144 results about "Subcutaneous fat" patented technology

The invention discloses a subcutaneous injection site detection and recommendation system based on an intelligent algorithm, and aims to improve the safety of long-term subcutaneous injection and the drug absorption efficiency and reduce the risk of related complications such as subcutaneous hemorrhage, subcutaneous induration and subcutaneous fat hyperplasia at the same time. Comprising a subcutaneous tissue detection module for acquiring subcutaneous vascular distribution, fat layer thickness and induration state of a target part through infrared imaging and ultrasonic technologies and generating subcutaneous tissue characteristic data; the data processing module analyzes the feature data by using an image recognition algorithm, and recognizes a blood vessel dense region, induration and a part where fat hyperplasia has occurred; the injection part recommendation module is used for evaluating an analysis result of the data processing module based on a machine learning algorithm in combination with personalized injection historical data of the patient, and generating an optimal injection part recommendation scheme avoiding a risk area; the intelligent imaging and data analysis technology is utilized, the subcutaneous injection part selection accuracy is improved, and the patient comfort and the treatment effect are improved.

The invention provides a Slicer-based deep learning fat muscle segmentation method and system, and is applied to the technical field of data processing. The method comprises the following steps: preprocessing preoperative CT image data of a target patient to generate skeletal muscle image features, subcutaneous adipose tissue image features and visceral adipose tissue image features; preprocessing the training sample set, adjusting a window width and a window level, performing normalization processing, and generating target training image data; training a preset fat muscle segmentation model based on a deep learning network based on the target training image data to generate a target fat muscle segmentation model; processing the skeletal muscle image features, the subcutaneous adipose tissue image features and the visceral adipose tissue image features based on a target adipose muscle segmentation model to generate target image segmentation information; and processing the target image segmentation information and the gene detection information of the target patient to generate preoperative early warning information of the target patient.

The invention belongs to the field of biology, and discloses a method for identifying RNA (Ribonucleic Acid) binding protein in porcine intramuscular fat cells or subcutaneous fat cells, which comprises the following steps: step 1, taking porcine muscle tissues or subcutaneous fat tissues to carry out meat mashing and digestion, and collecting mature intramuscular fat cells or subcutaneous fat cells; step 2, washing intramuscular fat cells or subcutaneous fat cells, and carrying out cross-linking treatment by adopting ultraviolet irradiation; step 3, collecting intramuscular fat cells or subcutaneous fat cells after cross-linking treatment, and performing lysis under the action of a cell lysis solution to obtain a lysis solution; step 4, adding magnetic beads into the lysate, and carrying out repeated resuspension and elution to obtain an eluent; and 5, separating the RNA binding protein from the magnetic beads, and incubating. According to the method, intramuscular fat cells or subcutaneous fat cells are treated by adopting a UV cross-linking solidification method, and then RNA binding protein is captured through magnetic beads, so that the RNA binding protein is successfully obtained.

The invention discloses allicin oleogel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The allicin oleogel is prepared from the following raw materials: allicin, an oil phase, a gelator and a surfactant, the gelator comprises beeswax and / or fruit wax; the surfactant comprises one or more of caprylic / capric polyethylene glycol glyceride, Tween 20 and polyglycerol fatty acid ester. The gel factor forms oil gel through crystal self-assembly, allicin is solidified and intercepted in the oil gel, the gel factor is optimized, and a surfactant is used in a matched manner, so that a release behavior similar to that of a mixed solution of free allicin and an oil phase can be obtained, and the transdermal release rate is improved. The allicin oil gel can effectively entrap allicin, cover the peculiar smell of the allicin and improve the stability of the allicin, and through abdominal transdermal administration, the medicine accumulation amount in subcutaneous adipose tissues is remarkably increased, and the treatment effect on obesity and complications thereof can be improved.

The invention discloses an endoscope pneumoperitoneum pressure system based on AI image evaluation and an intelligent adjusting method, and the method comprises the steps: 1, obtaining an original image of the abdominal cavity of a patient through CT equipment, carrying out the standardization processing of the original image, generating a standardized CT image data set, and constructing a three-dimensional dynamic model of the abdominal cavity of the patient based on an AI algorithm; in the second stage, quantitative analysis of subcutaneous fat thickness, visceral organ volume and operable space volume is carried out on the three-dimensional dynamic model by adopting an AI segmentation algorithm, and a personalized pneumoperitoneum pressure target value Ptarget and an adjustment threshold range are generated through a machine learning model in combination with basic illness state data of the patient; in the third stage, working data are collected in real time through a built-in sensor of the endoscope system, and the working data are input into the reinforcement learning model to dynamically calculate a pressure adjusting instruction delta P; through deep fusion of the AI technology and system closed-loop control, the intelligent level of the endoscope system is remarkably optimized, good hardware support is provided, and the function of optimizing the operation environment and effect is achieved.

The present invention features methods of manipulating subdermal fat in a treatment area. Such methods include inserting a needle (e.g., a micro-coring needle) through the dermis to the subdermal fat layer in order to excise a portion of tissue from the treatment area. These insertions result in a portion of the dermis and a portion of the subdermal fat to enter into the needle. Removal of the needle results in excision of the portion of dermis and subdermal fat that entered into the needle.

The utility model relates to the technical field of medical instruments, and discloses a PICC adjustable skin expanding needle which comprises a needle body, the needle body comprises a needle point, a sliding piece is assembled on the needle body in a sliding mode, a limiting protruding block is arranged at the bottom of the sliding piece, a locking column is arranged on the limiting protruding block, a movable column is arranged on the locking column, a limiting piece is arranged on the movable column, and a through hole is formed in the middle of the sliding piece. Transverse compression gaps are formed in the locking column, the movable column and the limiting piece, an embedding groove is formed in the locking column, the movable column is sleeved with a buckling piece, and a wedge-shaped embedding block is arranged in the buckling piece. The diameter of the through hole is larger than that of the needle body. The embedding groove is located in the vertical direction of the compression gap. The side face of the limiting protruding block is in a circular arc shape. The device has the advantages that the position of the limiter is adjusted according to the subcutaneous fat thickness prompted by B-ultrasonic, and a better puncture effect is achieved for different patients.

The invention relates to the technical field of human body measurement, and discloses a body index evaluation device, method and system. The basic concept is that the body fat rate of a user is calculated according to the waistline and gender of the user; combining the body fat rate with the height and the weight to calculate one or more of fat mass, subcutaneous fat weight, visceral fat weight, visceral fat grade, segmental fat weight, skeletal muscle weight, segmental muscle weight, sarcopenia evaluation, moisture weight, mineral weight, protein weight and cell moisture of the user; the calculation method of the body fat rate is as follows: the male body fat rate is equal to 36.4-((110-waistline) * 0.6), and the female body fat rate is equal to 48-((110-waistline) * 0.6); and the value range of the waistline is 60 to 110 cm. According to the method, accurate data are obtained through calculation, the user can make preliminary body screening in multiple aspects with extremely low cost, and the method can be used for the category of obesity and sarcopenia so as to reduce the cost of screening related diseases by the government.

The invention discloses a wearable health monitoring device, a control method thereof and a weight change prediction method, and belongs to the technical field of wearable equipment and health monitoring. The wearable health monitoring device comprises a main body, at least five supporting legs, a control module, a data acquisition module and a heating module, an attaching layer is arranged on the side, close to the skin, of the body, the attaching layer is made of a temperature-sensitive material with the viscosity changing along with the temperature, and the control module is used for controlling the heating module to work and adjusting the temperature of the attaching layer, so that the viscosity is adjusted. According to the wearable health monitoring device, dynamic viscosity adjustment can be achieved, wearing stability and comfort are both considered, the problem of skin sensitivity caused by long-term use of a traditional gel patch is avoided, collaborative analysis can be conducted on multi-dimensional physiological data such as the skin moisture content and the body fat layer thickness, and the weight change can be accurately speculated.

The near-infrared wearable subcutaneous fat metabolism monitoring device comprises a flexible substrate, a multi-wavelength NIR light source array, a photoelectric detector, a motion artifact suppression module, a wireless transmission unit, a fixing band and a photonic crystal enhanced detector, and the flexible substrate comprises a biocompatible layer, an optical window array and a pressure sensing layer. The wavelength of the multi-wavelength NIR light source array is 760nm / 850nm / 930nm / 980nm, the photoelectric detector is high-sensitivity InGaAs, the motion artifact suppression module is provided with an embedded signal processing module, the embedded signal processing module contains a motion artifact elimination algorithm, the wireless transmission unit is BLE5.0, the fixing band is connected with the flexible substrate, and the flexible substrate is connected with the fixed band. A first subcutaneous fat oxidation characteristic database based on time-frequency analysis is established by installing a fat oxidation dynamic fingerprint spectrum technology, FODS = summa 850980d [mu] a (lambda, t) dt.e-j2pif0tdt (f0 = 0.05 Hz) FODS = summa 850980dtd [mu] a (lambda, t). E-j2pif0tdt (f0 = 0.05 Hz), metabolic oscillation characteristics are extracted through wavelet-Hilbert transform, and a metabolic activity quantitative evaluation core algorithm WO2023 / 123456 is realized.

The application discloses a path planning method for subcutaneous deep layer injection of a mandible, which comprises the following steps: determining a target region of a subcutaneous deep layer which needs to be filled or improved in contour based on three-dimensional anatomical data of a mandible; the subcutaneous deep layer refers to a loose connective tissue gap between a subcutaneous fat layer and an upper periosteum layer; planning a main path which is substantially parallel to a baseline of a lower edge of the mandible or substantially coincides with a preset mandible contour line in the target region; the main path is located in the subcutaneous deep layer; planning a plurality of branch injection paths based on the main path; the starting points of the branch injection paths are distributed at intervals along the main path and extend alternately to the outside of both sides of the main path; and all the paths form a wheat ear-shaped topological structure with the main path as a central axis and the branch injection paths extending to both sides. The method effectively avoids excessive concentration of fillers in any dimension, thereby significantly reducing the swelling degree of local tissues caused by pressure concentration and being beneficial to shortening the recovery time.

The invention relates to the technical field of biology, in particular to a promoter with real skin specificity and application thereof. The promoter provided by the invention is selected from a promoter of any one or more of the following genes: GPN, FOS or APO. The promoter with true skin specificity provided by the invention can specifically express a target gene in dermis and remove off-target expression of liver and subcutaneous lipid membrane muscle at the same time, the promoter sequence is shorter than that of a broad-spectrum promoter, and the human hGPN promoter can be more safely applied clinically.

The invention belongs to the technical field of poultry breeding, and discloses siRNA for targeted inhibition of chicken PLCD4 gene expression and application thereof. The siRNA comprises PLCD4-853, PLCD4-528 and PLCD4-1870, and the siRNA comprises PLCD4-853, the siRNA can inhibit the expression of the chicken PLCD4 gene in a targeted manner, after the siRNA is transferred into chicken primary subcutaneous fat cells, the expression of the chicken PLCD4 gene can be effectively reduced, the inhibition efficiency reaches 50% or above, and the knock-down efficiency is very high; the siRNA identifies the gene function by specifically knocking down the expression of the chicken PLCD4 gene in vitro, can be used as a molecular marker to be applied to genetic breeding of subcutaneous fat deposition of high-quality broilers, and has great economic value and scientific research value.

This invention discloses a selection method for meat geese that comprehensively considers feed conversion efficiency and subcutaneous fat properties, relating to the field of poultry genetics and breeding. The method includes the following steps: S1 determining feed conversion efficiency of meat geese; S2 determining subcutaneous fat properties of meat geese; S3 calculating the family mean values ​​for each trait; S4 analyzing the correlation and heritability of each trait; S5 constructing a comprehensive selection index for feed conversion efficiency and subcutaneous fat properties of meat geese; and S6 selecting breeding geese with high comprehensive selection indices. This invention utilizes individual measurements and single-cage determination of feed conversion efficiency in meat geese, establishes a three-point method for accurately measuring subcutaneous fat thickness, and constructs a comprehensive selection index for residual feed intake, subcutaneous fat percentage, and subcutaneous fat thickness. It provides a selection method that comprehensively considers feed conversion efficiency and subcutaneous fat properties in geese, simultaneously improving feed efficiency and reducing subcutaneous fat properties, achieving simultaneous selection and synergistic improvement of multiple traits, and significantly enhancing breeding efficiency.

The content disclosed herein relates to a method of treating subcutaneous cellulite on the thighs or buttocks of a human subject by administering an effective amount of collagenase and evaluating a reduction in the severity of subcutaneous cellulite through one or more scales.

The abdominal wall retractor for the observation hole of the laparoscope comprises a first retraction arm and a second retraction arm, the first retraction arm and the second retraction arm are hinged through a hinged shaft, and the first retraction arm comprises a first retraction arm front section, a first retraction arm middle section and a first retraction arm rear section. The end part of the rear section of the first retraction arm is fixedly connected with a first operation ring; the second retraction arm comprises a second retraction arm front section, a second retraction arm middle section and a second retraction arm rear section, the end part of the second retraction arm rear section is fixedly connected with a second operation ring, and the end part of the first retraction arm front section is movably connected with a first retraction rod and a second retraction rod; and the end part of the front section of the second retracting arm is movably connected with a third retracting rod and a fourth retracting rod. The utility model has the beneficial effects that the abdominal wall of the observation hole and the subcutaneous fat layer can be expanded, and the anterior sheath layer and the peritoneal layer can be better exposed, so that the peritoneal layer and the anterior sheath layer can be better sutured under direct vision, related complications of a puncture hole are avoided, the use is safe and reliable, and the operation time of medical personnel is saved.

The content disclosed herein relates to a method of treating subcutaneous cellulite on the thighs or buttocks of a human subject by administering an effective amount of collagenase and evaluating a reduction in the severity of subcutaneous cellulite through one or more scales.

The application discloses a kind of based on near infrared multiband detection abdominal fat distribution analysis device and method, it is related to fat analysis field, the spectrum of the information of subcutaneous adipose tissue (SAT) mainly reflected by close-range probe acquisition, accurate estimation is combined with pre-training model individualized subcutaneous fat profile parameter. Then, these parameters are used to drive an optical forward propagation model, dynamically predict and generate the SAT contribution spectrum of the individual at the remote probe. Finally, subtract this accurate prediction SAT contribution signal from the mixed spectrum collected by the remote probe, thereby effectively stripping the strong background noise. The signal-to-noise ratio of the residual spectrum obtained is significantly improved, and the visceral fat index can be accurately analyzed through a special correction model, solving the core technical problem that VAT cannot be measured due to SAT signal interference.

The invention discloses a structural variation molecular marker influencing pig abdomen subcutaneous fat weight on a pig chromosome 5 and application of the structural variation molecular marker. The structural variation molecular marker is a DNA fragment inserted behind a 66120412bp site on a chromosome 5 of an international pig reference genome version 11.1; the nucleotide sequence of the DNA fragment is as shown in SEQ ID NO: 1. The structural variation molecular marker provided by the invention is remarkably related to the pig abdominal subcutaneous fat weight character, the pig abdominal subcutaneous fat weight character can be identified by identifying the structural variation molecular marker, and the pig abdominal subcutaneous fat weight character can be identified by selecting individuals carrying the structural variation molecular marker in the breeding process. The weight of abdominal subcutaneous fat of offspring pigs can be reduced, and the lean meat percentage of the offspring pigs is improved.

The present invention relates to a peptide having a lipolytic effect, and more particularly, to a composition for preventing, ameliorating or treating obesity comprising the peptide. The peptide having a lipolytic efficacy according to the present invention has excellent effects of reducing intracellular lipid droplets, reducing orange peel tissue, improving skin roughness, and reducing the interface length between dermis and subcutaneous fat layer, and can be used variously in the field of prevention, improvement, or treatment of obesity.

To provide a technology that can easily and stably provide a subcutaneous fat model having a well-developed subcutaneous fat layer and uniformly containing mature adipocytes. [Solution] A method for producing a subcutaneous fat model, comprising the step of culturing adipose stem cells or adipose progenitor cells by shaking them in a culture insert having a liquid-permeable membrane with a pore diameter of 3 μm or more at the bottom surface using a shaker, thereby producing a subcutaneous fat layer uniformly containing mature adipocytes.

The invention discloses an abdominal fat distribution analysis device and method based on near-infrared multi-band detection, relates to the field of fat analysis, and accurately estimates individualized subcutaneous fat profile parameters by combining a pre-training model through a spectrum which is acquired by a near-distance detector and mainly reflects subcutaneous fat (SAT) information. And then, driving an optical forward propagation model by using the parameters, and dynamically predicting and generating a due SAT contribution spectrum of the individual at the long-distance detector. And finally, subtracting the accurately predicted SAT contribution signal from a mixed spectrum collected by a long-distance detector, thereby realizing effective stripping of strong background noise. According to the residual spectrum obtained in this way, the signal-to-noise ratio of visceral fat (VAT) signals is remarkably increased, visceral fat indexes can be accurately analyzed through a special correction model, and the core technical problem that the VAT cannot be measured due to SAT signal interference is solved.

A PTH1 ligand-binding nucleic acid complex that is delivered to a target organ to regulate expression or editing of a target gene, or a transcription or translation product thereof is provided. The PTH1 ligand-binding nucleic acid complex includes a nucleic acid having an antisense strand with an oligonucleotide having a nucleotide sequence 12 to 30 nucleotides in length, complementary to a target transcription product, is bound to a PTH1 ligand. Such nucleic acid complexes are useful for the treatment of diseases caused by such a gene. The ligand-binding nucleic acid complex can be delivered to an organ, tissue, or cell in which the PTH1 receptor is expressed, such as the kidney, bone, and subcutaneous fat tissue, or the vascular endothelial cells. Thus, such nucleic acid complexes are useful for treatment of diseases in such organs.

The invention relates to the field of bone tissue engineering and the field of biomedical materials, in particular to application of an ultrasonic response piezoelectric collagen scaffold. According to the invention, full-thickness pigskin is used as a raw material, hair and subcutaneous adipose tissue are removed, and then decellularization is carried out so as to obtain the membrane-like scaffold. The membrane-like scaffold retains a complete three-stage structure of natural collagen, which is a source of the natural collagen having a piezoelectric effect; meanwhile, a piezoelectric signal detection result shows that periodic piezoelectric signals appear on the membrane-shaped stent, and then the collagen stent provided by the invention is proved to have an intrinsic piezoelectric effect. Experimental results show that mesenchymal stem cells can be attached to the surface of the collagen scaffold and can promote repair and regeneration of bone tissues, and in addition, rat subcutaneous ectopic bone regeneration experiments prove that the collagen scaffold provided by the invention has a good bone regeneration promoting effect under ultrasonic stimulation.

The disclosure relates to studying physical properties of biological tissues, and for example, to a method and system for indirect estimation of the abdominal subcutaneous fat area and the abdominal visceral fat area. The technical result is reduced complexity and increased accuracy and speed of estimation of the abdominal subcutaneous fat area and the abdominal visceral fat area with portable devices. A method for determining the abdominal visceral fat area and the subcutaneous fat area in a body section in an abdominal region, comprises: using a device with ultra-wide band (UWB) radar applied to the body in the abdominal region, emitting radiation into the body and measuring parameters of reflected radiation; based on the reflected radiation measurement data obtained by the UWB radar, determining the abdominal subcutaneous fat area (ASFA) in the body section, corresponding to the measurement point; acquiring anthropometric data and bio-electrical impedance value of the body; based on the bio-electrical impedance data of the body and the anthropometric data, determining total fat area (TFA) in the body section in the abdominal region; calculating the abdominal visceral fat area (AVFA) in the body section from the determined total fat area and the abdominal subcutaneous fat area.

1. Name of the Design Product: Electric Fat Burning Device. 2. Use of the Design Product: For massaging the skin to achieve the consumption of subcutaneous fat. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective view.

The invention discloses a medical-grade transmission method blood oxygen ring which comprises a main board used for monitoring human body blood oxygen saturation data and a lithium battery used for providing a power source, the main board and the lithium battery are packaged on the inner side of an upper ring body and the inner side of a lower ring body respectively, and a power line is arranged at the output end of the lithium battery. The power line penetrates through the upper ring, the lower ring is installed on a power supply interface of the main board, a transmitting tube and a receiving tube are arranged at the two ends of the main board respectively, the transmitting tube is used for transmitting red light and infrared light to penetrate through a finger pulp to detect the oxyhemoglobin saturation, the receiving tube is used for receiving transmission light signals after penetrating through finger pulp tissue, and the transmitting tube and the receiving tube are distributed at an included angle of 110 degrees. According to the medical-grade transmission-method blood oxygen ring, a transmission-type method is adopted for penetrating through the finger pulp, the blood oxygen saturation degree is measured according to the intensity of transmission light attenuated after penetrating through the skin, the fat layer and the capillary bed, scattering interference of an optical signal by bone tissue and the subcutaneous fat layer is avoided, and the accuracy of a measurement result is improved.

The present application belongs to the field of livestock and poultry breeding and feed processing technology, and particularly relates to a feed additive, a nutritional supplement, a feed and application thereof. The present application provides application of p-coumaric acid in improving carcass and meat quality, improving feed conversion rate, reducing fat deposition of livestock and poultry and improving fat metabolism of livestock and poultry. The results of the examples show that p-coumaric acid can effectively improve the feed conversion efficiency of growing pigs in the growth stage, which provides a reference for reducing feed waste in production and realizing cost reduction and benefit increase of animal husbandry; under the premise of not reducing or even improving the growth performance and slaughter rate of growing and fattening pigs, the p-coumaric acid can reduce the fat thickness, improve the pig carcass rating, improve the meat quality, and is beneficial to realize efficient production of high-quality pork and improve the market competitiveness of pork in China; the p-coumaric acid can also reduce the blood lipids of chickens, reduce fatty liver and reduce subcutaneous fat deposition, maintain normal metabolism of chickens and improve the health of chickens.

The invention discloses a construction method of a spontaneous lupus adipositis animal model, which comprises the following steps: constructing keratinocytes with genotypes of PPAR [gamma] flox / flox- / -Krt5-CreERT < 2 + > / -Adipoq-Cre < + > / -and PPAR [gamma] flox / flox- / -Krt5-CreERT < 2 + > / -Adipoq-CreERT < 2 + > / -and fat cells into a conditional PPAR [gamma]-active receptor gamma gene knockout mouse, so as to construct the animal model with the spontaneous lupus adipositis animal model. Then knocking out PPAR gamma genes in keratinocytes and adipocytes by using a gene knockout activator, so that the mice spontaneously have the phenotypes of lupus septicaemia, including local skin unhairing, lipoatrophy, persistent skin lesion, proteinuria and serum autoantibodies; histological examination finds that lobular adipositis, glomerular volume increase, mesangial cell hyperplasia, inflammatory cell infiltration, glomerular IgG deposition and the like are mainly caused by dermal immune cell infiltration and subcutaneous fat layer lymphocyte infiltration, clinical symptoms of patients with lupus adipositis are simulated, and an important tool is provided for related research of lupus adipositis.

The invention discloses a method for constructing a prediction model for subcutaneous fat hyperplasia caused by insulin injection. The method comprises the following steps: S1, selecting a plurality of participants for questionnaire survey according to inclusion standards; s2, performing ultrasonic inspection on all participants; s3, performing feature screening on the predicted variables by adopting LASSO regression; s4, developing a fat hyperplasia prediction model by using three algorithms of random forest, extreme gradient lifting and logistic regression, and selecting the fat hyperplasia prediction model with the optimal performance for research; and S5, explaining the influence of the predictive variables on the fat hyperplasia prediction model through an SHAP method. According to the method, a machine learning-based insulin injection-induced fat hyperplasia prediction model is created, the constructed extreme gradient lifting machine learning model shows relatively high efficiency in the aspect of predicting the occurrence of fat hyperplasia of the diabetic patient, and the diabetic patient with high-risk fat hyperplasia can be accurately identified.