6504 results about "Structure based" patented technology

A semiconductor light-emitting element is provided which has a structure that does not complicate a fabrication process, can be formed in high precision and does not invite any degradation of crystallinity. A light-emitting element is formed, which includes a selective crystal growth layer formed by selectively growing a compound semiconductor of a Wurtzite type, a clad layer of a first conduction type, an active layer and a clad layer of a second conduction type, which are formed on the selective crystal growth layer wherein the active layer is formed so that the active layer extends in parallel to different crystal planes, the active layer is larger in size than a diffusion length of a constituent atom of a mixed crystal, or the active layer has a difference in at least one of a composition and a thickness thereof, thereby forming the active layer having a number of light-emitting wavelength regions whose emission wavelengths differ from one another. The element is so arranged that an electric current or currents are chargeable into the number of light-emitting wavelength regions. Because of the structure based on the selective growth, the band gap energy varies within the same active layer, thereby forming an element or device in high precision without complicating a fabrication process.

The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a three dimensional structure of a lead antibody. The method comprises: providing an amino acid sequence of the variable region of the heavy chain (VH) or light chain (VL) of a lead antibody, the lead antibody having a known three dimensional structure which is defined as a lead structural template; identifying the amino acid sequences in the CDRs of the lead antibody; selecting one of the CDRs in the VH or VL region of the lead antibody; providing an amino acid sequence that comprises at least 3 consecutive amino acid residues in the selected CDR, the selected amino acid sequence being a lead sequence; comparing the lead sequence profile with a plurality of tester protein sequences; selecting from the plurality of tester protein sequences at least two peptide segments that have at least 10% sequence identity with lead sequence, the selected peptide segments forming a hit library; determining if a member of the hit library is structurally compatible with the lead structural template using a scoring function; and selecting the members of the hit library that score equal to or better than or equal to the lead sequence. The selected members of the hit library can be expressed in vitro or in vivo to produce a library of recombinant antibodies that can be screened for novel or improved function(s) over the lead antibody.

A method for determining a location of an object relative to a body structure includes: providing a location of a first part of the object relative to a second part of the object, said second part different from said first part; attaching a marker device to the body structure; detecting a location of the marker device relative to the body structure; positioning the object relative to the body structure; detecting a location of the first part of the object relative to the marker device; and calculating a relative location of the second part of the object relative to the location of the body structure based on the location of the first part relative to the second part, the location of the marker device relative to the body structure, and the location of the first part relative to the marker array.

Method and system to enable a user to view large collections of hierarchically linked information on a computer based display. A tree structure visualization is created which presents a representation of the complete collection of information on the display. The visualization fits completely within a fixed area of the computer based display, negating the need to scroll information into the display area. The visualization is based on identified focus nodes and through calculation of a Degree of Interest (DOI) for each of the nodes based in the structure. Layout and presentation of the visualization structure is based on the DOI values in combination with considerations of available display space. A user may dynamically manipulate views of the structure by selecting one or more focus nodes, thus causing a recalculation of the degree of interest.

A source-controlled Variable bit-rate Multi-mode WideBand (VMR-WB) codec, having a mode of operation that is interoperable with the Adaptive Multi-Rate wideband (AMR-WB) codec, the codec comprising: at least one Interoperable full-rate (I-FR) mode, having a first bit allocation structure based on one of a AMR-WB codec coding types; and at least one comfort noise generator (CNG) coding type for encoding inactive speech frame having a second bit allocation structure based on AMR-WB SID_UPDATE coding type. Methods for i) digitally encoding a sound using a source-controlled Variable bit rate multi-mode wideband (VMR-WB) codec for interoperation with an adaptative multi-rate wideband (AMR-WB) codec, ii) translating a Variable bit rate multi-mode wideband (VMR-WB) codecsignal frame into an Adaptive Multi-Rate wideband (AMR-WB) signal frame, iii) translating an Adaptive Multi-Rate wideband (AMR-WB) signal frame into a Variable bit rate multi-mode wideband (VMR-WB) signal frame, and iv) translating an Adaptive Multi-Rate wideband (AMR-WB) signal frame into a Variable bit rate multi-mode wideband (VMR-WB) signal frame are also provided.

Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.