245results about "Diagnostics using tomography" patented technology

A catheter configured for placement within a bodily lumen, comprises: a catheter sheath defining a first lumen for medical tools; and an exchange segment defining a second lumen for a guidewire. A proximal end of the exchange segment is joined with a distal end of the catheter sheath in a lengthwise direction forming an angle therebetween, such that the second lumen is laterally offset by a distance and angled with respect to the first lumen. When the catheter is placed within a patient's anatomy, the catheter sheath and / or the exchange segment straightens out so that the axis of the second lumen and the axis of the first lumen become substantially parallel to each other. The offset distance between the axes of sheath and exchange segment depends mainly on the diameter of the guidewire to be used, on the diameter of the sheath, and the angle of the junction.

The invention relates to the technical field of three-dimensional analysis, in particular to an oral cavity three-dimensional motion analysis system based on dynamic occlusion scanning. The system comprises an oral cavity occlusion feature extraction module, a dynamic occlusion reconstruction module, an occlusion track smoothing module and an oral cavity motion abnormity identification module, and a multi-view structured light scanner can be used for carrying out image scanning on the oral cavity in the dynamic occlusion process so as to obtain a multi-frame original occlusion image sequence; occlusal feature extraction and three-dimensional occlusal reconstruction are carried out on the multiple frames of original occlusal image sequences to construct corresponding three-dimensional occlusal model sequences; a dynamic occlusion trajectory prediction model is constructed based on the three-dimensional occlusion model sequence, oral cavity three-dimensional motion analysis and occlusion trajectory smoothing filtering processing are carried out, and a smooth three-dimensional occlusion motion trajectory is generated; and performing oral cavity motion abnormity identification according to the smooth three-dimensional occlusion motion track so as to generate an oral cavity occlusion three-dimensional motion abnormity identification result. According to the invention, accurate capture and analysis of three-dimensional motion of the oral cavity can be realized.

An apparatus for detecting and treating gastrointestinal pathology. The apparatus includes a wireless capsule, where the wireless capsule includes at least one of: an optical imaging system, a thermal imaging system, or a camera. The camera is a narrow band imaging system, a white light imaging system, or both.

An imaging system is provided comprising an imaging probe and at least one delivery device. The imaging probe comprises an elongate shaft, a rotatable optical core and an optical assembly. The elongate shaft comprises a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion. The rotatable optical core is positioned within the lumen of the elongate shaft and comprises a proximal end and a distal end. The rotatable optical core is configured to optically and mechanically connect with an interface unit. The optical assembly is positioned in the elongate shaft distal portion and proximate the rotatable optical core distal end. The optical assembly is configured to direct light to tissue and collect reflected light from the tissue. The imaging probe is constructed and arranged to collect image data from a patient site. The at least one delivery device is constructed and arranged to slidingly engage the imaging probe. Methods of introducing the imaging probe and the at least one delivery catheter into a patient are also provided.

The invention relates to an OCT (Optical Coherence Tomography) navigation uterine cavity adhesion and dissection postoperative residual adhesion prediction method, which comprises the following steps of: acquiring an interference signal of an intraoperative uterine cavity wall area by utilizing OCT equipment, and identifying an adhesion fiber microstructure which is not completely broken so as to judge the existence of an optically invisible residual adhesion microbridge; applying low-frequency bioelectrical stimulation to the wounded area of the uterine cavity during the operation, and marking the wounded area as a tissue repair electrical activity silent area if no blood flow micro-reaction is continuously detected; oCT micro-deformation sequence analysis is carried out on the region after intraoperative dissection is completed, mutation breakpoints of tissue elastic distribution are identified, and the potential risk that traction after-tack occurs in the region is predicted; detecting whether a metabolic oxidation reaction residual zone exists in the operation area or not so as to judge local tissue repair activity decline and re-adhesion tendency; local micro-intervention stimulation is applied to the tissue area judged to be high in risk, OCT imaging is carried out again to detect the reversibility of tissue optical response, and if an image is still fractured and red shift is enhanced, it is judged that the area is the postoperative irreversible adhesion residual area.

The invention discloses a cardiovascular three-dimensional optical coherence imaging system, and belongs to the technical field of medical instruments. A cardiovascular three-dimensional optical coherence imaging system comprises a host integration unit and an auxiliary diagnosis unit. The system solves the problem that accurate diagnosis and treatment requirements are difficult to meet in the prior art, interference signals are generated through the host integration unit, high-speed data processing is carried out in combination with the GPU, high-resolution cardiovascular tissue two-dimensional and three-dimensional images can be generated, powerful support is provided for early diagnosis and treatment of diseases, and the system is suitable for popularization and application. The auxiliary diagnosis unit establishes a cardiovascular disease diagnosis knowledge base based on a large amount of clinical case data, automatically identifies plaque types in a three-dimensional image by using a machine learning algorithm, can quickly and accurately provide diagnosis reference for doctors, and calculates a calcification radian score based on the distribution and geometric morphology of calcified plaques, so that the accuracy of diagnosis is improved. And the severity of lesion can be evaluated more accurately by quantitatively analyzing the poor attachment degree of the stent and the tissue prolapse volume.

In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's / subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and / or structural ophthalmic tests and output the test data.

An intraoral scanner comprises a first light source configured to generate first light that is monochromatic, a second light source configured to generate second light that is multichromatic, a third light source configured to generate third light. The intraoral scanner further comprises a mirror configured to direct at least the first light and the second light onto teeth of a patient, and to redirect first returning light, second returning light, and third returning light returning from the teeth to one or more sensors, wherein first returning light is associated with the first light, the second returning light is associated with the second light, and the third returning light is associated with the third light. The scanner further comprises the one or more sensors configured to perform hyperspectral imaging of the teeth based on at least one of the first returning light, the second returning light, or the third returning light.

There is provided a method of reconstruction of a target brain structure(s), comprising: reconstructing at least a part of a brain comprising boundaries of brain structures that include the target brain structure(s), wherein the reconstruction is insufficient for parceling of the target brain structure(s) into sub-structures of a same type of gray or white matter, reconstructing and parceling the target brain structure(s) using a reference atlas, segmenting and parceling at least one originating brain structure using the reference atlas, filtering white matter fibers to isolate at least one target white matter tract connecting the originating brain structure(s) and the target brain structure(s), and creating a 3D reconstruction of the target brain structure(s) and the target white matter tract(s), wherein the target white matter tract(s) and the target brain structure(s) are transformed and / or mapped to an anatomical native space.

Presented herein are systems and methods of determining density values from mammograms. A computing system may identify a first mammogram of a first breast region of a first subject. The first mammogram may have a first region of interest (ROI) corresponding to a first dense area of the first breast region. The computing system may apply the first mammogram to a machine learning (ML) model to generate a first segmentation map identifying the first ROI within the first mammogram. The computing system may determine a density value for the first dense area of the first breast region based on the first segmentation map.

The present invention provides an apparatus and method for detecting and predicting shape and underlying object properties. In accordance with an aspect of the present disclosure, there is provided an imaging apparatus having: an array of at least three co-planar electromagnetic transceiver defining a receiving plane; at least one deformable electromagnetic transceiver moveable orthogonally to the receiving plane; a two dimensional (2D) position tracking device configured to track a position of the electromagnetic transceiver on a surface 110 bounding a volume to be imaged; wherein the electromagnetic transceivers are configured to generate data from at least three depths below the surface for use in creating an image of the volume when the apparatus is moved along the surface.

Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.

A method of identifying changes in lung health using 3-dimensional image datasets, including acquiring two 3-dimensional image datasets of a lung, each 3-dimensional image dataset being acquired during a different breath; calculating a relative regional volume of a region of the lung for each of the two 3-dimensional image datasets; comparing the relative regional volumes calculated at each breath to assess a change in relative regional volume of the region between the two breaths, wherein the change in relative regional volume is indicative of a change in lung health.

A positioning apparatus for adjusting a posture of a patient for an imaging and / or interventional and / or therapeutic examination of the patient is provided. The apparatus comprises a patient support device, an interface unit, and a computing unit. The patient support device is adjustable such that one or more body segments of the patient may be arranged and / or fixed in a predetermined posture. The interface unit is configured to provide examination information indicative of an examination to be performed at the patient. The computing unit is configured to receive the examination information via the interface unit. The computing unit is further configured to determine, based on the examining information, a posture of one or more body segments of the patient for the examination. The computing unit is configured to generate one or more control signals, the one or more control signals being suited to control the patient support device such that the patient support device is adjusted such that the one or more body segments of the patient are arranged and / or fixed in the determined posture. The computing unit is further configured to provide the control signals to the patient support device, preferably via the interface unit.

Disclosed herein is a near-infrared imaging system for identifying a target feature in an object. The system comprises a near-infrared transmitter receiver array for transmitting near-infrared radiation into the object and receiving corresponding near-infrared radiation emitted from the object and a data processing system (215) configured to process near-infrared radiation received via the near-infrared transmitter receiver array in accordance with a near- infrared imaging model (216). The system further comprises signal transmitting means (205) arranged to transmit one or more further signals into the object; and signal receiving means (206) arranged to receive the one or more further signals from the object. The data processing system (215) is further configured to process one or more characteristics of the one or more further signals received by the signal receiving means (206) to generate one or more constraints (218) to apply to the near-infrared imaging model (216).

The invention relates to a three-dimensional fluorescence tomography imaging device, which comprises a shooting part, an image processing part, a plurality of exciting light emitting parts, a tomography light emitting part, a first reflecting mirror, a beam splitter, a second reflecting mirror, a multi-wavelength light source part and a wavelength adjustable light filter, the image processing part calculates the depth corresponding to each fluorescent image according to the depth information in the optical coherence tomography image, and combines each fluorescent image according to the depth to form a three-dimensional fluorescent tomography image of the shooting object corresponding to the first fluorescent developing agent.

An optical tomography device includes a sample optical path system for injecting light, scanned from a light source, into a sample corresponding to biological tissue; a reference optical path system for collecting the light scanned from the light source; and a detection unit for detecting a tomography image of the sample by interfering with sample light, transmitted from the sample optical path system and reflected from the sample, and reference light transmitted from the reference optical path system. The detection unit comprises: a nonlinear crystal which receives the sample light and the reference light and generates nonlinear light having a different wavelength than the sample light and the reference light; and an image sensor which detects a depth direction signal from the nonlinear light.

An intraoral scanner having a tomographic imaging function includes an OCT body configured to obtain an internal cross-sectional image of an oral structure; an OCT scan probe configured to irradiate the layer measurement light emitted from the OCT body onto the oral structure and transfer the reflected light to the OCT body; and a control / processing unit configured to control the OCT body, take a tomographic image of the oral structure, obtain two or more two-dimensional cross-sectional images, extract an internal crack area for the respective two-dimensional cross-sectional images, calculate cross-sectional position information of the internal crack, then arrange the position information of the internal crack obtained from the respective two-dimensional cross-sectional images in positions where the respective two-dimensional cross-sectional images have been obtained, and obtain three-dimensional shape information of the internal crack.

The present application provides a kind of optical angiography based on optical coherence tomography, first by optical coherence tomography system to biological tissue B scanning and C scanning, obtains three-dimensional structure image.The interference spectrum of each A scanning signal of B scanning is preprocessed, and the interference spectrum is decomposed into N sub-interference spectrum signals, N is greater than or equal to 2.Fourier transform is carried out to the sub-interference spectrum signal, and N groups of structure map data at the same position are obtained.Speckle variance is solved to N groups of structure map data, and speckle variance is averaged in depth direction.Compared with prior art, the present application angiography method does not need to repeat signal acquisition at the same position, greatly improves the acquisition speed of system, and can avoid the interference of traditional optical coherence tomography angiography system on reconstructed image caused by living sample shaking.

Method for operating a dental diagnostic imaging system for temporomandibular joint (TMJ) diagnostics and / or TMJ therapy, providing at least two modalities for generating (205, 210) three-dimensional image data, wherein a first image and at least a second image depicting the surface of the object (120) to be imaged are tomographically generated for a dental object (120) comprising at least one TMJ (105, 110), wherein the at least two three-dimensional image data generated (205, 210) in the at least two images are combined by means of a multimodal registration (225, 230) (225), wherein the generation (205, 210) of the at least two three-dimensional image data on the object (120) to be imaged is carried out with markings (125, 310 - 325) captured in the at least two images of different modalities (200).and wherein the at least two three-dimensional image data are spatially assigned to the temporomandibular joint (105, 110) by means of multimodal registration (225, 230) on the basis of the markers (125, 310-325) captured in the three-dimensional image data of both modalities (225), wherein the markers (125, 310-325) are arranged in a spatially restricted recording area for the at least two recordings of different modalities, wherein the markers (125, 310-325) are visible in the at least two recordings of different modalities, and wherein the image data generation is carried out at least by means of the first tomographic recording with the spatially restricted recording area corresponding to the markers (125, 310-325) (205, 210), wherein the spatially restricted recording area is arranged within the oral region of a patient for temporomandibular joint diagnostics and / or for temporomandibular joint therapy, characterized in thatthat the markings (125, 310 - 325) are arranged on a template (115) that can be precisely positioned within the patient's oral cavity, wherein the template (115) is placed in the restricted recording area (200) before the generation (205, 210) of the three-dimensional image data.

Epidural electrical stimulation (EES) systems and techniques for accessing and locating targeted spinal cord segments are disclosed. In some examples, a method includes providing a first set of electrodes of an EES system at a first set of locations on the dura mater of a spine of a mammal, the first set of locations on the dura mater corresponding to a first muscle group of the mammal; providing a second set of electrodes of the epidural electrical stimulation system at a second set of locations on the dura mater of the spine of the mammal, the second set of locations on the dura mater corresponding to a second muscle group of the mammal; and stimulating the first and second sets of locations on the dura mater by electrically energizing the first and second sets of electrodes, respectively, thereby activating the first and second muscle groups in a coordinated manner.

The present invention belongs to the field of molecular imaging technology and discloses a method, system, device and storage medium for rapid reconstruction of fluorescence molecular tomography. The method excites a specific fluorescent probe through an excitation light source and uses a data acquisition system to obtain light distribution information on the surface of biological tissues. The method constructs a linear relationship between the surface light source distribution and the fluorescent target based on a light transmission model and a finite element method. The linear relationship obtained is converted into an optimization problem to be solved. The optimization problem is quickly solved using an adaptive fast iterative shrinkage threshold algorithm, and the results are displayed to complete the reconstruction. The present invention adopts multi-point excitation and multi-angle measurement, and at the same time combines the light transmission model and the finite element method to establish a linear relationship between the measurement data and the fluorescent target, and converts it into an optimization problem. The adaptive fast iterative shrinkage threshold algorithm is used to quickly solve the optimization problem to be solved, thereby ensuring the reconstruction accuracy while also speeding up the reconstruction speed, effectively improving the efficiency of fluorescence molecular tomography.

Systems and methods of predicting microcalcification activity in a vascular vessel comprising either an artery or a vein, comprising the steps of: (a) measuring patient data comprising one or more of: the existence of and / or quantity of coronary plaques or visible markers of disease in a vascular tissue sample; the existence of and / or quantity of healthy tissue in the vascular tissue sample; one or more features that define an abnormal hemodynamic environment in a vessel; one or more geometric features that are associated with vascular remodeling and which influence hemodynamics in a vessel, and / or one or more material properties that influence vascular hemodynamics; and (b) calculating the microcalcification activity in the vessel as a function of the measurements taken in Step (a).

The present application discloses a system and interactive method for evaluating the cognitive function of a subject based on fNIRS. The head cap and near-infrared light emitting / receiving probe in the system enable the imaging range to cover the frontal lobe, temporal lobe, and occipital lobe; the cognitive assessment paradigm interactive device sequentially executes the inhibitory control assessment paradigm, the alert attention assessment paradigm, the selective attention assessment paradigm, the core attention network assessment paradigm, the working memory assessment paradigm, and the cognitive control assessment paradigm in a single-block mode in an order of execution from simple to difficult; the signal acquisition device collaboratively collects near-infrared brain function imaging time series data during the sequential execution of each assessment paradigm; the processing device evaluates the cognitive function of the subject based on the near-infrared brain function imaging time series data and the behavioral data generated based on the assessment paradigm. The present application can obtain brain function data of more dimensions associated with cognitive function in a relatively short period of time, which is convenient for clinical evaluation and analysis of the cognitive function of the subject from multiple angles based on fNIRS.

In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.

A photoacoustic tomography system includes a first ring-shaped mirror having a central axis therethrough and configured to converge light inwardly towards the central axis and a subject, and an adjustment mechanism configured to move the first ring-shaped mirror along the central axis to a plurality of different positions. Each position of the plurality of different positions allows the first ring-shaped mirror to illuminate a respective ring of light around a respective portion of the subject, and an acoustic signal detector is movable along the central axis such that acoustic signals can be detected from the respective portion of the subject when illuminated by the first ring-shaped mirror while at each respective position of the plurality of different positions.

The application discloses an imaging method for fusing photon weight and diffuse light brain tissue blood oxygen concentration change quantity and related products, and relates to the technical field of biological tissue blood oxygen imaging. The method comprises the following steps: acquiring experimental data obtained by irradiating a measured tissue with light sources of two wavelengths; performing the following calculation on the experimental data corresponding to each wavelength of the light source: calculating the average photon transmission path of the kth light probe combination in the ith voxel unit by using a formula; calculating the photon weight of the kth light probe combination in the ith voxel unit by using a formula; calculating the change quantity of the tissue absorption coefficient of the ith voxel unit by using a formula; and finally calculating the change quantity of the concentrations of oxyhemoglobin and deoxyhemoglobin by using the calculation data obtained by the two wavelengths. The application proposes a method for fusing photon weight, and by means of weight calculation, the accurate brain tissue blood oxygen concentration change quantity can be obtained by using a small amount of S-D combination photon signals.

An ophthalmic scanning system includes a first imaging modality, a second imaging modality different from the first imaging modality, and a control system that maps the first imaging modality to the second imaging modality by compensating for at least one of an optical-mechanical and an electro-mechanical projection difference between the first and second imaging modalities. The control system provides a scan location for the second imaging modality based on a scan location of the first imaging modality.

This image diagnosis catheter has an outer tube, an inner tube, an inner-tube support tube, and a drive shaft in this order, and further includes: an inner tube spacer that holds the inner-tube support tube so as to define an inner-tube support tube outer flow path; a connector hub movable to a distal end side and a proximal end side relative to the outer tube together with the inner tube, the inner-tube support tube, the drive shaft, and the inner tube spacer; and an inner flow path and an outer flow path through which a priming solution flows. An inner-tube-spacer proximal-side flow path is formed on the proximal end side relative to the inner tube spacer. At least the inner tube spacer defines an inner-tube-spacer partition flow path. The inner flow path includes the inner-tube-spacer proximal-side flow path and an inner-tube support tube inner flow path in this order from an upstream side to a downstream side. The outer flow path includes the inner-tube-spacer proximal-side flow path, the inner-tube-spacer partition flow path, and the inner-tube support tube outer flow path in this order from the upstream side to the downstream side.

The invention relates to a melanin aging evaluation method based on skins with different depths. The melanin aging evaluation method comprises the following steps: acquiring an ultrasonic image of a skin cross section structure and a photoacoustic image containing melanin photoacoustic signals; performing skin boundary positioning and extraction on the ultrasonic image; based on the boundary relation between the ultrasonic image and the photoacoustic image, the skin boundary of the ultrasonic image and the photoacoustic image is set to the same height, the ultrasonic image and the photoacoustic image are fused, and a three-dimensional image is obtained through reconstruction and used for researching melanin space distribution at different depth positions; based on the distribution characteristics of melanin photoacoustic signals along with the depth of the skin, the skin is divided into three anatomical characteristic areas of a keratinization layer (I), a basal layer (II) and a dermal superficial layer (III); respectively calculating the melanin deposition rate of the keratinization layer, the melanin metabolism rate of the substrate layer and the melanin content of the dermal superficial layer; and comprehensively evaluating the skin aging degree by combining a calculation result. The method can improve the accuracy of aging degree evaluation.