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Means for controlled sealing of endovascular devices

A technology of intracavity seals and seals, which can be applied to devices, blood vessels, and applications of tubular structures in the human body, and can solve problems such as mechanical constraints that are difficult to achieve

Inactive Publication Date: 2014-06-25
ENDOLUMINAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanical constraints of these seals are extremely difficult to achieve - requiring rapid activation in situ, pressure sufficient to secure but not deform or dislodge the implanted prosthesis, biocompatibility, and long-term retention of strength and flexibility in situ

Method used

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  • Means for controlled sealing of endovascular devices
  • Means for controlled sealing of endovascular devices
  • Means for controlled sealing of endovascular devices

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0204] Example 1: Preparation of Rapidly Swelling Hydrogels

[0205] Studies were performed to identify hydrogels that swelled substantially over a short period of time. The main factors affecting the swelling of polymerized and crosslinked hydrogels based on synthetic monomers are:

[0206] monomer type

[0207] Type of crosslinker

[0208] Concentration of monomer and crosslinker in the gel

[0209] Monomer to Crosslinker Ratio

[0210] Acrylic polymers are capable of rapid swelling and are considered to be well biocompatible. The polymers can be crosslinked to form hydrogels using a variety of commercially available crosslinking agents. These crosslinkers include bisacrylamide, di(ethylene glycol) diacrylate, and poly(ethylene glycol) diacrylate (MW 500 Da).

[0211] Materials and methods

[0212] Studies were performed to identify the appropriate combination of acrylic acid concentration, type of crosslinker, concentration of crosslinker, and ratio of monomer to c...

example 2

[0231] Example 2: Evaluation of Alternative Crosslinkers for Hydrogels

[0232] The rationale behind the chosen crosslinker is that instead of short crosslinkers with only two polymerizable groups, polyvalent crosslinkers (i.e. long-chain hydrophilic polymeric groups with multiple polymerizable groups) are used. things). Hydrogels that are much stronger than short-chain divalent crosslinkers are obtained. Although these gels are extremely firm, they have very good swelling characteristics. Extremely strong gels usually don't swell very well.

[0233] Derivatization of polyvinyl alcohol (PVA) with allyl glycidyl ether under alkaline conditions. Gels were prepared by combining acrylic acid with a PVA-based crosslinker followed by polymerizing the mixture by free-radical polymerization using ammonium persulfate and TEMED as initiators.

[0234] In principle, crosslinkers can be made from many different starting materials: a range of PVA as well as partially hydrolyzed polyvin...

example 3

[0245] Example 3: Demonstration of sealing in an in vitro model

[0246] Materials and methods

[0247] Figures 15A-15B The in vitro model of TAV implantation shown in was constructed using a tube in which a TAV formed from a detachable mesh 102 securing the heart valve leaflets 104 is placed. In the model, the mesh 102 is not evenly fixed into the tube, creating a paravalvular leak site 106 between the area of ​​the mesh 102 and the tube 100 .

[0248] TAV includes as above see Figures 2A-2C The expandable seals described. The seal 12 expands by exposing the seal 12 to the surrounding fluid (blood) using the thread 16, causing the hydrogel to expand and compress the seal 12 against the inside of the tube 100, causing the seal 12 to seal the perivalvular membrane Leakage site 108.

[0249] result

[0250] Figure 15A A paravalvular leak site 106 due to improper device placement is shown. Figure 15B Sealing of the leak site with the sealing bladder 108 is shown w...

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Abstract

Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the 'leak sites' such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority of U.S.S.N. 61 / 532,814 filed September 9, 2011, U.S.S.N. 13 / 476,695 filed May 21, 2012, and U.S.S.N. The entirety of the application is hereby incorporated by reference. technical field [0003] The present invention is directed generally to endoluminal devices and related systems and methods, and in particular to methods and devices for controllably actuating means for sealing an endoluminal prosthesis to a vessel wall. Background technique [0004] An aneurysm is a localized congestive dilation of a blood vessel caused by disease or weakening of the vessel wall. Aneurysms affect the ability of blood vessels to conduct fluid and can be life-threatening if left untreated. Aneurysms most commonly occur in arteries at the base of the brain and in the aorta. As the size of the aneurysm increases, the risk of rupture increases, which can lead to severe bleeding or other c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/56A61L27/34A61L24/00A61F2/24A61F2/07A61F2/90
CPCA61L27/52A61F2/24A61L27/34A61F2250/0069A61F2/82A61L31/145A61L27/56A61F2/0063A61L24/00A61F2002/823A61L27/16A61F2210/0061A61L2430/20A61F2/2418A61L24/0031A61L24/0036A61L24/06C08L33/08C08L29/04
Inventor J·索默-昆德森阿施施·苏蒂尔·密特拉马丁·肯恩·忠·NGP·M·V·旺B·C·鲍勃里尔
Owner ENDOLUMINAL SCI
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