60 results about "Autologous bone" patented technology

The invention discloses a preparation method and application of high-strength, high-inorganic-ratio and degradable organic-inorganic composite hydrogel, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by weight: 30 to 70 percent of calcium phosphate nano-cluster and 30 to 70 percent of sodium alginate. The organic-inorganic composite hydrogel is beneficial to proliferation and mineralization of bone cells, and more ideal bone guidance is realized. Experimental results prove that the material has good cytocompatibility, can quickly promote rat skull defect repair (8 mm limit bone injury repair time is shortened to 4 weeks), and has a more remarkable healing effect compared with a contrast autogenous bone graft material with an optimal clinical repair effect. The high-strength organic-inorganic composite hydrogel prepared by the invention is of a single-network structure, shows good mechanical properties, also has excellent degradability matched with tissues, and is beneficial to hard tissue repair.

The invention belongs to the technical field of bone tissue cryopreservation, and specifically is a method for long-term cryopreservation of autologous bone tissue, comprising the following steps: S1, obtaining a bone tissue sample, washing the bone tissue with physiological saline or phosphate buffer, and removing blood and other residues; S2, preparing a cryopreservation medium, pouring the cryopreservation medium into an inner barrel of a preservation device, wrapping the bone tissue sample with a gauze net bag and hanging it under the middle sealing cover of an outer barrel, and the outer barrel and the inner barrel can slide relative to each other, thereby sinking the bone tissue sample into the cryopreservation medium for preservation; S3, placing the preservation device in a freezing device to pre-freeze the bone tissue; S4, after the pre-freezing is completed, taking out the preservation device and putting it into a liquid nitrogen storage tank to preserve the bone tissue at low temperature; the invention separates the bone tissue and the cryopreservation medium before taking out, so as to reduce the subsequent cleaning workload, reduce the work intensity of medical staff, and improve work efficiency.

The invention provides a preparation method of a skull for autologous replantation, and relates to the technical field of skull treatment. The method comprises the following steps that the taken-out autologous skull is subjected to ultraviolet radiation and then conveyed into a clean room to be subjected to photographing treatment; sequentially carrying out iodophor soaking, alcohol soaking and normal saline flushing on the skull, and then carrying out surface tissue impurity removal and cleaning on the skull; putting the treated skull into a packaging bag, adding a cryopreservation solution to wrap the skull, and then performing vacuumizing and sealing treatment; and sterilizing and cooling the skull subjected to the sealing treatment, and finally feeding the skull into a bone library for cryopreservation. According to the method, the skull of a patient is taken out after an operation to serve as an autologous bone raw material, so that the skull has bone activity within a certain period of time, finally, the skull is replanted to the skull of the patient, the body burden and conflict psychology of the patient are reduced, the exclusive transportation, treatment and storage modes are adopted, the rejection of the patient is reduced, the risk of bone resorption is reduced, and the bone activity is guaranteed; the replanting rate is increased.

The utility model relates to an artificial dental implant in a planting area with insufficient bone height, which is integrally mounted in an alveolar bone planting hole and comprises an anchor bearing and a connecting column, the upper end of the connecting column is connected with an abutment for mounting a dental crown, and the lower end of the connecting column is vertically fixed at the top of the anchor bearing; the anchor seat sinks into the bottom of the alveolar bone implanting hole, the plane area of the anchor seat is increased compared with that of the connecting column, the anchor seat is provided with a plane bottom surface, the bottom surface is in contact with the bottom wall surface of the alveolar bone implanting hole, and the side surface of the anchor seat is tightly attached to the side wall of the alveolar bone implanting hole; and the space of the alveolar bone implanting hole at the side part of the connecting column is filled with autologous bone powder. The implant has the advantages that 1) the thinner connecting column is matched with the larger anchor seat to form a countersunk head anchor, and the implant is anchored in an alveolar bone by utilizing biological growth, so that the effect of enough stability can be achieved although the embedding depth is low, and the trauma risk of a nerve tube in an operation is solved; and 2) the bottom of the implant provided by the utility model is of a flat bottom structure, so that the occlusion stress is effectively dispersed, and the use risk is solved.

The invention relates to a 3D printing porous metal-ceramic assembled composite implant as well as a preparation method and application thereof. The 3D printing porous metal-ceramic assembled composite implant comprises a porous metal-ceramic implant body formed by compounding a 3D printing integrated porous metal module and a 3D printing integrated porous ceramic module, the porous metal-ceramic implant body and the net-shaped metal protection body are arranged on the periphery of the porous metal-ceramic implant body in a wrapping mode, and the assembled composite implant can be accurately matched with the appearance and the combination surface of bone tissue of a defect part. The composite implant disclosed by the invention has osteogenesis environment regulation and control functionalization, and can achieve the effects of immediately recovering the movement function of defective bone tissue, improving the tissue microenvironment of a bone defect part, accelerating new bone regeneration and guiding new bone to grow towards the interior of the porous metal implant, so that rapid osseointegration of a bone / metal implant interface is realized; and the long-term treatment effect of 3D printing porous metal implant / autologous bone fusion type repair after ceramic degradation is achieved.

The invention discloses a digital guide plate for oral cavity tumor excision and contemporaneous bone implantation and a preparation method, the digital guide plate comprises a tumor excision indication guide plate, an autogenous bone osteotomy indication guide plate, an implantation indication guide plate, an implantation reduction guide plate and an autogenous bone reduction guide plate, and the preparation method comprises the following steps: constructing a virtual model and determining a tumor excision range; oral implantation planning is conducted, the position and range of a reconstructed titanium plate are determined, a digital guide plate is printed in a 3D mode, and a temporary abutment is connected to an implantation reduction guide plate through model operation training. By applying the digital guide plate, tumor resection, autogenous bone resection, autogenous bone reduction and precise implant implantation can be achieved in the same operation process. The digitized guide plate is used for guiding the implant to be implanted, the position of the implant is used as a reference, autogenous bone reduction can be accurately guided, and the precision of implant repair can be remarkably improved. The technical problems that in the prior art, the implant position is judged according to experience of doctors, and the autogenous bone reduction precision is not ideal can be solved.

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The utility model provides an intraoperative autogenous bone granule crushing device, and belongs to the technical field of medical treatment. Comprising a bone crushing outer cylinder; the bone crushing inner cylinder is positioned in the bone crushing outer cylinder; a crushing structure is mounted on the bone crushing inner cylinder; the driving part is positioned on the bone crushing inner cylinder and is used for driving the bone crushing inner cylinder to rotate; the bone crushing ring is positioned on the inner wall of the bone crushing outer cylinder and is in threaded connection with the inner wall of the bone crushing outer cylinder; and the transmission rod is mounted on the driving part and rotates along with the driving part. According to the bone crusher, the crushing structure on the bone crushing inner cylinder is matched with the crushing structure on the inner wall of the bone crushing ring, the bone crushing ring can move up and down in the bone crushing outer cylinder through the two-way thread structure, bone crushing materials are crushed from multiple dimensions, and compared with the prior art, the bone crusher can more effectively enable the sizes of crushed bone particles to be more uniform, so that the bone crushing efficiency is improved. The strict requirements on the size and the uniformity of the small-particle crushed bone in the operation are met, and the stable performance of the crushed bone material in the subsequent operation is facilitated.

The invention belongs to the technical field of bone tissue cryopreservation, and specifically is a method for long-term cryopreservation of autologous bone tissue, comprising the following steps: S1, obtaining a bone tissue sample, washing the bone tissue with physiological saline or phosphate buffer, and removing blood and other residues; S2, preparing a cryopreservation medium, pouring the cryopreservation medium into an inner barrel of a preservation device, wrapping the bone tissue sample with a gauze net bag and hanging it under the middle sealing cover of an outer barrel, and the outer barrel and the inner barrel can slide relative to each other, thereby sinking the bone tissue sample into the cryopreservation medium for preservation; S3, placing the preservation device in a freezing device to pre-freeze the bone tissue; S4, after the pre-freezing is completed, taking out the preservation device and putting it into a liquid nitrogen storage tank to preserve the bone tissue at low temperature; the invention separates the bone tissue and the cryopreservation medium before taking out, so as to reduce the subsequent cleaning workload, reduce the work intensity of medical staff, and improve work efficiency.

The present invention relates to a guide for an autologous bone graft, in a printed model of a jaw (1) of a patient, which comprises a stop (3) formed by a perforated plate, from which support projections (4,5,6) emerge for supporting the alveolar bone of the patient's jaw or maxillary, which define through holes between the projections (4,5,6), the stop (3) having respective grooves (31) on the sides of the projections (4,5,6) to support the sheets (0). The invention may comprise brackets (2) that can be attached to the printed model, facing the grooves or a screw hole (32) for screwing to the teeth.

The invention belongs to the technical field of medical experimental animal models, and discloses a small animal model for skull base high-flow cerebrospinal fluid leakage and skull base reconstruction as well as a construction method and application of the small animal model. The technical obstacle that due to the fact that the nasal cavity of a small animal is narrow and the turbinate structure is complex, surgical instruments cannot reach the skull base through the nose is overcome, meanwhile, a modeling and repairing area is arranged on the rear nasal meatus and the top wall of the nasopharynx, and the temperature and humidity conditions and environment of the nasal mucosa are reserved; and the microenvironment for tissue healing after the endoscopic transnasal skull base surgery is restored on the pathophysiological level. The dissected marking points are clear, and compared with narrow anterior skull base low-flow cerebrospinal fluid leakage of small animals, the standardized bone defect constructed in the middle skull base butterfly saddle area can cause continuous and high-flow cerebrospinal fluid leakage; autologous bone flap and free mucous membrane repair is used, the method is the same as current clinical practice, and a new platform can be provided for screening of skull base repair materials or operation evaluation and retrograde intracranial infection research after an operation.

The invention provides an ultra-wide self-stabilizing cervical vertebra fusion cage which comprises a body, an upper conical surface is arranged at the top of the body, a lower conical surface is arranged at the bottom of the body, artificial hooked vertebra joints are arranged on the left side and the right side of the upper conical surface, a first fixing hole is formed in the front face of the body, and a second fixing hole and a third fixing hole are formed in the two side faces of the body respectively. A fixing plate is arranged at one end, close to the outer side, of each of the upper conical surface and the lower conical surface; a clamping groove is formed in the front surface of the body; and the fixing screw comprises locking teeth and fixing teeth. By widening the width of the fusion cage, increasing the contact area between the fusion cage and the autogenous bone, increasing the number and angle of the fixing holes and matching different upper and lower conical surfaces for a patient by means of a 3D printing technology, the technical scheme of the application effectively solves the problem of low stability of the cervical fusion cage in related technologies.

The invention discloses an autogenous bone taking instrument which comprises a bone taking device, a positioner and a positioning channel, and the bone taking device has various forms. The trephine bone extractor is mainly used for obtaining complete bone blocks; after the spiral bone fetcher is positioned, the spiral structure drives the cut bone blocks to enter the storage cavity; the ring cutting bone taking device can be used for completely cutting bone blocks; the spiral lifting bone taking device can store broken bone blocks in a centralized mode through a spiral structure. The bone taking bin is composed of a bin body and a bin cover, and bone scraps are cut through an incomplete circular groove. The bone scraper scrapes broken bones in the bone taking channel through the sharp cutting edge at the front end, and the broken bones can be taken out through the storage cavity. Three fixing needles are arranged on the edge of the positioner to facilitate intraoperative positioning, and a bone taking hole is formed in the middle and used for positioning the intraoperative bone taking device. The positioning channel is of an oval exposed structure and has two forms. The autologous bone extractor is high in bone extraction efficiency and operation precision, and the operation effect and the postoperative recovery effect of a patient can be effectively optimized.

This utility model relates to the field of orthopedic implant technology and discloses a prosthesis for defects after partial atlas resection. It aims to solve the problems of existing technologies, such as the lack of atlas prosthesis implants, long recovery times after autologous bone grafting, and the ineffective fixation of titanium mesh implants. This utility model includes a prosthesis that replaces the atlas, with bone screw holes to accommodate bone screw fixation contact points. The prosthesis includes an outer frame, which is a porous tubular or porous columnar structure. The cavity of the porous tubular structure is filled with autologous bone, allogeneic bone, or artificial bone. The upper and lower ends of the outer frame are provided with curved surfaces matching the facet joints of the occipital condyle and axis, and a support unit is provided within the outer frame. This utility model, combined with 3D printing technology, matches the shape of the corresponding segment and resection site, thereby replacing the resected segment, promoting the fusion of the atlantoaxial segment, and facilitating the restoration of the physiological function of the upper cervical spine.

The present invention provides a bone graft composite material and a manufacturing method therefor. The bone graft composite material is applied to wound repair of a user in orthopedic surgery and dental surgery, and is used to promote wound healing of the user, induce growth of an autologous bone cell of the user, and induce fusion of a transplanted bone of the user with the autologous bone cell. The bone graft composite material comprises a high molecular polymer, bone powder, and exosomes. Compared with the prior art, the bone graft composite material provided by the present invention has better osteoinductivity and compatibility, and can stably release biological factors, thereby promoting the repair and regeneration of bone.

The utility model discloses a bone tissue biopsy minimally invasive device, including sampling subassembly, cutting subassembly and cannula subassembly, sampling subassembly includes sampling piece and install the sampling handle on the sampling piece, cannula subassembly includes along the vertical direction set sleeve and along the horizontal direction set handle, the handle is installed on the top of sleeve, and the cutting subassembly is installed on the top of sleeve. The sampling piece extends into the sleeve, and the cutting assembly is installed at the bottom of the sleeve and connected with the sampling piece. The bone taking device can remarkably shorten the bone taking time, reduce trauma of the bone taking part and improve the efficiency and the curative effect of an autologous bone grafting operation at the same time.

The utility model belongs to the technical field of medical instruments, and particularly discloses an acetabular prosthesis which comprises an acetabular cup installed in an acetabular fossa. The acetabular cup and the filling block are connected in an embedded and clamped mode through the anti-rotation structure, and the acetabular cup and the filling block are fixed together through the first fixing nail. And the fixed wing is connected with the filling block and is fixed on the ilium wing. By means of the anti-rotation structure, when a patient implanted with the acetabular prosthesis moves and dislocation and slippage occur between the filling block and the acetabular cup, the first fixing nail cannot slightly move under the action of shearing force, the shearing force is borne by the anti-rotation structure, and the service life of the acetabular prosthesis is prolonged. According to the acetabular prosthesis, the first bone grafting groove and the supporting table are arranged on the filling block at intervals, the second bone grafting groove is formed in the acetabular cup, the weight of the acetabular prosthesis is reduced, autogenous bones or allogeneic bones of a patient can be implanted into the first bone grafting groove and the second bone grafting groove, the acetabular prosthesis is effectively prevented from loosening for a long time after being implanted, and the survival rate of the acetabular prosthesis is increased.

The invention discloses a personalized implantation structure and method for improving insufficient chin anterior movement in a chin shaping surgery, the personalized implantation structure comprises an implant and a chin anterior movement osteotomy matched with the implant, and the implant is fixed on the chin anterior movement osteotomy. Compared with the prior art, osteotomy forward movement and the implant are combined together to be applied to the chin forming operation, and when the chin bone mass of a patient is insufficient, supplementation can be conducted through the implant. Compared with an autogenous bone or an artificial bone for transplantation, the implant does not need to face the problems of absorption, rejection and the like, and the risk of a secondary operation cannot be increased; meanwhile, compared with the mode that the prosthesis is completely adopted for implantation, the burden of mandibular fibrous tissue can be relieved, and the risk of implant displacement can also be reduced.

The invention provides a 3D bone printing material which comprises biological bone meal with biological activity and bone cement, the biological bone meal is prepared from one or more of autogenous bone, allogeneic bone or animal bone, the bone cement comprises powder and liquid, the mass ratio of the biological bone meal to the bone cement is 1: 1-1: 12, and the mass ratio of the bone cement powder to the bone cement liquid is 0.5: 1-1.5: 1.

The invention discloses an activity maintaining process for deep low-temperature long-term cryopreservation of autologous bones, and belongs to the technical field of autologous bone preservation, and the autologous bones comprise the following raw materials in parts by weight: 1-2 parts of L-proline, 5-8 parts of a PVP / WS2 nano composite material, 0.1-0.5 part of a matrix metalloproteinase (MMPs) inhibitor, 1-2 parts of antifreeze protein (AFPs), 1-2 parts of an impermeable protective agent, 1-2 parts of trilauryl methyl ammonium chloride and 2-3 parts of an oxygen carrier. According to the autologous bone cryopreservation culture medium, the use of a traditional cryoprotectant DMSO can be reduced, the toxicity of the traditional cryoprotectant DMSO to cells and tissues is reduced, the damage of ice crystals to the cells in the cryogenic long-term cryopreservation process is effectively relieved, the integrity of collagenous fibers in bone tissues is maintained, and the reduction of the activity of growth factors is inhibited.

The utility model belongs to the field of medical instruments for lumbar intervertebral fusion in the spine orthopedics department, and particularly relates to a lumbar posterior lateral fusion cage. Comprising connecting plates and a cage body, the side of the cage body is open, the side wall of the cage body is in a sheet shape, the end of the cage body is in a U shape, through holes are evenly distributed in the side wall of the cage body, the connecting plates are arranged at the top end and the bottom end of the cage body, and connecting mechanisms are arranged on the connecting plates. The U-shaped cage body is of a three-dimensional hollow structure, autologous bones can be filled in the operation, a space is formed between an upper vertebral body and a lower vertebral body which are adjacent to each other in a fixing mode, therefore, the bone grafting cage is prevented from extruding deep nerves by bone grafting blocks, and high safety is achieved. The through hole is formed in the side wall of the cage body, blood supply in the vertebral fusion process is facilitated, and the vertebral fusion speed is increased.

The present invention discloses an active maintenance process for cryopreserving autologous bone at deep low temperature, belonging to the technical field of autologous bone preservation. The raw materials by weight include: 1-2 parts of L-proline, 5-8 parts of PVP / WS2 nanocomposite, 0.1-0.5 part of matrix metalloproteinase (MMPs) inhibitor, 1-2 parts of antifreeze protein (AFPs), 1-2 parts of non-permeating protective agent, 1-2 parts of trimethylammonium lauryl chloride, and 2-3 parts of oxygen carrier. This autologous bone cryopreservation medium can reduce the use of the traditional cryoprotectant DMSO, reduce its toxicity to cells and tissues, effectively slow down the damage of ice crystals to cells during long-term deep low temperature cryopreservation, maintain the integrity of collagen fibers in bone tissue, and inhibit the decrease in the activity of growth factors.

The present invention discloses a preparation method and application of a high-strength, high inorganic ratio and suitable degradability organic-inorganic composite hydrogel, belonging to the technical field of biomedical tissue engineering. The hydrogel contains 30 wt% to 70 wt% of calcium phosphate nanoclusters and 30 wt% to 70 wt% of sodium alginate. This organic-inorganic composite hydrogel is beneficial to the proliferation and mineralization of bone cells, achieving more ideal bone guidance. The experimental results prove that it has good cell compatibility and can rapidly promote the repair of rat cranial bone defects (the repair time of the 8 mm limit bone injury is shortened to 4 weeks). Compared with the autologous bone graft material with the best clinical repair effect in the control group, the healing effect is more significant. The high-strength organic-inorganic composite hydrogel prepared by the present invention is a single network structure, showing good mechanical properties, while taking into account excellent and tissue-matched degradability, which is beneficial to hard tissue repair.

The present invention provides a glenoid base and a shoulder joint prosthesis. The glenoid base includes: a substrate including a connection surface; a connection column disposed on the connection surface, and a receiving groove is provided on the connection column; a deformable coupling member connected to the connection column and located at the receiving groove, and the deformable coupling member deforms to have a received state located in the receiving groove and a coupling state extending outside the connection column. The technical solution of the present application effectively solves the problem of poor connection reliability between the glenoid base in the related art and the autologous bone.

The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.

The present invention relates to the field of bone processing technology, and specifically to a composite device for autologous bone harvesting and bone processing, comprising: a bone harvesting auxiliary device and a bone processing device; the bone harvesting auxiliary device comprises: a bone harvesting caliper, a guide sleeve and a depth-limiting Steinmann pin; the bone processing device comprises: a bone box, a fixing assembly and a cutting assembly. The composite device for autologous bone harvesting and bone processing of the present invention can accurately harvest materials based on preoperative imaging measurement results to avoid waste of resources. During the operation, the device can obtain cancellous bone, unicoral bone, bicortical bone and tricortical bone. At the same time, bone products of various shapes and sizes, such as bone particles, bone strips, bone slices, bone blocks, etc., can be prepared according to the requirements of the bone grafting area.

The present invention provides a prosthetic structure, comprising: a base portion; a porous portion disposed on one side of the base portion; a drug-carrying portion disposed within the base portion and / or the porous portion, the drug-carrying portion comprising: a drug delivery channel having an inlet end and an outlet end; an inner drug-carrying chamber communicating with the drug delivery channel, the inner drug-carrying chamber comprising an inner main cavity disposed at the inlet end and an inner extension cavity communicatively disposed on the cavity wall of the inner main cavity and extending away from the drug delivery channel; and an outer drug-carrying chamber communicating with the inner drug-carrying chamber, the outer drug-carrying chamber comprising an outer main cavity surrounding the outer side of the inner drug-carrying chamber and an outer extension cavity communicatively disposed on the cavity wall of the outer main cavity and extending away from the drug delivery channel. The technical solution of the present application effectively solves the problem in the related art of being unable to provide drugs for a long period of time at the location where the body's autologous bone contacts the prosthetic structure.

The utility model discloses a clamping type artificial bone, and belongs to the technical field of biomedical prostheses. The middle section of the clamping type artificial bone is a bone main body, and two ends are connecting ends; the middle section is in a square strip shape; the cross section of each connecting end in the width direction is in a transverse U shape, the connecting ends at the two ends of each connecting end are connected with the autogenous bone in a clamping mode, connection is firm, and displacement and looseness of the implanted artificial bone are prevented.

This invention provides an interbody fusion device, comprising: a shell and a vertebral lamina, wherein the height of the shell is not less than the height of the vertebral lamina, and an accommodating chamber is formed between the shell and the vertebral lamina. The vertebral lamina is symmetrically arranged vertically and vertically, and is provided with a first slide rail and a second slide rail, as well as a vertical groove and an annular groove. The vertebral lamina has a multi-layer design, with a first vertebral lamina and a second vertebral lamina respectively arranged from the inside out; a transmission device, comprising a first lifting column and a second lifting column, both of which have reverse threads on their outer surfaces; and a stop device, which is sleeved on the aforementioned first and second lifting columns and consists of a dovetail protrusion and a dovetail groove; and a driving device, comprising a retaining ring, a support rod, a support block, and a support groove. The retaining ring is detachably connected to the support rod and placed in the annular groove, and the support rod is inserted into the support groove and fixedly connected to the support block. The technical solution of this application can effectively solve the problem of damage to autologous bone caused by the surface of the prosthesis during surgery.