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Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for improving insulin resistance and related diseases

A technology of hydroxyphenyladenosine and insulin resistance, applied in the field of medicine, can solve problems such as difficulty in using diabetes drugs, liver dysfunction, weight gain, etc.

Inactive Publication Date: 2016-06-15
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, biguanides can cause gastrointestinal disorders or occasionally cause lactic acidosis, and thiazolidine derivatives can cause serious side effects such as fluid retention or weight gain, liver dysfunction, etc., so they must be used with caution
In addition, for insulin resistance in the non-diabetic or hyperglycemic state, it is actually difficult to use diabetes drugs
There is no report on the application of this compound in insulin resistance and related diseases

Method used

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  • Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for improving insulin resistance and related diseases
  • Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for improving insulin resistance and related diseases
  • Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for improving insulin resistance and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Effect of Triacetyl-3-Hydroxyphenyl (IMM-H007) on Diet-Induced Insulin Resistance Mice

[0035] Materials and methods

[0036] 1.1 Animals and experimental design

[0037] C57BL / 6J mice at 8 weeks old were fed adaptively for 1 week, then fed with high-fat diet (ResearchDiets, D12451) for 16 weeks, and the successful modeling mice were screened by insulin resistance test (ITT), and randomly divided into 6 groups according to body weight , were model control group, positive control group (rosiglitazone control group 15mg / kg and AICAR control group 375mg / kg), IMM-H007 low-dose group (50mg / kg), IMM-H007 medium-dose group (100mg / kg kg) and IMM-H007 high-dose group (200mg / kg), 7 rats in each group, and a normal diet control group (6 rats). Oral administration once a day, normal control group and model group were given the same volume of vehicle (0.1ml / 10g body weight).

[0038] 1.2 Detection indicators

[0039]1) Insulin resistance experiment: Insulin resistanc...

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Abstract

The invention discloses application of triacetyl-3-hydroxyphenyl adenosine, as shown in Formula (I), in preparing medicines for preventing, relieving or treating insulin resistance and related diseases, wherein the insulin resistance related diseases include type II diabetes, abnormal glucose tolerance, hyperinsulinemia, impaired glucose tolerance, hypertension, coronary disease, obesity and non-alcoholic fatty liver disease. Specifically, the triacetyl-3-hydroxyphenyl adenosine disclosed by the invention can improve the insulin sensitivity of peripheral tissues and the glucose tolerance of a body and the triacetyl-3-hydroxyphenyl adenosine can reduce insulin content, so that insulin resistance is improved (as shown in the Description).

Description

technical field [0001] The invention relates to the application of triacetyl-3-hydroxyphenyl adenosine and a pharmaceutical composition containing it in the preparation of medicines for preventing, alleviating or treating insulin resistance and related diseases, belonging to the technical field of medicine. Background technique [0002] Insulin resistance refers to the state in which more than the normal amount of insulin is required to obtain the various effects of insulin at the cell, organ, and individual levels, that is, a state of incomplete insulin action with reduced sensitivity to insulin, which is the main pathophysiological basis of type 2 diabetes . According to the current immunological research results, hypertension, diabetes, coronary heart disease, obesity and non-alcoholic fatty liver are all accompanied by insulin resistance. [0003] At present, oral drugs for insulin resistance mainly include traditional antidiabetic drugs such as metformin and thiazolidi...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P5/50A61P3/10A61P9/12A61P9/10A61P3/04A61P1/16
Inventor 朱海波李瑾
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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