The
growth factor profile,
connective tissue matrix constituents, and immunoprivileged status of urodele
extracellular matrix (ECM) and accompanying
cutaneous tissue, plus the presence of
antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for
xenotransplantation. In particular, a biological
scaffold biomaterial can be obtained by a process that entails (A) obtaining a
tissue sample from a urodele, where the tissue comprises ECM, inclusive of the
basement membrane, and (B) subjecting the
tissue sample to a
decellularization process that maintains the structural and
functional integrity of the
extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate
antigenicity and
immunogenicity for xenograft purposes. The
resultant urodele-derived
biomaterial can be used to enhance restoration of
skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical
inflammation, and to promote progression of natural healing and regeneration processes. In addition, the
biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue.