52 results about "Tissue elasticity" patented technology

A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.

A robotic system for flexible needle steering under ultrasound imaging. A robot is used to steer the needle along a predetermined curved trajectory by maneuvering the needle base. The needle tip position is detected by an ultrasound sensor and the tracking error of the needle tip from a predetermined needle path is input to a controller which solves the inverse kinematic based on the needle position, and the needle and tissue properties. The control algorithm uses a novel method to detect the elastic properties of the tissue by analyzing tissue motion at the region in front of the needle tip. The inverse kinematic solution may be performed on a model of the needle as a flexible beam having laterally connected virtual springs to simulate lateral forces exerted by the tissue elasticity. The system is able to direct the needle to a target within the tissue while circumventing forbidden regions.

A robotic system for flexible needle steering under ultrasound imaging. A robot is used to steer the needle along a predetermined curved trajectory by maneuvering the needle base. The needle tip position is detected by an ultrasound sensor and the tracking error of the needle tip from a predetermined needle path is input to a controller which solves the inverse kinematic based on the needle position, and the needle and tissue properties. The control algorithm uses a novel method to detect the elastic properties of the tissue by analyzing tissue motion at the region in front of the needle tip. The inverse kinematic solution may be performed on a model of the needle as a flexible beam having laterally connected virtual springs to simulate lateral forces exerted by the tissue elasticity. The system is able to direct the needle to a target within the tissue while circumventing forbidden regions.

An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

The present invention discloses a device and methods for characterizing vulnerable plaque and cancer tissue by measuring changes in tissue elasticity compared to that of normal tissue. The system includes a catheter with an expandable element at a proximal end. The expandable element is equipped with pressure sensors to detect changes in tissue elasticity and can be additionally equipped with sensors that detect tissue temperature and pH. For arterial tissue or tissue lining a body cavity, the device can also be equipped with width gauges that measure the diameter of the artery lumen or the width of any section of the body cavity. The distal end of the catheter may be attached to a motorized pullback device connected to a computer. Data collected by the device sensors are sent to the computer for processing and analysis.

An ultrasonic diagnostic apparatus having a function of obtaining a tomographic image and an elastic image is adaptable to not only a close examination mode, but also a screening mode, and obtains an elastic image suitable for each examination purpose. Accordingly, the ultrasonic diagnostic apparatus of the present invention comprises tomographic image acquisition means for transmitting an ultrasonic wave from a probe to a body being examined, and receiving a reflection echo signal corresponding to the transmission of the ultrasonic wave to obtain a tomographic image, elastic image acquisition means having a first acquisition mode for determining a tissue elasticity amount of a biomedical tissue of the body being examined on the basis of the reflection echo signal to obtain an elastic image, and display means for displaying at least the elastic image. The elastic image acquisition means has a second acquisition mode different from the first acquisition mode.

A system and method are provided for assessing the compliance of internal patient tissue for purposes of catheter guidance and / or ablation procedures. Specifically, the system / method provides for probing internal patient tissue in order to obtain force and / or tissue displacement measurements. These measurements are utilized to generate an indication of tissue elasticity. In one exemplary embodiment, the indication of elasticity is correlated with an image of the internal tissue area and an output of this image including elasticity indications is displayed for a user.

Methods for assessing viscoelastic properties of soft tissues are based on detecting an inflection point on a pressure-time plot when air is aspirated from a cavity placed over the tissue sample. A small diameter tube through which air aspiration is conducted is ultimately closed off by tissue being drawn into the cavity causing an abrupt change in pressure slope. First or second derivatives of the pressure-time plot can be used to detect the inflection point. Repeating the test with a different aspiration rates or after a predetermined relaxation time allows determining tissue viscosity and tissue creep in addition to tissue elasticity expressed as Young's modulus.

A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.

The invention provides a micro-elasticity imaging method based on a tissue microbubble dynamics model. According to the invention, a mother wavelet which has strong correlation with a microbubble signal and weak correlation with a tissue signal is established according to that microbubble vibration is influenced by characteristics of a surrounding tissue, and a tissue microbubble dynamics model can be used for establishing the relation of a microbubble vibration signal and tissue elasticity, the microbubble signal is detected for imaging through a pulse inversion and wavelet transform combined imaging algorithm, and when the detection signal is the closest to a model signal, the maximum tissue contrast ratio can be obtained, so that the elasticity parameters of the tissue within the range of a dozen to tens of microns around the tissue are obtained in a reverse derivation manner. The method can be applied to real-time monitoring on a high-intensity focused ultrasound therapeutic process and elasticity detection of a biological thin-layer tissue, can overcome the limitations that the general elasticity imaging requires external pressure, and is influenced by boundary conditions easily, and effectively improves the imaging resolution to the micron level from the millimeter level.

A method of monitoring the cryoablation of a target volume of tissue with ultrasound elastography, the method comprising acquiring a first elastography image encompassing said target volume of tissue, performing at least one cycle of freezing and thawing of tissue encompassed in said target volume, acquiring a second elastography image encompassing said target volume, and comparing said first and said second elastography images over said target volume. The elastography provides either relative or quantitative measurements of tissue elasticity. The elastography maps of tissue elasticity, before and after cryoablation of one region, can guide the cryoablation of another region. The use of elastography provided feedback to the operator to achieve effective treatment with cryoblation over a planned target.

The invention discloses a tissue inflammation activity detection method and apparatus. The detection method includes judging whether tissue has possibility of inflammation or not, if so, then determining inflammation activity according to tissue hardenability or parameter reflecting the tissue hardenability. Since the tissue hardenability or parameter reflecting the tissue hardenability can be measured by the noninvasive quantitative detection technology to tissue elasticity modulus, defects caused by biopsy are avoided, and tissue inflammation activity can be detected in a noninvasive, continuous and accurate manner.

The invention provides a tissue elasticity imaging method and a graphics processor. The tissue elasticity imaging method comprises the following steps: receiving first ultrasonic signals and second ultrasonic signals before and after tissue deformation; storing the first ultrasonic signals, the second ultrasonic signals, parameters contained in a cross-correlation algorithm into a global storage corresponding to a GPU; allocating corresponding processing threads for each data window according to the number of the data windows, carrying out parallel computing on the cross correlation coefficients of the first ultrasonic signals and second ultrasonic signals in the corresponding data windows through the processing threads, thus obtaining the displacement estimation value corresponding to each data window; carrying out filtering processing on the displacement estimation values to obtain strain estimation values corresponding to the displacement estimation values respectively; and carrying out imaging process on the strain estimation values to obtain the tissue elasticity imaging result. According to the invention, through the multi-thread parallel processing mode, while the accuracy of the tissue elasticity imaging result is guaranteed, and the processing speed of elasticity imaging is obviously improved.

Systems and methods for accessing, stabilizing and sealing a device attached to a tissue surface comprising a tissue attaching device having an outer base ring defining an opening therethrough and a distally projecting tissue attachment element. The systems variously utilize annular sealing flanges distally attached to the outer base ring outside or inside the tissue attachment element to create a fluid tight seal. The systems variously utilize coils with regions of differing pitch to create sealing tissue pressure. Methods for installing an apical attaching device with a transapical port into a patient, comprising assessing the patient's viability for installation of the apical attaching device by determining an Index of Tissue Elasticity (ITE).

The invention discloses a tissue elasticity detection method and device. A signal of a tissue in a detection area is obtained, and the signal reflects a movement state of the tissue in the detection area; whether the movement state meets a preset condition or not is judged; and when the movement state meets the preset condition, elasticity of the tissue in the detection area is detected. The problem that a movement state of a tissue in an area to be detected affects accuracy of elastic detection is solved, and the accuracy of the elasticity detection of the tissue in the detection area is improved.

A device for elastic ligature of tissues comprises: a first and a second element, one of which exhibits a support portion for at least a rubber ring, the elements being slidably coupled to one another such that a reciprocal sliding between the elements determines a release of a rubber ring from the support portion; a trigger, manually maneuverable by an operator and acting on at least the second element for realizing a reciprocal sliding between the elements; a connecting portion, connected to the trigger and to the second element and being elastically deformable in order to enable a reciprocal change of orientation between the trigger and the second element.

The invention provides a tissue evaluation method, device and apparatus and a computer-readable storage medium. The method includes the steps of acquiring examination results of a patient, inputting the examination results and a tissue identifier into a tissue evaluation model, and outputting an evaluation result, wherein the examination results include tissue elasticity, the thickness of subcutaneous tissue around the examined tissue and blood examination parameters. The tissue evaluation method, device and apparatus and the computer-readable storage medium have the advantages that the multiple examination results of the patient can be integrated, the evaluation result is output based on the tissue evaluation model, and thus medical staff can refer to the evaluation result to diagnose thepatient; compared with a method in which medical staff diagnose a patient directly according to an ultrasound result, the method is more accurate.

The invention relates to a monitoring system for continuously monitoring a tissue condition of a subject, wherein the monitoring system comprises a blood oxygen measurement module for measuring a blood oxygen signal of the subject, an elastic measurement module for measuring a tissue elasticity signal of the subject, and a processing module for processing the blood oxygen signal and the tissue elasticity signal of the subject to estimate the tissue condition of the subject and outputting the tissue condition. The tissue condition includes at least one of ulcer and bedsore. Through the monitoring system, early warning can be provided in the early stage of onset to remind patients and nurses to take timely measures.

An ultrasonic diagnostic apparatus having a function of obtaining a tomographic image and an elastic image is adaptable to not only a close examination mode, but also a screening mode, and obtains an elastic image suitable for each examination purpose. Accordingly, the ultrasonic diagnostic apparatus of the present invention comprises tomographic image acquisition means for transmitting an ultrasonic wave from a probe to a body being examined, and receiving a reflection echo signal corresponding to the transmission of the ultrasonic wave to obtain a tomographic image, elastic image acquisition means having a first acquisition mode for determining a tissue elasticity amount of a biomedical tissue of the body being examined on the basis of the reflection echo signal to obtain an elastic image, and display means for displaying at least the elastic image. The elastic image acquisition means has a second acquisition mode different from the first acquisition mode.

The invention relates to ultrasound methods and medical diagnostic apparatus using ultrasound probing for estimation of the biological tissue elastic properties by determining the propagation velocity of shear wave and imaging the elastic properties of tissue. The method is based on the determining the shear wave front propagation velocity along and perpendicular to the axis of excitation (Ox). In order to implement the method, a power ultrasound beam of waves is used for excitation of shear wave and a plurality of ultrasound pulses is sequentially transmitted to detect the tissue displacement by means of tissue response signals. The image of at least one parameter of tissue elasticity is acquired taking into account the noise level that occurred when determining the shear wave propagation velocity. The results are displayed in the form of images of the elasticity parameters and the noise level and indication of quantitative values of elasticity parameters and noise level. The technical result is to increase the accuracy and reliability of the measurements and increase the spatial resolution when imaging the biological tissue parameters in real time.

When tissue elasticity of a subject is measured, an ultrasound diagnostic apparatus sets a sound velocity for each of segment regions established by dividing the subject, processes reception signals output by a piezoelectric element array based on the set sound velocities, and performs tissue elasticity measurement based on the reception signals processed based on the set sound velocities. Owing to this configuration, when tissue elasticity of a subject is measured, the ultrasound diagnostic apparatus prevents the accuracy of tissue elasticity measurement from deteriorating due to image distortions.

Methods, systems, and computer readable media for taking measurements of a material, including determining material anisotropy, are provided. According to one aspect, a method for determining tissue anisotropy comprises: applying, to a tissue sample, a first force having a direction and having a coronal plane normal to the direction of the force, the first force having an oval or other profile with long and short axes within the coronal plane, the long axis being oriented in a first direction within the coronal plane, and measuring a first displacement of the tissue; applying, to the tissue sample, a second force, and measuring a second displacement of the tissue; and calculating a tissue elasticity anisotropy based on the measured first and second displacements. Furthermore, by applying the first and second forces multiple times, tissue viscosity, elasticity, or other anisotropy may be calculated from the multiple displacement measurements.

The invention relates to a tissue condition monitoring system which can be wirelessly charged. The tissue condition monitoring system comprises a blood oxygen measurement module for measuring a bloodoxygen signal of a subject, an elastic measurement module for measuring a tissue elasticity signal of the subject, a wireless charging module for wirelessly charging a battery of the monitoring systemand comprising multiple resonance coils, and a processing module for processing the blood oxygen signal and the tissue elasticity signal of the subject to estimate and output the tissue conditions ofthe subject, including at least one anabrosis and bedsores. By means of the monitoring system, early warning can be provided at the early stage of diseases attack, electric energy can be supplementedin time, and a user can be continuously and uninterruptedly monitored to remind a patient and a nurse worker of timely taking of measures.

In a methods for elastography in a defined region of an examined person, a radio-frequency pulse is radiated to manipulate a transverse magnetization in the defined region and at least one additional radio-frequency pulse with a spatial selectivity of the amplitude is radiated to generate shear waves in the defined region. A magnetic resonance signal from the defined region is detected and a determination of a value describing the tissue elasticity in the defined region is made based on the magnetic resonance signal.

In a methods for elastography in a defined region of an examined person, a radio-frequency pulse is radiated to manipulate a transverse magnetization in the defined region and at least one additional radio-frequency pulse with a spatial selectivity of the amplitude is radiated to generate shear waves in the defined region. A magnetic resonance signal from the defined region is detected and a determination of a value describing the tissue elasticity in the defined region is made based on the magnetic resonance signal.

The embodiment of the invention provides a tissue elasticity detection method, device and system. The method comprises the steps: obtaining a contact parameter between a detection probe and a to-be-detected object, the contact parameter being used for representing the contact degree between the detection probe and the to-be-detected object; if the contact parameter meets a first threshold condition, controlling the detection probe to transmit and receive an ultrasonic signal to the to-be-detected object so as to determine a target detection position of the to-be-detected object; and if the contact parameter meets a second threshold condition, controlling the detection probe to perform shear wave excitation on the target detection position of the to-be-detected object so as to measure the elasticity of the target detection position of the to-be-detected object. According to the embodiment of the invention, an operator can accurately judge the opportunity of ultrasonic signal emission and shear wave excitation, so that the stability and accuracy of a measurement result are improved.

The invention discloses a method and equipment for detecting tissue elasticity. According to the method, a first ultrasonic signal is transmitted to a tissue in a detection area; at least one imagingline of the first ultrasonic signal is tracked; a movement state of each imaging line is determined according to the imaging line of a plurality of time points; and a position of an imaging line whosemovement state meets preset conditions is selected, and tissue elasticity detection is carried out. The problem that a movement state of a tissue in an area to be detected affects accuracy of elasticity detection is solved, and the accuracy of elasticity detection for the tissue in the detection area is improved.