The invention discloses an enterprise power consumption load prediction method based on a k-means clustering radial basis function (RBF) neural network. The method includes steps: historical load data acquisition, meteorological data acquisition, date discrimination, neural network prediction, error calculation and correction, load curve drawing, and prediction data export. A prediction result is obtained by employing the neural network via the historical load data and meteorological factor input quantity, and correction is realized via an error correction module. Based on the requirement control technology of load prediction, with the combination of an industrial enterprise production plan and the condition of power consumption load usage, the system performs requirement control via a built-in requirement curve node determination method at a control point before the load prediction value reaches the maximum requirement, whether unnecessary loads are removed is determined, the current most appropriate energy-saving scheme is automatically selected, the maximum requirement is controlled in advance, over-load operation and even tripping operation can be effectively avoided, and safety and energy-saving production is guaranteed.