124results about "Diagnostics using tomography" patented technology

A catheter configured for placement within a bodily lumen, comprises: a catheter sheath defining a first lumen for medical tools; and an exchange segment defining a second lumen for a guidewire. A proximal end of the exchange segment is joined with a distal end of the catheter sheath in a lengthwise direction forming an angle therebetween, such that the second lumen is laterally offset by a distance and angled with respect to the first lumen. When the catheter is placed within a patient's anatomy, the catheter sheath and / or the exchange segment straightens out so that the axis of the second lumen and the axis of the first lumen become substantially parallel to each other. The offset distance between the axes of sheath and exchange segment depends mainly on the diameter of the guidewire to be used, on the diameter of the sheath, and the angle of the junction.

The invention relates to the technical field of three-dimensional analysis, in particular to an oral cavity three-dimensional motion analysis system based on dynamic occlusion scanning. The system comprises an oral cavity occlusion feature extraction module, a dynamic occlusion reconstruction module, an occlusion track smoothing module and an oral cavity motion abnormity identification module, and a multi-view structured light scanner can be used for carrying out image scanning on the oral cavity in the dynamic occlusion process so as to obtain a multi-frame original occlusion image sequence; occlusal feature extraction and three-dimensional occlusal reconstruction are carried out on the multiple frames of original occlusal image sequences to construct corresponding three-dimensional occlusal model sequences; a dynamic occlusion trajectory prediction model is constructed based on the three-dimensional occlusion model sequence, oral cavity three-dimensional motion analysis and occlusion trajectory smoothing filtering processing are carried out, and a smooth three-dimensional occlusion motion trajectory is generated; and performing oral cavity motion abnormity identification according to the smooth three-dimensional occlusion motion track so as to generate an oral cavity occlusion three-dimensional motion abnormity identification result. According to the invention, accurate capture and analysis of three-dimensional motion of the oral cavity can be realized.

An imaging system is provided comprising an imaging probe and at least one delivery device. The imaging probe comprises an elongate shaft, a rotatable optical core and an optical assembly. The elongate shaft comprises a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion. The rotatable optical core is positioned within the lumen of the elongate shaft and comprises a proximal end and a distal end. The rotatable optical core is configured to optically and mechanically connect with an interface unit. The optical assembly is positioned in the elongate shaft distal portion and proximate the rotatable optical core distal end. The optical assembly is configured to direct light to tissue and collect reflected light from the tissue. The imaging probe is constructed and arranged to collect image data from a patient site. The at least one delivery device is constructed and arranged to slidingly engage the imaging probe. Methods of introducing the imaging probe and the at least one delivery catheter into a patient are also provided.

The invention relates to an OCT (Optical Coherence Tomography) navigation uterine cavity adhesion and dissection postoperative residual adhesion prediction method, which comprises the following steps of: acquiring an interference signal of an intraoperative uterine cavity wall area by utilizing OCT equipment, and identifying an adhesion fiber microstructure which is not completely broken so as to judge the existence of an optically invisible residual adhesion microbridge; applying low-frequency bioelectrical stimulation to the wounded area of the uterine cavity during the operation, and marking the wounded area as a tissue repair electrical activity silent area if no blood flow micro-reaction is continuously detected; oCT micro-deformation sequence analysis is carried out on the region after intraoperative dissection is completed, mutation breakpoints of tissue elastic distribution are identified, and the potential risk that traction after-tack occurs in the region is predicted; detecting whether a metabolic oxidation reaction residual zone exists in the operation area or not so as to judge local tissue repair activity decline and re-adhesion tendency; local micro-intervention stimulation is applied to the tissue area judged to be high in risk, OCT imaging is carried out again to detect the reversibility of tissue optical response, and if an image is still fractured and red shift is enhanced, it is judged that the area is the postoperative irreversible adhesion residual area.

Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.

Disclosed herein is a near-infrared imaging system for identifying a target feature in an object. The system comprises a near-infrared transmitter receiver array for transmitting near-infrared radiation into the object and receiving corresponding near-infrared radiation emitted from the object and a data processing system (215) configured to process near-infrared radiation received via the near-infrared transmitter receiver array in accordance with a near- infrared imaging model (216). The system further comprises signal transmitting means (205) arranged to transmit one or more further signals into the object; and signal receiving means (206) arranged to receive the one or more further signals from the object. The data processing system (215) is further configured to process one or more characteristics of the one or more further signals received by the signal receiving means (206) to generate one or more constraints (218) to apply to the near-infrared imaging model (216).

The invention relates to a three-dimensional fluorescence tomography imaging device, which comprises a shooting part, an image processing part, a plurality of exciting light emitting parts, a tomography light emitting part, a first reflecting mirror, a beam splitter, a second reflecting mirror, a multi-wavelength light source part and a wavelength adjustable light filter, the image processing part calculates the depth corresponding to each fluorescent image according to the depth information in the optical coherence tomography image, and combines each fluorescent image according to the depth to form a three-dimensional fluorescent tomography image of the shooting object corresponding to the first fluorescent developing agent.

The present application provides a kind of optical angiography based on optical coherence tomography, first by optical coherence tomography system to biological tissue B scanning and C scanning, obtains three-dimensional structure image.The interference spectrum of each A scanning signal of B scanning is preprocessed, and the interference spectrum is decomposed into N sub-interference spectrum signals, N is greater than or equal to 2.Fourier transform is carried out to the sub-interference spectrum signal, and N groups of structure map data at the same position are obtained.Speckle variance is solved to N groups of structure map data, and speckle variance is averaged in depth direction.Compared with prior art, the present application angiography method does not need to repeat signal acquisition at the same position, greatly improves the acquisition speed of system, and can avoid the interference of traditional optical coherence tomography angiography system on reconstructed image caused by living sample shaking.

Method for operating a dental diagnostic imaging system for temporomandibular joint (TMJ) diagnostics and / or TMJ therapy, providing at least two modalities for generating (205, 210) three-dimensional image data, wherein a first image and at least a second image depicting the surface of the object (120) to be imaged are tomographically generated for a dental object (120) comprising at least one TMJ (105, 110), wherein the at least two three-dimensional image data generated (205, 210) in the at least two images are combined by means of a multimodal registration (225, 230) (225), wherein the generation (205, 210) of the at least two three-dimensional image data on the object (120) to be imaged is carried out with markings (125, 310 - 325) captured in the at least two images of different modalities (200).and wherein the at least two three-dimensional image data are spatially assigned to the temporomandibular joint (105, 110) by means of multimodal registration (225, 230) on the basis of the markers (125, 310-325) captured in the three-dimensional image data of both modalities (225), wherein the markers (125, 310-325) are arranged in a spatially restricted recording area for the at least two recordings of different modalities, wherein the markers (125, 310-325) are visible in the at least two recordings of different modalities, and wherein the image data generation is carried out at least by means of the first tomographic recording with the spatially restricted recording area corresponding to the markers (125, 310-325) (205, 210), wherein the spatially restricted recording area is arranged within the oral region of a patient for temporomandibular joint diagnostics and / or for temporomandibular joint therapy, characterized in thatthat the markings (125, 310 - 325) are arranged on a template (115) that can be precisely positioned within the patient's oral cavity, wherein the template (115) is placed in the restricted recording area (200) before the generation (205, 210) of the three-dimensional image data.

Systems and methods of predicting microcalcification activity in a vascular vessel comprising either an artery or a vein, comprising the steps of: (a) measuring patient data comprising one or more of: the existence of and / or quantity of coronary plaques or visible markers of disease in a vascular tissue sample; the existence of and / or quantity of healthy tissue in the vascular tissue sample; one or more features that define an abnormal hemodynamic environment in a vessel; one or more geometric features that are associated with vascular remodeling and which influence hemodynamics in a vessel, and / or one or more material properties that influence vascular hemodynamics; and (b) calculating the microcalcification activity in the vessel as a function of the measurements taken in Step (a).

The application discloses an imaging method for fusing photon weight and diffuse light brain tissue blood oxygen concentration change quantity and related products, and relates to the technical field of biological tissue blood oxygen imaging. The method comprises the following steps: acquiring experimental data obtained by irradiating a measured tissue with light sources of two wavelengths; performing the following calculation on the experimental data corresponding to each wavelength of the light source: calculating the average photon transmission path of the kth light probe combination in the ith voxel unit by using a formula; calculating the photon weight of the kth light probe combination in the ith voxel unit by using a formula; calculating the change quantity of the tissue absorption coefficient of the ith voxel unit by using a formula; and finally calculating the change quantity of the concentrations of oxyhemoglobin and deoxyhemoglobin by using the calculation data obtained by the two wavelengths. The application proposes a method for fusing photon weight, and by means of weight calculation, the accurate brain tissue blood oxygen concentration change quantity can be obtained by using a small amount of S-D combination photon signals.

This image diagnosis catheter has an outer tube, an inner tube, an inner-tube support tube, and a drive shaft in this order, and further includes: an inner tube spacer that holds the inner-tube support tube so as to define an inner-tube support tube outer flow path; a connector hub movable to a distal end side and a proximal end side relative to the outer tube together with the inner tube, the inner-tube support tube, the drive shaft, and the inner tube spacer; and an inner flow path and an outer flow path through which a priming solution flows. An inner-tube-spacer proximal-side flow path is formed on the proximal end side relative to the inner tube spacer. At least the inner tube spacer defines an inner-tube-spacer partition flow path. The inner flow path includes the inner-tube-spacer proximal-side flow path and an inner-tube support tube inner flow path in this order from an upstream side to a downstream side. The outer flow path includes the inner-tube-spacer proximal-side flow path, the inner-tube-spacer partition flow path, and the inner-tube support tube outer flow path in this order from the upstream side to the downstream side.

A computer-implemented image processing method for removing complex conjugate image data from image data in real-time using dispersion comprising receiving an image signal comprising image data including complex conjugate image data (902), performing baseline signal subtraction (906), resampling wavelength data to generate linear wavenumber image data (908, 910), processing the linear wavenumber image data to generate a complex conjugate resolved, CCR, result using at least one iteration of a CCR image processing algorithm (912), and computing a CCR image from the CCR result (914); and separating the resulting CCR image from the received OCT image data to remove the complex conjugate image data. The method may be performed in real-time and may use phase or magnitude data or a synthesis of the two when generating the image data from the CCR result.

Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

A high-dispersion single-mode hybrid optical fiber (1900) located in one of the reference arm or probe arm of an optical interferometer, wherein the hybrid fiber (1900) comprises at least two optical fibers (1902,1902), at least one of the at least two optical fibers having a different core diameter and at least one of the at least two optical fibers having different dispersion characteristics, the at least two optical fibers being fused together at their ends to form a hybrid optical fiber, and each of the at least two optical fibers having a length based on the core diameter of the optical fiber with respect to the central wavelength of the light beam passing through the hybrid optical fiber and a target GDD per unit length based on the target length of the hybrid optical fiber, wherein the hybrid optical fiber adds an additional GDD value compared to an optical fiber in the other of the reference arm or probe arm of an optical interferometer.

Imaging system for a cutaneous pigment disorder which comprises: - an device (A) for acquiring 2D images of the pigment disorder, comprising: a light source comprising at least one emitter and receivers, - a unit (B) for processing the 2D images acquired, - means (D1) for displaying the images processed. The invention further comprises: - means for positioning the receivers at at least two viewing angles, which positioning means are distributed along a spherical cap, - a structure for protecting the acquisition device (A) and an operator, comprising a receiver-positioning opening, the protection structure being intended to be positioned on the skin. The processing unit (8) comprises a 3D reconstruction module with a reflective Radon transform in order to obtain a 3D image which is reconstructed from the 2D images processed and the display means further comprise means (D2) for displaying the reconstructed 3D image.

In accordance with various embodiments of the present disclosure, a device for non-invasive medical imaging is provided. In some embodiments, the device comprises a photonic integrated circuit scale dual frequency comb (DFC), a hand-held wand, and at least one processing element. The wand comprises at least one emission point for emitting light from the DFC at a plurality of different wavelengths and at least three sensors. The wand directs the emitted light at one or more bodily structures. The sensors are adapted to detect acoustic waves from thermo-elastic changes in one or more elements within the bodily structures. The processing element is for generating an optical absorption spectrum from the detected acoustic waves, identifying one or more elements within the bodily structures based on the optical absorption spectrum, and generating a three-dimensional image of the elements based on the optical absorption spectrum from the detected acoustic waves.

The disclosure provides a breast dynamic optical tomography system based on fluorescence image guidance, comprising: a first lifting platform for adjusting the height of a light source module and a detection module; a second lifting platform for controlling the movement of a pressing plate; one side of the pressing plate is fixed on the second lifting platform, and the other side is used for pressing the tissue to be detected; the light source module generates detection light; the detection module samples the surface emission light of the detection light after passing through the tissue to be detected to obtain each wavelength emission light image; a host module processes the surface fluorescence image by using a fluorescence diffuse optical tomography method to obtain a segmentation image; the time sequence of the surface diffuse light image is demodulated to obtain the time sequence of the surface diffuse light image corresponding to each wavelength; and a diffuse optical tomography method is used to process the segmentation image and the time sequence of the surface diffuse light image corresponding to each wavelength to obtain the time sequence of the three-dimensional image of the absorption coefficient change corresponding to each wavelength.

Some disclosed methods involve controlling, by a control system, at least one sensor to capture image data corresponding to a current arterial location of an artery based on a current orientation of the apparatus. Some such methods involve obtaining, by the control system, calibration information associated with at least one calibrated arterial location at which the apparatus was previously calibrated, wherein the calibration information includes image data captured by the at least one sensor of the calibrated arterial location. Some such methods involve determining, by the control system, a threshold similarity between the image data corresponding to the current arterial location and the image data corresponding to the calibrated arterial location. Some such methods involve determining, by the control system and based on the threshold similarity, that the current orientation of the apparatus corresponds to the orientation of the apparatus when calibrated at the calibrated arterial location.

The invention relates to a method for reducing noise and decoupling local birefringence of intravascular polarization sensitive coherence tomography. The method comprises the following steps: acquiring a measurement Mueller matrix from a catheter polarization sensitive optical coherence tomography PS-OCT system; determining a reference measurement Mueller matrix; acquiring a global Mueller matrix; obtaining a medium depolarization moment according to a medium depolarization extraction method; calculating a pseudo-depolarization-free matrix; obtaining a noise depolarization matrix; calculating a standard deviation matrix for the noise depolarization matrix; obtaining a phase delay initial value delta0; generating a test noise depolarization matrix; generating a noise reduction global Mueller matrix; calculating a local Mueller matrix; calculating a local birefringence; and performing traversal calculation to obtain a local birefringence two-dimensional polar coordinate distribution diagram.

A method for detecting inflammatory activity, including: providing a catheter including a near-infrared fluorescence (NIRF) imaging system configured to perform NIRF imaging and an optical coherence tomography (OCT) imaging system configured to perform structural imaging; introducing a near-infrared fluorescent cathepsin-activatable imaging agent into a blood vessel; placing a distal end of the catheter within the blood vessel; obtaining, using the OCT imaging system, structural images of an atherosclerotic plaque within the blood vessel; obtaining, using the NIRF imaging system. NIRF images of the atherosclerotic plaque within the blood vessel; detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images; and identifying inflammation within the atherosclerotic plaque based on detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images.

An image diagnosis catheter, which includes an outer tube, an inner tube, an inner-tube support tube, and a drive shaft in this order, and further includes: an inner tube spacer that holds the inner-tube support tube so as to define an inner-tube support tube outer flow path; a connector hub movable to a distal end side and a proximal end side relative to the outer tube together with the inner tube, the inner-tube support tube, the drive shaft, and the inner tube spacer; and an inner flow path and an outer flow path through which a priming solution flows. An inner-tube-spacer proximal-side flow path is formed on the proximal end side relative to the inner tube spacer. At least the inner tube spacer defines an inner-tube-spacer partition flow path.

The application discloses a line illumination modulation dichromatic tomography imaging system, belonging to the technical field of multicolor tomography imaging, comprising: a line illumination modulation module, comprising two monochromatic light sources and a modulation light path, each light beam is modulated to form a line light spot focused on the focal plane of an objective lens, the position parameter of the line light spot is located on the center of a pixel row or the intersection line of adjacent pixel rows; the distance between the position parameters of the two line light spots is an integer multiple of 0.5 pixels; an imaging module, a multi-element detector with n rows of pixels is used to continuously scan imaging along a first direction, n mixed images are obtained, each mixed image corresponds to a row of pixels, each mixed image contains the signals of 2 channels, n is a positive integer; an image demodulation module is used to subtract the mixed images of two symmetrical pixel rows, the signals of one channel are eliminated from the mixed images, monochromatic images are demodulated, and the monochromatic images contain the signals of another channel. The application realizes synchronous dichromatic tomography imaging on a single detector.

A method of determining axial alignment of a lower limb includes determining a three-dimensional volume based on a scan of a lower limb of a patient, identifying a level of hip version by referring to a first axis of symmetry of a femoral neck and a second axis of symmetry of a distal portion of a femur, wherein hip version is defined by an angle between the first axis of symmetry and the second the second axis of symmetry, identifying a level of tibial torsion by referring to a third axis of symmetry of a proximal portion of a tibia and a fourth axis of symmetry of a distal portion of the tibia, wherein tibial torsion is defined by an angle between the third axis of symmetry and the fourth axis of symmetry, and providing the level of hip version and the level of tibial torsion to a user.

Some disclosed methods involve controlling, by a control system, at least one sensor to capture image data corresponding to a current arterial location of an artery based on a current orientation of the apparatus. Some such methods involve obtaining, by the control system, calibration information associated with at least one calibrated arterial location at which the apparatus was previously calibrated, wherein the calibration information includes image data captured by the at least one sensor of the calibrated arterial location. Some such methods involve determining, by the control system, a threshold similarity between the image data corresponding to the current arterial location and the image data corresponding to the calibrated arterial location. Some such methods involve determining, by the control system and based on the threshold similarity, that the current orientation of the apparatus corresponds to the orientation of the apparatus when calibrated at the calibrated arterial location.

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

The invention relates to an ultrasonic contrast image and dynamic image viewing method and viewing device. The viewing method comprises the following steps: under the condition that to-be-viewed image data is opened for manual viewing, receiving a first operation of setting a first viewing range by a user through an interaction component at a multi-frame first browsing step length; in response to detecting the first operation, positioning the image data to a viewing neighborhood containing a first viewing range; receiving a second operation executed by the user on the viewing neighborhood through the interaction component at a single-frame second browsing step length; and in response to the detected second operation, determining a corresponding current image frame when the user executes the second operation in the viewing neighborhood, and further positioning the image data to an adjacent frame of the current image frame so that the user can view the image data frame by frame. The method can help doctors to remarkably improve browsing efficiency and accurately position expected image frames, is convenient to operate and high in user friendliness, and can save time of the doctors and remarkably reduce workload of the doctors.

Methods of treating diseases associated with pathologic neuronal cells are provided. Accordingly, there is provided a method of treating a disease associated with pathologic neuronal cells characterized by aberrant excitability comprising: (a) administering into a first neural region of the subject a therapeutically effective amount of a polynucleotide encoding a bistable type II opsin attached to a heterologous ER export signal and / or membrane trafficking signal which enables trafficking of said bistable type II opsin to axon and / or dendrite terminals, wherein said first neural region comprises cell bodies of said pathologic neuronal cells; and (b) exposing a second neural region of said subject to light in a wavelength that activates said bistable type II opsin, wherein said second neural region comprises axon or dendrite terminals of said pathologic neuronal cells associated with a symptom of said disease, and wherein said first neural region and said second neural region are distinct.

Portable bimodal probe intended to be applied to a biological tissue to be examined, the probe comprising: - an ultrasonic transducer (34, 63) configured to transmit ultrasonic waves into the tissue and to receive ultrasonic waves reflected by the tissue, the transducer extending along a transverse axis; - at least two optodes (32, 60, 62a, 62b) arranged on either side of the transverse axis, such that the transducer extends between the two optodes; - each optode comprising a housing (52, 61), the housing comprising: a light transmitter (31) configured to transmit a light wave to the tissue; and / or an optical detector (32) configured to detect a light wave propagated by the tissue; - the optodes being designed such that at least one light transmitter and at least one optical detector are arranged on either side of the transducer; - at least one optical detector having a detection surface (53, 63a, 63b) formed of a semiconductor material and connected to an electronic card (54).

Disclosed herein are a method and apparatus for photoacoustic imaging (PAI) or ultrasound (US) imaging of biological tissue (18). The method comprises recording 2D-PAI and / or US images (46) of said biological tissue (18), each 2D-PAI or US image (46) being associated with a corresponding image plane (38), providing, prior to recording said 2D-PAI or US images (46) of said biological tissue (18), an optical pattern (28, 40) on or close to a surface of said biological tissue, said optical pattern (28, 40) comprising one or more optical dyes configured for absorbing light at a pattern-characteristic wavelength. The optical pattern (28, 40) is configured such that the location of the image plane (38) with respect to the optical pattern (28, 40) can be determined at least approximately from said representation of the optical pattern (28, 40) in said 2D-PAI image (46) and / or that the relative location of consecutively taken 2D-PAI images (46) with respect to each other can be at least approximately determined.