved in the China Center for Type Culture Collection on July 1, 2024, and the preservation number of the leuconostoc mesenteroides subsp. Mesenteroides NHNK-613 is CCTCC (China Center for Type Culture Collection) NO: M 20241431. The NHNK-613 has the functions of promoting 5-HT secretion, up-regulating intestinal aquaporin and brain-derived neurotrophic factor genes, metabolizing to generate gamma-aminobutyric acid, inhibiting the growth of candida albicans, inhibiting the formation of candida albicans filaments, combining the candida albicans filaments and up-regulating intestinal defensin and mucoprotein gene expression; the traditional Chinese medicine composition can be used for preparing products for improving constipation and depression.
Owner:QINGDAO NOVO NUOKANG BIOTECHNOLOGY CO LTD
Injectable photo-crosslinking hydrogel loaded with pseudolaric acid as well as preparation method and application of injectable photo-crosslinking hydrogel
The invention discloses an injectable photo-crosslinking hydrogel loaded with pseudolaric acid as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) respectively dissolving Gelma and HAMA in sterile PBS (Phosphate Buffer Solution) according to the dosage required by a final system; 2) mixing the two solutions, and adding a photoinitiator LAP pre-dissolved in the sterile PBS at 60 DEG C; 3) dissolving golden larch bark acetic acid in dimethyl sulfoxide to prepare a medicine solution with the concentration of 1.0 mg / mL, and then adding the medicine solution into the precursor solution under the condition of continuous stirring; and 4) carrying out 405 nm illumination crosslinking on the obtained precursor solution to form the hydrogel. The hydrogel three-dimensional network can continuously and controllably release pseudolaric acid, maintains a long-acting effective drug concentration at an infected part, shows a strong inhibition effect on a candida albicans standard strain and a clinical drug-resistant strain, and has a good application prospect in a model for treating candida vaginitis and fungal skin wound infection. And all the components show a remarkable'anti-infection-repair promoting 'integrated treatment effect.
Owner:QINGDAO UNIV
Green hydrothermal synthesis method of functionalized silver nanomaterial
PendingCN122057905ATransportation and packagingMetal-working apparatusEscherichia coliMethyl palmoxirate
The invention discloses a green hydro-thermal synthesis method of a functionalized silver nano-material, and the preparation method comprises a preparation method of a functionalized silver nano-colloid prepared from a sorbus pohuashanensis fruit extract and a preparation method of functionalized nano-silver solid powder. The invention discloses the green hydro-thermal synthesis method of the functionalized silver nano-material. The spherical nano-silver can stably suspend in a colloidal solution, and the material has the bacteriostatic effect (escherichia coli, staphylococcus aureus and candida albicans) and the effect of rapidly removing methylene blue and rhodamine B dye in water. The nano-silver material is spherical, the particle size of the nano-silver material ranges from 14 nm to 70 nm, and the average particle size of the nano-silver material is 36 nm. The sorbus pohuashanensis fruit extract attached and modified in the nano material accounts for nearly 7.0% of the total mass of the nano material. The green hydrothermal synthesis method is high in safety coefficient, convenient and rapid in operation process, small in pollution or free of pollution and high in repeatability, and the method has application and development potential.
Owner:NORTHEAST FORESTRY UNIV
Nano-catalysis antibacterial filter material for direct water dispenser and preparation method of nano-catalysis antibacterial filter material
PendingCN122006344AWater treatment compoundsWater/sewage treatment by irradiationK pneumoniaeStaphyloccocus aureus
The invention relates to the technical field of water treatment materials, and discloses a nano-catalytic antibacterial filter material for a direct water dispenser, which comprises the following components in percentage by mass: 8-20% of broad-spectrum nano-antibacterial component, 55-85% of base material, 4-10% of binder, 2-5% of dispersant and 2-6% of assistant, the broad-spectrum nano antibacterial component is Ag-TiO / ZnO-CuO quaternary composite nanoparticles, and the mass ratio of Ag to TiO to ZnO to CuO is 1: (2-4): (1-3): (0.5-1.5). According to the nano catalytic antibacterial filter material and the preparation method thereof, the inhibition and killing rates on gram-negative bacteria (escherichia coli, pseudomonas aeruginosa and klebsiella pneumoniae), gram-positive bacteria (staphylococcus aureus, bacillus subtilis and methicillin-resistant staphylococcus aureus) and fungi (candida albicans and aspergillus niger) are all greater than or equal to 99.9%.
Owner:SHAANXI ZHONGCIDAN IND CO LTD
Use of an antibacterial peptide having antifungal activity
The application relates to the technical field of antibacterial peptides, in particular to application of an antibacterial peptide with antifungal activity, and discloses antifungal activity, antibiofilm activity and an action mechanism of Jelleine-Ic on Candida albicans. Jelleine-Ic shows very strong antifungal activity on Candida albicans. Jelleine-Ic destroys the integrity of the cell wall of Candida albicans and enhances the permeability of the cell membrane of Candida albicans. In addition, Jelleine-Ic interacts with DNA when entering the fungal cell, influences the expression of genes involved in DNA replication and repair, and induces the generation of active oxygen in the cell, thereby accelerating the death of the fungal cell. According to the above results, Jelleine-Ic can effectively inhibit the growth of Candida albicans and has the potential for treating fungal infections.
Owner:ANHUI AGRICULTURAL UNIVERSITY