76results about "Diagnostics using tomography" patented technology

Disclosed herein is a near-infrared imaging system for identifying a target feature in an object. The system comprises a near-infrared transmitter receiver array for transmitting near-infrared radiation into the object and receiving corresponding near-infrared radiation emitted from the object and a data processing system (215) configured to process near-infrared radiation received via the near-infrared transmitter receiver array in accordance with a near- infrared imaging model (216). The system further comprises signal transmitting means (205) arranged to transmit one or more further signals into the object; and signal receiving means (206) arranged to receive the one or more further signals from the object. The data processing system (215) is further configured to process one or more characteristics of the one or more further signals received by the signal receiving means (206) to generate one or more constraints (218) to apply to the near-infrared imaging model (216).

The invention relates to a three-dimensional fluorescence tomography imaging device, which comprises a shooting part, an image processing part, a plurality of exciting light emitting parts, a tomography light emitting part, a first reflecting mirror, a beam splitter, a second reflecting mirror, a multi-wavelength light source part and a wavelength adjustable light filter, the image processing part calculates the depth corresponding to each fluorescent image according to the depth information in the optical coherence tomography image, and combines each fluorescent image according to the depth to form a three-dimensional fluorescent tomography image of the shooting object corresponding to the first fluorescent developing agent.

The present application provides a kind of optical angiography based on optical coherence tomography, first by optical coherence tomography system to biological tissue B scanning and C scanning, obtains three-dimensional structure image.The interference spectrum of each A scanning signal of B scanning is preprocessed, and the interference spectrum is decomposed into N sub-interference spectrum signals, N is greater than or equal to 2.Fourier transform is carried out to the sub-interference spectrum signal, and N groups of structure map data at the same position are obtained.Speckle variance is solved to N groups of structure map data, and speckle variance is averaged in depth direction.Compared with prior art, the present application angiography method does not need to repeat signal acquisition at the same position, greatly improves the acquisition speed of system, and can avoid the interference of traditional optical coherence tomography angiography system on reconstructed image caused by living sample shaking.

Method for operating a dental diagnostic imaging system for temporomandibular joint (TMJ) diagnostics and / or TMJ therapy, providing at least two modalities for generating (205, 210) three-dimensional image data, wherein a first image and at least a second image depicting the surface of the object (120) to be imaged are tomographically generated for a dental object (120) comprising at least one TMJ (105, 110), wherein the at least two three-dimensional image data generated (205, 210) in the at least two images are combined by means of a multimodal registration (225, 230) (225), wherein the generation (205, 210) of the at least two three-dimensional image data on the object (120) to be imaged is carried out with markings (125, 310 - 325) captured in the at least two images of different modalities (200).and wherein the at least two three-dimensional image data are spatially assigned to the temporomandibular joint (105, 110) by means of multimodal registration (225, 230) on the basis of the markers (125, 310-325) captured in the three-dimensional image data of both modalities (225), wherein the markers (125, 310-325) are arranged in a spatially restricted recording area for the at least two recordings of different modalities, wherein the markers (125, 310-325) are visible in the at least two recordings of different modalities, and wherein the image data generation is carried out at least by means of the first tomographic recording with the spatially restricted recording area corresponding to the markers (125, 310-325) (205, 210), wherein the spatially restricted recording area is arranged within the oral region of a patient for temporomandibular joint diagnostics and / or for temporomandibular joint therapy, characterized in thatthat the markings (125, 310 - 325) are arranged on a template (115) that can be precisely positioned within the patient's oral cavity, wherein the template (115) is placed in the restricted recording area (200) before the generation (205, 210) of the three-dimensional image data.

The application discloses an imaging method for fusing photon weight and diffuse light brain tissue blood oxygen concentration change quantity and related products, and relates to the technical field of biological tissue blood oxygen imaging. The method comprises the following steps: acquiring experimental data obtained by irradiating a measured tissue with light sources of two wavelengths; performing the following calculation on the experimental data corresponding to each wavelength of the light source: calculating the average photon transmission path of the kth light probe combination in the ith voxel unit by using a formula; calculating the photon weight of the kth light probe combination in the ith voxel unit by using a formula; calculating the change quantity of the tissue absorption coefficient of the ith voxel unit by using a formula; and finally calculating the change quantity of the concentrations of oxyhemoglobin and deoxyhemoglobin by using the calculation data obtained by the two wavelengths. The application proposes a method for fusing photon weight, and by means of weight calculation, the accurate brain tissue blood oxygen concentration change quantity can be obtained by using a small amount of S-D combination photon signals.

This image diagnosis catheter has an outer tube, an inner tube, an inner-tube support tube, and a drive shaft in this order, and further includes: an inner tube spacer that holds the inner-tube support tube so as to define an inner-tube support tube outer flow path; a connector hub movable to a distal end side and a proximal end side relative to the outer tube together with the inner tube, the inner-tube support tube, the drive shaft, and the inner tube spacer; and an inner flow path and an outer flow path through which a priming solution flows. An inner-tube-spacer proximal-side flow path is formed on the proximal end side relative to the inner tube spacer. At least the inner tube spacer defines an inner-tube-spacer partition flow path. The inner flow path includes the inner-tube-spacer proximal-side flow path and an inner-tube support tube inner flow path in this order from an upstream side to a downstream side. The outer flow path includes the inner-tube-spacer proximal-side flow path, the inner-tube-spacer partition flow path, and the inner-tube support tube outer flow path in this order from the upstream side to the downstream side.

A high-dispersion single-mode hybrid optical fiber (1900) located in one of the reference arm or probe arm of an optical interferometer, wherein the hybrid fiber (1900) comprises at least two optical fibers (1902,1902), at least one of the at least two optical fibers having a different core diameter and at least one of the at least two optical fibers having different dispersion characteristics, the at least two optical fibers being fused together at their ends to form a hybrid optical fiber, and each of the at least two optical fibers having a length based on the core diameter of the optical fiber with respect to the central wavelength of the light beam passing through the hybrid optical fiber and a target GDD per unit length based on the target length of the hybrid optical fiber, wherein the hybrid optical fiber adds an additional GDD value compared to an optical fiber in the other of the reference arm or probe arm of an optical interferometer.

In accordance with various embodiments of the present disclosure, a device for non-invasive medical imaging is provided. In some embodiments, the device comprises a photonic integrated circuit scale dual frequency comb (DFC), a hand-held wand, and at least one processing element. The wand comprises at least one emission point for emitting light from the DFC at a plurality of different wavelengths and at least three sensors. The wand directs the emitted light at one or more bodily structures. The sensors are adapted to detect acoustic waves from thermo-elastic changes in one or more elements within the bodily structures. The processing element is for generating an optical absorption spectrum from the detected acoustic waves, identifying one or more elements within the bodily structures based on the optical absorption spectrum, and generating a three-dimensional image of the elements based on the optical absorption spectrum from the detected acoustic waves.

The disclosure provides a breast dynamic optical tomography system based on fluorescence image guidance, comprising: a first lifting platform for adjusting the height of a light source module and a detection module; a second lifting platform for controlling the movement of a pressing plate; one side of the pressing plate is fixed on the second lifting platform, and the other side is used for pressing the tissue to be detected; the light source module generates detection light; the detection module samples the surface emission light of the detection light after passing through the tissue to be detected to obtain each wavelength emission light image; a host module processes the surface fluorescence image by using a fluorescence diffuse optical tomography method to obtain a segmentation image; the time sequence of the surface diffuse light image is demodulated to obtain the time sequence of the surface diffuse light image corresponding to each wavelength; and a diffuse optical tomography method is used to process the segmentation image and the time sequence of the surface diffuse light image corresponding to each wavelength to obtain the time sequence of the three-dimensional image of the absorption coefficient change corresponding to each wavelength.

Some disclosed methods involve controlling, by a control system, at least one sensor to capture image data corresponding to a current arterial location of an artery based on a current orientation of the apparatus. Some such methods involve obtaining, by the control system, calibration information associated with at least one calibrated arterial location at which the apparatus was previously calibrated, wherein the calibration information includes image data captured by the at least one sensor of the calibrated arterial location. Some such methods involve determining, by the control system, a threshold similarity between the image data corresponding to the current arterial location and the image data corresponding to the calibrated arterial location. Some such methods involve determining, by the control system and based on the threshold similarity, that the current orientation of the apparatus corresponds to the orientation of the apparatus when calibrated at the calibrated arterial location.

The invention relates to a method for reducing noise and decoupling local birefringence of intravascular polarization sensitive coherence tomography. The method comprises the following steps: acquiring a measurement Mueller matrix from a catheter polarization sensitive optical coherence tomography PS-OCT system; determining a reference measurement Mueller matrix; acquiring a global Mueller matrix; obtaining a medium depolarization moment according to a medium depolarization extraction method; calculating a pseudo-depolarization-free matrix; obtaining a noise depolarization matrix; calculating a standard deviation matrix for the noise depolarization matrix; obtaining a phase delay initial value delta0; generating a test noise depolarization matrix; generating a noise reduction global Mueller matrix; calculating a local Mueller matrix; calculating a local birefringence; and performing traversal calculation to obtain a local birefringence two-dimensional polar coordinate distribution diagram.

Some disclosed methods involve controlling, by a control system, at least one sensor to capture image data corresponding to a current arterial location of an artery based on a current orientation of the apparatus. Some such methods involve obtaining, by the control system, calibration information associated with at least one calibrated arterial location at which the apparatus was previously calibrated, wherein the calibration information includes image data captured by the at least one sensor of the calibrated arterial location. Some such methods involve determining, by the control system, a threshold similarity between the image data corresponding to the current arterial location and the image data corresponding to the calibrated arterial location. Some such methods involve determining, by the control system and based on the threshold similarity, that the current orientation of the apparatus corresponds to the orientation of the apparatus when calibrated at the calibrated arterial location.

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

The invention relates to an ultrasonic contrast image and dynamic image viewing method and viewing device. The viewing method comprises the following steps: under the condition that to-be-viewed image data is opened for manual viewing, receiving a first operation of setting a first viewing range by a user through an interaction component at a multi-frame first browsing step length; in response to detecting the first operation, positioning the image data to a viewing neighborhood containing a first viewing range; receiving a second operation executed by the user on the viewing neighborhood through the interaction component at a single-frame second browsing step length; and in response to the detected second operation, determining a corresponding current image frame when the user executes the second operation in the viewing neighborhood, and further positioning the image data to an adjacent frame of the current image frame so that the user can view the image data frame by frame. The method can help doctors to remarkably improve browsing efficiency and accurately position expected image frames, is convenient to operate and high in user friendliness, and can save time of the doctors and remarkably reduce workload of the doctors.

Methods of treating diseases associated with pathologic neuronal cells are provided. Accordingly, there is provided a method of treating a disease associated with pathologic neuronal cells characterized by aberrant excitability comprising: (a) administering into a first neural region of the subject a therapeutically effective amount of a polynucleotide encoding a bistable type II opsin attached to a heterologous ER export signal and / or membrane trafficking signal which enables trafficking of said bistable type II opsin to axon and / or dendrite terminals, wherein said first neural region comprises cell bodies of said pathologic neuronal cells; and (b) exposing a second neural region of said subject to light in a wavelength that activates said bistable type II opsin, wherein said second neural region comprises axon or dendrite terminals of said pathologic neuronal cells associated with a symptom of said disease, and wherein said first neural region and said second neural region are distinct.

Portable bimodal probe intended to be applied to a biological tissue to be examined, the probe comprising: - an ultrasonic transducer (34, 63) configured to transmit ultrasonic waves into the tissue and to receive ultrasonic waves reflected by the tissue, the transducer extending along a transverse axis; - at least two optodes (32, 60, 62a, 62b) arranged on either side of the transverse axis, such that the transducer extends between the two optodes; - each optode comprising a housing (52, 61), the housing comprising: a light transmitter (31) configured to transmit a light wave to the tissue; and / or an optical detector (32) configured to detect a light wave propagated by the tissue; - the optodes being designed such that at least one light transmitter and at least one optical detector are arranged on either side of the transducer; - at least one optical detector having a detection surface (53, 63a, 63b) formed of a semiconductor material and connected to an electronic card (54).

Disclosed herein are a method and apparatus for photoacoustic imaging (PAI) or ultrasound (US) imaging of biological tissue (18). The method comprises recording 2D-PAI and / or US images (46) of said biological tissue (18), each 2D-PAI or US image (46) being associated with a corresponding image plane (38), providing, prior to recording said 2D-PAI or US images (46) of said biological tissue (18), an optical pattern (28, 40) on or close to a surface of said biological tissue, said optical pattern (28, 40) comprising one or more optical dyes configured for absorbing light at a pattern-characteristic wavelength. The optical pattern (28, 40) is configured such that the location of the image plane (38) with respect to the optical pattern (28, 40) can be determined at least approximately from said representation of the optical pattern (28, 40) in said 2D-PAI image (46) and / or that the relative location of consecutively taken 2D-PAI images (46) with respect to each other can be at least approximately determined.

An optical apparatus (200) includes an outer jacket (230), common cladding (220), and multiple single mode fiber cores (210). The common cladding (220) is within the outer jacket (230) and is used as multimode fiber such that the outer jacket (230) clads the common cladding (220). The single mode fiber cores (210) are within the common cladding (220) such that the common cladding (220) clads the plurality of single mode fiber cores (210).

The present disclosure relates to methods for performing minimally invasive anatomical space access, e.g., minimally invasive subretinal access (MISA), in connection with the delivery of therapeutic modalities to an anatomical space of interest, e.g., the subretinal space, and system components adapted to facilitate such delivery.

Methods of treating diseases associated with pathologic neuronal cells are provided. Accordingly, there is provided a method of treating a disease associated with pathologic neuronal cells characterized by aberrant excitability comprising: (a) administering into a first neural region of the subject a therapeutically effective amount of a polynucleotide encoding a bistable type II opsin attached to a heterologous ER export signal and / or membrane trafficking signal which enables trafficking of said bistable type II opsin to axon and / or dendrite terminals, wherein said first neural region comprises cell bodies of said pathologic neuronal cells; and (b) exposing a second neural region of said subject to light in a wavelength that activates said bistable type II opsin, wherein said second neural region comprises axon or dendrite terminals of said pathologic neuronal cells associated with a symptom of said disease, and wherein said first neural region and said second neural region are distinct.

An imaging system is provided comprising an imaging probe and at least one delivery device. The imaging probe comprises an elongate shaft, a rotatable optical core and an optical assembly. The elongate shaft comprises a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion. The rotatable optical core is positioned within the lumen of the elongate shaft and comprises a proximal end and a distal end. The rotatable optical core is configured to optically and mechanically connect with an interface unit. The optical assembly is positioned in the elongate shaft distal portion and proximate the rotatable optical core distal end. The optical assembly is configured to direct light to tissue and collect reflected light from the tissue. The imaging probe is constructed and arranged to collect image data from a patient site. The at least one delivery device is constructed and arranged to slidingly engage the imaging probe. Methods of introducing the imaging probe and the at least one delivery catheter into a patient are also provided.

Disclosed are a method and an apparatus for examining bone formation of alveolar bone using an oral scanner having a tomographic function. The bone formation inspection method for alveolar bone comprises: a step of filling a bone graft material into an alveolar bone to be subjected to bone graft, suturing gingiva, and then acquiring a surface shape image of a portion where the alveolar bone is formed by using a surface shape acquisition optical system; a step for acquiring an internal cross-sectional image showing the state of the alveolar bone and the bone graft by means of an internal cross-sectional acquisition optical system at a predetermined position in the acquired surface shape image; a step of moving the oral scanner to acquire a gingival surface shape after a predetermined period of time has elapsed, and when the gingival surface shape at a position at which the internal cross-sectional image was previously acquired is detected, acquiring an internal cross-sectional image showing the state of the alveolar bone and the bone graft at the position using an internal cross-sectional acquisition optical system of the oral scanner; and a step for comparing the internal cross-sectional images acquired at predetermined intervals.

In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's / subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and / or structural ophthalmic tests and output the test data

A method for fluorescence imaging tomography includes placing at least one subject on an imaging platform. The method further includes controlling light emanating from a light source to project an illumination pattern comprising at least one line onto the at least one subject. The method further includes acquiring, at a plurality of locations on a detector, light intensity values at excitation wavelengths resulting from the projecting of the illumination pattern onto the at least one subject. The method further includes acquiring, at the plurality of locations on the detector, light intensity values at emission wavelengths resulting from a fluorescence response of fluorescent sources within the at least one subject to the projecting of the illumination pattern the at least one subject. The method further includes generating an image of the fluorescent sources within the at least one subject based on the acquired light intensity values and outputting the image.

The application discloses a line illumination modulation multicolor imaging system, belonging to the technical field of multicolor imaging, comprising: a line illumination modulation module, comprising m monochromatic light sources and a modulation light path, the wavelength of the light beam emitted by each monochromatic light source is different; each light beam passes through the modulation light path to form a line light spot focused on the focal plane of an objective lens, the illumination intensity of the line light spot on the focal plane of the objective lens is in Gaussian distribution in a first direction, the position parameters of each line light spot are different, and the line light spots of the m channels are superimposed to form m-color line illumination light; an imaging module is used for continuously scanning imaging along the first direction by using a multi-element detector with n rows of pixels, and at least m mixed images under the irradiation of the line illumination light are obtained, each mixed image corresponds to one row of pixels, and each mixed image contains signals of the m channels; and an image demodulation module is used for demodulating monochromatic images from the mixed images, and each monochromatic image corresponds to the signals of one channel. The application realizes synchronous multicolor imaging on a single detector.

A method of determining a surgical spinal correction for a subject using analysis of motion capture images of the subject, which uses the steps of obtaining pre-operative three- dimensional images of a spinal region, obtaining a pre-operative time sequenced set of images of the subject during a movement progression of said subject, calculating in a plurality of the motion capture images, alignment parameters relating to upper and lower body regions of the subject, and determining if any of the calculated alignment parameters are outside their predetermined acceptable ranges in one or more of the images, iteratively adjusting anatomical elements in three-dimensional images until all of the calculated alignment parameters are within their predetermined acceptable ranges; and adjusting spinal anatomy in the three-dimensional images according to the degree of adjustment of spinal parameters in the motion capture images to determine a surgical spinal correction.

There is provided a method of reconstruction of a target brain structure(s), comprising: reconstructing at least a part of a brain comprising boundaries of brain structures that include the target brain structure(s), wherein the reconstruction is insufficient for parceling of the target brain structure(s) into sub-structures of a same type of gray or white matter, reconstructing and parceling the target brain structure(s) using a reference atlas, segmenting and parceling at least one originating brain structure using the reference atlas, filtering white matter fibers to isolate at least one target white matter tract connecting the originating brain structure(s) and the target brain structure(s), and creating a 3D reconstruction of the target brain structure(s) and the target white matter tract(s), wherein the target white matter tract(s) and the target brain structure(s) are transformed and / or mapped to an anatomical native space.

This invention provides a method and apparatus for examining alveolar bone formation using an oral scanner with tomography capabilities. [Solution] A method for examining alveolar bone formation, comprising the steps of: filling the alveolar bone requiring bone grafting with bone graft material, suturing the gums to cover the bone graft material, obtaining a surface shape image of the portion where alveolar bone is to be formed using the surface shape acquiring optical meter; obtaining an internal cross-sectional image showing the state of the alveolar bone and bone graft material at a predetermined position in the obtained surface shape image using the internal cross-sectional acquiring optical meter; after a predetermined period of time has elapsed, moving the oral scanner to obtain the surface shape of the gums, and if the surface shape of the gums at a position where an internal cross-sectional image was previously obtained is detected, obtaining an internal cross-sectional image showing the state of the alveolar bone and bone graft material at that position using the internal cross-sectional acquiring optical meter of the oral scanner; and comparing the internal cross-sectional images obtained at predetermined intervals.

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

The application discloses a kind of scanning method and system of intraoral tomographic image based on machine vision, it is related to medical imaging technical field, the method includes: by miniaturized optical probe in oral cavity along preset trajectory moves and gathers image and information;Adaptive light compensation is executed, feature point extraction and matching, probe pose estimation;Carry out depth optimization and hole filling;Generation continuous tomographic slice;Realize the closed-loop control of tomographic image layer thickness consistency;The system includes: miniaturized optical probe module;Multi-modal data fusion and pose estimation module;Real-time depth optimization and hole repair module;Tomographic slice generation and layer thickness closed-loop control module;Central processing and display module.The application can improve the robustness and precision of probe motion trajectory estimation, repair depth map hole and distortion, ensure that tomographic slice sequence has uniform resolution in Z axis direction, and realize whole-process real-time or quasi-real-time processing, improve the practicability and diagnostic efficiency of system.