Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Components for controlled sealing of intravascular devices

A technology of intracavity seals and seals, which can be applied to devices, blood vessels, and applications of tubular structures in the human body, and can solve problems such as mechanical constraints that are difficult to achieve

Inactive Publication Date: 2016-08-24
ENDOLUMINAL SCI
View PDF26 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanical constraints of these seals are extremely difficult to achieve - requiring rapid activation in situ, pressure sufficient to secure but not deform or dislodge the implanted prosthesis, biocompatibility, and long-term retention of strength and flexibility in situ

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Components for controlled sealing of intravascular devices
  • Components for controlled sealing of intravascular devices
  • Components for controlled sealing of intravascular devices

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0204] Example 1: Preparation of Rapidly Swelling Hydrogels

[0205] Studies were performed to identify hydrogels that swelled substantially over a short period of time. The main factors affecting the swelling of polymerized and crosslinked hydrogels based on synthetic monomers are:

[0206] monomer type

[0207] Type of crosslinker

[0208] Concentration of monomer and crosslinker in the gel

[0209] Monomer to Crosslinker Ratio

[0210] Acrylic polymers are capable of rapid swelling and are considered to be well biocompatible. The polymers can be crosslinked to form hydrogels using a variety of commercially available crosslinking agents. These crosslinkers include bisacrylamide, di(ethylene glycol) diacrylate, and poly(ethylene glycol) diacrylate (MW 500 Da).

[0211] Materials and methods

[0212] Studies were performed to identify the appropriate combination of acrylic acid concentration, type of crosslinker, concentration of crosslinker, and ratio of monomer to c...

example 2

[0231] Example 2: Evaluation of Alternative Crosslinkers for Hydrogels

[0232] The rationale behind the chosen crosslinker is that instead of short crosslinkers with only two polymerizable groups, polyvalent crosslinkers (i.e. long-chain hydrophilic polymeric groups with multiple polymerizable groups) are used. things). Hydrogels that are much stronger than short-chain divalent crosslinkers are obtained. Although these gels are extremely firm, they have very good swelling characteristics. Extremely strong gels usually don't swell very well.

[0233] Derivatization of polyvinyl alcohol (PVA) with allyl glycidyl ether under alkaline conditions. Gels were prepared by combining acrylic acid with a PVA-based crosslinker followed by polymerizing the mixture by free-radical polymerization using ammonium persulfate and TEMED as initiators.

[0234] In principle, crosslinkers can be made from many different starting materials: a range of PVA as well as partially hydrolyzed polyvin...

example 3

[0245] Example 3: Demonstration of sealing in an in vitro model

[0246] Materials and methods

[0247] Figures 15A-15B The in vitro model of TAV implantation shown in was constructed using a tube in which a TAV formed from a detachable mesh 102 securing the heart valve leaflets 104 is placed. In the model, the mesh 102 is not evenly fixed into the tube, creating a paravalvular leak site 106 between the area of ​​the mesh 102 and the tube 100 .

[0248] TAV includes as above see Figures 2A-2C The expandable seals described. The seal 12 expands by exposing the seal 12 to the surrounding fluid (blood) using the thread 16, causing the hydrogel to expand and compress the seal 12 against the inside of the tube 100, causing the seal 12 to seal the perivalvular membrane Leakage site 108.

[0249] result

[0250] Figure 15A A paravalvular leak site 106 due to improper device placement is shown. Figure 15B Sealing of the leak site with the sealing bladder 108 is shown w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Expandable sealing members for endoluminal devices have been developed to enable controlled activation. The device has the following benefits: low profile mechanism (for both self-expanding and balloon-expanding prostheses), controlled non-free release of material, actively conforms to the "leak site" so as not to damage the prosthesis Leakage areas are filled without physical and functional integrity, and controlled activation on demand, which may not be pressure activation.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority of U.S.S.N. 61 / 532,814 filed September 9, 2011, U.S.S.N. 13 / 476,695 filed May 21, 2012, and U.S.S.N. The entirety of the application is hereby incorporated by reference. technical field [0003] The present invention is directed generally to endoluminal devices and related systems and methods, and in particular to methods and devices for controllably actuating means for sealing an endoluminal prosthesis to a vessel wall. Background technique [0004] An aneurysm is a localized congestive dilation of a blood vessel caused by disease or weakening of the vessel wall. Aneurysms affect the ability of blood vessels to conduct fluid and can be life-threatening if left untreated. Aneurysms most commonly occur in arteries at the base of the brain and in the aorta. As the size of the aneurysm increases, the risk of rupture increases, which can lead to severe bleeding or other c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/56A61L27/34A61L24/00A61F2/24A61F2/07A61F2/90
CPCA61F2/24A61F2/2418A61F2/82A61F2002/823A61F2210/0061A61F2250/0069A61L24/0031A61L24/0036A61L24/06A61L27/16A61L27/52A61L31/145A61L2430/20C08L33/08C08L29/04A61F2/0063
Inventor J·索默-昆德森阿施施·苏蒂尔·密特拉马丁·肯恩·忠·NGP·M·V·旺B·C·鲍勃里尔
Owner ENDOLUMINAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com