136 results about "Tooth Tissue" patented technology

Tooth tissues include the pulp mesenchyme that forms the dentin and an epithelium that is responsible for enamel formation. Cells from these tissues were obtained from porcine third molars and were seeded onto a biodegradable scaffold composed of a polyglycolic acid—polylactic acid copolymer. Cell polymer constructs were then surgically implanted into the omentum of athymic nude rats so that the constructs would have a blood supply and these tissues were allowed to develop inside the rats. Infrequently, columnar epithelial cells were observed as a single layer on the outside of the dentin-like matrix similar to the actual arrangement of ameloblasts over dentin during early tooth development. Developing tooth tissues derived from such cell polymer constructs could eventually be surgically implanted into the gum of an edentulous recipient where the construct would receive a blood supply and develop to maturity, providing the recipient with a biological tooth replacement.

A method for obtaining an image of tooth tissue directs incident light toward a tooth (20), wherein the incident light excites a fluorescent emission from the tooth tissue. Specular reflection of incident light from the tooth tissue is reduced. Fluorescence image data (50) is obtained from the fluorescent emission. Back-scattered reflectance image data (52) is obtained from back-scattered light from the tooth tissue. The fluorescence and back-scattered reflectance image data are combined to form an enhanced image (64) of the tooth tissue for caries detection.

A method for forming an enhanced image of tooth tissue for caries detection obtains fluorescence (50) and reflectance (52) image data from a tooth (20). Each pixel in the fluorescence image data is combined with its corresponding pixel in the reflectance image data by subtracting an offset to the reflectance image data value to generate an offset reflectance image data value, and then computing an enhanced image data value according to the difference between the fluorescence image data value and the offset reflectance image data value, whereby the enhanced image (64) is formed from the resulting pixel array of enhanced image data values.

Oral phototherapy applicators are disclosed that are sized and shaped so as to fit at least partially in a user's mouth with a plurality of bristles of elongate shape coupled to an apparatus body. The Applicators can be adapted to brush the user's teeth and further include at least one radiation emitter coupled to the body to provide phototherapeutic radiation to a portion of the oral cavity other than tissue in contact with the bristles. In one embodiment, the phototherapy emitter irradiates both a region of tissue in contact with the bristles and a portion of the oral cavity that is not in contact with the apparatus. For example, the apparatus can include at least one emitter that irradiates tooth tissue in contact with the bristles and gum tissue surrounding the tooth tissue.

A method for caries detection uses an image capture device (30, 32) to obtain fluorescence image data from the tooth (20) by illuminating the tooth to excite fluorescent emission. A first enhanced image of the tooth is then obtained by illuminating the tooth at a first incident angle, obtaining a back-scattered reflectance image data from the tooth tissue, and combining the back-scattered reflectance image data with the fluorescence image data. A second enhanced image of the tooth is then obtained by illuminating the tooth at a second incident angle, obtaining a back-scattered reflectance image data from the tooth tissue, and combining the back-scattered reflectance image data with the fluorescence image data. The first and second enhanced images are then analyzed to select and display the best-contrast image. This method provides high contrast images for carious regions (58) on all tooth surfaces.

A method for quantifying caries, executed at least in part on data processing hardware, the method comprising generating a digital image of a tooth, the image comprising intensity values for a region of pixels corresponding to the tooth, gum, and background; extracting a lesion area from sound tooth regions by identifying tooth regions, extracting suspicious lesion areas, and removing false positives; identifying an adjacent sound region that is adjacent to the extracted lesion area; reconstructing intensity values for tooth tissue within the lesion area according to values in the adjacent sound region; and quantifying the condition of the caries using the reconstructed intensity values and intensity values from the lesion area.

A method for quantifying caries, executed at least in part on data processing hardware, the method comprising generating a digital image of a tooth, the image comprising intensity values for a region of pixels corresponding to the tooth, gum, and background; extracting a lesion area from sound tooth regions by identifying tooth regions, extracting suspicious lesion areas, and removing false positives; identifying an adjacent sound region that is adjacent to the extracted lesion area; reconstructing intensity values for tooth tissue within the lesion area according to values in the adjacent sound region; and quantifying the condition of the caries using the reconstructed intensity values and intensity values from the lesion area.

A method for forming an enhanced image of tooth tissue for caries detection obtains fluorescence (50) and reflectance (52) image data from a tooth (20). Each pixel in the fluorescence image data is combined with its corresponding pixel in the reflectance image data by subtracting an offset to the reflectance image data value to generate an offset reflectance image data value, and then computing an enhanced image data value according to the difference between the fluorescence image data value and the offset reflectance image data value, whereby the enhanced image (64) is formed from the resulting pixel array of enhanced image data values.

A method for caries detection uses an image capture device (30, 32) to obtain fluorescence image data from the tooth (20) by illuminating the tooth to excite fluorescent emission. A first enhanced image of the tooth is then obtained by illuminating the tooth at a first incident angle, obtaining a back-scattered reflectance image data from the tooth tissue, and combining the back-scattered reflectance image data with the fluorescence image data. A second enhanced image of the tooth is then obtained by illuminating the tooth at a second incident angle, obtaining a back-scattered reflectance image data from the tooth tissue, and combining the back-scattered reflectance image data with the fluorescence image data. The first and second enhanced images are then analyzed to select and display the best-contrast image. This method provides high contrast images for carious regions (58) on all tooth surfaces.

Described are a handpiece, a coupling, and a device with a laser source and handpiece for emitting a laser beam for dental treatment. In order to avoid damage to the healthy tooth tissue, an improved determination of the tooth temperature by measurement of at least part of the heat radiation emitted from the treatment area using a temperature sensor, preferably an infra-red sensor, is carried out. Upon reaching or exceeding a temperature threshold, the emission of the laser beam to the treatment area is interrupted or the power output of the laser source reduced or the user made aware of the violation of the threshold value using an acoustic or visual signal. The temperature sensor can be located, e.g., on the handpiece or on the coupling, such as on the coupling tube.

Fluoride varnish compositions for temporary application and adhesion to a person's teeth. The composition includes a carrier comprising a resin and an adhesion promoting agent comprising an alkyl phosphoric acid. A fluoride ion source (e.g., a fluoride salt such as sodium fluoride) is dispersed within the carrier so as to provide biologically available fluoride ions to the tooth tissue being treated. The composition adheres only temporarily to tooth tissue (e.g., for a period of at least about 4 minutes, but not more than about 1 year), after which the composition spontaneously wears away as a natural result of the action of the tongue, saliva and / or other factors.

A root canal is filled and / or sealed using a hydrophilic sealing composition, optionally in combination with other filling materials. The sealing composition may include one or more resins that promote adhesion to hydrophilic dental tissues: The composition may be introduced into the root canal using a narrow cannula coupled to a high pressure hydraulic delivery device. In the case where a chemical cure composition is used to seal the root canal, a chemical initiator can be used to cause the mixed composition to harden over time. Hardening of at least a portion of the composition can be accelerated by including a photoinitiator and irratiating the mixed composition with radiant energy (e.g., from a dental curing lamp).

A method and a device for treating dental caries using microwave energy applied directly to teeth at frequencies that are lethal to the bacteria in caries, without being destructive to tooth tissues. The method and a device will have a significant economic and health impact, leading to a reduction in traditional surgical interventions, as well by improving access to care for those with health disparities.

A probe comprising two spaced electrodes is provided between which electrical resistance through enamel, dentine or tooth tissue is measured. The electrodes comprise inner and outer coaxial electrodes spaced by an insulating layer. The diameter of the probe is preferably 1 mm. The tip of the probe may be shaped to match the surface being measured. The signal from the probe is A to D converted for analysis. The rate of change of resistance gives a measure of the rate of change of moisture level (porosity). The porosity is related to tooth sensitivity and so the system can provide an objective measurement of tooth sensitivity.

The invention discloses a computer-aided design making method for a dental personalized integrated non-metal post core. The method comprises the following steps of: 1, performing tooth preparation to make a silicon rubber impression duplication defect tooth form; 2, acquiring impression three-dimensional data by using a high-accuracy optical scanner; 3, selecting a proper crown core from a database; 4, finishing stitching and processing of defect root canal and section data and crown core data through three-dimensional design software, and establishing a virtual model for the personalized integrated post core; and 5, importing post core data in an STL (Standard Template Library) format into a computer-aided making numerical control center, and selecting a proper non-metal blank to process into a personalized integrated post core entity. Through the computer-aided design making method for the dental personalized integrated non-metal post core, the processes of perfusion of a plaster model, making of a wax pattern and the like are saved, a processing period is shortened, a making error is reduced, higher accuracy can be achieved, the post core entity and the remaining tooth tissue have better fitness, the fracture resistance of a post core prosthesis can also be enhanced, and the risk of repair failure is reduced.

This invention relates generally to methods and compositions for bioengineering tooth tissue, as well as methods of producing new tooth tissue in a subject.

The invention is directed to a powder composition for air polishing the surface of hard dental tissue comprising a powder of water-soluble organic particles as component A, a powder of inorganic anti-caking agent(s) particles as component B and a powder of antihypersensitive acting particles as component C, the mean particle size of component A being in a range from about 15 to about 500 μm, the mean particle size of component C being in a range from about 0.5 to about 10 μm. The invention is also directed to a kit of parts comprising the powder composition and its use.

The invention relates to a method for isolating non-embryonic stem cells from a tissue that is located in immediate vicinity of immature, developing teeth or wisdom teeth. The invention further relates to non-embryonic stem cells derived from said tissue. The method according to the invention utilises a living soft tissue residing underneath the dental papilla 12 in immediate vicinity of the apical side of a developing tooth, which is clearly distinguished from other tooth tissue, such as dental papilla 12 or follicle. The pad-like tissue 16 can only be detected in a defined, specific developmental stage in an early phase of root formation. That is, identifying and separating the pad-like tissue 16 is only possible from the appearance of the bony alveolar fundus to the end of the formation of the root of the tooth.

The invention relates to a decalcified dental matrix of a mammal and a preparation method thereof. The raw material is from permanent teeth of the mammal. The preparation method comprises the following steps: (1) collecting permanent teeth of the mammal for later use; (2) soaking the permanent teeth in a 50% 84 disinfectant for sterilizing, wherein the time for sterilizing is 45 minutes and the temperature is 35-40DEG C; (3) removing useless parts of the teeth; (4) smashing tooth tissues into particles; (5) sterilizing the smashed tooth tissue particles, wherein the time for sterilizing is 45 minutes and the temperature is 35-40DEG C; (6) putting the treated tooth tissue particles into 0.65-0.72 equivalent weight of hydrochloric acid liquid for soaking for 10-16 hours at 34-38DEG C to finish decalcification; and (7) drying at low temperature, soaking in hydrogen peroxide for 30 minutes, so as to obtain the decalcified dental matrix of the mammal. The decalcified dental matrix of the mammal has better inductive bone regenerative action, and does not carry any pathogenic factor after being prepared into final products.

The invention provides a composite material for tooth hard tissue remineralization. The composite material comprises a simulation body fluid, and is improved in that the simulation body fluid is added with 0.1+ / -0.001% by weight of carboxymethyl chitosan and 0.025+ / -0.005% by weight of an amorphous calcium phosphate component. According to the present invention, after using the composite material, the remineralization effect can be provided for the demineralized tooth tissue, characteristics of no toxicity, no irritating, good biocompatibility and low allergenicity are provided, good inhibition effects are provided for oral cariogenic bacteria such as Streptococcus mutans, and the use effect is good.

The invention discloses a regulating method of a WDR63 gene in osteogenic differentiation and odontogenicdifferentiation processes of a mesenchymal stem cell. The cell is replanted by virtue of cell culture, chromatin immunoprecipitation reaction and data analysis, plasmid construction and virus infection, western blotting analysis, cell reproductive capacity determination and alkaline phosphatase and alizarin red dyeing subcutaneously of a nude mouse, and the regulating effect of the WDR63 gene in osteogenic differentiation and odontogenic differentiation processes of the mesenchymal stem cell and the effect of promoting regeneration of tooth tissues are found. By virtue of the adjusting effect of gene activity and function of the mesenchymal stem cell by trimethylation of lysine on the fourth site of histone 3, the regulating effect of the WDR63 gene in osteogenic differentiation and odontogenicdifferentiation processes of the mesenchymal stem cell and the effect of the WDR63 gene in promoting regeneration of tooth tissues, the WDR63 gene obtained probably has a promoting effect on osteogenic differentiation of stem cells from apical papilla.

The invention provides a method and device for analyzing an oral tissue and especially analyzing the tooth tissue of a tested target as well as a dental analysis system. An oral image of the tested target is processed, for example a color value of the oral image is adjusted, so that a to-be-analyzed oral tissue area, for example, all or partial teeth (such as at least one tooth or at least two teeth) in the oral cavity is highlighted. Therefore, the highlighted to-be-analyzed oral tissue area can be selected so as to be analyzed. By adopting the method and system, the health situation of the teeth can be conveniently and rapidly judged, the tested target does not need to be photographed for multiple times, and a complicated programming algorithm is not needed.

The invention relates to a method for isolation of multipotent stem cells from dental tissue in which the stem cells are extracted from a tissue structure and then cultured. The invention also relates to stem cells isolated by means of the method according to the invention as well as bone cells and nerve cells produced by means of the method according to the invention. The invention also relates to a method for producing a bank of stem cells in which the cells are stored by means of the method according to the invention. According to the present invention, the cells of a pad-like soft tissue that can be localized beneath the papilla directly on the apical side of an extracted immature tooth are cryopreserved in the tissue structure such that the tissue structure is disintegrated to extract the stem cells only after thawing. These results show that stem cells / progenitor cells can be isolated even after cryopreservation of the source tissue and these stem cells / progenitor cells respond to osteogenic stimulation. In addition, the response of cells after cryopreservation turns out to be stronger than that without cryopreservation.

The invention discloses an ultrasound auxiliary extracorporeal mouth fast grinding repairing simulation device which comprises an adjustable rack and a simulation grinding repairing system, wherein an axial ultrasound vibration system (3) and a horizontal ultrasound vibration system (4) are arranged in the simulation grinding repairing system, an energy exchanger A (3-5) and an energy exchanger B (4-5) are respectively arranged in the two systems, an ultrasonic wave power supply enables a workpiece to vibrate along the plumb line and the horizontal plane through the two energy exchangers, the linear vibrations of the two directions combine into elliptic vibration, the two-dimensional elliptic ultrasonic vibration of the workpiece is conducted, the Two-dimensional elliptic ultrasonic auxiliary fast cutting and grinding operation is conducted on tooth tissue and dentistry repairing materials, and the force, heat and noise change is observed to study the improving effect of the ultrasonic assistance to a mouth grinding operation. The simulation device is simple and compact in structure and convenient to operate.

A process for separating and culturing the ectomesenchyme stem cells which can be used for bone tissue engineering, muscle tissue engineering, tooth tissue engineering and repairing peripheral nerve nicludes such steps as preparing culture medium, separating, culturing and purifying.

Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF.

The invention discloses mesoporous bioactive glass / poly(lactic-co-glycolic acid) (PLGA) composite microspheres and a preparation method and application thereof. The mesoporous bioactive glass / poly(lactic-co-glycolic acid) (PLGA) composite microspheres are prepared by the following method of: firstly, preparing mesoporous bioactive glass by using a microemulsion technology in combination with a sol-gel template method, then sequentially adding PLGA, span 80 and the mesoporous bioactive glass into dichloromethane, and carrying out uniform stirring and ultrasonic dispersing to form S / O emulsion;and sequentially adding the S / O emulsion into prepared polyethylene solution W1 and W2 with different concentration, stirring to evaporate a solvent, and carrying out washing, centrifugation, and freeze-drying to obtain the product. The preparation process flow of the composite microspheres is easy to control, and due to the addition of the mesoporous bioactive glass, the bone induction capabilityand the drug loading and slow release capability of the composite microspheres are improved; and the composite microspheres have good application prospect in the fields of bone and tooth tissue repair, tissue engineering and slow release carriers such as drugs, proteins and genes and the like.

The invention discloses a 2.79 mu m Q-switched erbium laser dental instrument. The 2.79 mu m Q-switched erbium laser dental instrument comprises a laser power supply, a laser component, a laser water cooling system, a light guide output system, a gas and water spraying system and a central control system; the laser power supply is used for providing energy to the laser component; the laser component consists of a total-reflection chamber piece, a polarizer, a Q-switched crystal, a xenon lamp, a laser rod, a light condensing chamber, a wave plate and an output chamber piece; the laser water cooling system is used for cooling the laser rod and the xenon lamp in the laser component; the light guide output system is used for conducting laser, and is convenient to operate and use; the gas and water spraying system is used for spraying a mixture of gas and water to a laser acted tooth tissue, and has the effects of reducing the temperature of the tissue and participating laser treatment; the central control system is used for controlling the parameters of the laser power supply, the laser water cooling system and the gas and water spraying system to ensure the coordination work among the subsystems. The 2.79 mu m Q-switched erbium laser dental instrument has pulse Q-switched laser which has short pulse width and high peak power and acts the tooth tissue to improve ablation precision; meanwhile, the thermal damage to peripheral tissues also can be effectively reduced; the pain of a patient can be reduced effectively.

The invention discloses a high-biological activity composite material for promoting bone regeneration repair and a preparation method thereof. The preparation method comprises the following steps of respectively weighing 2 to 20wt% of foreign ion-doped calcium silicate powder, 40 to 60wt% of alpha-calcined gypsum powder and 20 to 40wt% of a mixed liquid, mixing them, stirring the mixture to obtain uniform paste, and carrying out hydration of the uniform paste to obtain the high-biological activity composite material which is a self-curing material. The high-biological activity composite material has self-curing performance, injectable performance, high strength and rapid degradation performance. The preparation method has simple processes. The high-biological activity composite material has excellent biological activity and degradability and can be used for fast and complete regeneration repair of bone defects in bone tooth tissue, root canal filling and slow-release carriers of bone disease-treatment drugs.