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5 results about "Contractility" patented technology
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Myocardial contractility represents the innate ability of the heart muscle (cardiac muscle or myocardium) to contract. The ability to produce changes in force during contraction result from incremental degrees of binding between different types of tissue, that is, between filaments of myosin (thick) and actin (thin) tissue. The degree of binding depends upon the concentration of calcium ions in the cell. Within an in vivo intact heart, the action/response of the sympathetic nervous system is driven by precisely timed releases of a catecholamine, which is a process that determines the concentration of calcium ions in the cytosol of cardiac muscle cells. The factors causing an increase in contractility work by causing an increase in intracellular calcium ions (Ca⁺⁺) during contraction.
Device capable of simultaneously measuring myocardial specific contractility and action potential
PendingCN121844038ABioreactor/fermenter combinationsBiological substance pretreatmentsContractilityCardiac muscle tissue
The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.
Owner:ENKI TISSUE DESIGN CO LTD +1
Systems and methods for uterine peristalsis imaging
Uterine peristalsis imaging (UPI) can provide objective, quantitative measures of uterine peristalsis (UP). Unlike other modalities, the contractile activity seen during UP can be quantitatively measured and reliably observed with UPI. With 3D accuracy, which takes into consideration the individual's unique uterine anatomy, the site of initiation and termination of the contraction are mapped along with the characterization of the direction, duration, and magnitude of the contractile forces. Novel peristalsis indices were developed for quantitative characterization of uterine contractile patterns. This includes measuring the duration and magnitude of UP. This assessment can be performed in a noninvasive way with little patient discomfort for a prolonged period.
Owner:WASHINGTON UNIV IN SAINT LOUIS
Device for measuring and recording the squeezing force of the heart ventricle and method for measuring and recording the squeezing force
The subject of the invention is a device (1) for measuring and recording the squeezing force of the heart ventricle exerted by the inner surface of the heart ventricle wall, which device (1) comprises a stabilizing system (2) with at least one measuring arm (3) extending therefrom, on which a sensor (9) is placed. The device (1) has a spatial design adapted to the interior of the left ventricle, allowing for multi-point contact with the endocardial surface. The subject of the invention is also a computer-implemented method of measuring and recording the squeezing force measured using a device (1) for measuring and recording the squeezing force of the heart ventricle.
Owner:CARDIOCARE SP ZOO SPOLKA KOMANDYTOWA
Micropillar constructs for measuring contractile force of annular tissues
PendingUS20260098854A1Additive manufacturing apparatus3D object support structuresBiomechanicsContractility
Owner:UNIV OF VIRGINIA PATENT FOUND
AAV vector for regulating smooth muscle contraction as well as construction method and application of AAV vector
The invention belongs to the technical field of biological medicines, and particularly relates to an AAV vector for regulating smooth muscle contraction as well as a construction method and application of the AAV vector. The AAV vector for regulating and controlling the contraction of the smooth muscle, disclosed by the invention, is obtained by inserting a gene for regulating and controlling the contraction of the smooth muscle between restriction enzyme cutting sites of multiple cloning sites of a pssAAV-CBA-LUC-P2A-GFP-bGH-141 vector. The obtained AAV vector expresses an exogenous gene, such as a gene ACTA2 for regulating smooth muscle contraction, and has the advantages of long time and good stability. Animal experiments show that the AAV vector can directly increase the contractility of smooth muscle by regulating expression of smooth muscle contraction related genes such as ACTA2, so that the aim of treating related diseases such as gastroesophageal reflux disease, fecal incontinence and the like is fulfilled.
Owner:NANJING DRUM TOWER HOSPITAL