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162 results about "Dentin" patented technology

Dentin (/ˈdɛntɪn/) (American English) or dentine (/ˈdɛnˌtiːn/ or /ˌdɛnˈtiːn/) (British English) (Latin: substantia eburnea) is a calcified tissue of the body and, along with enamel, cementum, and pulp, is one of the four major components of teeth. It is usually covered by enamel on the crown and cementum on the root and surrounds the entire pulp. By volume, 45% of dentin consists of the mineral hydroxylapatite, 33% is organic material, and 22% is water. Yellow in appearance, it greatly affects the color of a tooth due to the translucency of enamel. Dentin, which is less mineralized and less brittle than enamel, is necessary for the support of enamel. Dentin rates approximately 3 on the Mohs scale of mineral hardness. There are two main characteristics which distinguish dentin from enamel: firstly, dentin forms throughout life; secondly, dentin is sensitive.

Dental and medical treatments and procedures

A method treating a root canal in a tooth by introducing into the pulp chamber of a tooth and pulsing a laser light into the fluid reservoir so as to disintegrate pulp within the root canal without generation of any significant heat in said liquid fluid so as to avoid elevating the temperature of any of the dentin, tooth, or other adjacent tissue more than about 5″ C.
Owner:PIPSTEK LLC

Tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data

PendingCN120472096AImage enhancementImage analysisTooth TissueBiomedicine
The invention discloses a tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data, and belongs to the field of artificial intelligence and computer-aided biomedical engineering. The method comprises a CBCT intelligent segmentation module, an intraoral scanning intelligent segmentation module, an internal tissue segmentation module, a point cloud generation registration module and a parameterized bionic reconstruction module. The point cloud generation registration module further comprises a point cloud generation sub-module and a point cloud registration sub-module; the parameterized bionic reconstruction module further comprises a dentin reconstruction sub-module, a cancellous bone reconstruction sub-module and a gingival reconstruction sub-module. The invention aims to realize tooth semantic segmentation, point cloud reconstruction and parameterized bionic modeling of an organization structure under cross-modal data fusion, and provides high-precision bionic internal structure information for teeth in combination with an artificial intelligence model and parameterized modeling.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Preset tooth cutting method and system based on image data

The invention relates to the technical field of medical equipment, in particular to a preset tooth cutting method and system based on image data, and the method comprises the following steps: S1, obtaining multi-modal image data by using CT (Computed Tomography), MRI (Magnetic Resonance Imaging) and optical scanning technologies, and carrying out consistent analysis after preprocessing; and S2, performing automatic image segmentation by using a deep convolutional neural network (CNN). S3, optimizing the implant design through a generative adversarial network (GANs); s4, simulating and optimizing a cutting path through an augmented reality (AR) environment; and S5, laser micromachining is used for surface treatment of the implant. According to the method, the dentin cutting scheme matched with the specific shape and size of the bone defect area is designed through the data generated by scanning the three-dimensional shape of the complete tooth in advance, so that the image definition and the diagnosis accuracy are improved, the preoperative analysis is more accurate, and the subsequent personalized treatment design is effectively supported.
Owner:HOSPITAL OF STOMATOLOGY GUANGZHOU MEDICAL UNIVERSITY (YANGCHENG HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY)

Dental and medical treatments and procedures

A method treating a root canal in a tooth by introducing into the pulp chamber of a tooth and pulsing a laser light into the fluid reservoir so as to disintegrate pulp within the root canal without generation of any significant heat in said liquid fluid so as to avoid elevating the temperature of any of the dentin, tooth, or other adjacent tissue more than about 5° C.
Owner:PIPSTEK LLC

Diagnostic intraoral methods and apparatuses

Methods and apparatuses for taking, using and displaying three-dimensional (3D) volumetric models of a patient's dental arch. A 3D volumetric model may include surface (e.g., color) information as well as information on internal structure, such as near-infrared (near-IR) transparency values for internal structures including enamel and dentin.
Owner:ALIGN TECHNOLOGY INC

Apparatus and methods for treating root canals of teeth

Apparatus and methods for endodontic treatment of teeth provide effective cleaning of organic material (such as pulp and diseased tissue) from the root canal system. In an embodiment, a compressor system generates high pressure liquid (e.g., water) that flows through an orifice to produce a high-velocity collimated jet of liquid. The high-velocity jet is directed toward a surface of a tooth, for example, an exposed dentinal surface, and impingement of the jet onto the surface generates an acoustic wave that propagates throughout the tooth. The acoustic wave effectively detaches organic material from dentinal surfaces and tubules. The detached organic material is flushed from the root canal system by the liquid jet and / or by additional irrigation.
Owner:SONENDO INC

Oral ceramic restoration optical prediction matching method and system based on deep learning

The invention provides an oral ceramic restoration optical prediction matching method and system based on deep learning, relates to the technical field of oral medicine, and solves the limitation problems that existing oral restoration is low in clinical colorimetric accuracy, depends on artificial experience, has medical technology communication information deviation and the like. The method comprises the following steps: acquiring spectral data of natural teeth, dentin, enamel and different types of ceramics, and calibrating the semi-permeability of enamel and ceramic samples by using an extinction coefficient; obtaining a ceramic-dentin complex and composite spectrum data thereof, constructing a multi-layer sensor model and completing training; and splicing the dentin spectral data and the ceramic spectral data into an initial input vector, splicing the initial input vector with the calibrated semi-permeable constraint vector, and inputting the spliced initial input vector into a multi-layer sensor model to obtain a model matching result. The intelligent model for automatically generating the natural tooth defect repair scheme is established based on the deep learning technology, the intelligent repair design and the visual repair effect are achieved, and clinical application is effectively guided.
Owner:SICHUAN UNIV

Root canal filling material premixed with nano niobium silicate and preparation method of root canal filling material

The invention relates to a root canal filling material premixed with nano niobium silicate and a preparation method of the root canal filling material. The filling material is prepared from a) nano niobium silicate powder; b) calcium silicate compound powder; c) an X-ray radiation-resistant filler; the dosage of the component a) is 1-10% by mass, and the sum of the dosage of the component a), the dosage of the component b) and the dosage of the component c) is 40-90% by mass. According to the filling material disclosed by the invention, a proper amount of nano niobium silicate is introduced, so that the curing time can be remarkably shortened, the flowability is improved, the filling material can be bonded with tissues around a root canal, repair and regeneration of dentin are actively promoted in combination with the nano niobium silicate, and compared with an existing material, repair and regeneration after defect of an apical alveolar bone can be remarkably improved.
Owner:BEOGENE BIOTECH GUANGZHOU

Tooth wear evaluation model for evaluating safety of oral product as well as preparation method and application of tooth wear evaluation model

The invention discloses a tooth wear evaluation model for evaluating the safety of oral products and a preparation method and application thereof. The tooth wear evaluation model is at least obtained by grinding and polishing the surface of a tooth model, and the tooth model comprises at least one of an animal enamel block model, an animal dentin block model, a tooth-like material dental film model, a full-mouth animal enamel model and a tooth-like material full-mouth tooth model. According to the tooth wear evaluation model, the wear performance of the oral product can be conveniently tested in vitro.
Owner:GUANGZHOU STARS PULSE CO LTD +1

Diagnostic intraoral scanning and tracking

The present invention relates to diagnostic intraoral scanning and tracking. The present invention relates to methods and apparatus for acquiring, using, and displaying a three-dimensional (3D) volume model of a patient's dental arch. The 3D volume model may include surface information (e.g., color) as well as information about internal structures (e.g., near-infrared (Near-IR) transparency values ​​of internal structures including enamel and dentin).
Owner:ALIGN TECHNOLOGY INC

Method for accurately identifying Yangtze river dolphin and East Asian dolphin based on dentin 87Sr / 86Sr ratio

The invention discloses a method for accurately identifying a Yangtze river dolphin and an East Asian dolphin based on a dentin 87Sr / 86Sr ratio, which comprises the following steps: collecting a dolphin tooth sample, pretreating teeth, analyzing the dentin 87Sr / 86Sr ratio, measuring a tooth growth layer group, and reconstructing the 87Sr / 86Sr ratio change. The average values of different dentin 87Sr / 86Sr ratio change stages are compared with the Yangtze River main stream and ocean 87Sr / 86Sr ratios respectively, the habitat types of the dolphins in the forming period are judged, the dolphins are judged to be the Yangtze River dolphins or the East Asian dolphins according to the habitat types, and an important basis is provided for judging species of dead dolphin individuals at the Yangtze River estuary.
Owner:FRESHWATER FISHERIES RES CENT OF CHINESE ACAD OF FISHERY SCI

Device and kit for injection bonding multi-tooth dental restoration in a single treatment

Methods and kits of materials and supplies for restoring teeth by an injection molding process and / or mold overlays in situ in a patient's mouth so as to correct the imperfect teeth of the patient's dentition. The imperfect teeth are corrected by applying restoration materials using a mold of a corrected model of the patients dentition placed over the imperfect teeth. Adjacent teeth may be covered with a polymer release material prior to injection molding of teeth to be corrected, such that the teeth to be corrected have at least one tooth between them draped with the polymer release material to provide a space adjacent to each of the corrected teeth. The corrected teeth are then covered with the polymer release material in a second round of treatment and restoration material is applied to one or more previously covered teeth to provide a first layer which simulates the dentin layer of teeth. Thereafter a simulated enamel layer is applied over the dentin layer using one or more alternating molds and yet another simulated incisal layer is applied over the enamel layer using one or more alternating molds employing the techniques described.
Owner:VUILLEMOT WILLIAM C

Auxiliary treatment system and method for difficult-to-reverse suppurative periapical periodontitis

ActiveCN120661268AImage enhancementImage analysisInflammatory factorsPeriapical disease
The invention relates to the technical field of dental intelligent adjuvant therapy, and discloses an adjuvant therapy system and method for difficult-to-inverse suppurative periapical periodontitis, and the system comprises a multi-modal image fusion module which fuses CT / OCT images to generate a three-dimensional diagram, segments an infected region through a lightweight CNN, and outputs a probability diagram; the reinforcement learning debridement navigation module is used for optimizing the dentin injury risk by combining a biological membrane thickness dynamic planning path on the basis of a DDPG algorithm; the intelligent medicine control module is used for positioning a catheter according to an infection map, triggering medicine release by a pH / enzyme sensor and adjusting delivery pressure by PID; the biosensor monitoring module is used for detecting inflammatory factors, predicting the recurrence risk through LSTM, and triggering image rescanning and path updating when a threshold value is exceeded. Through multi-modal image fusion, reinforcement learning dynamic debridement navigation, microenvironment response type drug control and time sequence prediction closed-loop feedback, accurate elimination and relapse active inhibition of periapical periodontitis focuses are realized.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Anterior tooth layered resin filling repair method based on digital guide plate guiding

The invention belongs to the field of dental restoration digitalization, and particularly relates to an anterior tooth layered resin filling restoration method based on the guidance of a digital guide plate. Comprising the following steps: S1, obtaining a three-dimensional digital model of an abutment tooth preparation body; s2, generating a digital model of the dentin form of the defect part layer by layer by using oral cavity computer-aided design software; s3, completing the design of the enamel layer form on the digital model of the dentin form of the last layer of tooth defect part; s4, cover shell type guide plates covering adjacent teeth of the defective teeth are designed, and the cover shell type guide plates are numbered; s5, performing 3D printing on each layer of model and the guide plate, and checking the in-place condition of the guide plate; and S6, filling corresponding dentin resin and enamel resin in each stage of guide plate, resetting the guide plate filled with the resin to the oral dentition, and completing layered resin filling through illumination curing. According to the method, the process is optimized, the operation is simplified, and the operation precision is ensured by fully utilizing the advantages of the digital technology.
Owner:合肥市口腔医院

Method for 3D printing of gradient bionic tooth structure based on composite ceramic repair material

The invention relates to the technical field of bionic teeth, in particular to a method for 3D printing of a gradient bionic tooth structure based on a composite ceramic repair material, and the method comprises the following steps: S1, adopting lithium aluminum silicate series biological ceramic as a base material, and carrying out plasma ball milling treatment to obtain uniform powder; preparing slurry from the powder and polyethylene glycol diacrylate resin containing 3wt% of a photoinitiator according to a powder-water ratio of 42%-46%; s2, performing three-stage treatment on the slurry by using a vacuum defoaming unit; s3, constructing a gradient stress distribution model based on CT scanning data, and dividing an enamel layer, a dentin layer and a dental pulp cavity transition layer; s4, performing lamination forming on the slurry at the speed of 50 + / -5mm / s through a piezoelectric microdroplet injection system; and S5, carrying out sintering molding on the printed bionic tooth body structure by adopting a gradient sintering process. The problems that an interface between a restoration body and surrounding tissues is unstable and inflammatory reaction and rejection reaction easily occur due to the fact that a traditional restoration material is often difficult to accurately simulate the gradient structure of teeth are solved.
Owner:SICHUAN UNIV

Oral Care Compositions Comprising Dicarboxylic Acid

Oral care compositions including dicarboxylic acid and a fluoride ion source. A pH of the oral care composition can be from about 4.5 to about 7. The oral care composition can provide an enhanced anticaries benefit, a stain prevention benefit, and / or a stain removal benefit. The oral care composition can be a dentifrice composition that results in a calcium loss in dentin and / or enamel of less than 50 ppm.
Owner:PROCTER & GAMBLE CO

System and method for determining a dental condition based on the alignment of different image formats

PendingUS20250322521A1Image enhancementImage analysisCementoenamel junctionTooth enamel
A method for determining a dental condition comprising: receiving at least one volumetric image and at least one intra-oral surface scan image of a dental structure of a patient, wherein the dental structure includes at least one of a crown, root, gingiva or bone; aligning the at least one volumetric image with the at least one intra-oral surface scan image; identifying boundaries of the gingiva and the bone within the aligned images; and calculating distances between the identified boundary of the gingiva and cementoenamel junction (CEJ), the identified boundary of the bone and the CEJ, and the identified boundary of the gingiva and the identified boundary of the bone to determine the dental condition.
Owner:DGNCT LLC

Combined layered seal guide plate

The invention relates to the field of stomatology, in particular to a combined layered seal guide plate which comprises a base guide plate, a dentin layer seal guide plate and an enamel layer seal guide plate, a guide bearing piece is arranged in a preset area of the base guide plate, and a first moving piece is arranged on the outer surface of the dentin layer seal guide plate; a second moving part is arranged on the outer surface of the enamel layer seal guide plate; the dentin layer seal guide plate and the enamel layer seal guide plate are sequentially matched with the guide bearing part in the use process; according to the invention, the unified bearing guide piece is arranged on the substrate guide plate, and the subsequent dentin layer seal guide plate and enamel layer seal guide plate are guided and positioned by using the same bearing guide piece, so that the problem of inaccurate positioning between layers possibly caused by lack of common positioning reference of the traditional independent layered guide plate is effectively solved; therefore, the in-place accuracy and consistency of the seal guide plates of all the repairing layers in the repairing process are improved.
Owner:SICHUAN UNIV

Light-cured calcium hydroxide bottom-covering pith material and preparation method thereof

The invention belongs to the technical field of biomedical materials, and particularly relates to a light-cured calcium hydroxide bottom-covering pith-covering material and a preparation method thereof.The light-cured calcium hydroxide bottom-covering pith-covering material is prepared from, by mass, 1%-10% of calcium hydroxide, 10%-40% of acrylate monomers, 1%-10% of amphiphilic acrylate phosphate radical monomers, 0.1%-1% of a photoinitiator, 0.01%-0.1% of an inhibitor and the balance filler; wherein the amphiphilic acrylate phosphate radical monomer is neutralized by strong base; according to the preparation method disclosed by the invention, the amphiphilic acrylate phosphate radical monomer is neutralized by the strong base, so that the phenomenon that the amphiphilic acrylate phosphate radical monomer reacts with calcium hydroxide in advance to cause that a material is changed into a caking state from a flowing state is avoided; and meanwhile, the amphiphilic acrylate phosphate radical monomer neutralized by the strong base can still form a chemical bond with dentin in use, so that the phenomenon that the traditional light-cured calcium hydroxide underlayer pulp covering material falls off when encountering water in the dental restoration process is prevented.
Owner:CHANGZHOU DENGDASHI MEDICAL TECH CO LTD

Method for indicating the concentration level of an irrigation solution in the apical zone of a dental root canal

Method for electronically indicating a concentration of an irrigation solution in a root canal (RC) of a tooth (T), using a device able to be electrically connected to an endodontic instrument engaged in the canal and to a labial electrode, and including a screen to display the progression of the instrument in said canal relatively to a critical apical point of reference such as the cemento-dentinal junction (CDJ), said device being furthermore able to measure, in the vicinity of said point of reference, by conductimetry, a concentration of an electrolyte irrigation solution injected into the root canal.
Owner:MAILLARD THIERRY

Visual bionic dental pulp chip based on microfluidic device as well as preparation method and application of visual bionic dental pulp chip

The invention discloses a visual bionic dental pulp chip based on a microfluidic device, and a preparation method and application thereof, and belongs to the technical field of biomedicine. The visual bionic dental pulp chip comprises a micro-fluidic chip and a 3D cell reaction unit arranged on the micro-fluidic chip, a perfusion channel, a tube cavity and a liquid storage tank are arranged on the micro-fluidic chip; the 3D cell reaction unit comprises a light-cured gel coating which is coated at the bottom of the liquid storage tank and carries dentin matrix particles, and a bionic dental pulp tissue arranged on the surface of the gel coating. The invention discloses a preparation method and application of the visual bionic dental pulp chip. Based on the principle of organ chips, the micro-fluidic device is introduced into the construction of the bionic dental pulp chip, and the ecological niche of natural dental pulp tissue is simulated in vitro to the greatest extent.
Owner:成都世联康健生物科技有限公司

A dental sample digestion system and method

The present application relates to a kind of tooth sample digestion system and method, belong to tooth sample detection field, for solving the tooth sample digestion system in prior art in peeling enamel, using diamond line to cut tooth, after cutting, using scalpel and forceps to separate enamel and dentin, and manually grinding enamel, it is difficult to operate, low efficiency Problem;Including: enamel separation mechanism, enamel grinding mechanism and enamel digestion mechanism.Enamel separation mechanism is provided with grinding separation module, enamel on tooth is directly ground down, enamel is stripped down in small granular or powder form, it is convenient for subsequent enamel grinding mechanism to grind it, after grinding, enamel will become more delicate, digestion effect is better, digestion is more complete.Enamel stripping does not need to cut tooth, can realize automatic operation throughout, high efficiency.
Owner:XIAN MEDICAL UNIV

Detecting the distance of a probe to the pulp of a tooth

ActiveCN116634964BDentinTooth Tissue
A method and apparatus for detecting a distance of a probe contacting a tooth surface to a pulp of a tooth by determining an indication of a thickness of a dentin of the tooth is provided. The method includes illuminating tooth tissue of the tooth with the probe and then receiving data indicative of scattered light from the tooth tissue. A spectrum of the scattered light is then acquired and analyzed to further acquire a spectral analysis result. An indication of the thickness of the dentin of the tooth is then determined based on the spectral analysis result. The method can help prevent accidental exposure of the pulp during dental treatments such as drilling.
Owner:KONINKLIJKE PHILIPS NV

Systems and methods for dental treatment with ekf

PCT designated stageWO2026030297A1Head electrodesDental toolsOral tissueActive agent
This disclosure relates to systems and methods for the electrokinetic (EKF) delivery of therapeutic and cosmetic agents to oral tissues, including but not limited to enamel, dentin, cementum, gingiva, and mucosa. More specifically, it relates to modular, low-current dental treatment platforms configured to deliver active agents across or into oral tissues using flexible electrodes, voltage ramping logic, and optionally insulating or stabilizing structures.
Owner:T33 DENTAL INC

Method for reconstructing life history of Yangtze River main stream-Poyang Lake based on dentin Sr isotope ratio

The invention discloses a method for reconstructing the life resume of Yangtze River main stream-Poyang Lake based on a dentin Sr isotope ratio. The method comprises the following steps: collecting a tooth sample; cleaning the teeth; slicing the teeth; analyzing the 87Sr / 86Sr ratio sequence of the dentin; tooth growth layer group measurement and life history reconstruction. According to the method, the direct relation between the tooth dentin 87Sr / 86Sr ratio and the habitat 87Sr / 86Sr ratio is utilized, and the dentin 87Sr / 86Sr ratio is used as the agency of the cowfish habitat inversion. In-situ laser ablation analysis is adopted, the speed is high, the result accuracy rate is high, and the resolution ratio is high (0.25 micron level); moreover, the age information and the habitat information can be combined, the lifelong 87Sr / 86Sr ratio fluctuation condition can be provided, and the lifelong life history and migration condition of dead cowfish individuals can be traced.
Owner:FRESHWATER FISHERIES RES CENT OF CHINESE ACAD OF FISHERY SCI

Polypeptide derivative, nanofiber and application of polypeptide derivative and nanofiber in preparation of product for repairing subfissure of teeth

The invention discloses a polypeptide derivative, a nanofiber and application of the polypeptide derivative and the nanofiber in preparation of a product for repairing subfissure of teeth, the sequence of the polypeptide derivative comprises Nap-Phe-Phe-Gly-Asp-His-Thr-Lys-Glu, and Nap is 2-naphthylacetic acid. The polypeptide derivative is clear in chemical structure, small in molecular weight, single in component, simple in preparation process, low in cost, high in yield and easy to store. The polypeptide derivative disclosed by the invention is self-assembled in an aqueous solution to form the supramolecular hydrogel with a nanofiber microstructure, and the supramolecular hydrogel is high in stability and good in biocompatibility. The nanofiber hydrogel of the polypeptide derivative can interact with mineral ions and can form a crystal structure very close to natural hydroxyapatite, so that ordered formation of mineral crystals is induced at enamel and dentin hidden cracks.
Owner:TIANJIN DENTAL HOSPITAL

A pectin-coated volcanic stone oral abrasive loaded with saussurea involucrate extract and a preparation method thereof

The present application relates to the technical field of oral abrasive, in particular to a pectin-coated volcanic stone oral abrasive loaded with saussurea involucrate extract and a preparation method thereof. The oral abrasive comprises volcanic stone particles, saussurea involucrate extract, calcium pectin and an auxiliary agent. The volcanic stone particles serve as a natural porous abrasive, providing strength support and drug loading; the saussurea involucrate extract serves as an active ingredient, providing anti-inflammatory and antibacterial effects; the calcium pectin serves as a controlled-release agent and coating material, forming a gel network with calcium ions to control the release of the saussurea involucrate extract and wrapping the volcanic stone particles to form a flexible contact, buffering the direct friction of the abrasive on the tooth enamel; the components synergistically achieve the integrated effects of "physical cleaning-gel protection-traditional Chinese medicine treatment", ensuring the cleaning effect while reducing the dentin abrasion value, reducing the damage to the tooth enamel and effectively inhibiting oral pathogenic bacteria. The preparation method of the oral abrasive is simple, low in cost and has a broad application prospect.
Owner:HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV

Method and device for controlling root canal file based on dynamic torque and control equipment

The invention relates to the technical field of root canal treatment, in particular to a method, device and control equipment for controlling a root canal file based on dynamic torque, in the process that the root canal file is inserted into a root canal part and makes contact with dentin, real-time torque data generated by resistance in the process that the root canal file makes contact with the dentin are collected, and the real-time torque data are obtained; the method comprises the following steps: acquiring a real-time torque of a root canal part, performing target torque analysis matched with the real-time torque, so that the analyzed target torque meets the cutting requirement of the current dentin of the root canal part, and then controlling a root canal file to cut the dentin based on the analyzed target torque, so that the diameter change of the root canal file adapts to a root canal anatomical structure. The control accuracy of the torque of the root canal file is improved, so that the cutting accuracy, efficiency and safety of dentin are improved, the efficiency, accuracy and safety of root canal treatment are improved, and the user experience is improved. Meanwhile, the damage conditions such as bending and breakage of the root canal file can be reduced, and the service life of the root canal file is prolonged.
Owner:GUILIN WOODPECKER MEDICAL INSTR CO LTD

A method for constructing calcium phosphate nanoclusters biomimetic mineralized dentin using gallic acid

The present invention relates to the technical field of dentin repair, and in particular to a method for constructing a biomimetic mineralized dentin with calcium phosphate nanoclusters using gallic acid. The reagent combination includes a gallic acid-calcium phosphate solution, and the raw materials of the gallic acid-calcium phosphate solution include gallic acid, a calcium ion source, and a phosphorus ion source; the molar ratio of the calcium element in the calcium ion source to the gallic acid is 0.01-0.1, and the molar ratio of the calcium element in the calcium ion source to the phosphorus element in the phosphorus ion source is 0.1-5. This technical scheme can solve the technical problem that the prior art lacks an effective method for promoting dentin mineralization. By using gallic acid biomimetic mineralized dentin, by mixing gallic acid and calcium ion solution in a specific molar ratio, slowly adding a phosphate ion solution dropwise to the pre-mixed solution, a calcium phosphate nanocluster of biomimetic mineralized dentin can be prepared to achieve effective mineralization repair. Gallic acid is a cheap, edible compound, and this scheme has an ideal application and promotion prospect.
Owner:CHONGQING UNIV +1

DNMTi (at) ZIF-8 nano-composite and application thereof

The invention relates to the technical field of oral medicine, in particular to a DNMTi and ZIF-8 nano-complex and application thereof.The DNMTi and ZIF-8 nano-complex is technically characterized in that in-situ synthesized zeolite imidaze-8 (ZIF-8) is adopted for delivering a DNA methyltransferase inhibitor (DNMTi), dental pulp stem cell (DPSC) cell spheres are combined, the DNMTi and ZIF-8 nano-complex can be used for bionic therapy, the activity of medicine is prolonged, and the effect of treating dental pulp stem cells is achieved. And zinc ions are continuously released to activate a PI3K-AKT signal channel, so that the dentin differentiation of stem cells and the generation of blood vessels are promoted. Through accurate simulation of a tooth development microenvironment, the biomimetic therapy can realize regeneration of a dental pulp-dentin complex. The therapy for simulating the tooth development process not only solves the key problems in the dental tissue engineering, but also opens up a new direction for treating the dental pulp and periapical diseases, and highlights the wide application prospect in regenerative medicine.
Owner:SICHUAN UNIV