High-biological activity composite material for promoting bone regeneration repair and preparation method thereof

A bioactive, composite material technology, applied in the field of highly bioactive composite materials and preparations for promoting bone regeneration and repair, can solve problems such as difficulty in promoting bone defects, and achieve the effects of improving mechanical strength, excellent biological activity, and efficient degradability

Inactive Publication Date: 2013-08-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some studies have also proved that the degradation rate of pure calcium silicate porous ceramics in living animal bone injuries is faster than the osteogenesis rate of new bone, so it is difficult to meet the requirements of promoting bone defects. materials such as β-tricalcium phosphate to construct porous composites (Xu S, et al. Biomaterials , 2008; 29: 2588)

Method used

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  • High-biological activity composite material for promoting bone regeneration repair and preparation method thereof
  • High-biological activity composite material for promoting bone regeneration repair and preparation method thereof
  • High-biological activity composite material for promoting bone regeneration repair and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0045] 1) Will contain 0.24 mol / L CaCl 2 and 0.01 mol / L SrCl 2 200 mL of aqueous solution was added dropwise to 200 mL of magnetically stirred 0.25 mol / L sodium silicate aqueous solution. After the dropwise addition was completed, the reaction sediment was filtered, washed three times with deionized water, and then washed once with ethanol. 80 o C drying, and then placed in a high temperature furnace at 850 o Calcined at C for 2 hours to obtain strontium ion-doped calcium silicate powder, the particle size was analyzed by a particle size detector, and the particle size was between 2 and 26 μm, and the strontium content in the powder was 0.31 μm by atomic absorption spectrometry. %; It can be seen that the powder is calcium silicate (such as figure 1 shown), and its powder is fine particles with certain agglomeration (such as figure 2 shown).

[0046] 2) Prepare 4 L mixed aqueous solution with calcium sulfate dihydrate, sodium chloride and citric acid at the mass volume ...

Embodiment 2

[0049] 1) Will contain 0.27 mol / L Ca(NO 3 ) 2 and 0.01 mol / L MgCl 2 500 mL of the aqueous solution was added dropwise to 500 mL of magnetically stirred 0.28 mol / L sodium silicate aqueous solution. After the dropwise addition was completed, the reaction sediment was filtered, washed three times with deionized water, and then washed once with ethanol, and then at 85 o C drying, and then placed in a high temperature furnace at 1150 o Calcined at C for 2 hours to obtain magnesium ion-doped calcium silicate powder, the particle size was analyzed by a particle size detector, and the particle size was between 6 and 31 μm, and the magnesium content in the powder was 0.30 μm by atomic absorption spectrometry. %.

[0050] 2) Prepare 2 L mixed aqueous solution with calcium sulfate dihydrate, sodium chloride and citric acid at the mass volume concentration of 15%, 15% and 0.10% respectively. o C under continuous mechanical stirring for 4.5 hours, then filtered, washed twice with boi...

Embodiment 3

[0053] 1) Will contain 0.23 mol / L CaCl 2 and 0.02 mol / L Zn(NO 3 ) 2Add 1,000 mL of inorganic salt solution dropwise to 1,000 mL of magnetically stirred 0.25 mol / L sodium silicate aqueous solution. After the dropwise addition, filter the reaction sediment, wash it with deionized water three times, and then wash it once with ethanol. , at 80 o C drying, and then placed in a high temperature furnace at 750 o Calcined at C for 2 hours to obtain zinc ion-doped calcium silicate powder, the particle size was analyzed by a particle size detector, and the particle size was between 9 and 32 μm, and the zinc content in the powder was 1.45 μm by atomic absorption spectroscopic analysis. %.

[0054] 2) Prepare 5 L mixed aqueous solution with calcium sulfate dihydrate, sodium chloride and citric acid according to the mass volume concentration of 15%, 15% and 0.06% respectively. o Continue mechanical stirring at C for 6 hours, then filter, wash with boiling water twice, wash with ethan...

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Abstract

The invention discloses a high-biological activity composite material for promoting bone regeneration repair and a preparation method thereof. The preparation method comprises the following steps of respectively weighing 2 to 20wt% of foreign ion-doped calcium silicate powder, 40 to 60wt% of alpha-calcined gypsum powder and 20 to 40wt% of a mixed liquid, mixing them, stirring the mixture to obtain uniform paste, and carrying out hydration of the uniform paste to obtain the high-biological activity composite material which is a self-curing material. The high-biological activity composite material has self-curing performance, injectable performance, high strength and rapid degradation performance. The preparation method has simple processes. The high-biological activity composite material has excellent biological activity and degradability and can be used for fast and complete regeneration repair of bone defects in bone tooth tissue, root canal filling and slow-release carriers of bone disease-treatment drugs.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a composite material with high bioactivity for promoting bone regeneration and repair and a preparation method thereof. Background technique [0002] Bone damage caused by trauma, infection, tumor, osteoporosis, osteonecrosis, etc. requires filling and repairing of the defect to restore biological function. Autologous bone grafting has always been the gold standard for bone grafting, which not only provides a scaffold for new bone growth, but also contains a large number of active osteocytes that can promote osteogenesis and osteoinduction (Cypher TJ, Grossman JP. J Foot Ankle Surg . 1996; 35: 413). However, clinical effects cannot be effectively guaranteed during transplantation (Sandhu HS, Grewal HS. Orthop Clin North Am . 1999; 30: 685). At the same time, the amount of bone that can be obtained from autologous bone is extremely limited, causing secondary trauma, pain and other compl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02
Inventor 苟中入杨国敬林冕王俊诚杨贤燕陈晓怡张雷杨国利
Owner ZHEJIANG UNIV
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