7 results about "Contractility" patented technology

The invention discloses a method for non-contact human myocardial contractility detection by using millimeter waves, and relates to the technical field of myocardial contractility detection. The method for performing non-contact human myocardial contractility detection by using millimeter waves comprises the following steps: S1, constructing a millimeter wave radar array and initializing a space model; s2, adaptive adjustment of the dynamic space model; s3, millimeter wave echo signals are collected and preprocessed; s4, high-dimensional signal feature coding and dimension reduction; s5, myocardial contractility index mapping and clinical evaluation; through millimeter wave radar array construction and dynamic adjustment of a space model, non-contact accurate heart monitoring is realized, invasive operation of a traditional technology is avoided, discomfort of a patient is reduced, tiny motion changes of the heart can be captured with high precision, specific algorithm analysis is combined, the contractility of the cardiac muscle can be accurately evaluated, and the cardiac muscle can be accurately monitored. And real-time feedback is provided, and simple and convenient installation and operation can be realized without depending on a high-level technology of an operator.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

Uterine peristalsis imaging (UPI) can provide objective, quantitative measures of uterine peristalsis (UP). Unlike other modalities, the contractile activity seen during UP can be quantitatively measured and reliably observed with UPI. With 3D accuracy, which takes into consideration the individual's unique uterine anatomy, the site of initiation and termination of the contraction are mapped along with the characterization of the direction, duration, and magnitude of the contractile forces. Novel peristalsis indices were developed for quantitative characterization of uterine contractile patterns. This includes measuring the duration and magnitude of UP. This assessment can be performed in a noninvasive way with little patient discomfort for a prolonged period.

The subject of the invention is a device (1) for measuring and recording the squeezing force of the heart ventricle exerted by the inner surface of the heart ventricle wall, which device (1) comprises a stabilizing system (2) with at least one measuring arm (3) extending therefrom, on which a sensor (9) is placed. The device (1) has a spatial design adapted to the interior of the left ventricle, allowing for multi-point contact with the endocardial surface. The subject of the invention is also a computer-implemented method of measuring and recording the squeezing force measured using a device (1) for measuring and recording the squeezing force of the heart ventricle.

A PIV-based cardiac organoid contractility assessment method according to the present invention comprises the steps of: converting a captured video of a cardiac organoid into an image sequence; setting an interrogation window size and a step size for a PIV algorithm to a first value for each of the converted image sequences; configuring information on the cardiac organoid; calculating a deformation velocity of the cardiac organoid using the first value, information on the cardiac organoid, and the PIV algorithm; providing a real-time interactive tool for postprocessing of the deformation velocity; calculating multiple parameters that assess contractility of the cardiac organoid on the basis of a profile of the postprocessed deformation velocity; and outputting visual data and the multiple parameters used for analyzing contractility of the cardiac organoid, wherein the first value is reset to a second value considering continuity and calculation time of a deformation velocity vector field calculated at the step of calculating the deformation velocity of the cardiac organoid.

The invention belongs to the technical field of biological medicines, and particularly relates to an AAV vector for regulating smooth muscle contraction as well as a construction method and application of the AAV vector. The AAV vector for regulating and controlling the contraction of the smooth muscle, disclosed by the invention, is obtained by inserting a gene for regulating and controlling the contraction of the smooth muscle between restriction enzyme cutting sites of multiple cloning sites of a pssAAV-CBA-LUC-P2A-GFP-bGH-141 vector. The obtained AAV vector expresses an exogenous gene, such as a gene ACTA2 for regulating smooth muscle contraction, and has the advantages of long time and good stability. Animal experiments show that the AAV vector can directly increase the contractility of smooth muscle by regulating expression of smooth muscle contraction related genes such as ACTA2, so that the aim of treating related diseases such as gastroesophageal reflux disease, fecal incontinence and the like is fulfilled.