4 results about "Root caries" patented technology

The invention discloses a decayed tooth semantic segmentation method based on structure perception, and belongs to the field of oral clinical image analysis. The invention provides a segmentation method combining anatomical structure constraint and dynamic training regulation for solving the problem of supervision bias caused by low contrast of a dental caries focus, remarkable background structure interference and a minimum target. The method comprises the following steps: firstly, constructing a continuous space proximity field taking a focus as a center, and quantifying anatomical proximity of a background and the focus; and on the basis of a multi-scale fuzzy hierarchy generation mechanism, a progressive fuzzy background of a continuous anatomical gradient is generated through fuzzy layer interval selection and pixel-level weighted fusion so as to simulate a visual attenuation rule of dental caries focus centralization and weaken high-similarity gray background noise. In the training stage, a four-stage focusing gradient weight scheduling strategy is constructed, so that the model is gradually transited from global anatomical structure learning to focus area strengthening. The method does not need to change the basic structure of an existing segmentation network, and can improve the dissection consistency and boundary stability of dental caries segmentation.

Oral composition comprising glutamate, or glutamine, solvate or hydrate thereof, for use in the treatment and / or prevention of caries, wherein the composition is orally administered and increases the pH of the saliva, reducing the risk of caries development. Said oral composition increases the amount of health-associated bacteria and / or decreases the amount of disease-associated bacteria and is useful for the treatment and / or prevention of oral diseases, such as periodontal diseases, halitosis and diseases caused by Candida. Method to determine the response of a mammal to the treatment with glutamate, or with glutamine, solvate or hydrate thereof, comprising determining in saliva the amount of health-associated or disease-associated bacteria or a dysbiosis index, and identifying the mammal as responsive or non-responsive to the treatment.

This invention discloses a synergistic anti-caries oral care composition and its application. The composition comprises: (a) a single-domain antibody targeting the Streptococcus mutans surface protein PAc; (b) a plant extract complex containing kudzu root extract and phellodendron bark extract; and (c) gallic acid liposomes. This invention also provides a toothpaste containing this composition and a method for its preparation. Experiments have shown that the single-domain antibody can specifically bind to and disturb the Streptococcus mutans biofilm, increasing cell membrane permeability and synergistically promoting the entry of plant extracts into the cell to exert a bactericidal effect, achieving a clearance rate of over 98% for mature biofilms. Through formulation and process optimization, this invention solves the stability problem of antibodies in toothpaste; the product retains more than 90% of its activity after two years of storage at 25°C. The composition and product provided by this invention have the advantages of highly efficient removal of mature biofilms, synergistic effect, safety with low damage, and excellent stability, and have broad application prospects in the field of oral care.

To provide a carious tooth structure recovery agent that has convenience to treat multiple teeth at once, has aesthetics without discoloration of the treated area, and is capable of performing the preventive care for root surface caries and the initial caries treatment, and the carious tooth structure recovery agent contains a compound (a) having an acidic group represented by the following formula (I): R1—X (I) (in which R1 represents an organic group having 40 or less carbon atoms that has or does not have at least one (meth)acryloyloxy group, and X represents an acidic group), a zinc ion (b1), water (c), and a hydrophilic solvent (d), and substantially does not contain a crosslinkable polymerizable monomer.