246 results about "Oral Product" patented technology

The invention relates to 6-methyl nicotine glycollate and a preparation method thereof, an atomization matrix, a buccal product and an electronic atomization device. The preparation method of the 6-methylnicotine glycollate comprises the following steps: mixing 6-methylnicotine, glycollic acid and a metal catalyst for reaction to obtain a reaction solution containing the 6-methylnicotine glycollate; and carrying out physical adsorption treatment on the reaction liquid to prepare the 6-methyl nicotine glycolate. 6-methylnicotine and glycollic acid react under the action of a metal catalyst, so that the conversion rate of a reaction substrate can be effectively promoted, and residues of the reaction substrate are effectively reduced; the obtained reaction liquid is further subjected to physical adsorption treatment, so that the residual catalyst in the reaction liquid can be effectively removed, and the prepared 6-methyl nicotine glycolate has less heavy metal residue.

The invention relates to the technical field of microorganisms, in particular to plant lactobacillus BR32 with functions of preventing decayed teeth and improving inflammation and application of the plant lactobacillus BR32. The plant lactobacillus BR32 with the functions of preventing decayed teeth and improving inflammation, provided by the invention, has the preservation number of CGMCC No.32836, has an inhibiting effect on the growth of oral pathogens such as streptococcus mutans, candida albicans and porphyromonas gingivalis, is high in oxidation resistance, is beneficial to continuous oral cavity stability maintenance through a synergistic effect, also has relatively high hydrophobicity and self-agglutination capability, and can be used for preparing oral cavity health-care products. The compound is low in tooth environment corrosion, high in lysozyme tolerance and good in oral colonization capacity, does not have a hemolysis phenomenon in in-vitro hemolysis culture, is sensitive to common antibiotics and has relatively high food safety. The invention further provides a microbial agent, a probiotic product, a functional food, a fermented product, a bacteriostatic agent and an oral product containing the plant lactobacillus BR32 with the functions of preventing the decayed teeth and improving the inflammation, and the effects of preventing the decayed teeth, improving the inflammation, preventing dental plaque, relieving oral ulcer and the like are achieved.

The utility model discloses an oral cavity product, which comprises an oral soluble film and a support layer, the support layer has water-insoluble property, the support layer is arranged on at least one surface of the oral soluble film or embedded in the oral soluble film, the support layer is provided with at least one channel, and the channel is used for saliva to pass through the support layer. The supporting layer can play a supporting role, the probability that the oral dissolving film shrinks and even directly disintegrates in the attaching process is reduced, a user can smoothly attach the oral dissolving film to the position where the oral dissolving film needs to be placed when using an oral product, the use cost of the oral product is reduced, the supporting layer can keep the shape for a long time, and the service life of the oral dissolving film is prolonged. The oral product can be moved or withdrawn from the oral cavity at will according to requirements, so that the usability of the oral product is improved.

The invention discloses an elastic chewable nicotine oral product and a preparation method thereof. The elastic chewable nicotine oral product comprises a nicotine source and an additive, the nicotine source is dissolved in the mixed solution of the additive, so that the nicotine oral product forms a soft elastomer, and the nicotine is slowly released in the oral cavity through chewing; the nicotine source is extracted or chemically synthesized from tobacco; the additive comprises a gelling agent, and the gelling agent comprises one or a combination of more of gelatin, agar, konjac polysaccharide, xanthan gum, pectin, carrageenan, sodium alginate, semen plantaginis polysaccharide, guar gum, gellan gum, curdlan, whey protein, casein or soybean protein. The gel is added into the carrier to realize physical embedding of the nicotine, the elastic and chewable oral nicotine product can be obtained without bonding fixation, and the nicotine is released through gel swelling-diffusion regulation, so that the oral nicotine product has no residue in the oral cavity and does not pollute the package when being used, and the purposes of dynamically releasing the nicotine and improving the consumption experience are realized.

The invention relates to the technical field of oral products, and particularly discloses a manganese tungstate nanoparticle / hydrogen peroxide composition for tooth whitening and a preparation method thereof. The preparation method comprises the following steps: preparing manganese tungstate nano-particles, dispersing tungsten hexacarbonyl and a surfactant in a first organic solvent, adding an oleic acid / oleylamine ligand pair under a first reaction condition, and then carrying out stirring reaction, cooling, centrifuging, washing and drying under a second reaction condition to prepare the manganese tungstate nano-particles. And preparing a manganese tungstate nanoparticle / polyethylene glycol composite material, dispersing the manganese tungstate nanoparticles and a polyethylene glycol derivative in a second organic solvent, uniformly stirring, and carrying out nitrogen drying to prepare the manganese tungstate nanoparticle / polyethylene glycol composite material. The manganese tungstate nanoparticle / polyethylene glycol composite material is dissolved in artificial saliva, a hydrogen peroxide solution is added and mixed, and the manganese tungstate nanoparticle / hydrogen peroxide composition for tooth whitening is prepared.

The invention discloses a tooth wear evaluation model for evaluating the safety of oral products and a preparation method and application thereof. The tooth wear evaluation model is at least obtained by grinding and polishing the surface of a tooth model, and the tooth model comprises at least one of an animal enamel block model, an animal dentin block model, a tooth-like material dental film model, a full-mouth animal enamel model and a tooth-like material full-mouth tooth model. According to the tooth wear evaluation model, the wear performance of the oral product can be conveniently tested in vitro.

The invention discloses a stable buccal product based on pH regulator controlled release and a preparation method thereof, and relates to the technical field of nicotine buccal product preparation. The buccal product comprises the following components in parts by weight: 1-10 parts of a binder, 1-5 parts of a first filler, 2-5 parts of a wetting agent, 0.2-2 parts of a disintegrating agent, 1-2 parts of a pH regulator, 1-10 parts of nicotine ditartrate salt, 1-10 parts of nicotine resin, 30-50 parts of a second filler, 5-15 parts of a humectant, 0.3-1.5 parts of a sweetening agent, 0.5-5 parts of a cooling agent, 2-10 parts of a flavoring agent, 0.2-4 parts of an antioxidant and 1-5 parts of sodium chloride. And the pH regulator is carbonate. On the basis of the nicotine resin, the nicotine ditartrate salt which is comfortable in mouth feel and quick in head feeling is selected, meanwhile, the pH value of the buccal product powder is adjusted to be 6-6.5, and the technical effects of being stable in storage, free of sour taste, quick in head feeling and comfortable are achieved.

The invention discloses an antibacterial peptide and application thereof. The antibacterial peptide comprises one or more of an antibacterial peptide PFK with an amino acid sequence as shown in SEQ ID NO: 1, an antibacterial peptide PVK with an amino acid sequence as shown in SEQ ID NO: 2 and an antibacterial peptide PIK with an amino acid sequence as shown in SEQ ID NO: 3. The antibacterial peptides PFK, PVK and PIK disclosed by the invention have antibacterial effects on porphyromonas gingivalis, streptococcus mutans, acinetobacter baumannii, escherichia coli and staphylococcus aureus, and the antibacterial peptides PFK, PVK and PIK have relatively low hemolytic activity and relatively low cytotoxicity, so that the antibacterial peptides PFK, PVK and PIK can be used for preparing biological antibacterial preparations, anti-infection drugs or oral products.

The invention provides a preparation method of a nicotine load. The preparation method comprises the following steps: S1, preparing porous silicon dioxide; s2, mixing a first solution containing nicotine with porous silicon dioxide, and then drying to obtain a nicotine-silicon dioxide compound; s3, mixing a second solution containing polydopamine with the nicotine-silicon dioxide compound, and then washing and drying to obtain a polydopamine modified compound; s4, mixing a third solution containing trypsin substrate polypeptide with an activating agent to obtain a polypeptide activating solution; mixing a polypeptide activating solution with the polydopamine modified compound, and then washing and freeze-drying to obtain drug-loaded microspheres; and S5, mixing the drug-loaded microspheres with the temperature-sensitive gel, and dispersing the drug-loaded microspheres in the temperature-sensitive gel to obtain the nicotine load. The invention also provides a nicotine buccal product.

The invention provides a polypeptide and application thereof in preparation of a streptococcus mutans inhibitor. The amino acid sequence of the polypeptide is shown as SEQ ID NO: 1, and the polypeptide not only can effectively inhibit streptococcus mutans, but also is non-toxic to cells, and is suitable for preparing oral products which are excellent in antibacterial effect and can be used for a long time, so that oral diseases, especially caries, are prevented and treated. Moreover, the polypeptide disclosed by the invention is short in length, small in chemical synthesis difficulty, capable of being directly synthesized into a high-purity product, clear in effect and wide in application.

The invention provides a fragrant substance, a preparation method thereof and a nicotine buccal product, and the preparation method of the fragrant substance comprises the following steps: S11: uniformly mixing Roibos tea, agave and an extracting agent to obtain a mixture; s12, extracting the mixture, and dissolving the active substances of the Roibos tea and the active substances of the agave in an extracting agent to obtain an extracting solution; and S13, carrying out concentration treatment on the extracting solution to obtain the fragrant substance. The fragrant substance prepared by the method has the advantages of natural fragrance, smooth taste and the like.

The disclosure provides compositions configured for oral use, pouched products including such compositions, and methods of manufacturing the compositions and products. Example compositions configured for oral use include a filler component, water, and a 3-(1-methylpyrrolidin-2-yl)pyridine bearing one or more substituents on the pyridine ring.

The invention discloses a nicotine buccal product for promoting transdermal absorption, and relates to the technical field of nicotine buccal products. The buccal nicotine product for promoting transdermal absorption contains a transdermal absorption enhancer, and the transdermal absorption enhancer is selected from at least one of peppermint oil, wintergreen oil, menthol, azone and derivatives thereof, and sucrose monolaurate. According to the invention, the transdermal absorption enhancer is added into the buccal product, and the lipid fluidity is increased by interfering a cuticle phospholipid bilayer structure, so that the partition coefficient of nicotine in oral mucosa is changed, and the purposes of increasing the nicotine permeation rate and enhancing the nicotine uptake experience are achieved.

The disclosure provides an oral product configured for oral use, the oral product including a main body including a composition containing at least one water-soluble component capable of release from the main body when placed in the oral cavity, the main body having an outer surface; and a powder coating adhered to at least a portion of the outer surface of the main body, the powder coating including at least one flavorant or at least one active ingredient or a combination of at least one flavorant and at least one active ingredient. The disclosure also provides a method of forming an oral product, which includes receiving a main body including a composition containing at least one water-soluble component capable of release from the main body, the main body having an outer surface; and applying a powder coating composition to at least a portion of the outer surface.

The disclosure provides a composition configured for oral use, the composition including at least one filler and at least one oral care component, such as a probiotic, calcium glycerophosphate, urea, a quaternary ammonium salt, or a combination thereof. Example probiotics include probiotics from the genera selected from lactobacillus, streptococcus, and combinations thereof. The oral composition may additionally include one or more prebiotics selected from inulin, xylo-oligosaccharides (XOS), fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), isomalto-oligosaccharide (IMO), and combinations thereof. The composition can take various forms, including the form of a gel, pastille, gum, chew, melt, tablet, lozenge, granular material, powder, or pouched product.

An oral product includes a filler and an active ingredient. The filler includes a modified agglomerate and a surface modifier. The modified agglomerate includes a porous carrier. The surface modifier coats at least a portion of a surface of the agglomerate, is in pores of the agglomerate, or both coats at least a portion of the surface of the agglomerate and is in pores of the agglomerate. The surface modifier includes a sugar alcohol or a hydrophobic material. The active ingredient is admixed with the filler.

The disclosure provides compositions configured for oral use, such as pouched products. Example pouched products configured for oral use can include a composition enclosed within a water-permeable pouch, the composition including a particulate filler component; one or more sweeteners; and a releasable component selected from the group consisting of flavoring agents, active ingredients, and combinations thereof; wherein the composition is substantially free of sucralose.

The invention relates to the technical field of animal medicines, and particularly discloses a compound soft chewable tablet as well as a preparation method and application thereof. The compound soft chewable tablet comprises the following raw materials in percentage by weight: 0.4% of tofacitinib, 1% of an echinacea extract, 10-20% of pork liver powder, 10-20% of polyethylene glycol, 3-15% of a release agent, 0.3-1% of lauryl sodium sulfate, 1-3% of magnesium stearate, 2-5% of sucrose, 0.05-0.5% of a preservative, 11% of glycerol, 13-15% of soybean oil and the balance of corn starch. The tofacitinib citrate and the echinacea extract are adopted to prepare the soft chewable tablet, the process has no special requirements on equipment, the process is simple and feasible, and industrial production is utilized; by adopting conventional equipment such as a wet granulator, a mixer and a forming machine, the prepared oral product has the characteristics of stability, palatability, safety and effectiveness.

The disclosed technology includes cannabinoid oral products, and methods for making same. In some embodiments, the oral products are pouches including cannabinoid infused wafers. In some embodiments, the method of making the cannabinoid oral products includes preparing an emulsion, preparing a spray dry solution, spray drying solution into cannabinoid and carbohydrate particles, preparing a paste, preparing a wafer in a heated vacuum oven, fragmenting the wafer into cannabinoid infused wafer fragments, mixing the cannabinoid infused wafer fragments with starch, and dispensing the cannabinoid infused wafer fragments into pouches. The methods may also include labeling the oral products, for example, with a THC warning symbol.

The disclosure provides an oral composition adapted for oral use that includes sugarcane plant fiber in addition to one or more active ingredients, flavorants, or combinations thereof. The oral composition can be, for example, a pouched product wherein the oral composition is a particulate composition enclosed within a water-permeable pouch.

An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-stable polymer matrix. The oral product is adapted to release the nicotine or derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.

The present disclosure relates to non-therapeutic uses of compounds or combinations thereof to increase cognitive performance, alertness and / or energy levels of a human or animal, as well as an oral product comprising said compounds or combinations thereof.

Oral products containing a sensory agent with a spicy or tingling sensation are provided herein. Some sensory agents can be derived from Sichuan pepper (e.g., incorporated in the form of oil extracts thereof) and certain products can include one or more additional sensory agents. Some oral products are pouched products including an outer water-permeable pouch defining a cavity containing a composition comprising a water-soluble component capable of being released through the water-permeable pouch. Other such products include lozenges, meltable products, chewable products, gums, and the like.

The invention relates to an oral product for delivery of nicotine comprising or consisting of a composition comprising at least one nicotine salt of a fatty acid, at least one carrier, and water in an amount of less than 25% by weight, preferably in an amount of 5 % by weight to 15 % by weight, more preferably 5 % by weight to 10 % by weight, based on the total weight of the composition. The invention further relates to a method for preparing an oral product.

The present invention generally relates to the use of a sweetening composition comprising (i) a mycelia of an ascomycete or an aqueous extract thereof or (ii) an aqueous extract of a fruiting body of an ascomycete, to provide improved flavor to a product for oral administration, as well as to a sweetening composition comprising (i) a mycelia of an ascomycete or an aqueous extract thereof or (ii) an aqueous extract of a fruiting body of an ascomycete as well as to compositions comprising combinations of sweetening compositions and a product for oral administration.

The invention provides manufacturing equipment for buccal products, and belongs to the technical field of buccal products, the manufacturing equipment is used for preparing buccal products containing active substances and / or flavoring agents, and the manufacturing equipment comprises a feeding unit used for providing a base material; the material applying unit is arranged at the downstream of the material supplying unit and is used for applying a filling agent comprising an active substance and / or a flavoring agent to form a filling layer laminated with the base material; the film covering unit is arranged at the downstream of the feeding unit and is used for covering a film to form a film covering layer which is laminated with the base material and the filling layer, so that the buccal product is obtained; wherein the material applying unit comprises at least one material applying module, and one material applying module can be selectively used for forming at least one filling layer of each buccal product; the film covering unit comprises at least one film covering module, and one film covering module can be selectively used for forming at least one film covering layer of each buccal product. According to the manufacturing equipment, the buccal product with a more stable filling layer structure and better release uniformity can be manufactured.

The disclosure provides an oral composition adapted for oral use that includes at least one non- tobacco plant fiber material or powdered cellulose in addition to one or more active ingredients, flavorants, or combinations thereof, such as compositions including a non-tobacco plant fiber material or powdered cellulose having a D90 particle size of 120 microns or less. In some embodiments, the non-tobacco plant fiber material is sugarcane fiber. The oral composition can be, for example, a pouched product wherein the oral composition is a particulate composition enclosed within a water-permeable pouch.

The disclosure provides a pouched oral product configured for oral use, including a composition enclosed in a water-permeable pouch, wherein one or both of the composition and the water-permeable pouch include at least one humectant. The disclosure also provides a method of forming a pouched oral product configured for oral use, the method including providing a pouched oral product comprising a composition enclosed in a water-permeable pouch, the water-permeable pouch having an outer surface; placing the pouched oral product in a container for sale to a consumer; and applying a liquid composition to the outer surface of the water-permeable pouch to form a treated pouched product, the liquid composition comprising a humectant, wherein the applying occurs before or after placing the pouched oral product in the container.