6 results about "Biologic scaffold" patented technology

Encasement structures and methods of customizing patient drug delivery profiles using an encasement structure are described herein. Encasement structures can be configured to receive an implantable medical device and physicians can implant the medical devices within the encasement structures. Encasement structures can include at least one sheet of a bioscaffold material and one or more depots. Depots can be configured to release an active agent, such as an antibiotic, to the medical device within the encasement structure and / or the surrounding tissue. The depots can be insertable into or integrated with the at least one sheet of bioscaffold material.

The application discloses application of a Histatin-1 polypeptide in preparation of a preparation for promoting sciatic nerve regeneration or repair, and an amino acid sequence of the Histatin-1 polypeptide is shown as SEQ ID NO. 1. The Histatin-1 polypeptide can promote expression of a nerve differentiation index, promote recovery of a functional index after sciatic nerve injury, and promote recovery of a histological index after sciatic nerve injury, for example, recovery of myelin structure and morphology. In addition, in combination with gelatin methacrylate (Gel-MA) as a biological scaffold, slow release of the Histatin-1 polypeptide can be realized, continuous repair support can be provided for a nerve injury site, myelin repair effect is further optimized, a more efficient and more durable solution is provided for treatment of sciatic nerve injury, and the application has a wide application prospect in the field of treatment of myelinated nerve injury.

The application discloses a facial filling and lip sculpting method based on a pre-expanding autologous fat pad principle, belongs to the technical field of medical cosmetology and biological tissue engineering, and comprises the following steps: preparing a biological scaffold with a vascularization induction function, and the preparation raw material of the biological scaffold comprises the following components in parts by weight: 80-100 parts of polycaprolactone, 20-30 parts of gelatin, 5-10 parts of dopamine hydrochloride, 2-4 parts of deferoxamine, 3-6 parts of a zwitterionic polymer, 1-3 parts of an activator, 1000-1500 parts of an organic solvent and 500-800 parts of a tris-hydroxymethyl aminomethane-hydrochloric acid buffer solution. The thin film and high porosity are combined, so that the newly generated blood vessels can smoothly penetrate the scaffold and go deep into the interior, the blood supply dead angle in the central region is eliminated, and the probability of fat liquefaction and necrosis is reduced.

The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and / or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics. The scaffolds provide a promising stromal cell delivery vehicle for the remediation of fibrosis.

This invention provides a casein-derived 3D printing bio-ink, a bio-scaffold, and a method for preparing cell-cultured meat. The bio-ink is prepared from the following raw materials in parts by weight: gelatin: 15.6 parts; sodium alginate: 2.6 parts; casein: 4.2 parts; sodium hydroxide deionized water solution at pH=8: 52.5 parts; sterile 1×PBS buffer solution: 87.5 parts. Using this ink, a bio-scaffold is obtained through extrusion 3D printing and calcium chloride cross-linking. C2C12 cells are seeded onto the scaffold, and cell-cultured meat is obtained through proliferation-differentiation culture. This invention solves the problems of existing 3D printing bio-inks, such as limited performance, poor component compatibility, insufficient mechanical stability of bio-scaffold materials, and lack of nutritional components. The prepared bio-ink exhibits excellent mechanical properties and printing compatibility, providing key technical support for the industrial-scale preparation of cell-cultured meat.