112 results about "Fasting blood sugar" patented technology

The invention discloses an assistant hypoglycemic healthcare biscuit belonging to a healthcare food. The assistant hypoglycemic healthcare biscuit contains the following components which are measuredby grams and shown in a table. The food containing dietary fiber is prepared for diabetes patients to eat, not only complements daily dietary fiber, but also favorably regulates the circadian rhythm,prevents the blood sugar from rising, has the assistant healthcare function for decreasing the cholesterol of the postprandial blood sugar and the fasting blood sugar of the diabetes patients, prevents diseases, promotes rehabilitation and integrates functions, convenience, recreation, and the like into a whole.

The invention provides a preparation method and application of total flavone and total polysaccharide in cyclocarya paliurus leaves. The method comprises the steps of taking cyclocarya paliurus leavesas raw materials, executing extraction by an ethanol-water solvent, executing extraction by an organic solvent, executing elution by a chromatographic column and by macroporous resin to obtain totalflavone, conducting extraction on cyclocarya paliurus leaf dregs by hot water, executing precipitation, removing protein, and adsorbing impurities by macroporous resin to obtain total polysaccharide.Studies show that the total triterpenes, the total flavones, the total polysaccharides and their composition prepared by the method can effectively increase glucose uptake of 3T3-L1 adipocytes, obviously reduce the fasting blood glucose level of the hereditary diabetes db/db mice, has antidiabetic activity, and can be used for preparing products such as antidiabetic medicines, health foods, functional foods and the like for reducing blood sugar. The invention develops the comprehensive preparation method of total flavones and total polysaccharides in cyclocarya paliurus leaves and applicationof the mehtod in resisting diabetes, and provides a basis and a new application direction for popularization, utilization and deep processing of traditional Chinese medicinal materials and new food raw materials.

The invention discloses a moringa leaf extract with blood sugar lowering activity and a preparation method thereof. The preparation method comprises the following steps: crushing and sieving, performing alkali treatment, performing protease enzymolysis, performing cellulase enzymolysis, performing high-pressure homogenization, performing high-temperature extraction, performing low-temperature high-speed centrifugation, performing ultrafiltration separation and concentration, performing protease enzymolysis, performing low-temperature high-speed centrifugation, performing secondary ultrafiltration separation and concentration, performing freeze drying and the like to obtain the moringa leaf extract with the blood sugar lowering activity. The extract has the polysaccharide content of 30% orabove; an animal experimental model of a type-2 diabetic rat verifies that the extract has good blood sugar lowering activity and can effectively reduce the fasting blood glucose of the type-2 diabetic rat and enhance the oral glucose tolerance dosage thereof; the acting effect of the extract is similar to that of metformin with the same dosage. An extracting technology is simple, the whole technological process can meet a food-grade requirement, and the moringa leaf extract can be applied to the field of medicines, health-care products, food and the like.

The invention discloses a method for providing a new intervention target for preparation of antihyperglycemic medicines and using the irisin into development of diabetes-related medicines to prepare relatively good medicines for treating diabetes. After STZ/HFD-induced mice with diabetes are subjected to subcutaneous injection with irisin, the fasting serum glucose level is significantly reduced; the insulin sensitivity is significantly improved; by irisin, gluconeogenesis is reduced and glycogen synthesis is increased; the application proves that irisin is capable of significantly improving glucose metabolic disorder and insulin resistance in diabetes, is an effective target for treating diabetes, and can be developed as a novel antihyperglycemic medicine or medicine target; and a new way and means are provided for detection and treatment of diabetes.

The invention discloses lactobacillus reuteri capable of intervening in metabolic syndrome and application, and belongs to the technical field of microorganisms. The lactobacillus reuteri CCFM1145 screened by the invention can significantly improve the increase of serum total cholesterol content of metabolic syndrome mice caused by high fat diet. The weight rise of metabolic syndrome individuals is relieved, and the daily diet intake and the energy efficiency are remarkably reduced. Fasting blood glucose and insulin resistance index levels of metabolic syndrome individuals are significantly improved. The rise of Romboutsia in the intestinal tract caused by high fat diet is obviously relieved. The levels of anti-oxidative stress CAT and SOD in the liver are remarkably improved, serum lipopolysaccharide endotoxin is inhibited, and a colon barrier structure is maintained. The lactobacillus reuteri CCFM1145 disclosed by the invention can be used for preparing pharmaceutical compositions and fermented foods for relieving diseases such as metabolic syndrome, non-alcoholic fatty liver disease and diabetes mellitus and the like, and has a very wide application prospect.

The invention discloses application of bifidobacterium adolescentis CCFM1061 in preparation of functional microbial agents, foods and/or medicines. The bifidobacterium adolescentis CCFM1061 can be rapidly colonized in the intestinal tracts, can remarkably improve fasting blood glucose and oral glucose tolerance of type 2 diabetes induced by STZ and high-fat diet and decrease the area under a curvewhen glucose tolerance is reduced, can remarkably alleviate the increase of total cholesterol and the decrease of high-density lipoprotein cholesterol in serum of the type 2 diabetes caused by STZ and high-fat diet, can remarkably alleviate the insulin resistance of the type 2 diabetes, can remarkably improve the level of inflammation in liver tissues of the type 2 diabetes, and can remarkably alleviate the pathological damage of the pancreas, liver and other tissues of the type 2 diabetes. In addition, the bifidobacterium adolescentis CCFM1061 has strong adsorption capacity on perfluorooctanoic acid (PFOA), and has the capacity of relieving PFOA toxicity.

The invention belongs to the field of traditional Chinese medicine manufacturing, and relates to application of leonurine to preparation of a medicament for treating 2-type diabetes. Animal experiments prove that the fasting blood glucose of a 2-type diabetes mouse, i.e., a db/db mouse, can be lowered by the leonurine, and the tolerance of oral glucose is improved; and meanwhile, fasting plasma insulin is increased, the plasma triglyceride is reduced and the content of the plasma high-density lipoprotein is increased. Experiment results also show that the expression of liver glucose metabolic enzymes such as glucokinase, glucose-6-phosphatase and phosphoenolpyruvate carboxyl enzyme is adjusted by the leonurine in an Akt dependent mode; and the biological response of an inflammatory mediator, such as generation of TNF (Tumor Necrosis Factor)-alpha, degradation of IkB-alpha and subsequent phosphorylation of NF-kBp65, is suppressed. Through the leonurine, the inflammatory state of the 2-type diabetes can be corrected, and the symptoms of the 2-type diabetes can be improved; and the leonurine can be used as a treatment medicament to be applied to the treatment of the 2-type diabetes.

The invention relates to a beverage, and particularly relates to a beverage containing a fresh ginseng juice. The beverage is prepared by squeezing fresh ginseng with addition of water and is sterilized by an ultrahigh pressure device. In vivo animal experiments show that the fresh ginseng juice can significantly reduce fasting blood glucose of 2-type diabetes, increase the fasting insulin level and improve the islet function.

The invention provides an exenatide oral nanoparticle and a preparation method thereof. The exenatide oral nanoparticle contains exenatide and CSK-chitosan. The exenatide oral nanoparticle can substantially improve the oral administration absorption effect, improves the bioavailability, and realizes fast blood sugar lowering effect and stable blood sugar.

The invention discloses a bacterial strain as well as a composition and application, and relates to the technical field of strain separation and application. The Cristinia sp. provided by the invention can be applied to treatment or prevention of liver function impairment and liver function impairment related diseases, alimentary canal mucosal injury and alimentary canal mucosal injury related diseases, diabetes, obesity and obesity related diseases. The inventor verifies that the Cristinia sp. provided by the invention has no toxic or side effect on the kidney and can reduce the weight of the liver; the initial steatohepatitis focus can be treated; fat accumulation of liver cells can be slowed down; AST and ALT in serum can be reduced; and abdominal white fat inflammatory lesion can be reduced. The Cristinia sp. can also repair the digestive tract mucosa, recover the barrier function of the mucosa, and prevent and treat intestinal leakage, peptic ulcer and other diseases caused by barrier function impairment. The Cristinia sp. also has the effects of reducing fasting blood-glucose of a body, regulating insulin level and reducing body fat of mammals, and has the effects of preventing and treating diabetes and improving the metabolic function of obese patients.

The composition Chinese-Western medicine for treating diabetes consists of 28 kinds of Chinese medicinal materials including tuckahoe, prepared rhizome of rehmannia, figwort root, trichosanthes root, astragalus root, etc. and Western medicine Glibenclamide. It has the toxic side effect of the Western medicine overcome and fast blood sugar reducing rate as well as simple preparation process, determined curative effect, lasting medicine effect and no bad reaction.

The invention relates to the field of fruit juice processing and in particular relates to wolfberry and sea-buckthorn fruit juice and a preparation method thereof. The wolfberry and sea-buckthorn fruit juice is prepared from the following raw materials in parts by weight: 94 parts of fresh wolfberries and 9-12 parts of sea-buckthorn original pulp. By combining sweetness of the fresh wolfberries with acidity of fresh sea-buckthorns, a fruit juice product is more balanced in nutrient, beneficial components, sourness and sweetness by means of a proper proportion without adding saccharose and other components. The obtained fruit juice has the advantages of sour and sweet and mellow and fragrant in taste, orange red in color and luster and rich in nutrition, can be directly drunk and functional factors are gathered and protect one another to exert a better health-care effect. The fasting blood sugar and postprandial blood sugar are stable if crowds with increased blood sugar drink the fruit juice. Moreover, the sea-buckthorn in the components also can bring acidity and guarantee the quality for the fruit juice besides providing beneficial substances. The product has a shelf life of over 12 months on the premise of not adding a preservative. The product is moderate in cost and better in economical benefit.

The invention provides a making method of konjac noodle products suitable for diabetics. The making method comprises the following steps of refining glucomannan powder, performing charging, performingrefining, performing discharging to obtain noodles, performing shaping and performing cooking. The made noodle products are strong basicity foods, green and bright in appearance, and smooth and tenacious in mouth feel, and the pH value is 11.5-12. After the konjac noodle products suitable for diabetics are eaten by patients with fasting blood sugar being less than or equal to 9.5 mmol\l for 6 months, the blood sugar can be reduced to 6.1mmol\l or below; after the konjac noodle products suitable for diabetics are eaten by patients with fasting blood sugar being greater than 9.5 and smaller than 10 mmol\l for 9 months, the blood sugar can be reduced to 6.1mmol\l or below; after the konjac noodle products suitable for diabetics are eaten by patients with fasting blood sugar being greater than 10 and smaller than 11 mmol\l for 12 months, the blood sugar can be reduced to 6.1mmol\l or below; and after the konjac noodle products suitable for diabetics are eaten by patients with fasting blood sugar being greater than 11 and smaller than 16 mmol\l for 12 months or more, the fasting blood sugar can be reduced to 7mmol\l or below.

The invention provides a hypoglycemic peptide, which is provided with an amino acid sequence as shown in SEQ ID NO: 1. The invention also provides a modified peptide of the hypoglycemic peptide. A chemical group, an amino acid, polypeptide, protein or PEG is connected to the N end, C end or intermediate residue of the hypoglycemic peptide. The hypoglycemic peptide provided by the invention can perfect the glucose tolerance of KK-Ay mice, reinforce the glucose utilization ability of the KK-Ay mice, significantly improve the fasting blood glucose and glucose tolerance of the KK-Ay mice, significantly reduce serum total cholesterol and serum triglyceride, significantly perfect the SOD level, reduce the MDA level and protect the body cells against oxygen free radicals, the hypoglycemic peptide has glucose and lipid reducing functions and can resist metabolic syndrome. The hypoglycemic peptide can be used for preparing drugs or healthcare products for treating and/or preventing diabetes or hyperlipidemia.

The invention discloses application of triacetyl-3-hydroxyphenyl adenosine, as shown in Formula (I), in preparing medicines for preventing, relieving or treating insulin resistance and related diseases, wherein the insulin resistance related diseases include type II diabetes, abnormal glucose tolerance, hyperinsulinemia, impaired glucose tolerance, hypertension, coronary disease, obesity and non-alcoholic fatty liver disease. Specifically, the triacetyl-3-hydroxyphenyl adenosine disclosed by the invention can improve the insulin sensitivity of peripheral tissues and the glucose tolerance of a body and the triacetyl-3-hydroxyphenyl adenosine can reduce insulin content, so that insulin resistance is improved (as shown in the Description).

The invention discloses a Chinese medicinal composition for assisting in decreasing blood sugar and a preparation method thereof. The composition is prepared from medicinal materials of panaxadiol saponins, astragalus, large-head atractylodes rhizome, epimedium herb, malaytea scurfpea fruit, south dodder seed, dried ginger, oriental waterplantain rhizome, Indian buead, dogwood and the like as raw materials. The invention further provides a preparation method of the Chinese medicinal composition for assisting in decreasing blood sugar. By using the composition provided by the invention, the fasting blood sugar of a rat with high blood sugar due to mesoxyalyurea can be lowered effectively, and the sugar tolerance can be well regulated. Compared with a control sample group, the Chinese medicinal composition is remarkably lower in fasting blood sugar and remarkably superior in sugar tolerance regulating effect. Experiment results show that the Chinese medicinal composition has a better blood sugar degreasing effect than the conventional traditional Chinese medicine, and is high in safety and free from side effects.

The invention relates to an assistant hypoglycemic momordica grosvenori preparation, and particularly provides dry powder which is extracted from immature momordica grosvenori with a growing period of 30-80 days and of which the total saponin content is 60%-90%, and a preparation method of the dry powder in preparation of assistant hypoglycemic oral liquid, particle, capsule and tablet. The assistant hypoglycemic momordica grosvenori preparation is capable of reducing fasting blood-glucose of patients with impaired glucose tolerance and the patients with type 2 diabetes mellitus, and simultaneously is capable of obviously inhibiting blood glucose rise after the meal and relieving the degree of insulin resistance.

The invention discloses a composition for regulating blood sugar as well as a preparation method and application thereof. The composition comprises inulin, peanut peptide, galactooligosaccharide, isomaltooligosaccharide, beta-glucan and vitamin C; wherein the inulin is an inulin mixture with the polymerization degree of 24-60. The inulin is used as a main raw material, the polymerization degree of the inulin is optimized, and meanwhile, various prebiotics, dietary fibers and vitamin C are added, so that the components play a synergistic role, proliferation of intestinal probiotics can be promoted, and the intestinal environment can be improved; in addition, fermentation of beneficial bacteria can be promoted to generate short-chain fatty acid, the sensitivity of insulin of type II diabetes patients is improved, food intake is reduced, then blood sugar is effectively controlled, fasting blood glucose of the diabetes patients is remarkably reduced, and glycated serum protein and glucose tolerance levels are improved. The composition provided by the invention is comprehensive in nutrition and excellent in blood sugar reducing effect, and has important significance on treatment and prevention and treatment of diabetes.

The invention relates to the technical field of a medicine for treating diabetes mellitus, in particular to the traditional Chinese medicine composition for treating prediabetes, i.e., the impaired glucose tolerance including impaired glucose tolerance and fasting blood-glucose damage stages. The traditional Chinese medicine composition is prepared by the following raw materials in parts by weight: 1 to 10 parts of rhizoma atractylodis macrocephalae, 1 to 10 parts of dried lily bulb, 2 to 10 parts of radix rehmanniae recen, 2 to 10 parts of radix astragali, 1 to 5 parts of rhizoma coptidis, 2 to 6 parts of semen coicis, 2 to 6 parts of angelica sinensis in Min county and 2 to 6 parts of flos sophorae immaturus. The traditional Chinese medicine composition provided by the invention is suitable for prediabetes, i.e., the impaired glucose tolerance including impaired glucose tolerance and fasting blood-glucose damage stages, which mainly aims at shortness of breath and tiredness and polydipsia and polydipsia which are caused by deficiency of both qi and yin and damp and hot internal resistance, sticky greasy mouth, and the like. The traditional Chinese medicine composition is capable of tonifying qi and yin, clearing heat and expelling damp, and promoting blood circulation to remove blood stasis.

The invention discloses a healthcare product for the auxiliary treatment of type 2 diabetes, and a preparation method thereof, and relates to the medical healthcare field. The preparation method of the healthcare product comprises the following steps: taking towel gourd seeds of towel gourds, cleaning, baking in a 20-50DEG C baking box, shelling, grinding the shelled towel gourd seeds to form fine powder, and adding auxiliary materials to prepare a pharmaceutically acceptable formulation. The cooperation of the healthcare product and other blood sugar reducing medicines allows the fasting blood sugar of a type 2 diabetic patient to be stably reduced, and the effect to be more substantial than the single use of the blood sugar reducing medicines and blood sugar reducing healthcare products, and has no side effects.

The invention discloses an NAD<+> composition for intervening in high fasting blood glucose in the early stage of diabetes as well as a preparation method and a use method of the NAD<+> composition. The NAD<+> composition is prepared from the following components in parts by mass: 30-50 parts of nicotinic acid, 30-50 parts of nicotinamide, 25-45 parts of nicotinamide mononucleotide, 25-45 parts of nicotinamide adenine dinucleotide, 20-30 parts of inulin, 10-20 parts of galactooligosaccharide, 10 parts of yeast beta-glucan, 10 parts of chitosan, 10 parts of raffinose and 10 parts of vitamin C. The raw and auxiliary materials adopted by the invention are all food-grade and free of side effects; and the NAD<+> composition can be drunk only by brewing with warm water, and is convenient and fast. Meanwhile, the NAD<+> composition has beneficial effects on other aspects of the body such as fatigue resistance and immunity improvement.

The invention discloses an application of a traditional Chinese medicine composition in preparation of drugs for treating diabetes and diabetic nephropathy. The traditional Chinese medicine composition is prepared from radix astragali, fructus lycii, rhizoma dioscoreae, semen coicis, radix scrophularise, radix glehniae, herba ecliptae, dried human placenta, cortex eucommiae, radix notoginseng, herba leonuri, leeches, cicada ecdysis, semen plantaginis and radix achyranthis bidentatae. According to the application, proven by experimental researches, the traditional Chinese medicine composition has a very good effect of reducing fasting blood-glucose of rats suffering from the diabetic nephropathy, and the content of blood serum creatinine, urea nitrogen, kidney index and urinary protein in the rats suffering from the diabetic nephropathy can be remarkably lowered. Meanwhile, the traditional Chinese medicine composition has a very good effect of preventing renal tubular epithelial cells from fibrosis. Novel pharmaceutical preparations for clinical indications can be developed.

The invention discloses an application of annona squamosa seed total lactones and annona squamosa pivalolactone monomeric compounds thereof to preparation of medicines for controlling diabetes and diabetic nephropathy thereof. Through massive experimental selection, results show that the annona squamosa seed total lactones and the annona squamosa pivalolactone monomeric compounds thereof have theefficacy of reducing fasting blood sugar of rats suffering from diabetic nephropathy, the content of serum creatinine, the content of urea nitrogen and the content of urine protein of the rats suffering from the diabetic nephropathy can be notably reduced, and the annona squamosa seed total lactones and the annona squamosa pivalolactone monomeric compounds thereof have good effects of reducing blood sugar and protecting the kidney.