The invention provides a combination automatic control method with a single-joint manipulator under mixed suspension microgravity environments. The combination automatic control method comprises the following steps of 1, enabling a combination to be equivalent to an underwater robot, and establishing a kinematics equation and a dynamics equation; 2, approximating the dynamics equation of the combination by a radial basis function neural network, so as to obtain control force and control torque corresponding to the radial basis function neural network; 3, using a sliding mode control method, so as to obtain control force and control torque corresponding to sliding model control; 4, synthesizing the control force and control torque corresponding to the neural network and the control force and control torque obtained by the sliding model control method, and distributing thrust, so as to obtain a general vector which consists of thrust and joint torque of each propeller; approximating the thrust deviation of the corresponding thruster through the radial basis function neural network, so as to obtain the estimation value of the thrust deviation; 5, combining the results obtained in step 2, step 3 and step 4, obtaining the general vector consisting of the thrust and the joint torque of the corresponding propeller, and further obtaining the thrust and the joint torque of the corresponding propeller, so as to realize the automatic control.